Gene TLK1 (Mouse)

TLK1

Species: Mouse
Alias: Tlk1, TLK1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: TLK

Sequence

Name Sequence Type Origin Length Description Download
TLK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 268 Kinase domain by global Sugen HMM Fasta, JSON
TLK1.NA RNA Sugen 4050 None Fasta, JSON
TLK1.AA Protein Sugen 766 None Fasta, JSON

Protein domain

Protein domains of TLK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TLK1.AA TLK 456-734 77 5.2e-247 826.87 In-house 1-285 (285) Show / Hide 
Range on Protein: 456-734
Range on HMM: 1-285/285
Sequence Identity: 77% (221 aa)

YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKL
|.||||||.||||||||||||.|.||.|.|||||||.|..|||.||.|||||||.|||||||.|||||||||..|...|||||||||||||||||||||.
YQLLHLLGKGGFSEVYKAFDLHEFRYVACKIHQLNKNWKEEKKANYIKHACREYKIHKELDHCRIVKLYDYFEIDNNSFCTVLEYCEGNDLDFYLKQHKT

MSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYG-VDGMDLTSQGAGTYWYLPPECFVVGK-----EPP
|.|||||.|.||||..|.||||||||||||||||.||....|..|||||||||||||||||..|  ..||.|||||||||||||||||||||     .||
MPEKEARCIIMQIVCCLKYLNEIKPPIIHYDLKPQNIIFHKGNTCGEIKITDFGLSKIMDDEQYRHDHGMELTSQGAGTYWYLPPECFVVGKCEEFENPP

KISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL
|||.|||||||||||.|||||.||||||.|||.||..|||||||||||| ||.||.|.|.||||||.||.|||.||.||.|.||.
KISCKVDVWSVGVIFYQCLYGQKPFGHNMSQQQILEQNTILKATEVQFPSKPQVSNECKDFIRRCLQYRQEDRWDVQQLWNHPYM
Kinase TLK1.AA S_TKc 456-734 31 2.6e-77 264.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 456-734
Range on HMM: 1-231/231
Sequence Identity: 31% (92 aa)

YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEG--NDLDFYLKQH
| .| ..|.|.|..|||. .   .|. |.||                .|..|| .|.|. .|| ||||||.|    | .. |.|||.|   ||  |.|..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKR

KL------MSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGKE
.       ..| .||... ||..|| |. .    ||| |||| |||| .     .|||.||||....             .   || ||..|| .     
GRHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL-----

PPKISN-KVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLAN-------DPYL
  . .  |.|.||.|.|.. .|.|. ||          |.....|            |.||| |||.|| .  |.|  . .. .       .|..
--GYGKCKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TLK1.AA Pkinase 456-734 30 1.3e-64 225.82 Pfam 1-293 (293) Show / Hide 
Range on Protein: 456-734
Range on HMM: 1-293/293
Sequence Identity: 30% (94 aa)

YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGN----DLDFYLK
| ..  .|.|.|..|||. .  ...  ||||  ..|. ....|. .| .. .| .|.|.|.|| ||.|||.|    |  . |.|||||     ||  |..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKI--IKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIS

--QHKLM--SEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLV-DGTACGEIKITDFGLSKIMDDDSYGVDGMDLTSQGAGTYWYLPPECFVVGK
  .|. .  ||.|..... ||. .| |. .    ||| |||| |||.. .|. .  .||.||||.| .|           ..  .||.||..||      
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIR---

EPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQ----SQQDILQENTILKATEVQFPVKPVVS-------------------SEAKAFIRRCLAYRKEDRF
. .... |||.||.|.|... | || ||  ..    .  | .|     . ... |.     |                   .|.| ||..||..  ..| 
GGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRP

DVHQLANDPYL
  .|. ..|..
TAEQILQHPWF
Kinase TLK1.AA Ciliate-E2 456-734 24 2.3e-60 205.89 In-house 1-365 (365) Show / Hide 
Range on Protein: 456-734
Range on HMM: 1-365/365
Sequence Identity: 24% (93 aa)

YLLLHLLGRGGFSEVYKAFDLYEQR------------------YAAVKIHQLNKSWRDEKKENYH-KHACREYR----------IHKELDHPRIVKLYDY
| .. ..|.|.|. |||. .  .|.                  ....||  ..    .....    .| .|| .          | ..|.|| |.|.|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FSL-DTDTFCTVLEYCEGNDLDFYLKQHKLMS-----------EKEARSIVMQIVN---------------ALRYLNEIKPPIIHYDLKPGNILLVDGTA
|   |....  |.|||.|.||  |.|..|. .           |||.. |  ||..               ||.|| . .. ||| |.|| |||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-----

CGEIKITDFGLSKIMDDDSY----GVDGMDLTSQG----------------------AGTYWYLPPECFVVGK-----EPPKISNKVDVWSVGVIFFQCL
   |||.||||||. |||..    ..    ..  .                      .||. |..|| .  .|     .    . |.|.||.|||....|
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

YGRKPFGHNQSQQDILQENTILKATEVQFP----------------VKPVVSSEAKAFIRR----CLAYRKEDRFD-VHQLANDPYL
.|. ||              . |  ...||                 .  .| |.| .|..    .| .  | |..   |. | |..
FGKPPF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase TLK1.AA CAMK 461-734 20 2.7e-58 186.13 In-house 1-425 (425) Show / Hide 
Range on Protein: 461-734
Range on HMM: 1-425/425
Sequence Identity: 20% (89 aa)

LLGRGGFSEVYKAFDLYEQ------------RYAAVKI--------------------HQLNKSWRDEK-KENYHKHACREYRIHKE-------LDHPRI
 ||||.|..|.....   .            .  |.||                       ....| .. ...  |   ||..|.|        |||| |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLYDYFSL-----------DTDT--------FCTVL---EYCEGN----DLDFYLKQHKL---------------MSEKEARSIVMQIVNALRYLNEIK
.|||...               ..        .. |.   |||.|     ||  |...|.                ..|.||| .. ||. |..|. . .
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

PPIIHYDLKPGNILLVDGTAC--------------GEIKITDFGLSKIMDDDSYGVDG-----------------MDLTSQGAGTYWYLP-PECFVV---
  |.| |||| ||||.|                  . |||.|||.....|...   .                   .. .   ||  | . || .     
--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-------GKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDI-------LQENTILKATEVQFP-VKPV---------------VSSE--------
         | | .. |.|.||.||| . .| |. || .   ....        ....  | .. ..    |                .| |        
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

AKAFIRRCLAYRKEDRFDVHQLANDPYL
.| .||..| .  |.|. ..|  |.| .
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase TLK1.AA ULK 456-734 29 2e-57 197.12 In-house 1-329 (329) Show / Hide 
Range on Protein: 456-734
Range on HMM: 1-329/329
Sequence Identity: 29% (99 aa)

YLLLHLLGRGGFSEVYKAFDLYE----QRYAAVKIHQLNKSWRDEKK---ENYHKHACREYRIHKELD--------HPRIVKLYDYFSLDTD-TFCTVLE
| | | || | |  |||...       . . |.|. ...|  ....    .   .  ..| .| |.|.        || ||||||.|  ...  .  ..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCEGNDLDFYLKQHKL----------MSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTAC---------GEIKITDFGLSKIMDDDSYG
||.| ||. |.|..|            ||.||... .||.|....|.. .  ||| |.|| |||. .|..          | .||.|||..| .|.|.  
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME

VDGMDLTS-QGA---GTYWYLPPECFVVG--KEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDI------LQENTILKA-----TEVQFPVK---
 . |  .. .     ||  |  |. .     ..|.  . |.|.||.|.||...|||. ||  .  ....      | .|.   .     .  ||| .   
QQMMMTCVNE-KRLCGTPLYMAPQILQGQGEQKPYYDY-KCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGND

PVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL
|..|.| | .|||.| |  .||.. ..| | | .
PQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase TLK1.AA Ciliate-E2-Unclassified 456-734 25 1.4e-52 180.72 In-house 1-352 (352) Show / Hide 
Range on Protein: 456-734
Range on HMM: 1-352/352
Sequence Identity: 25% (90 aa)

YLLLHLLGRGGFSEVYKAFDLYEQRYA-----AVKIHQLN-KSWRDE-------KKENYHKHACREY---RIHKE--LDHPRIVKLYDYFSL-DTDTFCT
| ... .|.|||..|||. .  .. ..     . ||.. . |. . .       | .| .|.        .| ..  |.|| ........   |..... 
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VLEYCEGNDLDFYLKQ------------HKLMS-----EKEAR-----SIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIM
|.|||||.|| .|.|.            |....     |..|.      .  ||...| || . .  |||.|.|| |||. ..   ..|||.|||.||  
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

DDDSYGVDGM----------DLTSQGAGTYWYL----PPECFVV-GKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQ------------DILQEN
.....   .           ..... .||. |.    .||..   . . .|   |.|.||.|||....|.|. ||. |.. |            ...|  
QQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLY

TILKATEVQFPVKP------VVSSEAKAFIR----RCLAYRKEDRFDVHQLANDPYL
 . |. ..|||  |       .| ||| ||.    ..| .. . | .  |. | |..
QNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase TLK1.AA CAMKL 456-734 28 4.8e-45 141.6 In-house 1-297 (297) Show / Hide 
Range on Protein: 456-734
Range on HMM: 1-297/297
Sequence Identity: 28% (89 aa)

YLLLHLLGRGGFSEVYKAFD-LYEQRYAAVKIHQLNKSWRDEKKEN-------YHKHAC--REYRIHKELD---HPRIVKLYDYF-SLDT----DTFCTV
| ..  ||.|.|..|  | . .. ..  |.||   .| | |.....         .  .  ||..|.| |.   || |.|||. .   ..    . .. |
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LEYCEGND--LDFYLKQH----KLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLV-DGTACGEIKITDFGLSKIMDD--DSYGVDGMDLTS
.|||.| .  |  |...|    . |.|.||| .  ||| |. |. . .  |.| |.|| ||||  .|     |||.|||.| ....  . .|    .. .
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG--IVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPCIFGPG----QKLK

QGAGTYWYLPPECFVVGK-EPPKISNKVDVWSVGVIFFQCLYGRKPFG--HNQ--SQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRF
   |.. | .||  .. . . | .  |||.|| ||| .  ..|. ||   ...   . .|  .  . . .  ..|. . || ... .||. |    |.|.
TFCGSPPYMAPE--IFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRP

DVHQLANDPYL
 .||. |.| .
TIHQIMNHPWM
Kinase TLK1.AA TKL 462-722 19 2.9e-41 143.39 In-house 1-354 (364) Show / Hide 
Range on Protein: 462-722
Range on HMM: 1-354/364
Sequence Identity: 19% (71 aa)

LGRGGFSEVYKAFDLYE---------QRYAAVKIHQLNKSWRDEKKEN-------------------YHKHACREYRIHKELDHPRIVKLYDYFSLDTDT
.|.|||.||||.    .         .  |  |... | . .... ..                   . ..  .| .... |.|| ||... |    ...
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------FCTVLEYCEGND-LDFYLKQHKLMSEKEARSIVMQIVNALRYLNEIK------PPIIHYDLKPGNILLV-DGT----------ACGEI
            .| | |||.| . |....            .....|  .. ||   .      ||||| |||. |||.  ..|          | . .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KITDFGLSKIMDDDSYGVDGMD-------------LTSQGAGTYWYLPPECFVVGKEPP------------KISNKVDVWSVGVIFFQCLYGRKPFG-HN
||.|||||. |. ..   |.|               |.   ||. ...||..    . .            . | |.||.| |.... .| ...|.  ..
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

QSQQD------ILQENTILKATEVQFP----------VKPVVSSEAKAFIRRCLAYRKEDR
 ....      . ..  ..|      |            | .  . |  . .| ..  |.|
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKR
Kinase TLK1.AA STE 456-734 20 2.3e-39 136.7 In-house 1-359 (359) Show / Hide 
Range on Protein: 456-734
Range on HMM: 1-359/359
Sequence Identity: 20% (75 aa)

YLLLHLLGRGGFSEVYKAFDLY---------------EQRYAAVKIHQLNK---------SWRDE---KKENYHKHACREYRIHKELD--HPRIVKLYDY
. ..  .|.|.| .|||| .                  ... |.|.  |..         . . |   | .. ..   .| .|.|...  || ||| |..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC

FSLD------TDTFCTVLEYCEGNDLDFYLKQH--------------KLMSEKEARSIVMQIVNA-LRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKI
.  .       |. . ..||..|  ||  .|.               . ..|.. . |. ||. . | || . .  ||| |.||.||||        .|.
YFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL--------VKL

TDFGLSKIMDDDSYGV----------DGMDLTSQGAGTYWYLPPECFVVGKEP--PKISNKVDVWSVGVIFFQCLYGRKPF---GHNQSQQDILQEN---
.|||......|.. .           ..   .   .||  .  ||    ....  .. . |.|.||.|      . |. |.    . .    |....   
CDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQ

------TILKATEVQFPV-----------------KPVVSSEAKAFIRRCLAYRKEDRFDVHQLAN--DPYL
       |.. .  ..|                  .  .|.| | ||..|| .  ..| ...|| .   | .
QQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase TLK1.AA ULK 456-618 32 1.8e-34 119.78 In-house 1-192 (324) Show / Hide 
Range on Protein: 456-618
Range on HMM: 1-192/324
Sequence Identity: 32% (64 aa)

YLLLHLLGRGGFS-EVYKAFDLYE---QRYAAVKIHQLNKSWRDEKKENY----HKHACREYRIHKELD---HPR--IVKLYDYFSLDTD-TFCTVLEYC
| | | || | |   |||...      . | |.|. ...|  .. |.|..     .  ..| .| |.|.   ||   ||||||.|  ...  .. ..|||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKM-NKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYC

EGNDLDFYLKQHKL---------MSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTAC---------GEIKITDFGLSKIMDDDS
.| ||. |.|..|           ||.||... .||.|....|.. .  ||| |.|| |||. .|..          | .||.|||..|. |...
NGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNN
Kinase TLK1.AA PLK-Unclassified 456-611 36 9.4e-31 108.49 In-house 1-153 (264) Show / Hide 
Range on Protein: 456-611
Range on HMM: 1-153/264
Sequence Identity: 36% (60 aa)

YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQH--
|  .|.|| |||. .|.. ..   .  |.||    ||    .|.   .    | .||| |.|. ||| .. |  | .    .||||.. .|  |.| .  
YHRGHFLGKGGFAKCYQVKNIETKKIYAAKI--IPKSSL--TKNRARQKLISEIKIHKSLHHKNIVKFEHCFE-DHENVYILLEYCPNGTLMEYIKRRNF

-----KLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLS
     | ..| |......|||.|| ||   .  ||| |||.|||.| |     |.|| ||||.
QLFEKKRLTEYEVKCYTYQIVQALKYLHQNR--IIHRDLKLGNIFLNDNM---EVKICDFGLA
Kinase TLK1.AA ULK 654-734 32 5.6e-23 78.41 In-house 232-324 (324) Show / Hide 
Range on Protein: 654-734
Range on HMM: 232-324/324
Sequence Identity: 32% (30 aa)

KVDVWSVGVIFFQCLYGRKPFGHN-QSQQ----DILQE----NTILKATEVQFPVKP---VVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL
|.|.||.|.||...|||. ||  . ..|.    . ..      .. | . .||| .|   ..|.| | .|||.| |  .||.. ... | | .
KCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase TLK1.AA TyrKc 456-732 25 2.7e-13 -7.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 456-732
Range on HMM: 1-280/280
Sequence Identity: 25% (77 aa)

YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL--DHPRIVKLYDYFSLDT-------DTFCTVLEYCEGNDL
  |.. ||.| | ||||.      .  |||  . ..          ..  .|| || ..|  .|| ||.||    ..        .  . |.||... ||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLY-GVCTQQGRNFMYIEPLMIVMEYMPHGDL

DFYLKQHKL-MSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDD-SYGVDGMDLTS----QGA--GTYWYLP
. ||. |.   . |.  |.  || .  .|| .   ..|| ||   |.|. ..     .||.|||||.  .|| . |. .   ..    .|     .  ..
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PECFVVGKEPPKISNKVDVWSVGVIFF-QCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVV---------SSEAKAFIRRCLAYRKEDRFDVHQL
|||.  |    | . | |||| ||  .  . || .|      | ..  .  | .  .   . .|           ..|    ...| ..  |||    ..
PECINYG----KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

ANDP
  . 
HECF
Kinase TLK1.AA Pkinase_Tyr 507-619 32 3.3e-09 31.81 Pfam 52-167 (270) Show / Hide 
Range on Protein: 507-619
Range on HMM: 52-167/270
Sequence Identity: 32% (39 aa)

REYRIHKEL-DHPRIVKLYDYFSLDTDT--FCTVLEYCEGNDLDFYLKQH----KLMSEKEARSIVMQIVNALRYLNEIKPPIIHYDLKPGNILLVDGTA
|| .| |.| .|| ||.||   . . .    . |.||... ||. ||..|    .  . |.  .. .|| ... || ...  .|| ||   |.|. .   
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE---

CGEIKITDFGLSKIM-DDDSY
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NNVVKICDFGLARDIYNDDYY
Kinase TLK1.AA PLK-Unclassified 654-734 28 4.2e-07 22.8 In-house 188-264 (264) Show / Hide 
Range on Protein: 654-734
Range on HMM: 188-264/264
Sequence Identity: 28% (23 aa)

KVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATEVQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL
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EVDCWSFGCILYTLLIGKPPF----ETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase TLK1.AA Pkinase_Tyr 456-473 44 5.485289 0.58 Pfam 1-18 (270) Show / Hide 
Range on Protein: 456-473
Range on HMM: 1-18/270
Sequence Identity: 44% (8 aa)

YLLLHLLGRGGFSEVYKA
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ITFGKKLGEGAFGEVYKG