Gene SRPK2 (Mouse)

SRPK2

Species: Mouse
Alias: Srpk2, SRPK2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: SRPK

Sequence

Name Sequence Type Origin Length Description Download
SRPK2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 602 Kinase domain by global Sugen HMM Fasta, JSON
SRPK2.AA Protein Sugen 693 None Fasta, JSON
SRPK2.NA RNA Sugen 2936 None Fasta, JSON

Protein domain

Protein domains of SRPK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SRPK2.AA SRPK 90-691 50 0.0 1169.95 In-house 1-554 (554) Show / Hide 
Range on Protein: 90-691
Range on HMM: 1-554/554
Sequence Identity: 50% (322 aa)

YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPS---------------------DPNKDMVVQLIDDFKISGMNG
||||||||||||||||||||||..|.||||.||||.||||||.||||||.|||..||.                     |||...||||.|.||..|.||
YHVIRKLGWGHFSTVWLCWDMQYDRYVAMKIVKSAPHYTETAVDEIKLLQCVRKHDPNPQWMHFLKEYYEDYKRDCKEFDPNRCHVVQLLDHFKHRGPNG

IHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQ--
 |.|||||||||.|||||...||||.|..|||.|.||||.||||||.||.||||||||||.|.||...|..|||||.|||||.|...||.|.|.||||  
NHYCMVFEVLGHNLLKWIKHYNYQGMPMHCVKQIARQVLIGLDYLHRKCGIIHTDIKPENVLLCVNQDYIKRMAAEWTEWQKMGMQMPSSSMVQTAPQHQ

-QKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKILEENITSAEASGEQQDGEYQPEVTLKAADLEDTTEEETAKDNGEVEDQEEKEDAE
 |....|.|||||||.|||||.|.|..||..|.....|......                          .  . ||...|...|.| . |...|.|..|
TQCQQQKMSKNKKKKMKKKQKQQQEQQEKNQQQKQQMEDDQNDN--------------------------EDNNQEDNDNEQDNKNNQNQENNMENEQEE

KENAEKDEDDVEQELANLDPTWVESPKANGHIENGPFSLEQQLEDEEDDEDDCANPEEYNLDEPNAESDYTYSSSYEQFNGELPNGQHKTS-----EFPT
||| .|........ .. |... |..........                             ||.| ... .|..||......|..||..     .. |
KENTNKQKKNQKKKEQHKDKKEQECQNVQKQNND-----------------------------PNFE-SQN-DSQMEQETNSCNNQEHKQEKTMQCQDST

PLFSGPLEPVACGSVISEGSPLTEQEESSPSHDRSRTVSASSTGDLPKTKTRAADLLVNPLDPRNAD---KIRVKIADLGNACWVHKHFTEDIQTRQYRS
 ....  .. ..|.. || |..........                      |...||....|||||   ||..||||||||||||.|||||||||||||
KQQNKQ-DQQKEGQKQSEESECESEDMQEQ----------------------AGKFLVWWKNPRNADLDHKIKIKIADLGNACWVHHHFTEDIQTRQYRS

IEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWP
.||.|||||.|||||||||||||||||||||||||||||||||.|||||||||.|.||.||||||||||||||..||||||.|||||.|..||.|||.|.
PEVIIGAGYNTPADIWSTACMAFELATGDYLFEPHSGEDYSRDDDHIAHIIELCGKIPWHFALSGKYSREFFNKKGELRHIPKLKPWPLMNVLIEKYEWS

HEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWL
||.|.||.|||.|||...|||||.|.|||.||||
HEEAKQFEDFLMPMLHYNPEKRATAKECLQHPWL
Kinase SRPK2.AA CMGC 90-691 14 5.1e-128 423.12 In-house 1-513 (513) Show / Hide 
Range on Protein: 90-691
Range on HMM: 1-513/513
Sequence Identity: 14% (117 aa)

YHVIRKLGWGHFSTVWLCWD--------------MQGKRFVAMKVVKSAQHYTE-------------TALDEIKLLKCVR----------ESDPSDPNKD
|..|.|.|.|....|. |.|              ......||.| .|... |.|             .||.|||.||...          . ||..... 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRD-DPDNKHHN

MVVQLIDDFKISGMNGI-------------HVCMVFEVLGHHLLKWIIKSN--YQG------------------------LPVRCVKSIIRQVLQGLD--
 .|.|.| |. ....|              |...||| ..| |.. | . .  |||                        ... ... ...|.|.||.  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

YLHSKCK-IIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKI
|.||... |||.|.||||||.. .  ...|| .    | |      .                                                     
YCHSHWGNIIHRDLKPENILINHNCELITRM-M----W-KS-----E-----------------------------------------------------

LEENITSAEASGEQQDGEYQPEVTLKAADLEDTTEEETAKDNGEVEDQEEKEDAEKENAEKDEDDVEQELANLDPTWVESPKANGHIENGPFSLEQQLED
                                                                                                    
----------------------------------------------------------------------------------------------------

EEDDEDDCANPEEYNLDEPNAESDYTYSSSYEQFNGELPNGQHKTSEFPTPLFSGPLEPVACGSVISEGSPLTEQEESSPSHDRSRTVSASSTGDLPKTK
                                                                                                    
----------------------------------------------------------------------------------------------------

TRAADLLVNPLDPRNADKIRVKIADLGNACWVHKH------------------------FTEDIQTRQYRSIEVLIGAG----------YSTPADIWSTA
    | . ||.    ... |.||.| |.|.|.|.|                        .|....|| ||. |.|.|..          |.|| |.|| .
----D-W-NPC----QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVG

CMAFELATG--------DYLFEPHSGE-----DYSRDEDHIAHIIELLGSIPRHFALSGK-------YSREFFNRRGELRHITKLK--------------
|. .|. ||        ..|| .||..     ..... |....|...||... ... .||       ...|..|. . .......|              
CIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEF

-----------PWSLFDVLVEKYGWPHE--------------------------------DAAQFTDFLIPMLEMVPEKRASAGECLRHPWL
           ||  .  . ... | ..                                .  |. |.|  ||.. |.|| .| ..|.||..
ARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase SRPK2.AA S_TKc 90-691 12 3.6e-47 163.94 SMART 1-231 (231) Show / Hide 
Range on Protein: 90-691
Range on HMM: 1-231/231
Sequence Identity: 12% (76 aa)

YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGH---HLLKWI
|...||.| | |..|..|..   .| ||.|..|      |... ||..||          . . .|.|.| |        |..||.| ...    |.. |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK---------HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYI

IKSNYQG----LPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYV------RRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKN
 | ...|    .|   ......|....|.|.||. .||| |.||||||..     .      |..                                   
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-HIKICDFGLARQL-----------------------------------

KKKKLKKKQKRQAELLEKRLQEIEELEREAERKILEENITSAEASGEQQDGEYQPEVTLKAADLEDTTEEETAKDNGEVEDQEEKEDAEKENAEKDEDDV
                                                                                                    
----------------------------------------------------------------------------------------------------

EQELANLDPTWVESPKANGHIENGPFSLEQQLEDEEDDEDDCANPEEYNLDEPNAESDYTYSSSYEQFNGELPNGQHKTSEFPTPLFSGPLEPVACGSVI
                                                                                                    
----------------------------------------------------------------------------------------------------

SEGSPLTEQEESSPSHDRSRTVSASSTGDLPKTKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYST-PADIWST
                                                                      |  . |. |.. |||   ||.. ..|.|| 
----------------------------------------------------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

ACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMV
 |. .|...|  .|.         ... . ..|                                                      .. ||.  .|.. 
GCILYEMLCGYPPFP---------QMQMMFKKIG---------------------------------------------------SPEAKDFIRKCLQKD

PEKRASAGECLR-------HPWL
|||| .| |.|.       |||.
PEKRPTA-EALQDEWDIKCHPWF
Kinase SRPK2.AA CLK 90-232 30 3.6e-37 108.46 In-house 1-148 (350) Show / Hide 
Range on Protein: 90-232
Range on HMM: 1-148/350
Sequence Identity: 30% (48 aa)

YHVIRKLGWGHFSTVWLCWDMQG-KRFVAMKVVKSAQHYTETALDEIK-LLKCVRES-DPSDPNKDM--VVQLIDDFKI-SGMNGIHVCMVFEVLGHHLL
| .. .|| | |..|  |||..  |..|| |.....  |.| |  ||.  .| . |  ||   || .  .....| |.   |    |.|.||| .|  . 
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPN--NKYWEHCWKMNDWFDYGHG----HICIVFELYGLSIY

KWIIKSN------YQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMC
  . . |      |...| . .... .| .. .  || . |..||| |||||. .
DFMKSNNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLH-DMKLTHTDLKPENICFV
Kinase SRPK2.AA DYRK 90-232 30 1.6e-32 114.36 In-house 1-138 (320) Show / Hide 
Range on Protein: 90-232
Range on HMM: 1-138/320
Sequence Identity: 30% (44 aa)

YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKS
| ..  .| | |. |  ||| ...  ||.|.... . .  .|..|||.|.. ..    . .|  .|.. | |.  .    |.|.||| |   |   . . 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQ--DPDDKYHCVHMYDYFYHRN----HLCIVFELLSMNLYEFLKNN

NYQGL-PVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMC
. ||. ... |.....|.|..|..||.. .||| |.|||||...
HFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLK
Kinase SRPK2.AA DYRK2 90-230 34 9.5e-26 80.43 In-house 1-134 (318) Show / Hide 
Range on Protein: 90-230
Range on HMM: 1-134/318
Sequence Identity: 34% (48 aa)

YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKS
| .   .| | |  |  | |   | .|| |..   . . ..|. ||. |.  |. |.   |   .| . | |   .    |.|..|| |.  | . | | 
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKD--NTMNCVHMLDYFYFRN----HHCITFELLSMNLYEYIKKN

NYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENIL
..||. .. |   ....||.|. || | .||| | ||||||
HFQGFSLQLVRRFAHSILQCLRFLH-KNNIIHCDLKPENIL
Kinase SRPK2.AA HIPK 90-234 31 2.3e-24 73.23 In-house 1-136 (329) Show / Hide 
Range on Protein: 90-234
Range on HMM: 1-136/329
Sequence Identity: 31% (45 aa)

YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKS
| |.  || | |  |  ||    .  ||.|. |    |      |...|.|... .. . .   .|   . |.    .  |.|.|||.|   |  .  . 
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADEYH---FVRAYECFH----HKNHTCLVFEMLEQNLYDFQKQN

NYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVD
..  ||.. .. |. |||  |  | .   .|| |.||||| | ||
KFMPLPLKHIRPILQQVLTALMKLKELG-LIHADLKPENI-MLVD
Kinase SRPK2.AA DYRK 524-691 26 2.2e-23 83.99 In-house 138-320 (320) Show / Hide 
Range on Protein: 524-691
Range on HMM: 138-320/320
Sequence Identity: 26% (50 aa)

RNA-DKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSG
... .| ..|..| | .| .|....  || | ||. ||..|  |... |.||  |   || ||  ||   .||..    | .| |.|.|| .|...  .|
KQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLF---PGENE---YDQLACIMEVLGMPPKWMIDKG

--KYSREFFNR------------RG------ELRHITKLKPWSLFDVLVE--KYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWL
  .. ..||..            .       ... . ...  .      .  ...    |  ||.||.  .|.  |.|| .. . |.|||.
RCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase SRPK2.AA CDC2 90-230 33 5e-22 64.02 In-house 1-135 (301) Show / Hide 
Range on Protein: 90-230
Range on HMM: 1-135/301
Sequence Identity: 33% (50 aa)

YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTE-----TALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLK
|  |.|.| | .  |  | ||| .. ||.| ..  |   .     ||. || .||  ..    .||   .|.| | ...       . |||| | ..| |
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKD----HPN---IVKLHDVIHQ-----NKLYMVFEYLDMDLKK

WIIKSNY--QGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENIL
   .|.   . .|.  |||.. | |||....|.. .|.| |.|| |||
YMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQR-RIMHRDLKPQNIL
Kinase SRPK2.AA Pkinase 90-231 30 1.5e-20 73.7 Pfam 1-141 (293) Show / Hide 
Range on Protein: 90-231
Range on HMM: 1-141/293
Sequence Identity: 30% (47 aa)

YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALD------EIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGH---
||..||.| | |..|..| .    . ||.|..|   |  .  .       ||...| ..      ||   .|.|.| |      . |..||.| ...   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLN-----HPN---IVRLYDWFED----KDHIYMVMEYCEGGLY

--HLLKWIIKSNYQGL--PVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILM
   |  .|  ... ..  . . .|....|.|.||.|.|| ..||| |.||||||.
VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILI
Kinase SRPK2.AA DYRK1 90-232 29 5.9e-20 66.36 In-house 1-138 (321) Show / Hide 
Range on Protein: 90-232
Range on HMM: 1-138/321
Sequence Identity: 29% (43 aa)

YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKS
| ..  .| | |  |   .| | . .||.|..|  . . . |. ||.||  . . |.   .|  .|.|   |    |   |.|.|||.|   |   .   
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKE--MKYYIVHLKRHF----MFRNHLCLVFELLSYNLYDLLRNT

NYQGLPVRCVKSIIRQVLQGLDYLHS-KCKIIHTDIKPENILMC
...|  .  .. . .|... | .. .   .||| |.||||||.|
HFRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLC
Kinase SRPK2.AA CLK 531-635 30 8.4e-19 52.33 In-house 186-291 (350) Show / Hide 
Range on Protein: 531-635
Range on HMM: 186-291/350
Sequence Identity: 30% (34 aa)

VKIADLGNAC---WVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLG-SIPRHFALSG---K
... | |.|      | | .. ..||.||  ||  | |.|.| |.|| .|  ||| ||. ||  |.        .| | . ...|  || . . .    |
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHD------NREHLAMMERIMGMPIPQWMIQRTRRFK

YSREFFNRRGEL
 ....|......
VKQKYFYHNRLD
Kinase SRPK2.AA YAK 90-232 31 7.6e-18 56.84 In-house 1-140 (347) Show / Hide 
Range on Protein: 90-232
Range on HMM: 1-140/347
Sequence Identity: 31% (46 aa)

YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCV-RESDPSDPN-KDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWII
| |   || | |  |  |     .  .| ||.|. | |   |  ||..|.      || . | .  .. ..| |        | |.||| |   |   . 
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFF----VHKNHFCLVFEMLSNNLYEYLK

KSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMC
  .. |. .  ..    |.| |.  | .| .||| | |||||. |
QNKFCGFSFQLIRQWTKQILDGMCVLENK-QIIHCDLKPENIMLC
Kinase SRPK2.AA DYRK2 531-633 33 9.2e-17 50.72 In-house 143-245 (318) Show / Hide 
Range on Protein: 531-633
Range on HMM: 143-245/318
Sequence Identity: 33% (36 aa)

VKIADLGNACWVHK-HFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSG-----KY
.|..| |  | .|  ..  .||.| ||. || .|  |... |.||  | . || ||  ||    ||..    | .| ..|.||  |..|         ..
IKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLF---PGENE---NDQFACMMEVLGMPPKKFFDTWFYIHCFR

SREFFNRRG
 . |||...
RKYFFNSHC
Kinase SRPK2.AA Pkinase 530-691 22 1.1e-16 60.05 Pfam 150-293 (293) Show / Hide 
Range on Protein: 530-691
Range on HMM: 150-293/293
Sequence Identity: 22% (38 aa)

RVKIADLGNAC---WVHKHFTEDIQ-TRQYRSIEVLI-GAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKY
.|||.| | |.   . ... . ..  |. |.. ||.  | .|....|.||  |. .|...|  .|  ... .  .  |... | . .| ...        
CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCS

SREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWL
 . || .|    |                    |.    . ||.  .|.. |.|| .| ..| |||.
ISYFF-FRH-W-H-------------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase SRPK2.AA DYRK1 524-631 34 8.1e-16 51.58 In-house 138-239 (321) Show / Hide 
Range on Protein: 524-631
Range on HMM: 138-239/321
Sequence Identity: 34% (37 aa)

RNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGK
.|. .  .|| | | .| . .   . || | ||| |||.|  |..  |.||  |.  |. ||. ||   ||   | . | . .|.| ||  |.|.  .. 
CNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLF---SG---SNEVDQMNKIVEVLGMPPKHMIDQAP

YSREFFNR
 .. .|..
KAHKYFEK
Kinase SRPK2.AA DyrkP 528-589 45 1.1e-15 47.45 In-house 144-205 (323) Show / Hide 
Range on Protein: 528-589
Range on HMM: 144-205/323
Sequence Identity: 45% (28 aa)

KIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLF
| .||| | | .|..| |    .| | ||  ||.||  |    |.||  |.  || ||  ||
KCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLF
Kinase SRPK2.AA DyrkP 90-139 34 3.8e-09 25.55 In-house 1-50 (323) Show / Hide 
Range on Protein: 90-139
Range on HMM: 1-50/323
Sequence Identity: 34% (17 aa)

YHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLK
| ..  ||   ||    | | |  . . ||..   . | . ..||||||.
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLR
Kinase SRPK2.AA YAK 524-582 37 1.4e-08 24.83 In-house 140-198 (347) Show / Hide 
Range on Protein: 524-582
Range on HMM: 140-198/347
Sequence Identity: 37% (22 aa)

RNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFEL
.. .|  .|| | | .|   |  .  || | ||| |....  |.|  | ||  |   ||
CKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAEL
Kinase SRPK2.AA DyrkP 202-231 60 2.8e-08 22.64 In-house 111-139 (323) Show / Hide 
Range on Protein: 202-231
Range on HMM: 111-139/323
Sequence Identity: 60% (18 aa)

IIRQVLQGLDYLHSKCKIIHTDIKPENILM
|  |.| .|||.||  ..|| |.|||||||
ITQQILIALDYIHS-LRLIHCDLKPENILM
Kinase SRPK2.AA CLK 658-691 32 3.6e-07 16.79 In-house 317-350 (350) Show / Hide 
Range on Protein: 658-691
Range on HMM: 317-350/350
Sequence Identity: 32% (11 aa)

HEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWL
.... |. | .  |||  | || .... | ||. 
DPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase SRPK2.AA CDC2 666-691 50 7.8e-07 16.48 In-house 276-301 (301) Show / Hide 
Range on Protein: 666-691
Range on HMM: 276-301/301
Sequence Identity: 50% (13 aa)

DFLIPMLEMVPEKRASAGECLRHPWL
| |  ||   |.|| || | |.||..
DLLMQMLQYDPQKRISAKEALQHPYF
Kinase SRPK2.AA CDC2 543-589 35 2e-06 15.53 In-house 157-209 (301) Show / Hide 
Range on Protein: 543-589
Range on HMM: 157-209/301
Sequence Identity: 35% (19 aa)

HKHFT--EDIQTRQYRSIEVLIGAG-YSTPADIWSTACMAFEL---ATGDYLF
..  |   .. |. ||. |.| |.  |||| |.||  |   |.   .|  .||
IRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLF
Kinase SRPK2.AA TyrKc 90-306 16 1.4e-05 -132.49 SMART 1-280 (280) Show / Hide 
Range on Protein: 90-306
Range on HMM: 1-280/280
Sequence Identity: 16% (48 aa)

YHVIRKLGWGHFSTVWLC-WDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCV--RESDPSDPNKDMVVQLIDDFKISG---MNGIHVCMVFEVLGHHLL
 . ..||| |.| .|... |.    . || |..|.     |  ..|..... .  .      ||   .|.|.     .|   |    ...|.|   |  |
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGH-----HPN---IVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

KWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDD------------------------AYV------RR-------MAAEAT
|  ....   |...   |.  |. .| .||||| ..|| |.   |.|   .                          |.      ..       || |. 
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

EWQKA---------------------GAPPPSG-----SAVSTAPQQKPIGKISKNKKKKLKK-----KQKRQAELLEKRLQE-------IEELEREA
  ..                      |..|..|        . . ..   |.  .  .  .         .   .. ..  .|        .|. .. 
--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase SRPK2.AA DYRK2 664-691 35 1.6e-05 13.53 In-house 291-318 (318) Show / Hide 
Range on Protein: 664-691
Range on HMM: 291-318/318
Sequence Identity: 35% (10 aa)

FTDFLIPMLEMVPEKRASAGECLRHPWL
|.||.   .|  |..| .. . |.|||.
FIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase SRPK2.AA DyrkP 664-691 39 4.6e-05 11.87 In-house 296-323 (323) Show / Hide 
Range on Protein: 664-691
Range on HMM: 296-323/323
Sequence Identity: 39% (11 aa)

FTDFLIPMLEMVPEKRASAGECLRHPWL
| ||   .| .   .| .| | |.|||.
FIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase SRPK2.AA HIPK 530-582 37 9e-05 10.42 In-house 143-196 (329) Show / Hide 
Range on Protein: 530-582
Range on HMM: 143-196/329
Sequence Identity: 37% (20 aa)

RVKIADLGNACWVHKHFTED-IQTRQYRSIEVLIGAGYSTPADIWSTACMAFEL
|||. | | |  | |  ..  .| | ||  |...|  .    |.||  |   ||
RVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAEL
Kinase SRPK2.AA DYRK1 655-691 29 0.000272 10.42 In-house 285-321 (321) Show / Hide 
Range on Protein: 655-691
Range on HMM: 285-321/321
Sequence Identity: 29% (11 aa)

GWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWL
|   ||  .| | .  ||.  |..| .  . |.|...
GHSVEDYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase SRPK2.AA YAK 664-691 28 0.001321 7.68 In-house 320-347 (347) Show / Hide 
Range on Protein: 664-691
Range on HMM: 320-347/347
Sequence Identity: 28% (8 aa)

FTDFLIPMLEMVPEKRASAGECLRHPWL
|.||.  .|.  | .| ..     || .
FIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase SRPK2.AA HIPK 660-691 31 0.024167 2.63 In-house 298-329 (329) Show / Hide 
Range on Protein: 660-691
Range on HMM: 298-329/329
Sequence Identity: 31% (10 aa)

DAAQFTDFLIPMLEMVPEKRASAGECLRHPWL
|  .| . |  |. . ..|| .  | |.||. 
DRREFVHVLKKMCTWDAHKRITPCEALNHPFV