Gene Dusty (Mouse)

Dusty

Species: Mouse
Alias: Dusty, SgK496, A930019K20Rik
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: Dusty

Sequence

Name Sequence Type Origin Length Description Download
Dusty.AA Protein Sugen 927 None Fasta, JSON
Dusty.NA RNA Sugen 5262 None Fasta, JSON
Dusty.kin_dom Protein Kinase Domain None 265 None Fasta, JSON

Protein domain

Protein domains of Dusty.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Dusty.AA SgK496 650-913 90 7.50000000001e-228 763.24 In-house 1-265 (265) Show / Hide 
Range on Protein: 650-913
Range on HMM: 1-265/265
Sequence Identity: 90% (240 aa)

PKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGG-GSSVAVLLIMERLHRDLYTGLKAGLT
|||.||.|||||||||.||||||||.||.|||||||.|||||||.|||||||.|||.|.||.||||||||||| |.|.||||||||.||||||..||...
PKLEQEIGRGQYGVVYSCDNWGGHFHCAVKSVVPPDDKHWNDLAMEFHYMRSIPKHDRIVDVHGSVIDYNYGGMGCSIAVLLIMERMHRDLYTAIKANME

LETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGSIKLPE
||.||.||||||||||.||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||
LEERLHIALDVVEGIRYLHSQGLVHRDIKLKNVLLDKHNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGHIKLPE

AFERCASKDHLWNNVRRGTRPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPMLRSIMDRLCK
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
AFERCASKDHLWNNVRRGTRPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPMLRSIMDRLCK
Kinase Dusty.AA TKL 656-895 20 4.8e-41 142.68 In-house 1-355 (364) Show / Hide 
Range on Protein: 656-895
Range on HMM: 1-355/364
Sequence Identity: 20% (74 aa)

LGRGQYGVVYLC--DNWGGHF------PCALKSVVPPD-------------------------EKHWNDLALEFHYMRSL-PKHERLVDLHGSVIDYNYG
.|.| .|.||     .||| .      . | |     .                         | .|.   .|.  |  .  .|. .| . |.... ..|
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

G------GSSVAVLLIMERL-HRDLYTGLKAGLTLETRLQIALDVVEGIRFLHSQG--------LVHRDIKLKNVLLDKQNR--------------AKIT
.      |..    ..||   . .|.  |     .. |...|||.  |. .|||..        ..|||.| ||.|.|. ..              .||.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKIC

DLGFCK-------PEAMM---------------SGSIVGTPIHMAPELFT-----------------GKYDNSVDVYAFGILFWYICSGSIKLPEAFERC
|.|...        ...|               .....||| .||||..                  ..|. ..|||.|||..| |... .     ..  
DFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----PYYDY

ASKDHL---------WNNVRRGTRPERL------------PVFDEECWQLMEACWDGDPLKRP
 . ...         . .. .| ||..             | ....  .||. ||| || |||
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRP
Kinase Dusty.AA Pkinase 650-895 21 3e-39 139.88 Pfam 1-282 (293) Show / Hide 
Range on Protein: 650-895
Range on HMM: 1-282/293
Sequence Identity: 21% (64 aa)

PKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWND--LAL--EFHYMRSLPKHERLVDLHGSVIDYNYGGGSSVAVLLIMERL-HR----DLY
 ..|. .|.| .|.||.| . |     |.| .  ..||.| |  ...  | ..|..| .|.  | |.... |       .  . ..|| . .     ||.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-------KDHIYMVMEYCEGGLYVMDLF

----TGLKAGL--TLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRA----KITDLGFC----KPEAMMSGSIVGTPIHMAPEL--FTGKYD
    |  . ..  . ..   ... ...|. ..||.| .|||.|. |.|.|...      ||.| |..            ...|||  ||||.  .  .|.
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

NSVDVYAFGILFWYICSGSIKLPEA--FERCASKDHLWNNVRRGTRPERLPVFD--------------------EECWQLMEACWDGDPLKRP
 .||....|..... ..|    |..   .. ...... ......  ..  |  .                    ||| .... |.. || |||
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP
Kinase Dusty.AA S_TKc 650-904 19 3.5e-39 137.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 650-904
Range on HMM: 1-231/231
Sequence Identity: 19% (54 aa)

PKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSLPKHERLVDLHGSVIDYNYGGGSSVAVLLIMERLHR---DLYTGLKAG
 ......|.| .|.||.| . . .  .|.| .        ...  |   ...  .|. .| |...  |          . ..|| .     ||.. .|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD--------DHLYMVMEYCDGDLGDLFDYIKKR

--------LTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDN-SVDVYAFGILFW
        ..  .   ..  ..... ..||.| .|||.|  |.|||.  . ||.| |...       ...|||  ||||..  .|.  ..|....|....
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCILY

YICSGSIKLPEAFERCASKDHLWNNVRRGTRPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQ--------PML
  ..|    |         . ......           ..|...... |.. || |||   . |        | .
EMLCGYPPFP-------QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase Dusty.AA TK 650-904 15 3.3e-30 97.86 In-house 1-486 (486) Show / Hide 
Range on Protein: 650-904
Range on HMM: 1-486/486
Sequence Identity: 15% (75 aa)

PKLGQELGRGQYG---VVYLC-------------------------DNWGGHFPCALKSVV---PPDEKHWND--------------LALEFHYMRS-LP
 .||..||.||.|   .||..                         .  ||. |.| | .    . ...   |              .|.|   |.. | 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHERLVDLHG--------------------SVIDYNYGGGS---SVAVLLIMERLHRDLYTGLKAG----------------------------------
.|. .| |.|                     .. .   .|.   |    |   | ..  .   ...                                  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LTLETRLQIALDVVEGIRFLHSQ------GLVHRDIKLKNVLLDKQNR-----------AKITDLGFCK
                               ||....| ..... .| ..|||.      ..||||.   |.|....|.           .||.| | ..
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------PEAMMSGSIVGTPIH------------------------------MAPELFT----------GKYDNSVDVYAFGILFWYICS-GSIKLP--E
        .   ..  . .  .                              |||| ..          ||.    ||..||.| | |.. |    .   
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

AFERCASK---DHLWNNVRRG--------------TRPERLPVFD--------------EECWQLMEACWDGDPLKRPLLGIVQPML
  .....    . . ...|||               |... |                 ||  .||  ||. || .||    .. .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Dusty.AA Dicty5 751-908 29 1.5e-27 91.91 In-house 105-260 (260) Show / Hide 
Range on Protein: 751-908
Range on HMM: 105-260/260
Sequence Identity: 29% (48 aa)

TRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCK-PEAMMSGSI-VGTPIHMAPELFTGK-YDNSVDVYAFGILFWYICSGSIKLP
..| .|.|.  ..|.||| . .|||.|  |.|. .   .|| | |     ..     . |||.  ||.|||.|. |.. .|||.|||  | .    .   
QQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEM----FTRK

EAFERCASKDHLWNNVRRGTRPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPMLRSIM
|...  .. .   . |  | ||.  .    |   | ..||   | .||    .  ...||.
EPYDNINNWN-IPVMVMKGERPTIPKDCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase Dusty.AA Ciliate-E2-Unclassified 747-842 24 4.1e-26 87.57 In-house 135-266 (352) Show / Hide 
Range on Protein: 747-842
Range on HMM: 135-266/352
Sequence Identity: 24% (33 aa)

LTLETRL-----QIALDVVEGIRFLHSQG-LVHRDIKLKNVLLDKQN---RAKITDLGFCK-------------------PEAMMSGSIVGTPIHM----
.| .  .     ...  ...|. .||...  .|||||. |.|.|...   . ||.|.|..|                   .. ||. ...|||. |    
FTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMW-TFCGTPNYMPQYT

APELFTG-KYDNS----VDVYAFGILFWYICSG
|||.. | .||.|    .|....|... ... |
APEVLQGQNYDHSKAYKCDIWSLGVILYEMLFG
Kinase Dusty.AA ULK 753-836 27 1.1e-24 83.11 In-house 133-246 (329) Show / Hide 
Range on Protein: 753-836
Range on HMM: 133-246/329
Sequence Identity: 27% (31 aa)

LQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDK------------QNRAKITDLGFCKP------EAMMSGSIV------GTPIHMAPELFTGK-----Y
.|.  . ..| ..||... .|||||. |.|...            ....||.| ||.|       |. |  . |      |||. |||... |.     |
IQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPY

DNS-VDVYAFGILF
... .|.. .|..|
YDYKCDIWSLGCIF
Kinase Dusty.AA ULK 753-836 27 1.4e-24 84.14 In-house 129-242 (324) Show / Hide 
Range on Protein: 753-836
Range on HMM: 129-242/324
Sequence Identity: 27% (31 aa)

LQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDK------------QNRAKITDLGFCKP------EAMMSGSIV------GTPIHMAPELFTGK-----Y
.|.  . ..| ..||... .|||||. | |. .            ....||.| ||.|       |..|  ..|      |||. |||... |.     |
IQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPY

DNS-VDVYAFGILF
... .|.. .|..|
YDYKCDIWSLGCIF
Kinase Dusty.AA Ciliate-E2 759-842 23 2.5e-24 80.38 In-house 169-292 (365) Show / Hide 
Range on Protein: 759-842
Range on HMM: 169-292/365
Sequence Identity: 23% (31 aa)

VVEGIRFLHSQG-LVHRDIKLKNVLLDKQNRAKITDLGFCK--------------PEAMMSGS---------------------IVGTPIHMAPELFTGK
.......|||..  .|||||. |.|.      ||.|.|..|               . .|  .                     |.|||  |||| . ||
IILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGK

----------YDNSVDVYAFGILFWYICSG
          || ..|....|... . ..|
KYDNQQKQKGYDYKCDIWSLGVILYEMLFG
Kinase Dusty.AA CAMK 759-835 21 2.5e-23 71.39 In-house 188-323 (425) Show / Hide 
Range on Protein: 759-835
Range on HMM: 188-323/425
Sequence Identity: 21% (29 aa)

VVEGIRFLHSQGLVHRDIKLKNVLLDKQ-----------------NRAKITDLGFC--KPE------------------------AMMSGSIVGTPIHMA
........||.. ||||.|. |.|||.                  |  ||.| ||   ...                          .    .|||  ||
ICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMA

-PELFTGK---------------YDNSVDVYAFGIL
 ||.. ||               |. ..|. . |..
APEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVI
Kinase Dusty.AA LISK-DD1 747-835 35 3.5e-23 80.81 In-house 120-220 (290) Show / Hide 
Range on Protein: 747-835
Range on HMM: 120-220/290
Sequence Identity: 35% (37 aa)

LTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQ----NRAKITDLGFCKPEAMMSGS----------IVGTPIHMAPELFTG-KYDNSVDVYA
.. . |. ||||. .. ..||| ...||| | || |.|.     .|.|. |.|| .   |....          |.||.. ||||. .| .|| |.||. 
IPWKLRVKIALDIACAMAYLHSKNIIHRDLKSKNILVDENGDSQWRIKVCDFGFAR---MFEQKKNQQNNRHMTICGTDNWMAPEVILGMSYDWSCDVFS

FGIL
||..
FGMV
Kinase Dusty.AA Pkinase_Tyr 651-904 25 1.6e-20 70.12 Pfam 2-270 (270) Show / Hide 
Range on Protein: 651-904
Range on HMM: 2-270/270
Sequence Identity: 25% (71 aa)

KLGQELGRGQYGVVYLCDNW----GGHFPCALKSVVPP--DEKH--WNDLALEFHYMRSLPKHERLVDLHGSVI-DYNYGGGSSVAVLLIMERLHR-DLY
..|..||.|..|.||..       ... |.| |.. ..  ....  . |.  |   |..|..|. .| |.| .. .   .      ....||     ||.
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-----QIYIVMEYMPHGDLL

TGLKAG------LTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPE-------AMMSGSIVGTPIH-MAPE-LFTGKYDN
. |..       ||... ||..... .|  .|.|....|||.  .|.|....| .||.| | ..          . .|.    ||  |||| ...||.  
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK--LPIKWMAPECINYGKFTT

SVDVYAFGILFWYICS-GSIKLPEAFERCASKDHLWNNV-RRGTRPERLPVFDEECWQLMEACWDGDPLKRPLLGIVQPML
  ||..||.| | |.. |    | ... . |   . . . ..| | .. .   .|  .||  ||. || .||    .. .|
KSDVWSFGVLMWEIFTYGE--QP-TYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Dusty.AA TyrKc 650-904 22 3.8e-18 67.52 SMART 1-280 (280) Show / Hide 
Range on Protein: 650-904
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

PKLGQELGRGQYGVVYLCDNWGGHFPCALKSVVPPDEKHWNDLALEFHYMRSL-PKHERLVDLHGSVIDYNYGG-------GSSVAVLLIMERLHRDLYT
 .||..||.|..|.||..       ..| |.. .       |.  |   |..| ..|. .| |.| ...    .       .    |.  |.    . | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQ----QGRNFMYIEPLMIVMEYMPHGDLKDYL

GLKAG-LTLETRLQIALDVVEGIRFLHSQGLVHRDIKLKNVLLDKQNRAKITDLGFCKPEAMM------SGSIV------GT---PIH-MAPELF-TGKY
  . . |.... |...... .| ..|||....|||.   |.|.......||.| | ..           .  ..      |    ||  |||| . .||.
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

DNSVDVYAFGILFWYICSGSIKLPEA--FERCASKDHLWNNVRRGTRPERLPV--------FDEECWQLMEACWDGDPLKRPLLGIVQPML
    ||..||.. | |..   . ..   ..   | ... ..|..| |... |           .|  |.|. ||. || .||    .   .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Dusty.AA CAMK 655-667 61 4.6e-05 11.47 In-house 1-13 (425) Show / Hide 
Range on Protein: 655-667
Range on HMM: 1-13/425
Sequence Identity: 61% (8 aa)

ELGRGQYGVVYLC
.||||..|.|.||
TLGRGSFGKVKLC
Kinase Dusty.AA Ciliate-E2 650-670 38 0.000625 9.36 In-house 1-21 (365) Show / Hide 
Range on Protein: 650-670
Range on HMM: 1-21/365
Sequence Identity: 38% (8 aa)

PKLGQELGRGQYGVVYLCDNW
 |. . .|.|..|.||.| .|
YKFIKKIGQGNFGSVYKCKVW
Kinase Dusty.AA Ciliate-E2-Unclassified 651-667 41 0.004134 6.66 In-house 2-18 (352) Show / Hide 
Range on Protein: 651-667
Range on HMM: 2-18/352
Sequence Identity: 41% (7 aa)

KLGQELGRGQYGVVYLC
|... .|.|..|.||.|
KIIKQIGQGGFGKVYKC
Kinase Dusty.AA LISK-DD1 655-666 50 0.106894 2.21 In-house 1-12 (290) Show / Hide 
Range on Protein: 655-666
Range on HMM: 1-12/290
Sequence Identity: 50% (6 aa)

ELGRGQYGVVYL
| |.| .| ||.
EIGKGSFGKVYK