PKR

Species: Mouse
Alias: PKR, Prkr
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: PKR

Sequence

Name Sequence Type Origin Length Description Download
PKR.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 259 Kinase domain by global Sugen HMM Fasta, JSON
PKR.AA Protein Sugen 515 None Fasta, JSON
PKR.NA RNA Sugen 4312 None Fasta, JSON

Protein domain

Protein domains of PKR.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Dsrm PKR.AA dsrm 9-74 29 1.8e-18 69.92 Pfam 1-67 (67) Show / Hide
Range on Protein: 9-74
Range on HMM: 1-67/67
Sequence Identity: 29% (20 aa)

YMDKLNK-YRQMHGVAITYKELSTSGPPHD-RRFTFQVLIDEKEFPEAKGRSKQEARNAAAKLAVDIL
.. .|.  | | .|  . |..... ||||. ..|| .. ...|.. ...|..|.||...||..|...|
PKSQLQEYYCQKNGWKPPYYYIEQ-GPPHHCPTFTCTCTVNGKKYGTGWGSNKKEAKQQAAMKALQKL

Dsrm PKR.AA dsrm 96-160 36 1.7e-14 55.54 Pfam 1-67 (67) Show / Hide
Range on Protein: 96-160
Range on HMM: 1-67/67
Sequence Identity: 36% (25 aa)

YIGLVNS-FAQKKKLSVNYE---QCEPNSELPQRFICKCKIGQTMYGTGSGVTKQEAKQLAAKEAYQKL
.... .  ..||... ..|.   | .|  . | .|.| |... . ||||.| .|.||||.||..|.|||
PKSQLQEYYCQKNGWKPPYYYIEQ-GPPHHCP-TFTCTCTVNGKKYGTGWGSNKKEAKQQAAMKALQKL

Kinase PKR.AA PKR 242-500 83 5.4e-213 713.88 In-house 1-272 (272) Show / Hide
Range on Protein: 242-500
Range on HMM: 1-272/272
Sequence Identity: 83% (226 aa)

FEDIEEIGLGGFGQVFKAKHRIDGKRYAIKRVKYNTEKAEHEVQALAELNHVNIVQYHSCWEGVDYDPEHS-------------MSDTSRYKTRCLFIQM
|.||||||.||||||||||||||||||.|||||||.|||||||||||.|.|||||.|||||.|.|||||||             |.||||||||||||||
FKDIEEIGSGGFGQVFKAKHRIDGKRYVIKRVKYNNEKAEHEVQALAKLDHVNIVHYHSCWDGFDYDPEHSDDSLESSDYDPENMKDTSRYKTRCLFIQM

EFCDKGTLEQWMRNRNQSKVDKALILDLYEQIVTGVEYIHSKGLIHRDLKPGNIFLVDERHIKIGDFGLATALENDGKSRTRRTGTLQYMSPEQLFLKHY
|||||||||||||||.|.||||.||||||||||.||.|||||.||||||||.|||||||||||||||||.|||.|||||||||.||||||||||.|..||
EFCDKGTLEQWMRNRRQEKVDKVLILDLYEQIVKGVDYIHSKKLIHRDLKPSNIFLVDERHIKIGDFGLVTALKNDGKSRTRRKGTLQYMSPEQIFSQHY

GKEVDIFALGLILAELLHTCFTESEKIKFFESLRKGDFSNDIFDNKEKSLLKKLLSEKPKDRPETSEILKTL
||||||.|||||||||||.||||.|||||||.||.|||||||||||||.||.||||.||||||.|||||.||
GKEVDIYALGLILAELLHVCFTEFEKIKFFEDLRDGDFSNDIFDNKEKTLLQKLLSKKPKDRPNTSEILRTL

Kinase PKR.AA PEK 310-502 25 2.7e-87 296.34 In-house 331-655 (655) Show / Hide
Range on Protein: 310-502
Range on HMM: 331-655/655
Sequence Identity: 25% (84 aa)

EHSMSDTSRYKT-------------RCLFIQMEFCDKGTLEQWMRNR------------------------------------------NQSKVDKALIL
| ....|...|.             ..|.||||.|.|.||..|..|.                                          |....|| ...
EEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCW

DLYEQIVTGVEYIHSKGLIHRDLKPGNIFLVDERH-----IKIGDFGLATALE--------------------NDGKSRTRRT-----------------
.. .||..|..||||.|.|||||||.|||| .. .     .||||||||| .|                    .........|                 
RIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQNSPTGQDTHMWSNN

--------------------GTLQYMSPEQLFLK-----HYGKEVDIFALGLILAELLHTCFTES-EKIKFFESLRK------GDFSNDIFDNK---EKS
                    ||. |||||||  .     ||.. ||...||.|..|.... ||.. |..|.. .||.      |||....||||   ...
YHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQAD

LLKKLLSEKPKDRPETSEILKTLAE
.....|| .|..||....||...  
FIQWMLSHDPQQRPSAQQILQHEFF

Kinase PKR.AA S_TKc 242-501 30 9.7e-66 225.63 SMART 1-231 (231) Show / Hide
Range on Protein: 242-501
Range on HMM: 1-231/231
Sequence Identity: 30% (84 aa)

FEDIEEIGLGGFGQVFKAKHRIDGKRYAIKRVKYNTEKAEHEVQALAELNHVNIVQYHSCWEGVDYDPEHSMSDTSRYKTRCLFIQMEFCDK--GTLEQW
.| ...|| |.||.|.|..|. .|...|||..|   |... |.| | . .| |||... ...                   .|.. ||.||   |.| . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-----------------DHLYMVMEYCDGDLGDLFDY

MRNRNQ----SKVDKALILDLYEQIVTGVEYIHSKGLIHRDLKPGNIFLVDERHIKIGDFGLATALENDGKSRTRRTGTLQYMSPEQLFLKHYGK-EVDI
...|.     .. .   .  .  ||. ..||.||.| ||||||| ||.| .  ||||.|||||. |       |   ||. ||.|| |   .||| ..|.
IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDW

FALGLILAELLH--TCFTESEKIKFFESLRKGDFSNDIFDNKEKSLLKKLLSEKPKDRPETSEILK--------TLA
 ..| ||.|.|   . |   .  . |. ..         .   |....|.|   |..||   |.|.           
WSCGCILYEMLCGYPPFP--QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase PKR.AA Pkinase 242-500 26 1.4e-61 215.74 Pfam 1-293 (293) Show / Hide
Range on Protein: 242-500
Range on HMM: 1-293/293
Sequence Identity: 26% (83 aa)

FEDIEEIGLGGFGQVFKAKHRIDGKRYAIKRVKYNTEKAEH--------EVQALAELNHVNIVQYHSCWEGVDYDPEHSMSDTSRYKTRCLFIQMEFCDK
.. .. || |.||.|.|..|. .||..|.|..|. .|| .         |.| ...||| |||... ..|                |...  . ||.|..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---------------KDHIY-MVMEYCEG

G----TLEQWMRNRNQSKV--DKALILDLYEQIVTGVEYIHSKGLIHRDLKPGNIFLVDERHI----KIGDFGLATAL-ENDGKSRTRRTGTLQYMSPEQ
|     |  ... ... ..  .   . .   ||. |.||.||.| ||||||| ||..... ||    ||.|||||  . .  .   | ..||. ||.|| 
GLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV

LF-LKHYGKEVDIFALGLILAELLH--TCFTES------EKIKFFESLRKGDFSNDIF----------------------DNKEKSLLKKLLSEKPKDRP
.   ..||..||....|.||.|.|   . | ..      .... ..  ...... |..                      .   |...|..|  .||.||
IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP

ETSEILKT--L
   .||.   .
TAEQILQHPWF

Kinase PKR.AA CAMK 247-498 17 2.5e-47 150.14 In-house 1-421 (425) Show / Hide
Range on Protein: 247-498
Range on HMM: 1-421/425
Sequence Identity: 17% (73 aa)

EIGLGGFGQVFKAKHRIDG------------KRYAIKRVKY--------------------------------NTEKAEHEVQALAE-------LNHVNI
..| |.||.|....|. ..            ...||| ..                                 . .. ..|.. .         |.| ||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQYHSCWEGVDYDPEHSMSD--TSRY----KTRCLFIQM---EFCDKGTLEQWMRNRNQSK-----------------VDKALILDLYEQIVTGVEYIHS
.. .  .|  .| .   ..|  | ..    |...... |   |.|. | | . . .. ...                 .. .    .  ||. .|.|.||
IKLYEVYEDPHYFK-N-TNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS

KGLIHRDLKPGNIFLVDE-----------------RHIKIGDFGLATALEN-----------------------DGKSRTRRTGTLQYMS-PEQLF----
.. .|||||| || |.|                    ||| |||.|. ..                        .|.  . . ||. ||. || |     
HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

----------LKHYGKEVDIFALGLILAELLHTCFTESEK---------------IKFFESLRKGDFSNDIFDNKE------------------------
           . ||...|. ..| ||  .|  ..   ..                . ||  .||... . .  ..                        
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

-KSLLKKLLSEKPKDRPETSEILK
 |.|..|.|   |..|.  ...|.
CKDLIRKMLQVDPEKRMTIEQCLN

Kinase PKR.AA STE 242-445 23 4.9e-44 152.61 In-house 1-262 (359) Show / Hide
Range on Protein: 242-445
Range on HMM: 1-262/359
Sequence Identity: 23% (65 aa)

FEDIEEIGLGGFGQVFKAKHRI---------------DGKRYAIKRVKYNT------------------EKAE---HEVQALAELN--HVNIVQYHSCWE
.|.||.|| |.||.|.||...                 |...|||......                  |. .   .|.. . ..|  | |||.|. | .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

GVDYDPEHSMSDTSRYKTR--CLFIQMEFCDKGTLEQWMR---NRNQ---------SKVDKALILDLYEQIVTG-VEYIHSKGLIHRDLKPGNIFLVDER
  . .           .     |.| ||..| |.|.. ..    ...         ....  .|     ||. |  .|.||.. ||||.||.||.|    
KEGHN-----------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----

HIKIGDFGLATALEND----------------GKSRTRRTGTLQYMSPEQLFL------KHYGKEVDIFALGLILAELL
 .|. |||... |...                .. |.  .||  .|.|| .        |.|.  .||  ||. . |..
-VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA

Kinase PKR.AA TKL 248-500 19 2.2e-41 143.81 In-house 1-364 (364) Show / Hide
Range on Protein: 248-500
Range on HMM: 1-364/364
Sequence Identity: 19% (76 aa)

IGLGGFGQVFKAKHRI--------DGKRYAIKRVKYNT-------------------------------EKAEHEVQALAELNHVNIVQYHS-CWEG---
|| ||||.|.|.|.|         .||  |.|. | .                                .. | |.  .  |.| ||||.   | ..   
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-VDYDPEHSMSDTSRYKTRCLFIQMEFCDKGTLEQWMRNRNQSKVDKALILDLYEQIVTGVEYIHS--------KGLIHRDLKPGNIFLVDERH------
 | ..|           .  |.| ||.|..|.|.  .           .....  .|  |..| ||        ...||||||. ||.. .  .      
CVCMHPV--------GPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYM

--------IKIGDFGLATALENDGK-------------------SRTRRTGTLQYMSPEQLFLK----------------HYGKEVDIFALGLILAELLH
        .||.||||.. ....|.                    . .. ||...|.|| |  .                 | . .|... |..| |.| 
YNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILT

TCFTESEKIKFFESLRKGDFSNDIFDNKEK----------------------------SLLKKLLSEKPKDRPETSEILKTL
 |  ...   . . ... . . ..|    .                            .|...  ...|..||  .||||.|
RCRPYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase PKR.AA GCN2 320-502 27 8.7e-40 136.84 In-house 278-511 (511) Show / Hide
Range on Protein: 320-502
Range on HMM: 278-511/511
Sequence Identity: 27% (67 aa)

KTRCLFIQMEFCDKGTLEQWMRNR--NQSKVDKALILDLYEQIVTGVEYIHSKGLIHRDLKPGNIFLVDERHIKIGDFGLATA-----------------
... |.||||.|...|| |   |   .. ..    .  .  ||. |. ||||.| ||||||| ||||  ....|||||||||                  
EVHYLYIQMEYCEGKTLRQYIDNHGWCMDHD---ELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQKQQQQ

---------------LENDGKSRT-------------RRTGTLQYMSPEQLFLKHYGKEVDIFAL-GLILAELLHT-CFTESEKIKFFESLRKGDFSNDI
               ..|. .|..             ...||  ||.|||.  .||.. ||...| |.|. |...    |..|...    ||    |. .
ASSHWAIQNEICQDDQFNQQQSQFSQWDQQDEQVHHTGKVGTPFYMCPEQQ-KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLR----SCEF

---FD-------NKEKSLLKKLLSEKPKDRPETSEILKTLAE
   ||        .........|. .|. || ....|..   
PQDFDKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL

Kinase PKR.AA PEK 324-399 42 1.7e-39 128.79 In-house 414-514 (758) Show / Hide
Range on Protein: 324-399
Range on HMM: 414-514/758
Sequence Identity: 42% (43 aa)

LFIQMEFCDKGTLEQWMRNR-NQSKVDKALILDLYEQIVTGVEYIHSKGLIHRDLKPGNIFLVDE-RH-----------------------IKIGDFGLA
..|||. | | ||..||||| . . ......|..  ||..||.||||||.|||||||.|||.. .  |                       ||||||||.
MYIQMQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDGGHQIIKIGDFGLV

T
|
T

Kinase PKR.AA Ciliate-E2 323-498 22 1.7e-35 119.32 In-house 108-361 (365) Show / Hide
Range on Protein: 323-498
Range on HMM: 108-361/365
Sequence Identity: 22% (59 aa)

CLFIQMEFCDKGTLEQWMRNRNQS---------KVDKALILDLYEQIVT---------------GVEYIHSKG-LIHRDLKPGNIFLVDERHIKIGDFGL
.... ||.|. |.|.....|....         . .   |... .||.                ..||.|||.  ||||.|| ||..     ||| ||||
NIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGL

AT----------------ALENDGKSRTRRTG----------------TLQYMSPEQLFLKH---------YGKEVDIFALGLILAELLHTCF---TESE
..                 . . .  ..| .|                |. ||.|| |  |          |....||..|| || |.|   .    . .
SKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPFQQQIK

--KIKFFESLRKGDFSN-------DIFDNKEK--SLLKK----LLSEKPKDRPE-TSEILK
  ||.|..     | ..       . ..  ..   |.||    .|  .|. |.   ..||.
QCKIDFPCPEWQKD-TQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN

Kinase PKR.AA PEK 242-306 40 6.4e-31 104.41 In-house 1-87 (655) Show / Hide
Range on Protein: 242-306
Range on HMM: 1-87/655
Sequence Identity: 40% (35 aa)

FEDIEEIGLGGF-GQVFKAKHRIDGKRYAIKRVKYNT---------------------EKAEHEVQALAELNHVNIVQYHSCWEGVD
||.|...| ||| |||.|.....||..|||||.|.|                      ||...||..|| ||| ||| ||..| ...
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKP

Kinase PKR.AA WEE 324-444 30 8.2e-29 93.82 In-house 80-229 (297) Show / Hide
Range on Protein: 324-444
Range on HMM: 80-229/297
Sequence Identity: 30% (45 aa)

LFIQMEFCDKGT--LEQWM--RNRNQSKVDKALILDLYEQIVTGVEYIHSK-GLIHRDLKPGNIFLVDER--------------------HIKIGDFGLA
..||||.|..|   | .|     ... .   ..| ..  .|..|. .|||. |..| |.||.|||.  .                      .||||||..
MYIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHV

TALE-NDGKSRTRRTGTLQYMSPEQLF-LKHYGKE--VDIFALGLILAEL
| .. |. ..     |   ||.|| |   .||..    |||.||. . ||
TDMNSNNNNPHQEQEGDSRYMAPEILQGYYHYTHLYKADIFSLGITIYEL

Kinase PKR.AA PEK 409-502 28 1.3e-26 84.91 In-house 646-758 (758) Show / Hide
Range on Protein: 409-502
Range on HMM: 646-758/758
Sequence Identity: 28% (33 aa)

TRRTGTLQYMSPEQLFLK----------------HYGKEVDIFALGLILAELLHT-CFTESEKIKFFESLRKGDFSNDIFDN---KEKSLLKKLLSEKPK
| ..||. ||||||.  .                .|   |||..||||..||.|    |..|.|. . .||.|..   .|..   .|  ... ..|  | 
TVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHPGFSTQMERIRTMCDLRNGQWPK-WFTQKYPQEYEFIQQMMSMNPD

DRPETSEILKTLAE
 ||....|.. .  
ERPTADQISMHDFF

Kinase PKR.AA NEK 323-423 33 2.8e-26 89.81 In-house 80-196 (286) Show / Hide
Range on Protein: 323-423
Range on HMM: 80-196/286
Sequence Identity: 33% (39 aa)

CLFIQMEFCD-KGTLEQWMRN-RNQS----KVDKALILDLYEQIVTGVEYIHSK-----GLIHRDLKPGNIFLVDERH----IKIGDFGLATALENDG-K
||.| ||.|. .|.|.|  ..  .|       .   |.|   |.. .. |.|..       .|||.|| |||| ...     .||||||..  |...  .
CLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDM

SRTRRTGTLQYMSPEQL
 .|  .||  |||||..
AYTTQVGTPYYMSPEVC

Kinase PKR.AA PEK 242-303 38 2.5e-20 63.51 In-house 1-75 (758) Show / Hide
Range on Protein: 242-303
Range on HMM: 1-75/758
Sequence Identity: 38% (29 aa)

FEDIEEIGLGGFGQVFKAKHRIDGKRYAIKRVKYNT--------EKAEH-----EVQALAELNHVNIVQYHSCWE
|| |. .| |||| ||.||   |. .|||||.             .        || .|| |.| ||| |.. |.
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVMREVRTLAMLDHHNIVRYFNAWL

Kinase PKR.AA WEE 242-303 40 2.6e-20 64.92 In-house 1-75 (297) Show / Hide
Range on Protein: 242-303
Range on HMM: 1-75/297
Sequence Identity: 40% (30 aa)

FEDIEEIGLGGFGQVFKAKHRIDGKRYAIKRVK-----YN-TEKAEHEVQALAELN-------HVNIVQYHSCWE
|. .. || | ||.|.|...||||. ||||. |     |.  . | .||.|...|        | .||.|.| ||
FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWE

Kinase PKR.AA NEK 242-299 34 1e-17 59.3 In-house 1-70 (286) Show / Hide
Range on Protein: 242-299
Range on HMM: 1-70/286
Sequence Identity: 34% (24 aa)

FEDIEEIGLGGFGQVFKAKHRIDGKR-----YAIKRVKYN------TEKAE-HEVQALAELNHVNIVQYH
.| |..|| | ||.|.|.....|||      |..|.....      ...|  .||. |..|.| ||| |.
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYY

Kinase PKR.AA TyrKc 242-500 21 3.1e-15 23.52 SMART 1-280 (280) Show / Hide
Range on Protein: 242-500
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

FEDIEEIGLGGFGQVFKAKHRIDGKRYAIKRVKYNTEKAE--HEVQALAEL--NHVNIVQYHSCWEGVDYDPEHSMSDTSRYKTRCLFIQMEFCDKGTLE
 . ....| | ||.|.|.. .      |.| .| .. ...  .| . . .|  .| |||. . .           |..        |.| ||....| | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN---FMYI------EPLMIVMEYMPHGDLK

QWMRNRNQSKVDKALILDLYEQIVTGVEYIHSKGLIHRDLKPGNIFLVDERHIKIGDFGLATALEND---------GKSRT---RRT-GTLQYMSPEQLF
.  |..    .  .  |.   ||  | ||.|||..|||||   |. . .....||.||||. ....|          ....   ..|   .  |.|| ..
DYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

LKHYGKEVDIFALGLILAELLHTCFTESEK--------IKFFESLRKG---DFSND--------IFDNKEKSLLKKLLSEKPKDRPETSEILKTL
 . .  . |... |  . |..  . .  .         .  .| ...|   .   .          |   . . |.   |.|.|||  ||| . .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF

Kinase PKR.AA GCN2 242-302 37 1.2e-13 43.77 In-house 1-70 (511) Show / Hide
Range on Protein: 242-302
Range on HMM: 1-70/511
Sequence Identity: 37% (26 aa)

FEDIEEIGLGGFGQVFK-AKHRIDGKRYAIKRVKYNTEKAEH--------EVQALAELNHVNIVQYHSCW
|| |...| |||||| | .. . ||. ||||. . |  . ..        ||  |. |.| ..|.|.  |
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAW

Kinase PKR.AA Ciliate-E2 242-303 22 8.5e-12 36.75 In-house 1-102 (365) Show / Hide
Range on Protein: 242-303
Range on HMM: 1-102/365
Sequence Identity: 22% (23 aa)

FEDIEEIGLGGFGQVFKAKHRIDGKR-----------------------YAIKRVKYN----TEKAEHEVQ-------------ALAELNHVNIVQYHSC
.. |. || |.||.|.|.|.. ..|.                       ||.|..| |    ... .|. .              | .||| ||.... |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

WE
..
FQ

Kinase PKR.AA Pkinase_Tyr 328-413 34 1.1e-10 36.79 Pfam 86-174 (270) Show / Hide
Range on Protein: 328-413
Range on HMM: 86-174/270
Sequence Identity: 34% (31 aa)

MEFCDKGTLEQWMRNR--NQSKVDKALILDLYEQIVTGVEYIHSKGLIHRDLKPGNIFLVDERHIKIGDFGLATALENDGKS-RTRRTG
||.. .| |    |..  .. ...   .|.   ||  | || .||..|||||   |. . .....||.||||| ...||.   |.|  |
MEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGG

Kinase PKR.AA NEK 476-502 25 0.022918 4.61 In-house 260-286 (286) Show / Hide
Range on Protein: 476-502
Range on HMM: 260-286/286
Sequence Identity: 25% (7 aa)

KSLLKKLLSEKPKDRPETSEILKTLAE
..|. ..|   |..|| ...||..   
QNLISQMLQKDPEQRPSCNQILEMPFI

Kinase PKR.AA Pkinase_Tyr 242-299 22 0.053887 7.38 Pfam 1-70 (270) Show / Hide
Range on Protein: 242-299
Range on HMM: 1-70/270
Sequence Identity: 22% (16 aa)

FEDIEEIGLGGFGQVFKAKHR--IDGKRY--AIKRVKYNTEKAE-------HEVQALAEL-NHVNIVQYH
 . ....| | ||.|.|.. .   |....  |.| .| .. . .       .|.. . .| .| |||...
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY