Gene RYK (Mouse)

RYK

Species: Mouse
Alias: RYK, Ryk
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Ryk

Sequence

Name Sequence Type Origin Length Description Download
RYK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 267 Kinase domain by global Sugen HMM Fasta, JSON
RYK.NA RNA Sugen 2456 None Fasta, JSON
RYK.AA Protein Sugen 594 None Fasta, JSON

Protein domain

Protein domains of RYK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
WIF RYK.AA WIF 47-180 43 5.9e-84 286.14 SMART 1-146 (146) Show / Hide 
Range on Protein: 47-180
Range on HMM: 1-146/146
Sequence Identity: 43% (64 aa)

SVSLYLSEDEVRRLLGLDAELYYVRNDLISHYALSF------NLLVPSETNFLHFTWHAKS---KVEYKLGFQVDNFVAMGMPQVNISAQGEVPRTLSVF
.|.......|.|||.|.||||||||...|.|||..|      ...||......||||.|..   .|.|....|.|....|.||.|||..||.||.||.|.
HVNMWINKHEMRRLIGVDAELYYVREGHINHYAHNFRKAQQRMYPVPANIHYMHFTWQAVGQAHYVHYFINVQSDDQEVMPMPIVNIPHQGTVPHTLQVW

RVELSCTGKVD--SEVMILMQLNLTVN-SSKNFTVLNFKRRKMCYK
.||..|.|..|  .|.|..|......| |.||||.|||.|.|.||.
QVEYKCSGHRDGVAEFMVTMYVMVKYNRSTKNFTHLNFRRKKICYQ
WIF RYK.AA WIF 50-178 33 1.5e-65 225.34 Pfam 1-145 (145) Show / Hide 
Range on Protein: 50-178
Range on HMM: 1-145/145
Sequence Identity: 33% (48 aa)

LYLSEDEVRRLLGLDAELYYVRNDLISHYALS-----F------NLLVPSETNFLHFTWHAKSKVEYKLGFQV---DNFVAMGMPQVNISAQGEVPRTLS
....| .|..|.|..||.||..|. ..|||..     |      ...|||... ..|||....|..|...|||   ..  .|..|..||| ||.||.. .
MWINEHQVMMLIGVSAEIYYIHNGHVNHYAHDPNFSHFRKAQQRMPPVPSNVHYVNFTWQSLGKHKYHYNFQVLYSSDQQIMKRPTLNISHQGRVPHEAK

VFRVELSCTGKVDSEVMILMQLNLTVNSSK--NFTVLNFKRRKMC
.|...| |.|......   ..|... ..||  |.|.|.|||.|.|
EFSIDLPCSGNRSGQATFTVNLEVMHRRSKPNNNTPLRFKRKKIC
Kinase RYK.AA Ryk 317-583 59 1.1e-230 737.1 In-house 1-292 (292) Show / Hide 
Range on Protein: 317-583
Range on HMM: 1-292/292
Sequence Identity: 59% (173 aa)

ITLKDVLQEGTFGRIFHGILVDEKDPN------------KEKQTFVKTVKDQASEVQVTMMLTESCKLRGLH-HRNLLPITHVC--------IEEGEKPM
|......||||||||.|||.....|.|            .....|||||||.||..||..||.|||.|.|.. |.|.||..|||        ||....|.
IQYSCLVQEGTFGRIYHGIWNQVDDVNNGDVDDEEDTFCDCQDVFVKTVKDHASQMQVHCMLQESCLLYGISPHQNILPVLHVCSFGRFDRPIEDHDPPF

VVLPYMN-WGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHRDLAARNCVIDDT---LQVKITDNALSRDLFPMDYHCLGDNENR
|..|.|| |||||.||..|........||||...||||||||..||..|......|.|.|.||||||..   |||||.|.||||||||||||||||||||
VCYPHMNNWGNLKQFLQDCRHDKPKCHQAISTHQLVHMAIQITMGMMHLHKHRIVHKDIATRNCVIDEQNGRLQVKICDSALSRDLFPMDYHCLGDNENR

PVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL
||.||.||||.....|.|||||.||||.||||||||.||..||||||..|||||||..||.|||||||.||||||...|||||.||||||||
PVKWMSLESLQHKHYSHASDVWSFGVTMWELMTLGQMPYMEIDPFEMYHYLKDGYRLQQPFNCPDELFTVMACCWHCMPEERPTFQQLVQCL
Kinase RYK.AA Pkinase_Tyr 317-583 36 2.2e-120 408.36 Pfam 1-270 (270) Show / Hide 
Range on Protein: 317-583
Range on HMM: 1-270/270
Sequence Identity: 36% (101 aa)

ITLKDVLQEGTFGRIFHGILVDEKDPNKEKQTFVKTVKDQASEVQ--VTMMLTESCKLRGL-HHRNLLPITHVCIEEGEK--PMVVLPYMNWGNLKLFLR
||.  .| || ||....|.. . .. |.. .  ||..|..|.. |    ... |   .. | || |..    ||...||   ...|..||  |.|. .||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

QCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHRDLAARNCVIDDTLQVKITDNALSRDLFPMDYH-CLGDNENRPVRWMALESLVNNEFSSAS
. .    ...|... .||..|..|||.||.||...  |||||||||| ......|||.|  |.||... ||    ...   |..|||.|.. ...|...|
KHR----EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKS

DVWAFGVTLWELMTLGQTP-YVDIDPFEMAAYL-KDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL
|||.|||..||..|.|..| | .....|. .|. .|||| ..| |||||.  .|  ||. |||.|| |......|
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase RYK.AA TyrKc 317-583 35 5.6e-118 399.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 317-583
Range on HMM: 1-280/280
Sequence Identity: 35% (106 aa)

ITLKDVLQEGTFGRIFHGILVDEKDPNKEKQTFVKTVKDQASEVQVTMMLTESCKLRGL--HHRNLLPITHVCIEEG------EKPMVVLPYMNWGNLKL
|||...| || ||....|..          |  ||..|. |    . ... |   .. |  || |.. .  ||...|      | .|.|. || .|.|| 
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHRDLAARNCVIDDTLQVKITDNALSRDLFPM-------DYHCL--GDNEN--RPVRWMA
.|| ..         .. .||.....||||||.||... .|||||||||| ... ..|||.|  ||||.          ||     .....   |.||||
YLRKHRPK-------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

LESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVD-----IDPFEMAAYLKDGYRIAQPIN--------CPDELFAVMACCWALDPEERPKFQQLVQCL
.|..  ..|...||||.|||..||..|.||.|| .     ....|. .|.|.|||  || |        ||||.. .| .||. |||.|| |.....|.
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase RYK.AA TK 317-583 20 5.9e-97 325.59 In-house 1-486 (486) Show / Hide 
Range on Protein: 317-583
Range on HMM: 1-486/486
Sequence Identity: 20% (101 aa)

ITLKDVLQEGTFG---RIFHGILVDEKDPNKEKQTF--------------------VKTVK--DQASEVQVTM--------------MLTESCKLRG--L
||| ..| || ||   ... |.. .... | ..                       ||..|  | .|. .  .               . | ....   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHRNLLPITHVCIEEGEK-----------PMVVLPYMNWGN----LKLFLRQCKLVEAN-----------------------------------------
|| |.. .  || ....|           .|.|. ||. |.    |. .||.|.  . .                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------NPQAISQQDLVH-------------------MAIQIACGMSYLARR------EVIHRDLAARNCVIDDTLQ-----------VKITDNA----
        |......||..                   |. ||||||.||...       ..||||||||| ... ..           .||.|      
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LSRDLFPMDYHCLGD------------------------NENRPVRWMALESLVNNE---------FSSASDVWAFGVTLWELMTLG-QTPYVDID
    |.||. . |. .  .                        .   |.|||| |.|  ..         |...||||.|||..||..|.| ...| ...
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

P---------FEMAAYLKDG--------------YRIAQPINCP--------------DELFAVMACCWALDPEERPKFQQLVQCL
           |.  ||..|              .| .|| .||              .|.. .| .||..|||.|| |.||...|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RYK.AA TK-Unique 317-583 33 9e-84 284.62 In-house 1-294 (294) Show / Hide 
Range on Protein: 317-583
Range on HMM: 1-294/294
Sequence Identity: 33% (98 aa)

ITLKDVLQEGTFGRIFHGILVDEK-DPNKEKQTFVKTVKDQASEVQVTMMLTESCKLRGLH-HRNLLPITHVCIEEGEKPMVVLPYMNWGNLKLFLRQCK
....||..|| || ...| ..  . . .| |.  ||..|| |..... ..| |   .. |  | |.. .  .|.. .| .| ...|.  |||  .||.|.
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

LV-----------------EANNPQA-ISQQDLVHMAIQIACGMSYLAR--REVIHRDLAARNCVIDDTLQVKITDNALSRDLF-PMDYHCLGDNENRPV
 .                 .. .. . || .||.| |.||||||.|||.  ....||||.|||. . . ...||.|  ..||.  . .|   .  .  |.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWMALESLV--NNEF-SSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINC-PDELFAVMACCWALDPEERPKFQQLVQCL
||||.|||    . . .. ||||.|||..||..|||..|| .... ..   ..||||  || .| ..|.. .| .|| ..||||| | |... |
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase RYK.AA Met 318-577 36 9e-81 264.5 In-house 1-271 (271) Show / Hide 
Range on Protein: 318-577
Range on HMM: 1-271/271
Sequence Identity: 36% (101 aa)

TLKDVLQEGTFGRIFHGILVDEKDPNKEKQTFVKTVK--DQASEVQVTMMLTESCKLRGLHHRNLLPITHVCIE-EGEKPMVVLPYMNWGNLKLFLRQCK
 . ||.  | || ..|| . |..   .| .  .|. .   .  . ..   |.|    ....|.| |    .|.. ||. |.||||||  | || | |   
HFDDVIGQGHFGCVYHGMYHDNDG--NEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRN--

LVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHRDLAARNCVIDDTLQVKITDNALSRDL-FPMDYHCLGDNEN---RPVRWMALESLV--------
  . ||| .    ||.  . |.|.||.|.| .  .|||||.||| .|  . ||. |  |.||.     |    .       ||.|||.|.|         
--PQNNPCV---RDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCP

NNE-FSSASDVWAFGVTLWELMTLGQTPYVDIDP-FEMAAYLKDG--YRIAQPINCPDELF-AVMACCWALDPEERPKFQ
 .  |...|||| ||| .||||| | .|| ..|. |    .|. |   |  ||  ||| |   || |||  .||.|| | 
TYRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase RYK.AA Axl 317-581 40 1.2e-74 254.27 In-house 1-267 (267) Show / Hide 
Range on Protein: 317-581
Range on HMM: 1-267/267
Sequence Identity: 40% (111 aa)

ITLKDVLQEGTFGRIFHGILVDEKDPNKEKQTFVKTVK-DQASEVQVTMMLTESCKLRGLHHRNLLPITHVCIEEGE-----KPMVVLPYMNWGNLKLFL
..|  .| || || .  | |  | |    |   ||..| |  .. ..   | |   ..   | | . .  |||.  |     ||||.||.| .| |  ||
FVLGKMLGEGEFGSVMEGQLKQE-DGSFVKVA-VKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFL

RQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHRDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSAS
   .| .  .|  .  | ||.  . ||||| ||. |. ||||||||||.. . . | . |  ||. ..  ||   |     ||.|.|.|||  . . | |
LYSRLGD--QPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQGCIAKMPVKWIAIESLADRVYTSKS

DVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQ
||||||||.||.|| |||||  ..  ||  || .| |. || .| |||...|  || .||..|| | .| .
DVWAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase RYK.AA UTK 317-583 29 7.8e-72 244.96 In-house 1-296 (296) Show / Hide 
Range on Protein: 317-583
Range on HMM: 1-296/296
Sequence Identity: 29% (88 aa)

ITLKDVLQEGTFGRIFHGILVDEKDPNKEKQTFVKTVK-DQASEVQVT---MMLTESC---KLRGLH-HRNLLPITHVCIEEGEKPMVVLPYMNWGNLKL
. | . | .| || .... ....... .| .  ||. . . ... . .     . |.     .  .| |.|.|   .||  |.  .|.|. ||  |.|  
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRS

FLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHRDLAARNCVIDDT-------LQVKITDNA---LSRDLFP--------MDYHCLGDNEN
.|| ..     .| . .  ....|| .||.||.||... ..||||||||| ...        ...|| |     .||..           .| .  .. .
YLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQD

R-PVRWMALESLVNN-EFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDG--YRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL
| |.|||| |.|...  |...||||.|||..||..| |..|| ..   . .. . .|  || ..|  ||.... .|  ||. ||.||| |..||| .
RWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase RYK.AA EGFR 317-584 33 4.3e-66 218.38 In-house 1-258 (258) Show / Hide 
Range on Protein: 317-584
Range on HMM: 1-258/258
Sequence Identity: 33% (90 aa)

ITLKDVLQEGTFGRIFHGILVDEKDPNKEKQTFVKTVKDQASEVQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVVLPYMNWGNLKLFLRQCKLV
. .  ||  | ||... || . |   |      .| ...| .. .   || |   . .. | .|. .  ||...    ..|  || .|.|  ..|| |  
LKKVKVLGSGAFGTVYKGIWIPE-GENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ--MQLVTQYMPYGCLLDYVRQHK--

EANNPQAISQQDLVHMAIQIACGMSYLARREVIHRDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFG
      .|  |.|.  ..||| ||.||  ....||||||||  .    .|||||  |.. | . .     .    |..|||||.. .  . ..||||..|
-----DNIGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYG

VTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLT
||.||||| || ||  |   |    |..| | .|| .|   .. ||  || .|.. ||.|..|.. . 
VTCWELMTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase RYK.AA Musk 416-583 39 4.1e-62 203.97 In-house 115-282 (282) Show / Hide 
Range on Protein: 416-583
Range on HMM: 115-282/282
Sequence Identity: 39% (67 aa)

VEANNPQAISQQDLVHMAIQIACGMSYLARREVIHRDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAF
| .  |   .  ..  || |||||| ||  .  .||||| ||| | ..  ||| |  |||     ||    .|.  |.|||..||.  | |. .|||||.
VSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESIWYNQFTYESDVWAY

GVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL
|| |||.   .  ||  .   |   | ..|.. . | ||| .....|  ||   | .|| |.|. .|.
GVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase RYK.AA RTKB 317-583 33 9e-61 203.6 In-house 1-264 (264) Show / Hide 
Range on Protein: 317-583
Range on HMM: 1-264/264
Sequence Identity: 33% (89 aa)

ITLKDVLQEGTFGRIFHGILVDEKDPNKEKQTFVKTVKDQASEVQVTMMLTESCKLRGL-HHRNLLPITHVCIEEGEKPMVVLPYMNWGNLKLFLRQCKL
. |   | .| ||  | . .| ..  |.|.   .|. | .||. .    ..|   .  |  | |.. |   |  . | ...   . . |||  .||.|  
VWLGEKLGNGAFGEVFQA-WVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQD-EPYILLVELCELGNLRDYLRMCRA

VEANNPQAISQQDLVHMAIQIACGMSYLARREVIHRDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSAS-DVWA
 .  ||| ..|. ||  . ||||||..| ...||||||.||| ..|  |. || | ...| .   .|    .    |..||| ||.    ... | |||.
SQ-HNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECYETTCT--RLPIKWMAPESWAHRIYTTKSGDVWS

FGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL
|||| ||  .|| |||.    ...  .| .|.|  .|   | . ...|  ||......|| |. ||. .
FGVTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase RYK.AA FGFR 424-583 45 3.9e-59 200.19 In-house 133-293 (293) Show / Hide 
Range on Protein: 424-583
Range on HMM: 133-293/293
Sequence Identity: 45% (74 aa)

ISQQDLVHMAIQIACGMSYLARREVIHRDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELM
..| ||| .| |.| || ||| | .|||||||||  . |    || |  |.||   .||     |   |. |||.|.|  . . . |||| .|| ||| |
LTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIM

TLGQTPYVDID-PFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCL
|.|..||  |    |. .||| |.|.  | ||. |.. .|  ||   |..|| | |||  |
TYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase RYK.AA S_TKc 317-590 19 5e-19 70.45 SMART 1-231 (231) Show / Hide 
Range on Protein: 317-590
Range on HMM: 1-231/231
Sequence Identity: 19% (54 aa)

ITLKDVLQEGTFGRIFHGILVDEKDPNKEKQTFVKTVKDQASEVQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVVLPYMNW--GNLKLFLRQCK
 .. ... .|.||. . .. ..       ..  .| .|         ... |   |.  || |.  .  |. .  ..  .|. |..   |.|. ......
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRG

LVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHRDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSS-ASDVW
    .  . ..  .  ... ||.|.. |. .. .|||||   |  .|.  ..||.|  |.| |    ... |        .|| | |    ..  ..|.|
RHGLR--FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCG-----TPWYMAPEVL---GYGKCKCDWW

AFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQ--CLTEFHAAL
..|..|.|... |..|.   ....|   ..           ..|.   .  |.  |||.||   .. |   .   |  .
SCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RYK.AA Pkinase 494-583 18 1.4e-10 38.48 Pfam 176-293 (293) Show / Hide 
Range on Protein: 494-583
Range on HMM: 176-293/293
Sequence Identity: 18% (22 aa)

RWMALESLV-NNEFSSASDVWAFGVTLWELMTLGQTPYVDI------DPFEMAAYLKD-GYRIAQPINCP-------------------DELFAVMACCW
..|| | .  ... ....|.|..|..|.|... |..|. .       |. .| .  ..  ..   |  |.                   .|.  .. .|.
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

ALDPEERPKFQQLVQC--L
..||..|| ..|..|   .
CKDPKKRPTAEQILQHPWF
Kinase RYK.AA Pkinase 317-470 17 4.2e-09 33.26 Pfam 1-155 (293) Show / Hide 
Range on Protein: 317-470
Range on HMM: 1-155/293
Sequence Identity: 17% (30 aa)

ITLKDVLQEGTFGRIFHGILVDEKDPNKEKQTFVKTVKDQASEVQVTMMLT---ESCKLRGLHHRNLLPITHVCIEEGEKPMVVLPYMNWG----NLKLF
.... .. .|.||. .... ... .     .  ||..| .  . .. . ..   | . .. |.| | . . ... . . .. .|..|.. |     |. .
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDY

LRQCKLVEANNPQAI--SQQDLVHMAIQIACGMSYLARREVIHRDLAARNCVIDDTLQV----KITD
..        .  ..  | ... ... ||..|. |. .. .|||||   |. ||.. ..    ||.|
IST------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICD
Kinase RYK.AA FGFR 317-359 31 0.00141 8.0 In-house 1-45 (293) Show / Hide 
Range on Protein: 317-359
Range on HMM: 1-45/293
Sequence Identity: 31% (14 aa)

ITLKDVLQEGTFGRIFHGILV--DEKDPNKEKQTFVKTVKDQASE
 ||  .| || ||..  .  .  |.. |.||    || .|. ...
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTD