Gene RET (Mouse)

RET

Species: Mouse
Alias: Ret, RET
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Ret

Sequence

Name Sequence Type Origin Length Description Download
RET.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 284 Kinase domain by global Sugen HMM Fasta, JSON
RET.NA RNA Sugen 6064 None Fasta, JSON
RET.AA Protein Sugen 1115 None Fasta, JSON

Protein domain

Protein domains of RET.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Cadherin RET.AA Cadherin 81-102 25 16.971231 0.94 Pfam 41-67 (102) Show / Hide 
Range on Protein: 81-102
Range on HMM: 41-67/102
Sequence Identity: 25% (7 aa)

HE--NDWIRINETTGL---LYLNQSLD
..  ..| ||.. ||    ... ..||
NPDPGHWFRIDPDTGDNGIITTTKPLD
Cadherin RET.AA Cadherin 172-262 31 8.3e-15 54.27 Pfam 1-102 (102) Show / Hide 
Range on Protein: 172-262
Range on HMM: 1-102/102
Sequence Identity: 31% (32 aa)

VSFRVRENRPPGTFY-HFHMLPVQ-FLCPNISVKYSLLGGD---SLPFRCDPDCLE---VSTRWALDRELR-EKYVLEALCIVA--GPGANKETVTLSFP
 .|.|.|| |.|||  ...    . .|.|| ...||.|||.   .  ||.|||  .   ..|.. |||| . ..|.|  ..  .  |. .   |.|.   
YHFSVCENAPVGTFVMTVTATDPDDPLGPNWRIFYSILGGNPDPGHWFRIDPDTGDNGIITTTKPLDREQQNGQYHLTVMATDHDDGGPPRSSTTTVTIT

VT
|.
VC
CA RET.AA CA 191-271 16 0.000403 11.56 SMART 1-121 (121) Show / Hide 
Range on Protein: 191-271
Range on HMM: 1-121/121
Sequence Identity: 16% (21 aa)

LPVQFLCP-----NIS------VKYSLLGGDSLPFRCDPD-----------CLEVSTRWALDRELR---------EKYVLEALCIVAGPGANK-------
. .  .       |        |.||..|    .|. ||.           .....|. .|||| .         ..| |.     .|.  .        
VTATDPDEGHNGPNGQPNDPEMVTYSIVG----WFSIDPNTGTNYPSLVYCEIWITTTKPLDREEQFNKNEQRHHPQYTLTVQATDGGGPPPPDSHPTRK

------ETVTLSFPVTVYDEDDSAP
       . | .. ..| |..| .|
FQQNPPLSSTCTVTIHVLDVNDNPP
Cadherin RET.AA Cadherin 486-507 32 1.442596 4.67 Pfam 78-102 (102) Show / Hide 
Range on Protein: 486-507
Range on HMM: 78-102/102
Sequence Identity: 32% (8 aa)

TVVATDR-Q--TRRQTQASLVVTVE
||.|||. .  . | . .....||.
TVMATDHDDGGPPRSSTTTVTITVC
Kinase RET.AA Ret 725-1008 73 3.2e-256 857.46 In-house 1-293 (293) Show / Hide 
Range on Protein: 725-1008
Range on HMM: 1-293/293
Sequence Identity: 73% (216 aa)

LVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKEN-ASQSELRDLLSEFNLLKQVNHPHVIKLYGACSQDG--PLLLIVEYAKYGSLRGFLRDSR
|.|..|||||.||.||||.||...|..|||||||||||.| |..||..||||||.|||||||||||||||||.||.  |..|||||.|||.||.|||.||
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQVNHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRLSR

KIGPAYVSGGGSRNSSSLDHPD-ERVLT-----MGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKKSKGRIP
||||.|....|.||.|..|||| ..|..     |...|||||||..||.||.|||||||||||||.||||||..|||||||.|||||.|||||.||.|||
KIGPYYEYSIGNRNCSIVDHPDGKDVINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIP

VKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEK
|||||||||.||.|||.|||||||||.|||||.|.|||||||||||..|||||.||.||.||||||||.|.|||||||||||||..||||.||
VKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGANPYPGIPPERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase RET.AA Pkinase_Tyr 725-1006 41 1.3e-153 520.86 Pfam 1-270 (270) Show / Hide 
Range on Protein: 725-1006
Range on HMM: 1-270/270
Sequence Identity: 41% (122 aa)

LVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSE--LRDLLSEFNLLKQV-NHPHVIKLYGACS-QDGP--LLLIVEYAKYGSLRGFLR
...||.||||.||.|.|.|..  ..  . ..||||||||.|....  ..|...| ...||  .||....|||.|. |..|  .....||...|.|. .||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

DSRKIGPAYVSGGGSRNSSSLDHPDERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSY-VKKSKGRIPVK
. |                    .|.. ||| ||....|||..||.||......||||||||.||.|....||.||||.||.|..| | .|...|..|.|
KHR--------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIK

WMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNP-YPGIPPERLFNLL-KTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL
||| |.... ..||.|||||||||.|||.|.|. | |||...|...... . |.||..|.||..|.|.||.|||...|..|| |..|  .|
WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase RET.AA TyrKc 725-1006 38 1.1e-150 507.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 725-1006
Range on HMM: 1-280/280
Sequence Identity: 38% (122 aa)

LVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLLKQV--NHPHVIKLYGACSQD-------GPLLLIVEYAKYGSLRG
..|||.||||.||.|.|.|.         ..||||||||.|    ..|...| ......  .||....|||.|.|.       .||....||...|.|. 
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLRDSRKIGPAYVSGGGSRNSSSLDHPDERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEE-------DSYVK
.||..|.                        |.| ||.||.|||..||.||......||||||||.||.|.. .||||||||||.|..       | |.|
YLRKHRPK-----------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRK

KS--KGR--IPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPG-----IPPERLFNLLKTGHRMERPDN--------CSEEMYRLMLQCWKQ
|.   |.  .|..|||.|.......||.||||||||..||| |.|. ||||     ..........|.|.||..|.|        |..|||..|.|||. 
KEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHE

EPDKRPVFADISKDL
.|..|| |..| ...
DPEDRPTFSEIHECF
Kinase RET.AA FGFR 725-1006 48 7.6e-143 480.85 In-house 1-293 (293) Show / Hide 
Range on Protein: 725-1006
Range on HMM: 1-293/293
Sequence Identity: 48% (146 aa)

LVLGKTLGEGEFGKVVKATAFRLKGR--AGYTTVAVKMLKENASQSELRDLLSEFNLLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSR
|.|||.|||| ||.|..|.|. ..    .  .||||||||.|..  .| || ||   .| .  |. .|.| |.|.|.|||  ||||.. | || |||  |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

KIGPAYVSGGGSRNSS----SLDHPDERV--------LTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKK
  |. |     ...|.     . .. | .        ||  ||.|.|.|. |||.|||  | .||||||||.|| ..  |||.||||.||. . | | |.
PPGMDY-----KKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKT

SKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIP-PERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL
. || |.|||| |.||| .||.||||||.||||||| |.|| |||.||  | |. .||.|||||.| |||.|.| .| |||. .|. || |. .  .|
TNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase RET.AA VEGFR 725-1006 43 2.3e-129 436.09 In-house 1-332 (332) Show / Hide 
Range on Protein: 725-1006
Range on HMM: 1-332/332
Sequence Identity: 43% (144 aa)

LVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLLKQV-NHPHVIKLYGACS---QDGPLLLIVEYAKYGSLRGFLRDS
| ||| ||.| ||.|..|.|| ... .. ||||||||||.|  || | |.||  .|. . .|  |  . |.|    | |||. |||| ..| |  .||. 
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

RKI----------------------------------GPAYVSGGGSRNSSSLD--HPDER-------VLTMGDLISFAWQISRGMQYLAEMKLVHRDLA
|.                                   .   ..|...|   |.|   |||         ||| |||... |. ||| .||. | .|||||
RMYFVPYPDKSPHMRQRKECMGPQDHQDHKRRRDSGNSFQSSFGSFFRMKKSYDDVEPDEVFEDMWKDPLTMEDLICYSFQVARGMEFLASRKCIHRDLA

ARNILVAEGRKMKISDFGLSRD-VYEEDSYVKKSK-GRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIP-PERLFNLLKTGHRMERP
|||||..|    ||.||||.|.  |  . ||.| . || | ||||.||.||..|||.|||||.||.|||| .||| ||||.   | ..| || | ||..|
ARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSPYPGVQIDEEFCNRLKDGYRMRAP

DNCSEEMYRLMLQCWKQEPDKRPVFADISKDL
| |  |.|. ||.|| .||  || |..  . |
DYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase RET.AA TK 725-1006 25 2.2e-128 432.77 In-house 1-486 (486) Show / Hide 
Range on Protein: 725-1006
Range on HMM: 1-486/486
Sequence Identity: 25% (126 aa)

LVLGKTLGEGEFG---KVVKATAFRLK--------------------GRAGYTTVAVKMLKENASQSELRDLL-------------SEFNLLKQVN----
..|||.||||.||   .| |.......                    .. | |.|||||||| ...|. . ..             .| . .|. .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPHVIKLYGACSQD------------GPLLLIVEYAKYGS----LRGFLRDSRKIGPAYVSGGG---------------------SRNSSSLDHPDER-
 ||....|||.|.|.            .|.....||...|.    || .||..|. .  . ....                     |..|.| . |.|. 
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

-------------------------------VLTMGDLISFAWQISRGMQYLAEM------KLVHRDLAARNILVAEGRK-----------MKISDFG--
                                ||| .|. ..|||..||.||...      ..|||||||||.||.|. .            ||.|||  
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LSRDVYEEDSYVKKS------------------------KGRIPVKWMAIESLFDHI---------YTTQSDVWSFGVLLWEIVTLG-GNPYPG
      |.||.|..| |..||                        .|..|..||| |.|.|..         .||.|||||||||.|||.|.| . .|.|
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

IPP---------ERLFNLLKTG--------------HRMERPDNCS--------------EEMYRLMLQCWKQEPDKRPVFADISKDL
..          . ....|..|              .||..|..|.              ||.|.||.|||. .|..|| |... . |
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RET.AA TK-Unique 725-1006 40 3.4e-122 412.25 In-house 1-294 (294) Show / Hide 
Range on Protein: 725-1006
Range on HMM: 1-294/294
Sequence Identity: 40% (122 aa)

LVLGKTLGEGEFGKVVKATAFRLKGRAGYT-TVAVKMLKENASQSELRDLLSEFNLLKQVN-HPHVIKLYGACSQDG-PLLLIVEYAKYGSLRGFLRDSR
|..|...|||.|| | .........  . .  |||||||.||.. . .|.|.|....|..  ||......|.|  .. | ..| ||. .|.|...|| .|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

KI--GP---AYVSGGGSRNSSSLDHPDERV----LTMGDLISFAWQISRGMQYLAE--MKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKK-
.   ..   . .         ...|. ...    ....||..||||| .||.|||.  .| |||||.|||.|..|. . ||.|||..|||| .  |... 
PAMRQHQTYGNLK-------FDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMC

SKGRIPVKWMAIESLF--DHIY-TTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNC-SEEMYRLMLQCWKQEPDKRPVFADISKD
|.||||..||| |||   ...| ||.|||||||||.|||.|||. ||||.|.... .... |.||..|..| |.||| || .||. ||..|| |..| . 
SQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHR

L
|
L
Kinase RET.AA UTK 725-1006 36 1.5e-109 370.29 In-house 1-296 (296) Show / Hide 
Range on Protein: 725-1006
Range on HMM: 1-296/296
Sequence Identity: 36% (113 aa)

LVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLK-ENASQSELR---DLLSEFN---LLKQVN-HPHVIKLYGACSQDGPLLLIVEYAKYGSLRGF
. ||..||.|.|| | ||.. . .....   |||| .. . ..| | .   |.. | .   ..||.. ||.|..|.| |.|..|.....||.. |.|| .
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRDSRKIGPAYVSGGGSRNSSSLDHPDERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGR-------KMKISDFG---LSRDVYE----
||..|.  |                ...  ||. .....||.|.||||||.....|||||||||.||.. |       . ||.|||   .||.|.     
LRRHRPTPP----------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFS

----EDSYVKKS-KGRIPVKWMAIESLFDH-IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTG--HRMERPDNCSEEMYRLMLQCWKQEPD
    |. |....  .|.|..||| |.| .|  .||.||||||||..|||.| |  ||||.  ....  .  |  .||..|. |....||||..||...|.
NRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQ

KRPVFADISKDL
.|| | |. . .
ERPDFEDLVQQM
Kinase RET.AA Tie 733-1006 48 7e-105 320.22 In-house 1-267 (267) Show / Hide 
Range on Protein: 733-1006
Range on HMM: 1-267/267
Sequence Identity: 48% (133 aa)

EGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSRKI--GPAYVS
|| ||.|.||.   .|   .   ||.||.|| ||. . ||   |  .. .|  || .| | ||| . | | . .|||.|| |  ||| || |   ||. .
EGNFGQVMKAM---IKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRVIETDPAFAR

GGGSRNSSSLDHPDERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKKSKGRIPVKWMAIESLFDHIY
  ..|    .       |.   .. ||  . ||||||.. ...|||||||||||.|    ||.||||||    .. ||||  ||.||.|||||||   .|
EHTTRFKVNV----ASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSR---GDEVYVKKTMGRLPVRWMAIESLNYSVY

TTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL
||.|||||.||||||||.||| || |.    |.. |  |.|||.| || .|.| || |||.. | .|| || |  .|
TTKSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase RET.AA Src 725-1006 36 1.4e-95 323.87 In-house 1-255 (255) Show / Hide 
Range on Protein: 725-1006
Range on HMM: 1-255/255
Sequence Identity: 36% (103 aa)

LVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSRKIG
. | . ||.| || | ...        | | |||| ||.     .  ..| | ...|.. |.....||  |||. | . . || . |||  .|..     
IKLCRKLGQGQFGEVWMGY------WNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-----

PAYVSGGGSRNSSSLDHPDERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYE--EDSYVKKSKGRIPVKWMAIE
                 ...| | . .||..|.|...||.|| .|...||||||||.|| |.   |. |||| | . .  .| |. ..  ..|.||.| |
----------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPE

SLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYR-LMLQCWKQEPDKRPVFADISKDL
 .  . .|. |||||||.||.|||| |  ||||   .  .  .. | || .|.|| .|.|  .|||||...|..|| |. . . |
AINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase RET.AA Fer 725-1007 30 2.6e-88 299.68 In-house 1-283 (283) Show / Hide 
Range on Protein: 725-1007
Range on HMM: 1-283/283
Sequence Identity: 30% (93 aa)

LVLGKTLGEGEFGKVVKAT-AFRLKGRAGYT----TVAVKMLKENASQSE-LRDLLSEFNLLKQ-VNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFL
 .||| |||| ||.| |.. ....|   . .     |.||..|..... | ..... | .....  .||.|.|.|| |... |.... |... |||. .|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RDSRKIGPAYVSGGGSRNSSSLDHPDERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAE-GRKMK--ISDFGLSRD--VYEEDSYVKKSKG
. . ..                      .... ..| .. |...||.|| ... .|||.||||.|. . . | |  |||||.||.  .|..|.. |    
KKNKNK----------------------TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKAC

RIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPG----IPPERL-----FNLLKTGHRMERPDNCSEEMYRLML-QCWKQEPDKRPVFADI
..|..|.| |.. . ||.. .|||||||..||| | |  ||||    . .  .      .  | |..|  |... .|....|. |||...|..|| ...|
KVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEI

SKDLE
 . |.
CQKLK
Kinase RET.AA PDGFR 843-1006 52 8.1e-84 268.94 In-house 194-358 (358) Show / Hide 
Range on Protein: 843-1006
Range on HMM: 194-358/358
Sequence Identity: 52% (87 aa)

DERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKKSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLL
|..|||  ||..|. |. .|| .||    |||||||||.|...|.  || |||| ||. .  .|| |   | |||||| ||.|| .|||||||||.|.||
DSNVLTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILL

WEIVTLGGNPYPGIPPERLF-NLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL
||| .||||||||.| .  | .. | | ||..|.  .||.|  | .||  .| ||| |  ... |
WEIFSLGGNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase RET.AA S_TKc 725-1010 22 1.6e-47 165.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 725-1010
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

LVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLLKQVNHPHVIKLYGACSQDGPLLLIVEYAKY--GSLRGFLRDSRK
  .....|.| |||| |..  .         ||.|..|        .....| ..||. .||...|||...   . | .. ||.    |.|. .... ..
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

IGPAYVSGGGSRNSSSLDHPDERVLTMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKKSKGRIPVKWMAIE
 |.                   ....  .  ....|| ....|. ... .||||   |||. |    ||.||||.| .         .       .|| |
HGL------------------RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPE

SLFDHIYTT-QSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISK-----DLEKMM
 |    |..  .|.||.|..|.| .. |  |.|   ....|....           |.|.  .. .|.. .|.|||   .. .      .   .
VL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RET.AA Pkinase 725-1006 21 3.3e-42 150.34 Pfam 1-293 (293) Show / Hide 
Range on Protein: 725-1006
Range on HMM: 1-293/293
Sequence Identity: 21% (69 aa)

LVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLL---SEFNLLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYG----SLRGFL
...|...|.| ||.|     .. . .    .|||| .|     |. .  .   ||  ..| .|||....||...  .. . .. ||.  |    .|  ..
YHIGRKIGSGSFGCV-----YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

RDSRKIGPAYVSGGGSRNSSSLDHPDERVL--TMGDLISFAWQISRGMQYLAEMKLVHRDLAARNILVA-EGRK---MKISDFGLSRDVYEEDSYVKKSK
.                        .....  .. .......|| ||..|. .|. .||||   |||.  .|      ||.||||.. .. . ...  . 
ST----------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTT

GRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI-------PPERLFNLLKTGHRMERPDNCS-------------------EEMYRL
      .|| | .  .  |.. .|.||.|..|.| .. |  |.||        . ..... ...  . ..|  ||                   ||.  .
FCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDF

MLQCWKQEPDKRPVFADISKD--L
.  |... | ||| ...| ..  .
IKWCLCKDPKKRPTAEQILQHPWF
Kinase RET.AA PDGFR 725-821 44 3.5e-28 87.26 In-house 1-98 (358) Show / Hide 
Range on Protein: 725-821
Range on HMM: 1-98/358
Sequence Identity: 44% (44 aa)

LVLGKTLGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSR
|..||||| | ||||| |||. |       .|||||||. |  ||   | ||   . .  .|  .. | |||   || ..| ||  || |  .|.  |
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKR