Trb2

Species: Mouse
Alias: AW319517, Trb2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CAMK
Family: Trbl

Sequence

Name Sequence Type Origin Length Description Download
Trb2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 245 Kinase domain by global Sugen HMM Fasta, JSON
Trb2.AA Protein Sugen 343 None Fasta, JSON
Trb2.NA RNA Sugen 3234 None Fasta, JSON

Protein domain

Protein domains of Trb2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Trb2.AA Trbl 66-308 68 4.4e-205 653.9 In-house 1-256 (256) Show / Hide
Range on Protein: 66-308
Range on HMM: 1-256/256
Sequence Identity: 68% (175 aa)

LLEPLEGDHVFRAVHLHSGEELVCKVFEISCYQESLAPCFCLSAHSNINQITEILLGETKAYVFFERS-------------YGDMHSFVRTCKKLREEEA
.|||.||.||..|.|.|.|.|..||||.|.||||.|.|.|||..|..|..|.|..|||.|||.||||.             .|||||.||..|.|.||||
CLEPFEGEHVYCAIHCHTGHEYQCKVFPIQCYQEELRPYFCLPGHQHIRRIHEVILGEQKAYIFFERTPQERDSTGGVTGVHGDMHSYVRHRKRLCEEEA

ARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRY
||||.|...||||||..|.||||||||.|.|||||||...||||||..|..|.||||.||||||||||||||.|.|||||||||.|||||||||||||||
ARLFHQMCQAVAHCHQHGIVLRDLKLRRFVFKDEERTKLQLESLEDSCIMTGEDDSLWDKHGCPAYVSPEILCTQGSYSGKAADMWSLGVMLYTMLVGRY

PFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHPWF
||||.||..||.|||||||.|||.|||||.||||..||||||||.|.|.||.||||
PFHDSEPCNLFTKIRRGQFCIPEHLSPKARCLIRCLLRREPSERMTAQHILLHPWF

Kinase Trb2.AA CAMK 75-308 17 1.2e-65 210.19 In-house 10-425 (425) Show / Hide
Range on Protein: 75-308
Range on HMM: 10-425/425
Sequence Identity: 17% (74 aa)

VFRAVHLHSG------------EELVCKVFEIS-------------------------------CYQESLAPCFCLSA---------HSNINQITEILLG
|....| ...            ..  .|. . .                                 .. .    ...          | || .. |.   
VKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYED

-------------------ETKAYVFF---ERSYG-----DMHSFV--RTC-------------KKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRK
                   ... | ..   |   |     |. ...  ..|             ... |.||.|.| ||.|||..||. . | ||||.  
PHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPEN

FIFKDEER---------------TRVKLESLEDAYILRG-----------------------DDDSLSDKHGCPAYVS-PEILNTSG------------S
  . | ..                 .|.     | ....                       ... ...  |.|.|.. ||.|| .|             
ILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKP

YSGKAADVWSLGVMLYTMLVGRYPFHDI-------------EPSSLFSKIRRGQFN-IPETLSP-----------------------KAKCLIRSILRRE
| |...|.||.||.||.||.|..|| .              ... || ||..|... .|. .||                        .|.|||..|...
YYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVD

PSERLTSQEILDHPWF
|..|.| ...|.|||.
PEKRMTIEQCLNHPWM

Kinase Trb2.AA MELK 110-308 33 7.1e-40 133.76 In-house 56-254 (254) Show / Hide
Range on Protein: 110-308
Range on HMM: 56-254/254
Sequence Identity: 33% (66 aa)

HSNINQITEILLGETKAYVFFER-SYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDS
| .| |.  ..  | | .. .|  . |.|  ..   ..| |||.  .| || ||.|. |  |   ||||   ..|... . ..    |      | |   
HQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHN

LSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHPWF
|    | |||  ||...   .| |  |||||.|..||....|  || |   . .. || .| .. |. |||..| |.| .|  .|  |.  ...|.||| 
LQTCCGSPAYAAPELIQGK-QYIGSEADVWSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV





Kinase Trb2.AA CAMKL 216-308 34 2.7e-36 113.23 In-house 197-297 (297) Show / Hide
Range on Protein: 216-308
Range on HMM: 197-297/297
Sequence Identity: 34% (36 aa)

PAYVSPEILNT-SGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPS-------SLFSKIRRGQFNIP--ETLSPKAKCLIRSILRREPSERLTSQEILDH
|.| .|||..    .| |...|.||.||.||.|..|..|| |   .        |. ||..| ...|    .|  .. |||..| . |..| | ..|. |
PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

PWF
||.
PWM

Kinase Trb2.AA Ciliate-E2-Unclassified 134-308 21 2e-34 116.79 In-house 105-352 (352) Show / Hide
Range on Protein: 134-308
Range on HMM: 105-352/352
Sequence Identity: 21% (54 aa)

YGDMHSFVRTCKK-----------------LREEEAA-----RLFYQIASAVAHCHDGG-LVLRDLKLRKFIFKDEER-TRVKLESLEDAYILRGD----
.||.. . . .||                 . |..|.     ..|.|| ..  ..|  .  . ||.|.   .|... .  ..|.  .  .. .  .    
GGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD

-----------DDSLSDKHGCPAYV----SPEILNTSGSYSG--KAADVWSLGVMLYTMLVGRYPFHDIEPSS----------------LFSKIRRGQFN
           .. .... | | |     .||.|   . .    ...|.||||| || || |.||| |    .                |...|  ....
TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQ

IPE--------TLSPKAKCLIR----SILRREPSERLTSQEILDHPWF
.|.        ..||.|| .|.    ..|   |..|.| ..|| ||||
FPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase Trb2.AA AMPK 214-308 44 5.5e-34 98.32 In-house 161-254 (254) Show / Hide
Range on Protein: 214-308
Range on HMM: 161-254/254
Sequence Identity: 44% (42 aa)

GCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHPWF
| | | .||.  ..  | |   |.|| || || || |. || | . ..|. ||. |.. ||. |||.|| ||...|.  | .|.| ..|  ||||
GSPCYAAPEMI-SGKLYCGPEVDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF

Kinase Trb2.AA MARK 214-308 41 6.3e-33 105.1 In-house 167-262 (262) Show / Hide
Range on Protein: 214-308
Range on HMM: 167-262/262
Sequence Identity: 41% (40 aa)

GCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFH--DIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILDHPWF
| |.| .|||.. .  | |...|.||||| ||.|..|..||   ...   |. ||.||.. ||  .|.... ||...|   |.|| | .||. |||.
GTPPYMAPEIFL-KKPYDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM

S_TKc Trb2.AA S_TKc 64-308 25 4.4e-32 113.83 SMART 1-231 (231) Show / Hide
Range on Protein: 64-308
Range on HMM: 1-231/231
Sequence Identity: 25% (68 aa)

YLLLEPL-EGD--HVFRAVHLHSGEELVCKVFEISCYQESLAPCFCLS-AHSNINQITEILLGETKAYVFFERSYG---DMHSFVRTCKK------LREE
| .|... .|    |....| ..|..  .|.      .  .    .|.  | || .. ..    .. |...|   |   |.... . ...      . | 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-

EAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVG
.|....|||..|...||. | . ||||     . .    ..|.     | .|       .   | | |..||.|    .|.....|.||.|..|| ||.|
HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCG

RYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEILD-------HPWF
. ||.  ..  .| ||.          || || .|| .|...|..|.|  |.|        ||||
YPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase Trb2.AA RSK 214-308 36 3.4e-31 109.97 In-house 170-278 (278) Show / Hide
Range on Protein: 214-308
Range on HMM: 170-278/278
Sequence Identity: 36% (40 aa)

GCPAYVSPEILN---TSGSYSGKAADVWSLGVMLYTMLVGRYPFHD---IEPSSLFSKIRRGQ--FNIP--ETLSPKAKCLIRSILRREPSERLT-----
.  .|. ||.|.     | .. ||.|.||||| .|.||.|. ||.      .. .. .|..|.  ...|  ..||. || |||  | |.|. ||.     
YTIEYMAPEMLKRANQQGGHD-KACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQD

SQEILDHPWF
 .||..||||
AEEIKQHPWF

Kinase Trb2.AA Ciliate-E2 216-308 29 1.8e-30 101.82 In-house 251-365 (365) Show / Hide
Range on Protein: 216-308
Range on HMM: 251-365/365
Sequence Identity: 29% (36 aa)

PAYVSPEILNTSGSY-------SGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIP------------------ETLSPKAKCLIRS---
| |..|||||  . .        ....|.|||||.|| || |..||        . .|  .....|                  . .|...| ||.    
PGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGK

-ILRREPSERLT-SQEILDHPWF
 .| ..|..|.|  ..||.||||
RMLQKDPEKRITGWEQILNHPWF

Kinase Trb2.AA TSSK 217-308 34 1.2e-28 91.18 In-house 193-289 (289) Show / Hide
Range on Protein: 217-308
Range on HMM: 193-289/289
Sequence Identity: 34% (34 aa)

AYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHD--IEPSSLFSKIR-RG-QFNI--PETLSPKAKCLIRSILRREPSERLTSQEILDHPWF
||..||||  .  |..|..||||.|| ||.|..|. || |   ..  .   .. .. .| .   ...|. .| |||..|. .|..|....||. |.| 
AYAAPEIL-RGIPYDPKWYDVWSMGVILYIMVCGCMPFDDDKSNIHKMLWQQQEHKVCFPKPHSCWISQECKDLIRHMLQPHPCNRPHINEICHHCWM

Kinase Trb2.AA Pkinase 216-308 26 2.7e-28 101.11 Pfam 175-293 (293) Show / Hide
Range on Protein: 216-308
Range on HMM: 175-293/293
Sequence Identity: 26% (32 aa)

PAYVSPEILNTSGSYSGKAADVWSLGVMLYTMLVGRYPFHDI------EPSSLFSKIRRGQFNIPETLS---------------------PKAKCLIRSI
| |..||... .|.| |...|.||.|..|| || || || .       ..  .. .|.....  ..  .                     . .| .|...
PWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

LRREPSERLTSQEILDHPWF
|.. |..|.| ..|| ||||
LCKDPKKRPTAEQILQHPWF

Kinase Trb2.AA TSSK 135-178 36 8.8e-11 31.6 In-house 102-151 (289) Show / Hide
Range on Protein: 135-178
Range on HMM: 102-151/289
Sequence Identity: 36% (18 aa)

GDMHSFVRTC------KKLREEEAARLFYQIASAVAHCHDGGLVLRDLKL
||. .....       . |.||.| ..| |..|||..||. . | ||||.
GDLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCHSHNVVHRDLKC

Kinase Trb2.AA CAMKL 135-178 36 8.8e-11 30.49 In-house 106-155 (297) Show / Hide
Range on Protein: 135-178
Range on HMM: 106-155/297
Sequence Identity: 36% (18 aa)

GD--MHSFV--RTCKK--LREEEAARLFYQIASAVAHCHDGGLVLRDLKL
|.  .. ..  . ...  . |.|| |.| || |||..||. | | ||.|.
GEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKP

Kinase Trb2.AA AMPK 110-178 33 6.1e-10 25.76 In-house 58-128 (254) Show / Hide
Range on Protein: 110-178
Range on HMM: 58-128/254
Sequence Identity: 33% (24 aa)

HSNINQITEIL-LGETKAYVFFERS-YGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLRDLKL
| .| |  |..   .|  ... |    |.  ...   ..| |.||.|.| || |.|  ||. . | ||||.
HPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQEREACRFFQQIISGVEYCHRHMIVHRDLKP

Kinase Trb2.AA MARK 135-178 41 8.9e-09 25.0 In-house 87-132 (262) Show / Hide
Range on Protein: 135-178
Range on HMM: 87-132/262
Sequence Identity: 41% (19 aa)

GDMHSFVRTC--KKLREEEAARLFYQIASAVAHCHDGGLVLRDLKL
|.......     .| |||| |.| || |||  ||. . | ||.|.
GELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKP

TyrKc Trb2.AA TyrKc 64-308 16 2e-06 -116.96 SMART 1-280 (280) Show / Hide
Range on Protein: 64-308
Range on HMM: 1-280/280
Sequence Identity: 16% (47 aa)

YLLLEPL-EGDH--VFRAVHLHSGEELVCKVFEISCYQESL---APCFCLS--AHSNINQITEILLGE-------TKAYVFFE-RSYGDMHSFVRTCKK-
  |.. | ||    |....     ..   |.   .. .| .   |   |     | || ..  . . .          .. .|  ..|| ... | ... 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LREEEAARLFYQIASAVAHCHDGGLVLRDLKLRKFIFKDEERTRV------KLESLEDAYILRGDDDSLSDKHGCP-----AYVSPEILNTSGSYSGKAA
|  ..     .|||.  .. |. ... |||  |    ... . ..      .    .|.   ..|  . . . |.         .|| .   | ..  . 
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT-TKS

DVWSLGVMLYTML-VGRYPFHD-----IEPSSLFSKIRRGQFNIPETL---------SPKAKCLIRSILRREPSERLTSQEILDHPWF
|||| ||... ..  |  |  .     .... .. ....|    .            ...   ....  ...|..| | .||  |  |
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF

Kinase Trb2.AA Pkinase 135-178 26 3e-06 22.95 Pfam 85-136 (293) Show / Hide
Range on Protein: 135-178
Range on HMM: 85-136/293
Sequence Identity: 26% (14 aa)

G----DMHSFVR--TCKKL--REEEAARLFYQIASAVAHCHDGGLVLRDLKL
|    | .....    ...   |.|. . .|||......||. | . ||||.
GLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKP

Kinase Trb2.AA Ciliate-E2 145-178 20 7.4e-05 12.58 In-house 140-189 (365) Show / Hide
Range on Protein: 145-178
Range on HMM: 140-189/365
Sequence Identity: 20% (10 aa)

KKLREEEAARLFYQIAS---------------AVAHCHDGG-LVLRDLKL
|.. |.|......||..               |. ..|  .  . ||.|.
KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKP

Kinase Trb2.AA RSK 147-178 40 0.000898 10.1 In-house 101-132 (278) Show / Hide
Range on Protein: 147-178
Range on HMM: 101-132/278
Sequence Identity: 40% (13 aa)

LREEEAARLFYQIASAVAHCHDGGLVLRDLKL
. |.||.  ...|..|| | |. | . ||||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKP