Gene PRKX (Mouse)

PRKX

Species: Mouse
Alias: PRKX, Prkx
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: AGC
Family: PKA

Sequence

Name Sequence Type Origin Length Description Download
PRKX.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 255 Kinase domain by global Sugen HMM Fasta, JSON
PRKX.AA Protein Sugen 355 None Fasta, JSON
PRKX.NA RNA Sugen 3204 None Fasta, JSON

Protein domain

Protein domains of PRKX.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PRKX.AA PKA 46-300 61 2.3e-199 668.58 In-house 1-263 (263) Show / Hide 
Range on Protein: 46-300
Range on HMM: 1-263/263
Sequence Identity: 61% (162 aa)

WDTIATVGTGTFGRVNLVKEKTGRQYCALKIMSIPDVIRLKQEQHVQNEKAVLKEINHPFLI-KLLWTGHDNRFLYMLMEFVPGGELFTYLRNRGRFSSV
...|.|.|||.|||| |...|.. .|.|.|........||||..|| ||| .|..|.|||.. |. || .|.|.|||.||.|||||.|.|||..||||. 
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

ASVFYAT-EIVCAIEYLHSKEIVYRDLKPENILLDREGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSK-GHGRAVDWWALGILIFEMLSGFPPFF
 . |||. .||.|.|||||..|.||||||||||.|..||||.||||||||..||||||||||||||||.|||| |||..||||||||||.|||.|.|||.
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDDRTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYPPFY

DD--NPFGIYQKILACKIDFPRQLDFTS---KDLIKKLLVVDRTRRLGNMKNGAEDIKRHRWF
|.  .|..||.||...||.|||..|      ||||||||.||.|.|.||||||..|||.|.||
DHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase PRKX.AA AGC 46-300 32 5.4e-176 459.66 In-house 1-395 (395) Show / Hide 
Range on Protein: 46-300
Range on HMM: 1-395/395
Sequence Identity: 32% (130 aa)

WDTIATVGTGTFGRVNLVKEK------TGRQYCALKIMSIPD-VIRLK--QEQHVQNE------------KAVLKEIN----------HPFLIK-LLWTG
 . . ..|.|.||.| ||..|      .  .|.|.|...  . ....|  ...|...|            . .|...|          |||..| |  . 
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

HDNRF--LYMLMEFVP---------GG-ELFTYLR---NRGRFSSVASVFYATE-------IVCAIEYLHS-KEIVYRD-LKPENILLDREGHIKLTDFG
.|..   ||..||..|         || |||..|.   ..|||.  .. ||| |       ||.|.||||| . |..|| |||||||||..|||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

FAKKLV-----------------------------------------------------DRTWTLCG--TPEYLAPEVIQSKGHGRAVDWWA--LGILIF
..|...                                                     |||||.||  ||||.|||..    .|.|.|||.  ||.|..
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLSGFPPFFDDN----------PFGIYQKIL------ACKIDFP----------RQLDFTSKDLIKKLLVVDRTRRLGNMKN-----GAEDIKRHRWF
|||.| |||..||          |. ..|||.       .|. ||          |...   ||||||||..|...|||...|     |||.||.| ||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PRKX.AA SGK 46-300 39 3.3e-119 369.91 In-house 1-283 (283) Show / Hide 
Range on Protein: 46-300
Range on HMM: 1-283/283
Sequence Identity: 39% (113 aa)

WDTIATVGTGTFGRVNLVKEKTG------------------RQYCALKIMSIPDVI-------RLKQEQHVQNEK-AVLKEINHPFLIKLLWTGHDNRFL
 | . ..| | ||.| .|| |                     .  |.|. .   .|       . |.. |.. |.  .|| ..|||...|         |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YMLMEFVPGGELFTYLRNRGRFSSVASVFYATEIVCAIEYLHSKEIVYRDLKPENILLDREGHIKLTDFGFAK---KLVDRTWTLCGTPEYLAPEVIQSK
|. |..| |||.| .|. ...|.   . ||| |||||.|||||. |.|||||||||||| .||..||||| .|   |  | | | |||||||||||.. .
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

GHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILACKIDFPRQLDFTSKDLIKKLLVVDRTRRLGNMKNGAEDIKRHRWF
.|.|.|||| ||.. .||..| |||.. |    |..|.  .. .|.|   . .|||. ||  |.. |||  |.....||.| .|
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLG-TKRDFMEIKNHPFF
Kinase PRKX.AA Akt 47-300 44 4e-117 375.98 In-house 2-264 (264) Show / Hide 
Range on Protein: 47-300
Range on HMM: 2-264/264
Sequence Identity: 44% (116 aa)

DTIATVGTGTFGRVNLVKEKT-GRQYCALKIMSIPDVIRLKQEQHVQNEKAVLKEINHPFLIKLLWTGHDNRFLYMLMEFVPGGELFTYLRNRGRFSSVA
| .   | |.||.| |||.|  .. | |.|. .    |  .| .|.. |. .|. .||||...|     ..  ||. |....|||||..|. ..|||   
DFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDR

SVFYATEIVCAIEYLHSKEIVYRD-LKPENILLDREGHIKLTDFGFAKKL-VDR---TWTLCGTPEYLAPEVIQSKGHGRAVDWWA-LGILIFEMLSGFP
  ||. ||..|||.|||| |.||| |||||||.|..|||.||||| .|.  . .   | |.||||||||||... .||..|||||. ||....||. |.|
ARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRP

PFFDDNPFGIYQKILACKIDFP--RQLDFTSKDLIKKLLVVDRTRRLGNMKNGAEDIKRHRWF
||....    ..||. ... ||  ....   ||||..||  |...|||. .|.|..|||| ||
PFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase PRKX.AA AktR 46-300 42 4.2e-113 382.04 In-house 1-268 (268) Show / Hide 
Range on Protein: 46-300
Range on HMM: 1-268/268
Sequence Identity: 42% (115 aa)

WDTIATVGTGTFGRVNLVKEK--TGRQYCALKIMSIPDVIRLKQEQHVQNEKAVLK-EINHPFLIKLLWTGHDNRFLYMLMEFVPGGELFTYLRNRGRFS
 . ..  | |.||.| ||..|  ...|| |.|. .  . |...|..|...|. ... ..||||..||  .  ... |. .||..||||||..|.....||
FHVYKCLGKGAFGKVYLVQKKRDNQKQY-AMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFS

SVASVFYATEIVCAIEYLHSK-EIVYRDLKPENILLDREGHIKLTDFGFAK---KLVD--RTWTLCGTPEYLAPEVIQS-KGHGRAVDWWALGILIFEML
   . ||. .|. |.||||..  |.|||||||||||| .||.|.|||| .|   . ..  .. ..||||||.|||.|.  |||...|||||.||.|.||.
EEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMV

SGFPPFFDDNPFGIYQKILACK-IDFPRQLDF--TSKDLIK-KLLVVDRTRRLGNMKNGAEDIKRHRWF
.| |||...|   ..|||. .  . ||   .|  . ||||. |||  . . |||  .||.|.||.| ||
TGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase PRKX.AA PKG 47-300 47 1.9e-106 359.92 In-house 2-260 (260) Show / Hide 
Range on Protein: 47-300
Range on HMM: 2-260/260
Sequence Identity: 47% (123 aa)

DTIATVGTGTFGRVNLVKEKTGR-QYCALKIMSIPDVIRLKQEQHVQNEKAVLKEINHPFLIKLLWTGHDNRFLYMLMEFVPGGELFTYLRNRGRFSSVA
. ||| | | |||| ||. . .  .  |||.|    ..  .|..|. .|| .. | . .| ..|  |  |....|||||   |||| | || ||.|   .
KIIATLGVGGFGRVELVQYNHQKSRTFALKCMKKRHIVDTRQQEHIMSEKNIMMECRCDFIVRLYRTFRDQKYVYMLMEACMGGELWTILRDRGHFDDKT

SVFYATEIVCAIEYLHSKEIVYRDLKPENILLDREGHIKLTDFGFAKKLV--DRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFD
. ||.  .| | .|||.| |.||||||||..||..| .|| |||||||.    .||| |||||| |||.|  ||| |.||.||||||..| | | |||  
TRFYCACVVEAFDYLHRKNIIYRDLKPENLMLDNRGYCKLVDFGFAKKIGQGRKTWTFCGTPEYVAPEIILNKGHDRSVDYWALGILMCELLTGNPPFSG

DNPFGIYQKILAC--KIDFPRQLDFTSKDLIKKLLVVDRTRRLGNMKNGAEDIKRHRWF
 .|  .|. ||    ...|||.   . ...||||     | |||. ||| .|||.|.||
SDPMKTYNIILKGIDMWEFPRKITRWAQNMIKKLCRDNPTERLGYQKNGINDIKKHKWF
Kinase PRKX.AA S_TKc 46-300 37 3.4e-101 343.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 46-300
Range on HMM: 1-231/231
Sequence Identity: 37% (99 aa)

WDTIATVGTGTFGRVNLVKEKTGRQYCALKIMSIPDVIRLKQEQHVQNEKAVLKEINHPFLIKLLWTGHDNRFLYMLMEFVPG--GELFTYLRNRGR---
.. . ..| |.||.| ....|   ...|.||..          .|...| ..||. .||...||. . .|  .||| ||...|  |.||.|...|||   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSSVASVFYATEIVCAIEYLHSKEIVYRDLKPENILLDREGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGR-AVDWWALGILIFEMLS
   |.     ||. .|.||.||.||. |..|||||||||||.  |||..|||.|..|     |.||||.|.||||.   |.|. ..|||..|....|||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GFPPFFDDNPFGIYQKILACKIDFPRQLDFTSKDLIKKLLVVDRTRRLGNMKNGA--EDIKRHRWF
| |||   ... ...||.          .   ||.|.|.|..| ..|..  .  .  .||| | ||
GYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PRKX.AA Ciliate-E2b 47-300 38 1.3e-95 290.98 In-house 2-272 (272) Show / Hide 
Range on Protein: 47-300
Range on HMM: 2-272/272
Sequence Identity: 38% (105 aa)

DTIATVGTGTFGRVNLVKE-KTGRQYCALKIMSIPDVIRLKQEQHVQNEKAVLKEINHPFLIKLLWTGHDNRFLYMLMEFVPGGELFTYLRNRG--RFSS
. |   | | || |.||.. |. .|| |.|  |.  .|    | | ..|| ||. .||||..|.. .  |....|..|||. |.|||...|. |   .| 
IYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCISKNQIIQQNMEKHMLQEKNVLEKCNHPFIMKFIRSFKDDQHMYFMMEFCNGMELFDVIREIGRLLLST

VASVFYATEIVCAIEYLHSKEIVYRDLKPENILLDREGHIKLTDFGFAKKLVD------RTWTLCGTPEYLAPEVIQ-----SKGHGRAVDWWALGILIF
  | ||  .|. ..||||...|.|||.|||||..| .|..|| |.| || . .      || |..|||.|.|||.||      || . .|| |..||  .
YDSQFYIASICLCLEYLHNQNIIYRDIKPENIMVDHKGYMKLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLY

EMLSGFPPFFDD--NPFGIYQKILAC--KIDFPRQL-DFTS-KDLIKKLLVVDRTRRLGNMKNGAEDIKRHRWF
|...| .|.  |  .|  |||.|.    .|.||  . |  . |.|. ..|      |||      .  | | ||
EFMCGYVPWAEDVQDPYEIYQEIIKKYDEIQFPSYCKDKMADKKLMLQCLQKMPEVRLGGS---YSWLKSHPWF
Kinase PRKX.AA RSK 49-300 39 2.9e-94 319.49 In-house 1-278 (278) Show / Hide 
Range on Protein: 49-300
Range on HMM: 1-278/278
Sequence Identity: 39% (111 aa)

IATVGTGTFGRVNLVKEK----TGRQYCALKIMSIPDVIRLKQ-EQHVQNEKAVLKEIN-HPFLIKLLWTGHDNRFLYMLMEFVPGGELFTYLRNRGR--
.   |.| .| | |....    ||..| | |. .   ... .    |.  |  .|.... |||...|  . ...  ||. ||...|||||| |.....  
LKVLGQGGYGKVFLCRKCTHHDTGQIY-AMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFG

-FSSVASVFYATEIVCAIEYLHSKEIVYRDLKPENILLDR---EGHIKLTDFGFAKK-LVD---RTWTLCGTPEYLAPEVIQ----SKGHGRAVDWWALG
 ||     ||. |||.|.|.||.. |..|||||||||.|    |||||||||||.|.   |   .| | |.| ||.|||..      .||..|.||| ||
CFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

ILIFEMLSGFPPFFD---DNPFGIYQKILACK--IDFP--RQLDFTSKDLIKKLLVVDRTRRLGNMKNGAEDIKRHRWF
.|..|||.|.|||     .|.  | ..|. .|   ..|    |  . ||||.|.| .|  .|||  ...||.||.| ||
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase PRKX.AA Pkinase 46-300 31 1.8e-91 314.97 Pfam 1-293 (293) Show / Hide 
Range on Protein: 46-300
Range on HMM: 1-293/293
Sequence Identity: 31% (95 aa)

WDTIATVGTGTFGRVNLVKEKTGRQYCALKIMSIPDVIRLKQEQHVQ-NEKAVLKEINHPFLIKLLWTGHDNRFLYMLMEFVPGG----ELFTYLR--NR
. .. ..| |.||.| . ..|  ..  |.||.. ..    |...|.  .| ...|..|||. ..|. . .|.. .|| ||...||    .||.|..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRF--SSVASVFYATEIVCAIEYLHSKEIVYRDLKPENILLDREGHI----KLTDFGFAK---KLVDRTWTLCGTPEYLAPEVIQ-SKGHGRAVDWWALG
|.|  |     ||...|....||.||. |..|||||||||.|..|||    |..|||.||      ....|.||||.|.|||||. ....|..||.|..|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCG

ILIFEMLSGFPPFFDD------NPFGIYQKILACKIDFPRQLD---------------------FTSKDLIKKLLVVDRTRRLGNMKNGAEDIKRHRWF
....|||.| ||| ..      ..  ....|. ....|... .                      . ||.||..| .| ..|..     ||.|. | ||
CILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPWF
Kinase PRKX.AA Ciliate-E2 46-300 27 1.4e-86 293.91 In-house 1-365 (365) Show / Hide 
Range on Protein: 46-300
Range on HMM: 1-365/365
Sequence Identity: 27% (105 aa)

WDTIATVGTGTFG-----RVNLVKE------------------KTGRQYCALKIMSIPDVIRLKQEQHVQ----------NEKAVLKEINHPFLIKLLWT
 . |   |.|.||     .| .|..                  |.  .. |.|||.  ... .|||.|.           ||| .|...|||..||. ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

GH--DNRFLYMLMEFVPGGELFTYLRNR-----------GRFSSVASV---------------FYATEIVCAIEYLHSKE-IVYRDLKPENILLDREGHI
    |.  .|. ||.. ||.|| |..|.           ..|.                    ||...|..|.||||||  |..||.||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLTDFGFAKKLV----------------------------------DRTWTLCGTPEYLAPEVIQSKG---------HGRAVDWWALGILIFEMLSGFPP
|..|||..||.                                   . ..|.||||.|.|||....|.         .. ..|.|.||....|||.| ||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FFDDNPFGIYQKILACKIDFPRQ----------------LDFTSK--DLIKK----LLVVDRTRRLGNMKNGAEDIKRHRWF
|        .|.|. |||||| .                .. . .  |||||    .|..|   |..    |.|.|. | ||
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase PRKX.AA p70 94-300 41 1.4e-85 290.6 In-house 78-299 (299) Show / Hide 
Range on Protein: 94-300
Range on HMM: 78-299/299
Sequence Identity: 41% (93 aa)

EKAVLKEINHPFLIKLLWTGHDNRFLYMLMEFVPGGELFTYLRNRGRFSSVASVFYATEIVCAIEYLHSKEIVYRDLKPENILLDREGHIKLTDFGFAKK
|  .| |..|||...|.   ..|  || . |. .|||||. |   | .      ||. ||.||.|.||.. |.||||||||..|.  ||..|||||  |.
ERNILEEVKHPFICDLHYAFQTNGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKE

LVDR-------------TWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILACK--IDFPRQLDFTSKDLIKKLLVV
 .               |.|.|||.|| |||..  .||..|||||.||.|.. || | |||  .|.  .  ||| .|  .  |  |    .|||||||  
SIHDGAVDEEDPENVNATHTFCGTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKR

DRTRRLGNMKNGAEDIKRHRWF
. | |.|   . |.||..| .|
HPTQRWGAGPEDAADIQEHPFF
Kinase PRKX.AA TyrKc 46-294 18 8.8e-14 0.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 46-294
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

WDTIATVGTGTFGRVNLVKEKTGRQYCALKIMSIPDVIRLKQEQHVQNEKAVLKEI--NHPFLIKLLWTGHDN-------RFLYMLMEFVPGGELFTYLR
   . . | | ||.| . . |   . .| | .          ..   .|  .....  .|| ...|.    .          |...||..|.| |  |||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NRGR-FSSVASVFYATEIVCAIEYLHSKEIVYRDLKPENILLDREGHIKLTDFGFAKKLVDR-------TWTLC----GTPE-----YLAPEVIQSKGHG
.... ..    . ... | |  |||||| .. |||   |.|.......| .||| .... |                 |.        .|||.|. .   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

RAVDWWALGILIFEMLS-GFPPFFD-----DNPFGIYQKILACKIDFPRQL----------DFTSKDLIKKLLVVDRTRRLGNMKNGAEDI
 . | |. |....|... | .|  .      ... ..... . .   . .           |   . ..|.    |   |  ....  |..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRP-TFSEIHECF
Kinase PRKX.AA S_TK_X 301-355 20 3.8e-11 44.26 SMART 1-79 (79) Show / Hide 
Range on Protein: 301-355
Range on HMM: 1-79/79
Sequence Identity: 20% (16 aa)

RGVEWESVPQ--RKLKPPIVPKLS----GDGDISNFE-TYPESELDKTPSVS-----------------DKDLETFKNF
||. |. . .  ....||..||..    ...|.|||.  ..| . . ||  .                 |. .. ...|
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PRKX.AA Pkinase_Tyr 119-241 27 2.6e-10 35.53 Pfam 82-216 (270) Show / Hide 
Range on Protein: 119-241
Range on HMM: 82-216/270
Sequence Identity: 27% (37 aa)

LYMLMEFVPGGELFTYLRN----RGRFSSVASVFYATEIVCAIEYLHSKEIVYRDLKPENILLDREGHIKLTDFGFAKKL-------VDRTWTLCGTPEY
.|. ||..|.| | .|||.    .....    . ....| .. |||.|| .. |||   |.|.......| .||| |. .       . |. .       
IYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKW

LAPEVIQSKGHGRAVDWWALGILIFEMLS-GFPP-F
.|||.|. .    . | |. |.|..|... |  | .
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY