Gene RSK4 (Mouse)

RSK4

Species: Mouse
Alias: RSK4, Rps6ka6
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation: Secondary Group: CAMK, Secondary Family: RSKb, Secondary Subfamily: RSKb,

Classification

Group: AGC
Family: RSK
Subfamily: RSKp90

Sequence

Name Sequence Type Origin Length Description Download
RSK4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON
RSK4.AA Protein Sugen 767 None Fasta, JSON
RSK4.NA RNA Sugen 4339 None Fasta, JSON
RSK4.kin_dom2 Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of RSK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RSK4.AA AGC 93-350 33 2.2e-185 484.52 In-house 1-395 (395) Show / Hide 
Range on Protein: 93-350
Range on HMM: 1-395/395
Sequence Identity: 33% (134 aa)

FDLLKVLGQGSFGKVFLVRKKTGP---DAGQLYAMKVLRKAS---LKVR-DRVRTKME------------RDILVEVN----------HPFIVK-LHYAF
|..|||.|.||||||.|||||.|.   | |..||||||.|.    .| . .  .|. |            |.||...|          |||||| |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTEGK--LYLILDFLR---------GG-DVFTRLS---KEVLFTEEDVKFYLAE-------LALALDHLHR-LGIVYRD-LKPENILLDEIGHIKLTDFG
|.. .  ||......          || . |..|    ||  |.|| ..||.||       ..|||..||. .||..|| |||||||||| |||||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKESVD--------------------------------------------------QEKKAYSFCG--TVEYMAPEVVNRRGHSQSADWWS--YGVLMF
|.|| ..                                                  .......|||  | ||||||..    .....||||  .|.||.
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLTGTLPFQGK----------DRNETMNMIL------KAKLGMP----------QFLSAEAQSLLRMLFKRNPANRLGSE-------GVEEVKRHAFF
|||||  ||.|.          ...|... |.      . |. .|          ...| ||..|...|....|..|||.        |.||.|.| .|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase RSK4.AA RSK 93-350 53 4.2e-183 614.59 In-house 1-271 (271) Show / Hide 
Range on Protein: 93-350
Range on HMM: 1-271/271
Sequence Identity: 53% (144 aa)

FDLLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLRKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTE
..|....|||||.||....|....|..|.||||...||...|.|||....||.|| ...|||||||||.||.|||.|.|.||.|||| |.||.|.. |.|
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE

EDVKFYLAELALALDHLHRLGIVYRDLKPENILLDEI----GHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLT
..||||.||.|||...|| .|||.|||||||||.|.     ||||..|||..|.. |.......||.|..||||||..|.||.|..||||.||||.||||
REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLT

GTLPFQGKDRNETMNMILKAKLGM-------PQFLSAEAQSLLRMLFKRNPANRLGS--EGVEEVKRHAFF
|..|||.|.|...||.|...||||       ..|.|.||..||||...|.|.||||.  .|||..|.|..|
GCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase RSK4.AA RSK 96-350 53 6.2e-166 557.55 In-house 1-278 (278) Show / Hide 
Range on Protein: 96-350
Range on HMM: 1-278/278
Sequence Identity: 53% (148 aa)

LKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLRKASLKVRDR-VRTKM-ERDILVEVN-HPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVL---
|||||||..|||||.||.|. |.||.||||||.|| ...|.. .|..| ||.|| ... |||||.||||||||||||||....|||. ||.|.||.    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTEEDVKFYLAELALALDHLHRLGIVYRDLKPENILLDE---IGHIKLTDFGLSKE-SVDQEKKAYSFCGTVEYMAPEVVN----RRGHSQSADWWSYGV
|.|....||.||..||..||| .||..|||||||||.|.    |||||||||..|. . |.......||.|.||||||...    ..||....|||| ||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LMFEMLTGTLPFQG---KDRNETMNMILKAK--LGMP--QFLSAEAQSLLRMLFKRNPANRLG--SEGVEEVKRHAFF
||.||||| .||||   ..|.|.|. |.|.|  |.||  |.||.||..|.|....|.|..|||   ...||.|.|..|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase RSK4.AA Akt 93-350 47 3.1e-142 457.54 In-house 1-264 (264) Show / Hide 
Range on Protein: 93-350
Range on HMM: 1-264/264
Sequence Identity: 47% (126 aa)

FDLLKVLGQGSFGKVFLVRKKTGPDAGQLY-AMKVLRKASLKVRDRVR-TKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLF
||.|||||.|||||||||.||   | ...| |||||.|  .  .. |. || || ||. .||||||.|||.|||. |||...|.  ||. |. |...  |
FDFLKVLGKGSFGKVFLVKKK---DTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRF

TEEDVKFYLAELALALDHLHRLGIVYRD-LKPENILLDEIGHIKLTDFGLSKES-VDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWS-YGVLMFEML
.|.  .|| ||. ||..|||  .|.||| |||||||.|. |||.||||||.||  . .  |...|||| ||.|||. |  ||....|||.  |..|.||.
SEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMM

TGTLPFQGKDRNETMNMILKAKLGMP--QFLSAEAQSLLRMLFKRNPANRLG--SEGVEEVKRHAFF
.| .||  .|. . .  |. ... .|   ..| |...|.. | ...| .|||  .....|.||| .|
CGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase RSK4.AA p70 93-350 46 7.29999999999e-138 464.3 In-house 1-299 (299) Show / Hide 
Range on Protein: 93-350
Range on HMM: 1-299/299
Sequence Identity: 46% (139 aa)

FDLLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLRKASL--KVRDRVRTK-------------------------MERDILVEVNHPFIVKLHYAFQTE
| ||||||.| .||||.||| || |.|..|||||||||.     .|   |.                          || || ||.||||..|||||||.
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

GKLYLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHRLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKK----------AYSFCG
|||||||..| ||  |. | ..  . |. ..|||.|  .|| ||| .||.||||||||..|.. ||..||||||.|||.   ..           ..|||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAK--LGMPQFLSAEAQSLLRMLFKRNPANRLG--SEGVEEVKRHAFF
| ||||||.. | ||..  |||| |.||. ||||  || |  | .|.. |||.|  | .|  |..|.  |.. | ||.|. |.|   | ......|.||
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase RSK4.AA SGK 93-350 40 1.3e-137 427.79 In-house 1-283 (283) Show / Hide 
Range on Protein: 93-350
Range on HMM: 1-283/283
Sequence Identity: 40% (116 aa)

FDLLKVLGQGSFGKVFLVRKKTG---------------PDAGQLYAMKVLRKASLK-------VRDRVRTKM-ER-DILVEVNHPFIVKLHYAFQTEGKL
||.|||.|.||||||..|..|                    ...||||||.|..          .  .. .| || .||. ..|||||.|||||||. ||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLILDFLRGGDVFTRLSKEVLFTEEDVKFYLAELALALDHLHRLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRR
|. .|.. ||. |  | .|  | |  ..|| ||...||..|| . |.||||||||||||  ||..||||||.|| . ....  .||||.||.|||| . .
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

GHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSE-GVEEVKRHAFF
.|. . |||. | ...||..|  ||  .....    |.. .| .|.. |..| .|.  | ...| .|||.  . .|.|.| ||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase RSK4.AA S_TKc 93-350 33 4.6e-106 359.59 SMART 1-231 (231) Show / Hide 
Range on Protein: 93-350
Range on HMM: 1-231/231
Sequence Identity: 33% (90 aa)

FDLLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLRKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRG--GDVFTRLSKEVL-
...|...|.|.||||...|.|     |...|.|...          ... |..|| . .||.||||...||. ..||...... |  ||.|... |    
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----FTEEDVKFYLAELALALDHLHRLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQ-SADWWSYGVLM
     |.| ...||......||...|..||..||||||||||||  |||..||||...        ..|||| .||||||.   |..  ..|||| |...
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

FEMLTGTLPFQGKDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEE----VKRHAFF
.|||.|  ||.  . ......|.          | || ...| .....|..|..   . .    .| | .|
YEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RSK4.AA MSK 96-345 39 2.7e-104 352.79 In-house 1-277 (277) Show / Hide 
Range on Protein: 96-345
Range on HMM: 1-277/277
Sequence Identity: 39% (110 aa)

LKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLRKASLKVRDRVRTK--MERDILVEV-NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTE
|||||.|. ||.|..|| .. |.|.|||||.|.|| .  . ..      || .|  . .||.||.||||||.. ..||......||  ||...|   |.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

EDVKFYLAELALALDHLHRLGIVYRDLKPENILLDEI---GHIKLTDFGLSKESVDQ-EKKAYSFCGTVEYMAPEVVNR-----RGHSQSADWWSYGVLM
. . ....|| .|.||.| .||..|||||||||.|..   ||.||.|||.... . . |....|.|.| .|||||...|      |.... |||| ||..
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVIL

FEMLTGTLPFQ--GKDRN-------ETMNMILKAKLGMP----QFLSAEAQSLLRMLFKRNPANRLGSE--GVEEVK
..||||  |||  ..||        | |  |.|..   |    |  |..|. |.. |  ..|. ||| .  ...|.|
YTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase RSK4.AA Pkinase 93-350 27 1.2e-92 318.87 Pfam 1-293 (293) Show / Hide 
Range on Protein: 93-350
Range on HMM: 1-293/293
Sequence Identity: 27% (84 aa)

FDLLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLRKASLKVRDRVRTKM--ERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGG----DVFTRLS-
. .....|.||||.|.. ..|  ..   ..|.|...| . |   ...     |  |. ..|||.||.|...|......|.......||    | |...| 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-KEVLF--TEEDVKFYLAELALALDHLHRLGIVYRDLKPENILLDEIGHI----KLTDFGLSKE--SVDQEKKAYSFCGTVEYMAPEVVN-RRGHSQSAD
 ..  |  .|...|||. ... .|...|. ||..|||||||||.|. |||    |..||||.|      ..  ...|||| .||||||.. ........|
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVD

WWSYGVLMFEMLTGTLPFQGK------DRNETMNMILKAKLGMPQFLS---------------------AEAQSLLRMLFKRNPANRLGSEGVEEVKRHA
.||.|....|||.| .||.|.      | .. ...|....|  . . .                      |...... .....|. |..    |... | 
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHP

FF
.|
WF
Kinase RSK4.AA Ciliate-E2 93-350 23 2.8e-88 299.57 In-house 1-365 (365) Show / Hide 
Range on Protein: 93-350
Range on HMM: 1-365/365
Sequence Identity: 23% (90 aa)

FDLLKVLGQGSFGKVFLVRK-KTGP-------------------DAGQLYAMKVLRKASLKVRDRVRTKM-----------ERDILVEVNHPFIVKLHYA
....|..|||.||.|..... |..                    .....||||...|  ..   ..   |           |. || ..|||.|.|....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--TEGKLYLILDFLRGGDVFTRLS------------------KEVL-FTEEDVK-------FYLAELALALDHLHRLG-IVYRDLKPENILLDEIGHI
||  .. ..||..... ||| | ..                   ||.. .... ..       ||.|.. ||| .||  . |..||.||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLTDFGLSKESVDQEK-------------------------------KAYSFCGTVEYMAPEVVNRRG---------HSQSADWWSYGVLMFEMLTGTLP
|..||||||.  |...                                ....||| .|||||..|. .         .. ..|.|| ||...|||.| .|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FQGKDRNETMNMILKAKLGMPQF------------------LSAEAQSLLRM----LFKRNPANRLGSEGVEEVKRHAFF
|        .. |.. |.  |..                  .| |.. |..     .....| .|..  | |... | .|
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT--GWEQILNHPWF
Kinase RSK4.AA CAMK 98-350 22 8e-84 269.87 In-house 1-425 (425) Show / Hide 
Range on Protein: 98-350
Range on HMM: 1-425/425
Sequence Identity: 22% (97 aa)

VLGQGSFGKVFLVRKK-TG---------PDAGQLYAMKVLRKASLK--------------------------VRDRVRTKMERDILVE-------VNHPF
.||.||||||.|.. | |.          . || .|.|.. |  ||                           .|| . . | .|.         ..|| 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

IVKLHYAFQ------------TEGK--------LYLIL---DFLRGG----DVFTRLSKE---------------VLFTEEDVKFYLAELALALDHLHRL
|.||. ...            |  |        .|...   ..  ||    |.| .. .                  |||.....|   .. |....| .
IIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

GIVYRDLKPENILLDEI-----------------GHIKLTDFGLSKESVDQE-----------------------KKAYSFCGTVEYMA-PEVVNR----
.|| |||||||||||.                  . ||..|||....  . |                       .| . |||| |||| |||.|.    
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

----------RGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMN-------------MILKAKLG-MPQF-----------------------LSAEA
          .......| || ||... ||.|..||.|...||...             .|.|.|    | .                       .|.|.
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

QSLLRMLFKRNPANRLGSEGVEEVKRHAFF
..|.| . ...| .|.    .|....| ..
KDLIRKMLQVDPEKRM---TIEQCLNHPWM
Kinase RSK4.AA CAMK1 93-336 29 4.4e-64 185.16 In-house 1-265 (276) Show / Hide 
Range on Protein: 93-336
Range on HMM: 1-265/276
Sequence Identity: 29% (78 aa)

FDLLKVLGQGSFGKVFLVRKKTG-PDAGQLYAMKVLR-KASLKVRDR---VRTKMERDILVEV---NHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRL
. . |..| |.|..|.|. .|      |. ||.|..  | ..|  |.    . ..| .|.  |   .||.|.|..  .... ..||... . ||. | | 
YEFGKEIGRGAFSEVYLCTHKETQT-NGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI

SKEVLFTEEDVKFYLAELALALDHLHRLGIVYRDLKPENILLDEI-GH--IK--LTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVNR---RGHSQSADW
 .   .||.|      ... |. ..| .||| |||||||.|.  .  .  ||  . ||||||   ..| . .  ||| .|.||||...    ..... | 
VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDM

WSYGVLMFEMLTGTLPFQGKD-RNETMNMILKAKLGMPQF----LSAE-AQSLLRMLFKRNPANRL
|| ||  . .|.|  ||....  || . .|.|.....| .     | . |  ... . . .| .|.
WSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRY
Kinase RSK4.AA S_TK_X 351-412 36 2.6e-20 74.72 SMART 1-79 (79) Show / Hide 
Range on Protein: 351-412
Range on HMM: 1-79/79
Sequence Identity: 36% (29 aa)

ASIDWNKLYK--REVQPPFRPASG----KPDDTFCFDPEFTAKTPKDSPGLPASANAHQL-----------FKGFSFVA
..|||.|||.  .|..|||.|        | ||  |||||| .||...|  |.. |...            | ||..|.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase RSK4.AA Pkinase_Tyr 93-314 26 4.2e-19 65.33 Pfam 1-237 (270) Show / Hide 
Range on Protein: 93-314
Range on HMM: 1-237/270
Sequence Identity: 26% (63 aa)

FDLLKVLGQGSFGKVFLVRKK-TGPDAGQLYAMKVLRKASLKVRD--RVRTKMERDILVEV-NHPFIVKLHYAFQ-TEGK--LYLILDFLRGGDVFTRLS
  ..|.||.|.||.|.. . |  . . ..  | |.| | .   ..  |     |  |. .  .|| ||.|. .    ..   .|... .  .||  . | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----EVLFTEEDVKFYLAELALALDHLHRLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQEKKAY-SFCG----TVEYMAPEVVNRRGHSQSADW
|    .  .| .|   . .. | ....|.. ... |||   |.|..| ...| .||||..    ...  |    |     .  ||||. | .  .   | 
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

WSYGVLMFEMLT-GTLP-FQGKDRNETMNMILKAKLGMPQ
||.||||.|..| |  | ..| . .| ...| .    ||.
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC
Kinase RSK4.AA TyrKc 93-349 22 4.1e-17 54.03 SMART 1-280 (280) Show / Hide 
Range on Protein: 93-349
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

FDLLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLRKASLKVRDRVRTKMERDILVEV--NHPFIVKLHYAFQTE-------GKLYLILDFLRGGDVFTR
  |.|.|| | ||.|.. . |      .  | |.|.. .     |     |  |. ..  .|| ||.|. .  ..       . |.... .  .||   .
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LSKEVL-FTEEDVKFYLAELALALDHLHRLGIVYRDLKPENILLDEIGHIKLTDFGLSKESVDQ-----EKKAYSF----CGT----VEYMAPEVVNRRG
| |    .. .|   .    |   ..||. ... |||   |.|..| ...| .|||||..  |      .|. |.     .|     .  ||||. | . 
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

HSQSADWWSYGVLMFEMLT-GTLPFQG-----KDRNETMNMILKAKLGMPQFL---------SAEAQSLLRMLFKRNPANRLGSEGVEEVKRHAF
 .   | ||.||.|.|..| |  |  |     ..  | .. . . .  ..            ..|  .. ..  ...|..|   . .    .. |
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI----HECF
Kinase RSK4.AA Pkinase_C 374-414 39 3.5e-11 42.61 Pfam 5-46 (46) Show / Hide 
Range on Protein: 374-414
Range on HMM: 5-46/46
Sequence Identity: 39% (17 aa)

PDDTFCFDPEFTAKTPKDSP--GLPASANAHQLFKGFSFVATS
|.||  ||||||  .|.|.|  .   |.... .| ||..|. .
PTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase RSK4.AA RSK 446-703 56 6.2e-188 630.63 In-house 1-271 (271) Show / Hide 
Range on Protein: 446-703
Range on HMM: 1-271/271
Sequence Identity: 56% (153 aa)

YELKEDIGIGSYS---VCKRCIHSASNVEFAVKIIDKNKRDPS-----EEIEILMRYGQHPNIISLKEVFDDGKYVYLVTDLMKGGELLDRILKKKCFSE
|||.|.|| ||.|   |||.|.|...| ..|.|||.|..||..     ||..|..|||.||.|. |..||.|...||...|.|.||.|.||.||.|.|||
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE

QEASNVLYVITKTVECLHSQGVVHRDLKPSNILYMDESAHPDSIKICDFGFAKQLRGENGLLLTPCYTANFVAPEVLTQQGYDAACDIWSLGVLLYTMLA
.|.......|....|.|||||.|||||||.||||.|||..|..|||||||||||||.|||.|.|.|||||..||||| .||.|.|||.||.|||.|.||.
REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLT

GYTPFSNGPNDTPEEILLRIGNGRFSLSGGIWDNISRGAKDLLSHMLHMDPHQRYTA-----EQVLKHPWI
|.||| |.|.|||..|..||..|.||...|.||.||. |||||..|||.|||.|..|     ||...|||.
GCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase RSK4.AA RSK 448-703 42 2e-154 519.34 In-house 1-278 (278) Show / Hide 
Range on Protein: 448-703
Range on HMM: 1-278/278
Sequence Identity: 42% (119 aa)

LKED--IGIGSYSVCKRCIHSASNVEFAVKIIDKNKRDPS--------EEIEILMRYGQHPNIISLKEVFDDGKYVYLVTDLMKGGELLDRILKKKC---
||..  .| |....|..|.|.... ..|.|...|.|....        .|..||.|..|||.|..|...|......||......||||.....|.|.   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSEQEASNVLYVITKTVECLHSQGVVHRDLKPSNILYMDESAHPDSIKICDFGFAKQLRGE-NGLLLTPCYTANFVAPEVLT----QQGYDAACDIWSLG
||| ||. ... |...||.||.||..||||||.||||.||| .. .||..||||.||.| . |... |.|||....|||.|.    | |.|.|||.||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

VLLYTMLAGYTPFSNGPND-TPEEILLRIGNGRFSLSGGIWDNISRGAKDLLSHMLHMDPHQRYT-----AEQVLKHPWI
||.|.||.|..|| . ||| ...||. ||..|.|||....|...|. ||||...|||.|||.|..     ||....|||.
VLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase RSK4.AA CAMK1 446-703 40 1.6e-118 346.17 In-house 1-276 (276) Show / Hide 
Range on Protein: 446-703
Range on HMM: 1-276/276
Sequence Identity: 40% (114 aa)

YELKEDIGIGSYSVCKRCIHSAS---NVEFAVKIIDKNKRDPS----------EEIEILMRYG--QHPNIISLKEVFDDGKYVYLVTDLMKGGELLDRIL
||... || |. |. ..|.|  .   . ..|.|.|||.|               ||||. . .  .|||||...|.... ...|||..|..||||.|||.
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

KKKCFSEQEASNVLYVITKTVECLHSQGVVHRDLKPSNILYMDESAHPDS-IK--ICDFGFAKQLRGENGLLLTPCYTANFVAPEVLTQ---QGYDAACD
.|....|..|...   | . || .||.|.||||||| |.|| |..  .|| ||  |.||| .|.. ....|. |.| |  .||||||..   ..|| |||
EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKD--EDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACD

IWSLGVLLYTMLAGYTPFSNGPNDT-PEEILLRIGNGRFSLSGGIWDNISRG-AKDLLSHMLHMDPHQRYTAEQVLKHPWI
.|| || .|..| || ||     ..  .|..  | .. .      ||||| . |||...|||  || .|||.||.|.||||
MWSIGVITYILLCGYPPFY---DENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase RSK4.AA AGC 446-703 23 1.5e-106 275.93 In-house 1-395 (395) Show / Hide 
Range on Protein: 446-703
Range on HMM: 1-395/395
Sequence Identity: 23% (93 aa)

YELKEDIGIGSYSVCKRCIHS------ASNVEFAVKIIDKNK---------RDPS-------------EEIEILMRYGQ---------HPNIIS-LKEVF
.|..  || ||.. .  . .       ...  .|.|...| .          .               || .||... .         ||.|.. |.  |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

DDGKY--VYLVTDLMK---------GG-ELLDRIL---KKKCFSEQEASNVLYV-------ITKTVECLHS-QGVVHRD-LKPSNILYMDESAHPDSIKI
 | ..  .|.| ..|.         || ||. ..    |...|.|..|   .         |.  .| ||| .|..||| ||| |||  ..      ||.
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED----GHIKL

CDFGFAKQLRGE-----------------------------------------------------NGLLLTPCYTANFVAPEVLTQQGYDAACDIWS--L
.|||..|.....                                                     .  .  || |....|||.|    |. |||.||  |
TDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPC-TPEYMAPEIL----YGKACDWWSFGL

GVLLYTMLAGYTPFSNGPND-------TPEEILLRIGNGRFSLSGGIW------------DNISRGAKDLLSHMLHMDPHQRYT----------AEQVLK
|.|.| ||.||.||.. ...       .|.|.  .| |||. .. ..             ...|  ||||....|. || .| .          ||.. .
GCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKN

HPWI
||| 
HPWF
Kinase RSK4.AA CAMK 451-703 25 3e-101 327.02 In-house 1-425 (425) Show / Hide 
Range on Protein: 451-703
Range on HMM: 1-425/425
Sequence Identity: 25% (110 aa)

DIGIGSYSVCKRCIHSASN------------VEFAVKIIDK--------------------------------NKRDPSEEIEILMRYG------QHPNI
 .| ||... |.|||  ..            ...|.|||||                                ...    ||||...        .||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ISLKEVFDDGKY-------------------VYLVT---DLMKGGEL----LDRILKKKC---------------FSEQEASNVLYVITKTVECLHSQGV
|.| ||..|..|                   .|.|.   ... ||||    .|.| ...|               |.|.||. .   |   |. .||...
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPSNILYMDESAHPD-------------SIKICDFGFAKQLRG-----------------------ENGLLLTPCYTANFVA-PEVLTQ------
||||||| |||. | . . |              |||.|||||.....                       |. .. |.| |  ..| |||| .      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------QGYDAACDIWSLGVLLYTMLAGYTPFSNGPND----------TPEEILLRIGNGRFSLSGGI------------WDNISRG--------AKD
        ..|. .||.||.||.||.|| || ||    ..          ...|.. .| .|...                 ||.||          .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LLSHMLHMDPHQRYTAEQVLKHPWI
|...||  || .|.|.||.|.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase RSK4.AA S_TKc 446-703 35 3.1e-100 340.2 SMART 1-231 (231) Show / Hide 
Range on Protein: 446-703
Range on HMM: 1-231/231
Sequence Identity: 35% (98 aa)

YELKEDIGIGSYSVCKRCIHSASNVEFAVKIIDKNKRDPSEEIEILMRYGQHPNIISLKEVFDDGKYVYLVTDLMKG--GELLDRILKKKC------FSE
||. . || |.......|.|  .. ..|.|||.   ..   ||.||..  .||||. |..||.| ...|.|.... |  |.|.|.| |...      |.|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

QEASNVLYVITKTVECLHSQGVVHRDLKPSNILYMDESAHPDSIKICDFGFAKQLRGENGLLLTPCYTANFVAPEVLTQQGYDA-ACDIWSLGVLLYTML
 .|  ..| | . .| .||.|..||||||.|||  .       |||||||.|.||        | | | ...|||||   ||.  .||.||.|..|| ||
-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

AGYTPFSNGPNDTPEEILLRIGNGRFSLSGGIWDNISRGAKDLLSHMLHMDPHQRYTAEQVLK-------HPWI
.||.||.     ...... .||              |. |||.....|..|| .|.|| ..|.       |||.
CGYPPFP-----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RSK4.AA Pkinase 446-703 33 5.3e-100 343.34 Pfam 1-293 (293) Show / Hide 
Range on Protein: 446-703
Range on HMM: 1-293/293
Sequence Identity: 33% (100 aa)

YELKEDIGIGSYSVCKRCIHSASNVEFAVKIIDKNKRDPSE--------EIEILMRYGQHPNIISLKEVFDDGKYVYLVTDLMKGG----ELLDRIL--K
|.... || ||......|.|  .. ..|||||.| ......        ||.|. |  .||||. |...| |....|.|.... ||    .| |.|   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

KKCF--SEQEASNVLYVITKTVECLHSQGVVHRDLKPSNILYMDESAHPDSIKICDFGFAKQL-RGENGLLLTPCYTANFVAPEVLT-QQGYDAACDIWS
..||  ||.|. ...| | . .| .||.|..||||||.|||. ..   ....||||||.|||.    |. . |.| | ...||||.  .|.|. ..|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGVLLYTMLAGYTPFSNG----PNDTPEEILLRIGNGRFSLSGGIWDNIS-----------------RGAKDLLSHMLHMDPHQRYTAEQVLKHPWI
.|..|| || |..||..     . ... ... ||. .... .   |..||                 . .||... .|..||..|.||||.|.|||.
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase RSK4.AA MSK 448-703 36 9.8e-87 293.22 In-house 1-277 (277) Show / Hide 
Range on Protein: 448-703
Range on HMM: 1-277/277
Sequence Identity: 36% (101 aa)

LKED--IGIGSYSVCKRCIHSASNVEFAVKIID-----KNKRDPSE---EIEILMRYGQHPNIISLKEVFDDGKYVYLVTDLMKGGELLDRILKKKCFSE
||.   .| |....|..| |. .. ..|.||.        .. ...   |. .| .  ||||| .|...| |    ||| .. .||||. .| |.. |.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

QEASNVLYVITKTVECLHSQGVVHRDLKPSNILYMDE--SAHPDSIKICDFGFAKQLRGE-NGLLLTPCYTANFVAPEVLT----QQG-YDAACDIWSLG
.|.. ..  .   |...|. |..|||||| |||. ||  ..|   .|. |||||. .  . .  . .||.|  . |||.|.    |.| ||.|||.||||
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGH---VKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLG

VLLYTMLAGYTPFS---NGPN---DTPEEILLRIGNGRFSLSGGIWDNISRGAKDLLSHMLHMDPHQRYTAEQVLKHPWI
|.||||| |  ||     .      .  ||  ||  |.||. |  | |.|  ||||.. .|  ||  | ...  ..| |.
VILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase RSK4.AA Ciliate-E2 446-703 25 2.3e-77 263.35 In-house 1-365 (365) Show / Hide 
Range on Protein: 446-703
Range on HMM: 1-365/365
Sequence Identity: 25% (98 aa)

YELKEDIGIGSYSVCKRCIHSASNVEFA-----------------------VKIIDKNKRDPSEEIEILMR----------------YGQHPNIISLKEV
|.. . || |.... ..| .   . .||                       .||. ||.    . .. .||                  .||||| ..|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FD--DGKYVYLVTDLMKGGELLDRILKK-----------KCFSEQEASNVLYVITK---------------TVECLHSQG-VVHRDLKPSNILYMDESAH
|   | ...|||... .||.|.|.| ..           |.|.|.|.... . |..                .| |||.. ..|||.||.|||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

PDSIKICDFGFAKQLRGENG-------------------------------LLLTPCYTANFVAPEVLT---------QQGYDAACDIWSLGVLLYTMLA
   |||.|||..|..  .|                                .  | |.|....|||.|          |.||| .||||||||.|| || 
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GYTPFSNGPNDTPEEILLRIGNGRFSLSGG--------------IWDNISRGAKDLLSH----MLHMDPHQRYT-AEQVLKHPWI
|..||           .  | .. ....                .|...|  .|||..     ||  || .|.| .||.|.|||.
GKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase RSK4.AA p70 496-703 28 2.2e-31 110.61 In-house 86-299 (299) Show / Hide 
Range on Protein: 496-703
Range on HMM: 86-299/299
Sequence Identity: 28% (63 aa)

QHPNIISLKEVFDDGKYVYLVTDLMKGGELLDRILKKKCFSEQEASNVLYVITKTVECLHSQGVVHRDLKPSNILYMDESAHPDSIKICDFGFAKQLRGE
.||.|. |   | ..   ||. . . ||||     ..  . |  |.  |  |.   | ||..|.. ||||| |..  ..  |   ..  |||  |.   .
KHPFICDLHYAFQTNGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCM-LNQQGH---VVLTDFGLCKESIHD

NGL----------LLTPCYTANFVAPEVLTQQGYDAACDIWSLGVLLYTMLAGYTPFSNGPNDTPEEILLRIGNGRFSLSGGIWDNISRGAKDLLSHMLH
             ..| | |  . |||.|.  |.. |.| ||||.|.| || |  ||     ... ..   |  |.  |.  .    . ...||.  .| 
GAVDEEDPENVNATHTFCGTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFT---GENRKKTIDKILKGKQGLK--LPPYLTHEMRDLIKKLLK

MDPHQRYT-----AEQVLKHPWI
 .| || .     |... .||. 
RHPTQRWGAGPEDAADIQEHPFF
Kinase RSK4.AA SGK 497-642 38 2.7e-27 80.96 In-house 84-225 (283) Show / Hide 
Range on Protein: 497-642
Range on HMM: 84-225/283
Sequence Identity: 38% (57 aa)

HPNIISLKEVFDDGKYVYLVTDLMKGGELLDRILKKKCFSEQEASNVLYV--ITKTVECLHSQGVVHRDLKPSNILYMDESAHPDSIKICDFGFAKQLRG
|| |..|.  |   .. |.| | . |||.   . . |.|.| .|    |.  |    | |||| ...||||| |||  |   |   ....||| .|.   
HPFIVNLHYAFQTKWKLYFVMDYVNGGEMFYHLQREKHFPEDRA--RFYAAEIVCALEYLHSQDIIYRDLKPENIL-LDHQGH---CCLTDFGLCKEGIK

ENGLLLTPCYTANFVAPEVLTQQGYDAACDIWSLGVLLYTMLAGYTPF
.|    | | |    |||||  |..| . | |.|| .|| |. |  ||
TNDTTFTFCGTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPF
Kinase RSK4.AA Akt 552-644 40 4.4e-26 80.31 In-house 114-205 (264) Show / Hide 
Range on Protein: 552-644
Range on HMM: 114-205/264
Sequence Identity: 40% (39 aa)

ECLHSQGVVHRD-LKPSNILYMDESAHPDSIKICDFGFAKQL-RGENGLLLTPCYTANFVAPEVLTQQGYDAACDIWS-LGVLLYTMLAGYTPFSN
|.|||.... || ||| ||| ||.  |   |...||| .|.    ..    | | |.   |||.| ..|.. |.|.|. ||...| |. |  || |
EHLHSKNIIYRDYLKPENIL-MDKDGH---ICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYN
Kinase RSK4.AA TyrKc 446-709 18 2.3e-14 9.54 SMART 1-280 (280) Show / Hide 
Range on Protein: 446-709
Range on HMM: 1-280/280
Sequence Identity: 18% (56 aa)

YELKEDIGIGSYSVCKRCIHSASNVEFAVKIIDKNKRDPSE---EIEILMRYG-QHPNIISLKEVFDDG-------KYVYLVTDLMKGGELLDRILKKKC
 .|.. .| | . .  ... .   .. ||| . ...    .   |..|....| .||||. |  |  ..       . ...|. .|..| |.|.. |.. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-FSEQEASNVLYVITKTVECLHSQGVVHRDLKPSNILYMDESAHPDSIKICDFGFAKQLRGE-----NGLLLTPCY--TANFV------APEVLTQQGYD
 .. ..  .  . | .  | |||....||||   |.|. ..      .||.||| .. .  .     ..   ..     ....      |||..    . 
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

AACDIWSLGVLLYTMLA-GYTPFSN---GPNDTPEEILLRIGNGRFSLSGGIWDN--------ISRGAKDLLSHMLHMDPHQRYTAEQVLKHPWITQREQ
 . |.|| ||... ..  | .| ..       ...|.. .. .|.      . .|         .    .. .   | ||..| | ...        .|.
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMP---QPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--------HEC

L
.
F
Kinase RSK4.AA Pkinase_Tyr 446-633 25 3.2e-14 48.78 Pfam 1-205 (270) Show / Hide 
Range on Protein: 446-633
Range on HMM: 1-205/270
Sequence Identity: 25% (55 aa)

YELKEDIGIGSYSVCKRCIHS----ASNVEFAVKIIDKNKRDPSE--------EIEILMRYGQHPNIISLKEVFD-DGKY--VYLVTDLMKGGELLDRIL
 .. . .| |.. . ....        ... |||.. |.. ....        |..|.. .|.||||..|  |   .|.   .|.|. .|..| |||   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----KKCFSEQEASNVLYVITKTVECLHSQGVVHRDLKPSNILYMDESAHPDSIKICDFGFAKQL-------RGENGLLLTPCYTANFVAPEVLTQQGY
|    |. .. ..  .  . | |  | |.|.. .||||   |.|  .    .  .|||||| |. .       |   |  |    .    |||..    .
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKF

DAACDIWSLGVLLY
  . |.|| |||..
TTKSDVWSFGVLMW
Kinase RSK4.AA Akt 670-703 38 1e-05 14.26 In-house 226-264 (264) Show / Hide 
Range on Protein: 670-703
Range on HMM: 226-264/264
Sequence Identity: 38% (15 aa)

DNISRGAKDLLSHMLHMDPHQRY-----TAEQVLKHPWI
|.||  .|||.| .|. ||..|      .|...  ||| 
DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase RSK4.AA Akt 496-540 37 0.000608 8.4 In-house 58-102 (264) Show / Hide 
Range on Protein: 496-540
Range on HMM: 58-102/264
Sequence Identity: 37% (17 aa)

QHPNIISLKEVFDDGKYVYLVTDLMKGGELLDRILKKKCFSEQEA
.|| |..|.  | . .. |.|.| ..||||   . .|. |||..|
NHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDRA
Kinase RSK4.AA SGK 671-703 27 0.000776 7.21 In-house 247-283 (283) Show / Hide 
Range on Protein: 671-703
Range on HMM: 247-283/283
Sequence Identity: 27% (10 aa)

NISRGAKDLLSHMLHMDPHQRYTAE----QVLKHPWI
..|  |.||.   |. || .|  .     .. .||. 
QMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF