Gene PLK1 (Mouse)

PLK1

Species: Mouse
Alias: PLK1, Plk
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: PLK
Subfamily: PLK1

Sequence

Name Sequence Type Origin Length Description Download
PLK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 248 Kinase domain by global Sugen HMM Fasta, JSON
PLK1.NA RNA Sugen 2171 None Fasta, JSON
PLK1.AA Protein Sugen 603 None Fasta, JSON

Protein domain

Protein domains of PLK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PLK1.AA PLK 53-305 65 3.1e-200 657.59 In-house 1-258 (258) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-258/258
Sequence Identity: 65% (169 aa)

YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQKEKMSMEISIHRSLAHQHVVGFHDFFEDSDFVFVVLELCRRRSLLELHKRR-KALTEP
| ||.||||||||||.|. | .||.|.|.|.|||||. ||||.||| .|| |||.| |...|.||.||||...|..|||.|..|||...|||| |.||||
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEP

EARYYLRQIVLGCQYLHRNQVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYEGERKKTLCGTPNYIAPEVL--SKKGHSFEVDVWSIGCIMYTLLVGKP
|.|||..||| |..|||....|||||||||||||....||||||||||..||.||||||.||||||||||||  .|.|||.|||.||.||||||||.|||
EVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKP

PFETSCLKETYLRIKKNEYSIPKH--INPVAASLIQKMLQTDPTARPTIHELLNDEFF
||||...|||| |||.|.||.|.|  |...|..||||||...|. ||||...|...||
PFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase PLK1.AA PLK1 53-305 76 6.8e-181 599.64 In-house 1-253 (253) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-253/253
Sequence Identity: 76% (194 aa)

YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQKEKMSMEISIHRSLAHQHVVGFHDFFEDSDFVFVVLELCRRRSLLELHKRRKALTEPE
|..||||||||||.|.||.|.|||||||||.||||||.|.||..||..||.|||.|.|.|.|.||.||||...|..||||||||||.||||||||.||||
YEKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPE

ARYYLRQIVLGCQYLHRNQVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYEGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFE
.|||..|||.||||||.|..|||||||||||||..|.|||||||||||.||.|||||||||||||||||||.|||||||||.||||||||.||.|.||||
CRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLNKKGHSFEVDIWSIGCIMYILLFGQPPFE

TSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIHELLNDEFF
|.||||||.|||||||.||.||...||.||.|||..|||.||||...||||||
TKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase PLK1.AA PLK2 53-305 55 2.1e-161 523.75 In-house 1-257 (257) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-257/257
Sequence Identity: 55% (143 aa)

YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQKEKMSMEISIHRSLAHQHVVGFHDFFEDSDFVFVVLELCRR----RSLLELHKRRKAL
| ||. |||||||.|.|. | ||  |.|.||||.|   |||| |||  || .|| | | |.|.|| .||| | ....||.|.|    .|..   | |. |
YCRGKLLGKGGFARCYEMTDMDTHYVYAVKIVPHSRVAKPHQREKMEREIELHRQLRHRHIVQFHHHFEDRDNIYILLEYCSRQVPLKSMAHMWKVRHHL

TEPEARYYLRQIVLGCQYLHRNQVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYEGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGK
|||| |||.|||| |  |||  ..|||||||||.|.|.  |||||||||| ..| |.....|.||||||||||||...|||.| |.|. ||||||.|.| 
TEPEVRYYMRQIVSGLRYLHQQCIIHRDLKLGNFFINDNMEVKIGDFGLAARLEPEEHCHRTMCGTPNYIAPEVLNRQGHSCESDIWALGCIMYTMLCGR

PPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIHELLNDEFF
|||||. ||||| .|. | | .| |  |.| .|| .||  ||  || . ... ..||
PPFETANLKETYRCIRHNHYHMPTHLSPPARHLIARMLSPDPEDRPSLDHIIRHDFF
Kinase PLK1.AA PLK-Unclassified 53-305 54 1.8e-146 492.88 In-house 1-264 (264) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-264/264
Sequence Identity: 54% (143 aa)

YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQKEKMSMEISIHRSLAHQHVVGFHDFFEDSDFVFVVLELCRRRSLLELHKRR-------
| ||.||||||||||... . .||...| ||.||| | |  ...|   || || || |...| | ..|||.. |  .||.|   .| |..|||       
YHRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEK

KALTEPEARYYLRQIVLGCQYLHRNQVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYEGERKKTLCGTPNYIAPEVL-SKK-GHSFEVDVWSIGCIMYT
| |||.|...|. ||| . .||| | .|||||||||.|||.. ||||.|||||||.|..||.||| ||||||||||.|  |. |||.|||.||.||| ||
KRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYT

LLVGKPPFETSCLKETYLRIKKNEYSIP--KHINPVAASLIQKMLQTDPTARPTIHELLNDEFF
||.|||||||.  | || .|| |.|| |  .||   | .|||. |...|  |||| ..... |.
LLIGKPPFETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase PLK1.AA S_TKc 53-305 33 4.4e-97 329.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-231/231
Sequence Identity: 33% (90 aa)

YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQKEKMSMEISIHRSLAHQHVVGFHDFFEDSDFVFVVLELCRR--RSLLELHKRRKA---
|  .| .|||.|.|..   . .|....| ||..          |..  ||.|...  | ..| ..|.|.| |....|.|.|     .|... |.|.    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LTEPEARYYLRQIVLGCQYLHRNQVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYEGERKKTLCGTPNYIAPEVLSKKGHSF-EVDVWSIGCIMYT
   ..| .||.|..||... .|.|....||||||  |..|.|  ..||.|||||...       .|.||||.|.|||||   |... ..|.||.|||.| 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIHELLN-------DEFF
.|.|.|||.   ..... .|.           | | ..|.|.|| ||. |||. |.|.       ...|
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PLK1.AA AGC 53-305 21 5.3e-95 245.39 In-house 1-395 (395) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-395/395
Sequence Identity: 21% (87 aa)

YVRGRFLGKGGFAKCFEISDA------DTKEVFAGKIVPKSL--------LLKPHQKE------------KMSMEISIHRSLA------HQHVVG-FHDF
.   . .|||.| |..   .       ||....| |.. |.          ..  . |            .  .|   |.  .      |. .|   |  
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTH-NHPIKSHHPFIVKILHYS

FEDSDF--VFVVLELCR----------R-RSLLELHK--RRKALTEPEARYYLRQ-------IVLGCQYLHR-NQVIHRD-LKLGNLFLNEDLEVKIGDF
|.| |   .. |.|..              ..| |..  ... ..|..||.|. .       |||. .|||. . .|||| ||. |. |.||  .|. ||
FQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDF

GLATKVEYEG--------------------------------------------------ERKKTLCG--TPNYIAPEVLSKKGHSFEVDVWS--IGCIM
||....  .|                                                  .| .|.||  ||.|.|||.|    .....| ||   ||.|
GLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLM

YTLLVGKPPFETS----------CLKETYLRIK------KNEYSIP----------KHINPVAASLIQKMLQTDPTARPT----------IHELLNDEFF
| .|.|.|||               .|.. .|.      ...  .|          ... | | .||.|.|. ||. |..          . |. | ..|
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PLK1.AA CAMK 58-305 21 6.6e-95 306.22 In-house 1-425 (425) Show / Hide 
Range on Protein: 58-305
Range on HMM: 1-425/425
Sequence Identity: 21% (92 aa)

FLGKGGFAKCFEISDADTK------------EVFAGKIVPKSLLLK-------------------------PHQKEKMSMEISIHRSLA-------HQHV
 ||.|.|.| ..  .  |.            . .| ||..|. | .                         |. ....  ||.|...|        | ..
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VGFHDFFEDSDF-------------------VFVVL---ELCRRR----SLLELHKRR---------------KALTEPEARYYLRQIVLGCQYLHRNQV
. .....||...                   .. |.   |.|        |..  ...               . .|| |||.| |||. . .|.| . .
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKLGNLFLNED-----------------LEVKIGDFGLATKVEY-----------------------EGERKKTLCGTPNYIA-PEVLSK------
.|||||. |. |...                   .|| |||.|.|..                        ||.  || |||| |.| ||||..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------KGHSFEVDVWSIGCIMYTLLVGKPPFETS-------------CLKETYLRIKKNEYS-IPKHINPV-----------------------AAS
        .......|.||.|.|.|..|.|.|||. .             ...|.. .|.| .|. .|... |.                       . .
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIQKMLQTDPTARPTIHELLNDEFF
||.||||.||. |.||.. ||....
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PLK1.AA Pkinase 53-305 28 3e-88 304.28 Pfam 1-293 (293) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-293/293
Sequence Identity: 28% (84 aa)

YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQKEKMS-MEISIHRSLAHQHVVGFHDFFEDSDFVFVVLELCRRR----SLLELHK--RR
|..|| .|.|.|.....  . .| ...| ||..|.   .  ....   .||.|...| | ..| ..|.|||.| . .|.|.|.      .| .. .  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KAL--TEPEARYYLRQIVLGCQYLHRNQVIHRDLKLGNLFLNEDLEV----KIGDFGLATKV-EYEGERKKTLCGTPNYIAPEVLS-KKGHSFEVDVWSI
...  .| |.. |..||. | .|.|.. .||||||. |...... ..    ||.||||| .. .  ..  .|.||||.|.||||.   .... .||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCIMYTLLVGKPPFETS------CLKETYLRIKK--NEYSIPKHIN-------------------PVAASLIQKMLQTDPTARPTIHELLNDEFF
|||.| .| |.|||  .      . .. . ||..  .....|. ..                   . . ..| ..|. ||. |||....|....|
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PLK1.AA CAMKL 53-305 28 3.2e-86 275.15 In-house 1-297 (297) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-297/297
Sequence Identity: 28% (86 aa)

YVRGRFLGKGGFAKCFEISD-ADTKEVFAGKIVPKSLLLKPHQKEKMSM------------EISIHRSLA---HQHVVGFHDFFEDSDF------VFVVL
|  |. ||||.|.|     .   |.|  | ||. |. . .  ...|.              ||.|...|    |.... ... .|....      .. |.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELCRRRS--LLELHKRR----KALTEPEARYYLRQIVLGCQYLHRNQVIHRDLKLGNLFLNEDL--EVKIGDFGLATKVE-Y---EGERKKTLCGTPNYI
|.|   .  |..  ...    . ..|.||| | |||| . .|.|.. ..|||.|. |. | |.    .|| |||.... . .   .|.  || ||.|.| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEVLSK--KGHS-FEVDVWSIGCIMYTLLVGKPPFETSCLK-------ETYLRIKKNEYSIPKHINP-VAASLIQKMLQTDPTARPTIHELLNDEFF
|||....  | .  ..||.||.| |.|....|. ||.  ...       . |..|..  | .|... .  . .||.||||..|. |||||...|....
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase PLK1.AA SAK 53-305 39 1.2e-78 267.42 In-house 1-254 (254) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-254/254
Sequence Identity: 39% (100 aa)

YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQKEKMSMEISIHRSLAHQHVVGFHDFFEDSDFVFVVLELCRRRSLLE-LHKRRKALTEP
|  .  |||||||  .      |    | |.. | |. |    ...  |. ||  | |  ..    .|||. .|..|||.|.   ..  ...| .  || 
YQVQHLLGKGGFACVYRAKCIHTHQEVAIKMIDKKLMQKTGMVQRVRNEVEIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHRMRPFTEE

EARYYLRQIVLGCQYLHRNQVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYEGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPF
||| ...||| |  |||   ..|||| | |. |  |...|| ||||||...   |.  |.|||||||.||. ..  |  . ||||.||..||||.|.|||
EARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQLKMPHEKHYTMCGTPNYISPEIATRTAHGLQSDVWSLGCMLYTLLIGRPPF

ETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIHELLNDEFF
.|   |.|  ..   || .| |.   |  ||.|||. .|. | |.   |   | 
DTDAVKNTLNKVMMAEYIMPAHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM
Kinase PLK1.AA ULK 53-305 27 2.3e-76 260.04 In-house 1-324 (324) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-324/324
Sequence Identity: 27% (88 aa)

YVRGRFLGKGGFA-KCFEISDADT---KEVFAGKIVPKSLLLK-PHQ------KEKMSMEISIHRSLA---HQH--VVGFHDFFEDSDF--VFVVLELCR
|.  . |||| |. | ..  . .|   ....| |...|. . | ...      ...   ||.| . |    |..  .| ..|.||.|..  .. ..|.| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

RRSLLELHKRRKA---------LTEPEARYYLRQIVLGCQYLHRNQVIHRDLKLGNLFLNEDL------------EVKIGDFGLATKVEYEG---ERKKT
   | .. |..|          |.|.||. ...||. |...|| ...||||.|. |. ....              .||.|||.| .|....      .|
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

LC------GTPNYIAPEVLS----KKGHS-FEVDVWSIGCIMYTLLVGKPPFETSCLKETYLR--------------IKKNEYSIPK-----HINPVAAS
..      ||| | ||..|.    .| .. ...|.||.|||.| .| ||.||...   ..||.              ||..   .||     .| |   .
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LIQKMLQTDPTARPTIHELLNDEFF
||..||| |.. | ...|..| ..|
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase PLK1.AA ULK 53-305 27 3.2e-76 259.54 In-house 1-329 (329) Show / Hide 
Range on Protein: 53-305
Range on HMM: 1-329/329
Sequence Identity: 27% (91 aa)

YVRGRFLGKGGFAKCFEISDADTK----EVFAGKIVPKS-LLLKPHQ------KEKMSMEISIHRSLA--------HQHVVGFHDFFEDSDF--VFVVLE
|.  . |||| |.| ..  . .||    |..| |...|. .  |...      ..    || | . |         |...| ..|.||.|..  .. ..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

LCRRRSLLELHKRRKA----------LTEPEARYYLRQIVLGCQYLHRNQVIHRDLKLGNLFLNEDL------------EVKIGDFGLATKVEYEG----
.|    | .. |..|           |.|.||. ...||. |...|| ...||||.|. |  ....              .||.|||.| .|....    
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

-ERKKT----LCGTPNYIAPEVLS----KKGHS-FEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIP--------------------KHIN
 .   .    ||||| | ||..|.    .| .. ...|.||.|||.| .|.|||||...   ..||.|..... .|                    ..| 
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

PVAASLIQKMLQTDPTARPTIHELLNDEFF
|   .||..||| |.. | ...||.| ..|
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase PLK1.AA Pkinase_Tyr 92-236 28 2.3e-16 56.07 Pfam 42-199 (270) Show / Hide 
Range on Protein: 92-236
Range on HMM: 42-199/270
Sequence Identity: 28% (46 aa)

PHQ--KEKMSMEISIHRSL-AHQHVVGFHDFFE-DSDF--VFVVLELCRRRSLLE-LHKR---RKALTEPEARYYLRQIVLGCQYLHRNQVIHRDLKLGN
..|  .|..  |..| ..|  |...| ..     ...   ...|.|..   .||. |.|.   ...|| ..   . .||  |..||.... |||||   |
HEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARN

LFLNEDLEVKIGDFGLATKVEYEGE---RKKTLCGTP-NYIAPEVLSKKGHSFEVDVWS
  ..|.. |||.|||||  . |. .   ||.. .  |    |||... .  . . ||||
CLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS
Kinase PLK1.AA TyrKc 53-304 22 2.2e-15 25.89 SMART 1-280 (280) Show / Hide 
Range on Protein: 53-304
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

YVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQKEKMSMEISIHRSL--AHQHVVGFHDFFEDS-------DFVFVVLELCRRRSLLE-LH
 . |. || | | . ..   ..  .  | | . ..       .| .  |..| ..|   |...| ..    ..       . ...|.|..   .|.. |.
ITLGKKLGEGAFGEVYK-GTWK--IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KRRKALTEPEARYYLRQIVLGCQYLHRNQVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYE---GERKKTLC-----GTP-----NYIAPEVLSKKGHS
|.|. |. ..  ..  ||  |..|||....|||||   |  ..|.. |||.||||. ... .   ||.|..       |.         |||.. ..  .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

FEVDVWSIGCIMY---TLLVGKPPFET-----SCLKETYLRIKKNEY-SIPKH--------INPVAASLIQKMLQTDPTARPTIHELLNDEF
.. |||| |  |.   |.  |..| .         .| . ..|. ..  .|..          .   .....  . ||  |||  |.  ..|
TKSDVWSFGVCMWEIFTY--GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
POLO_box PLK1.AA POLO_box 417-480 32 1.7e-26 99.15 Pfam 1-74 (74) Show / Hide 
Range on Protein: 417-480
Range on HMM: 1-74/74
Sequence Identity: 32% (24 aa)

YSDKYGLGYQLCDNSVGVL-FNDSTRLILYNDGD-SLQYIE--RDGTESYLTVSS------HPNSLMKKITLLN
|..|||..|||....|.|. |||.|..||  ... ...||.  ......... |.      .| .|.||.|.| 
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK
POLO_box PLK1.AA POLO_box 515-584 51 4.5e-32 117.67 Pfam 1-74 (74) Show / Hide 
Range on Protein: 515-584
Range on HMM: 1-74/74
Sequence Identity: 51% (38 aa)

FRTRSAIILHLSNGTVQINFFQDHTKLILCPLMA-AVTYIN--EKRDFQTYRLSLLEEYGC-CKELASRLRYAR
.||...|. .|||||||.||| ||||.|||| |  |||||.  ... .|||.|| ..|.|| ...|...|.|..
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK