Trb3

Species: Mouse
Alias: Ifld2, Trb3
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CAMK
Family: Trbl

Sequence

Name Sequence Type Origin Length Description Download
Trb3.AA Protein Sugen 354 None Fasta, JSON
Trb3.NA RNA Sugen 2051 None Fasta, JSON
Trb3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 245 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of Trb3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Trb3.AA Trbl 73-315 63 6.00000000001e-198 630.98 In-house 1-256 (256) Show / Hide
Range on Protein: 73-315
Range on HMM: 1-256/256
Sequence Identity: 63% (162 aa)

LLEREQGSCSYRALHCPTGTEYTCKVYPASEAQAVLAPYARLPTHQHVARPTEVLLGSRLLYIFFTKT-------------HGDLHSLVRSRRGIPESEA
.||...|...|.|.||.||.||.|||.|....|..|.||..||.|||..|..||.||....||||..|             |||.||.||.|....|.||
CLEPFEGEHVYCAIHCHTGHEYQCKVFPIQCYQEELRPYFCLPGHQHIRRIHEVILGEQKAYIFFERTPQERDSTGGVTGVHGDMHSYVRHRKRLCEEEA

AGLFRQMASAVAHCHKHGLVLRDLKLRRFVFSNCERTKLVLENLEDACVMTGSDDSLWDKHACPAYVGPEILSSRPSYSGKAADVWSLGVALFTMLAGRY
|.||.||..||||||.||.||||||||||||...|||||.||.|||.|.|||.||||||||.|||||.||||....||||||||.|||||.|.|||.|||
ARLFHQMCQAVAHCHQHGIVLRDLKLRRFVFKDEERTKLQLESLEDSCIMTGEDDSLWDKHGCPAYVSPEILCTQGSYSGKAADMWSLGVMLYTMLVGRY

PFHDSEPVLLFGKIRRGTFALPEGLSAPARCLIRCLLRKEPSERLVALGILLHPWL
|||||||..||.|||||.|..||.||..||||||||||.|||||..| .||||||.
PFHDSEPCNLFTKIRRGQFCIPEHLSPKARCLIRCLLRREPSERMTAQHILLHPWF

Kinase Trb3.AA CAMK 140-315 19 3.6e-54 172.58 In-house 143-425 (425) Show / Hide
Range on Protein: 140-315
Range on HMM: 143-425/425
Sequence Identity: 19% (56 aa)

THG----DLHSLVRSR---------------RGIPESEAAGLFRQMASAVAHCHKHGLVLRDLKLRRFVFSNCER---------------TKLVLENLED
. |    || . ....               . ..|.||. .|||..|||..||.|. | ||||.    ... ..                .. .     
SGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGF

ACVMTGS-----------------------DDSLWDKHACPAYVG-PEILSSRP------------SYSGKAADVWSLGVALFTMLAGRYPFHDS-----
|......                       .. ...   .|.|.  ||.|.. .             | |...|.||.|| |..|| |..|| ..     
ANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEI

--------EPVLLFGKIRRGTFA-LPEG-----------------------LSAPARCLIRCLLRKEPSERLVALGILLHPWL
        ..  || ||..| .   |.                        .|. ...|||..|...|..|. .  .| |||.
CEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM

Kinase Trb3.AA SgK495 143-313 36 4.3e-36 109.3 In-house 1-171 (171) Show / Hide
Range on Protein: 143-313
Range on HMM: 1-171/171
Sequence Identity: 36% (63 aa)

DLHSLVRSRRGIPESEAAGLFRQMASAVAHCHKHGLVLRDLKLRRFVFSNCERTKLVLENLEDACVMTGSDDSLWDKHACPAYVGPEILSSRPSYSGKAA
 |   |   . . | |.  .|  . . |   |.  .| |||||   |  ||   .. . |      .    | | |.   |||. |..|| || | || .
NLQHHVIHEKRLSERETVYIFHDVVRIVEALHQKNIVHRDLKLGNMVL-NCHTHQITITNFCLGKHLVSEHDLLKDQRGSPAYISPDVLSGRP-YRGKPS

DVWSLGVALFTMLAGRYPFHDSEPVLLFGKIRRGTFALPEG--LSAPARCLIRCLLRKEPSERLVALGILLHP
|.| ||| ||||| | .|| || |  || ||.   . .|.    |    |||| ||  .|..|| |  ..   
DMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPQDGRVSENTVCLIRKLLVLDPQQRLTATQVIEAV

Kinase Trb3.AA MELK 142-315 31 1.2e-31 105.16 In-house 82-254 (254) Show / Hide
Range on Protein: 142-315
Range on HMM: 82-254/254
Sequence Identity: 31% (57 aa)

GDLHSLVRSRRGIPESEAAGLFRQMASAVAHCHKHGLVLRDLKLRRFVFSNCERTKLVLENLEDACVMTGSDDSLWDKH---AC---PAYVGPEILSSRP
|..   . ..  . |.|.  .|||. ||.|. |  |   ||||   ..| .  . ||.   |   |  |       |.|    |   |||  ||... . 
GEMFDYIIRQDRLEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGL---CAKT---KGRKDYHNLQTCCGSPAYAAPELIQGK-

SYSGKAADVWSLGVALFTMLAGRYPFHDSEPVLLFGKIRRGTFALPEGLSAPARCLIRCLLRKEPSERLVALGILLHPWL
.| |  |||||.|. |.... |  || |    ... || .| .  |. ||  .. |.| .|  .|  |.    .| |||.
QYIGSEADVWSMGILLYVLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV

Kinase Trb3.AA GIN4 142-315 31 2e-29 90.84 In-house 119-293 (293) Show / Hide
Range on Protein: 142-315
Range on HMM: 119-293/293
Sequence Identity: 31% (56 aa)

GDLHSLVRSRRGIPESEAAGLFRQMASAVAHCHKHGLVLRDLKLRRFVFSNCERTKLVLENLEDACVMTGSDDSLWDKHACPAYVGPEILSSRPSYSGKA
|.|  .. ..  .|| ||   |||.   |. ||  ... ||||    .  .  . .. .     | . |   . |      | |  ||| . .| | | |
GELFNYLVDHGPLPEREAIHYFRQIIIGVSYCHAFNICHRDLKPENLLLDHKYN-RIKIADFGMAALET-DNKLLETSCGSPHYAAPEIVMGIP-YHGFA

ADVWSLGVALFTMLAGRYPFHDS--EPVLLFGKIRRGTFALPEG--LSAPARCLIRCLLRKEPSERLVALGILLHPWL
.|||| || || .| |. || .       |  |. .| . .|.   .|  |. ||| .|  .|  |.    || || .
SDVWSCGVILFALLTGHLPFDEEDGNIRKLLLKVQKGKYEMPSDDEISREAQDLIRKILVVDPEKRIKTRDILKHPLI

Kinase Trb3.AA AMPK 223-315 38 2.9e-28 81.06 In-house 163-254 (254) Show / Hide
Range on Protein: 223-315
Range on HMM: 163-254/254
Sequence Identity: 38% (36 aa)

PAYVGPEILSSRPSYSGKAADVWSLGVALFTMLAGRYPFHDSEPVLLFGKIRRGTFALPEGLSAPARCLIRCLLRKEPSERLVALGILLHPWL
| |  ||. |... | |   |.|| || |. || |. || |..   |. ||. | . .|. ||  |. ||...|.. | .|.    |  |||.
PCYAAPEMISGKL-YCGPEVDIWSCGVILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF

Kinase Trb3.AA CAMKL 223-315 33 3.9e-27 83.51 In-house 197-297 (297) Show / Hide
Range on Protein: 223-315
Range on HMM: 197-297/297
Sequence Identity: 33% (35 aa)

PAYVGPEILSS-RPSYSGKAADVWSLGVALFTMLAGRYPFHDSEPV-------LLFGKIRRGTFALP--EGLSAPARCLIRCLLRKEPSERLVALGILLH
|.|  |||...   .| |...|.||.|| |..|. |..|| |           .|. ||..| .  |    .| ..| ||| .| . |..|  .  |. |
PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

PWL
||.
PWM

Kinase Trb3.AA MARK 223-315 40 7.2e-26 81.69 In-house 169-262 (262) Show / Hide
Range on Protein: 223-315
Range on HMM: 169-262/262
Sequence Identity: 40% (38 aa)

PAYVGPEILSSRPSYSGKAADVWSLGVALFTMLAGRYPFHDSE--PVLLFGKIRRGTFALPEGLSAPARCLIRCLLRKEPSERLVALGILLHPWL
|.|  |||....| | |...|.||||| |..|. |..|| ..    . |. ||.|| .  |  .|. .| ||. ||   |.||  .  |. |||.
PPYMAPEIFLKKP-YDGPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM

Kinase Trb3.AA RSK 224-315 32 5.7e-25 88.42 In-house 173-278 (278) Show / Hide
Range on Protein: 224-315
Range on HMM: 173-278/278
Sequence Identity: 32% (35 aa)

AYVGPEILS---SRPSYSGKAADVWSLGVALFTMLAGRYPFHD---SEPVLLFGKIRRGT--FALP--EGLSAPARCLIRCLLRKEPSERLV-----ALG
.|. ||.|     .  .. ||.|.||||| ...||.|. ||.    . .  .. .|..|.  . .|  . ||..|. ||| .| ..|. ||      |  
EYMAPEMLKRANQQGGHD-KACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEE

ILLHPWL
|. |||.
IKQHPWF

S_TKc Trb3.AA S_TKc 68-315 22 1.4e-24 88.86 SMART 1-231 (231) Show / Hide
Range on Protein: 68-315
Range on HMM: 1-231/231
Sequence Identity: 22% (59 aa)

LGPYILLEREQGSCSYRALHCPTGTEYTCKVYPASEAQAVLAPYARLPTHQHVARPTEVLLGSRLLYIFFTKTHG---DLHSLVRSRRG------IPESE
     .. .   .. |.. |  || .. .|. .   ..  ..   .   | .. .  .|      ||...    |   ||... ..|..      .|| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

AAGLFRQMASAVAHCHKHGLVLRDLKLRRFVFSNCERTKLVLENLEDACVMTGSDDSLWDKHACPAYVGPEILSSRPSYSGKAADVWSLGVALFTMLAGR
|. ...|...|...||.|| . ||||     ...     . .     |...             | |. ||.|    .|.....|.||.|. |. ||.|.
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGY

YPFHDSEPVLLFGKIRRGTFALPEGLSAPARCLIRCLLRKEPSERLVALGILL-------HPWL
 ||.  .. ..| ||.          | .|. .|| .|.|.|..|. |  .|        |||.
PPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase Trb3.AA TSSK 224-315 33 2.6e-22 70.03 In-house 193-289 (289) Show / Hide
Range on Protein: 224-315
Range on HMM: 193-289/289
Sequence Identity: 33% (33 aa)

AYVGPEILSSRPSYSGKAADVWSLGVALFTMLAGRYPFHD--SEPVLLFGKIR-RG-TFAL--PEGLSAPARCLIRCLLRKEPSERLVALGILLHPWL
||. |||| ..| |..|..||||.|| |..|. |. || |  |..  .   .. .. .|     ...|. .. ||| .|. .|..|. .  |. |.|.
AYAAPEILRGIP-YDPKWYDVWSMGVILYIMVCGCMPFDDDKSNIHKMLWQQQEHKVCFPKPHSCWISQECKDLIRHMLQPHPCNRPHINEICHHCWM

Kinase Trb3.AA Pkinase 223-315 24 1.5e-16 59.63 Pfam 175-293 (293) Show / Hide
Range on Protein: 223-315
Range on HMM: 175-293/293
Sequence Identity: 24% (29 aa)

PAYVGPEILSSRPSYSGKAADVWSLGVALFTMLAGRYPFHDS------EPVLLFGKIRRGTFALPEGLS---------------------APARCLIRCL
| |. ||..    .| |...|.||.|. |. || || || ..      ..  .. .|... .  ..  .                      ... .|...
PWYMAPEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

LRKEPSERLVALGILLHPWL
|.| |..|. |  || |||.
LCKDPKKRPTAEQILQHPWF

Kinase Trb3.AA CAMKL 131-185 29 7.2e-14 40.5 In-house 79-155 (297) Show / Hide
Range on Protein: 131-185
Range on HMM: 79-155/297
Sequence Identity: 29% (23 aa)

RLLYIFFTKTH----------------GD--LHSLVRSR----RGIPESEAAGLFRQMASAVAHCHKHGLVLRDLKL
.|. .. |..|                |.  |.  ....    . .||.||  .|||. |||..||.|| | ||.|.
KLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKP

Kinase Trb3.AA TSSK 141-185 43 1.3e-13 41.03 In-house 101-151 (289) Show / Hide
Range on Protein: 141-185
Range on HMM: 101-151/289
Sequence Identity: 43% (22 aa)

HGDLHSLVRSR------RGIPESEAAGLFRQMASAVAHCHKHGLVLRDLKL
|||| . .. |      ....|..|  .||||.|||..|| |. | ||||.
HGDLLEYIQRRTQERCCGALHEEQARKWFRQMVSAVKYCHSHNVVHRDLKC

Kinase Trb3.AA MARK 131-185 28 1.6e-11 34.08 In-house 63-132 (262) Show / Hide
Range on Protein: 131-185
Range on HMM: 63-132/262
Sequence Identity: 28% (20 aa)

RLLYIFF--TKTH-----------GDLHSLVRSR--RGIPESEAAGLFRQMASAVAHCHKHGLVLRDLKL
.|....   |..|           |.|.. ....  . ..|.||  .|||. |||  ||... | ||.|.
KLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKP

Kinase Trb3.AA AMPK 142-185 38 3.6e-09 23.44 In-house 85-128 (254) Show / Hide
Range on Protein: 142-185
Range on HMM: 85-128/254
Sequence Identity: 38% (17 aa)

GDLHSLVRSRRGIPESEAAGLFRQMASAVAHCHKHGLVLRDLKL
|.| . . ... ..| ||. .| |. |.|  ||.|. | ||||.
GELFDYIVKHGRLQEREACRFFQQIISGVEYCHRHMIVHRDLKP

Kinase Trb3.AA Pkinase 141-185 24 6.4e-08 29.09 Pfam 84-136 (293) Show / Hide
Range on Protein: 141-185
Range on HMM: 84-136/293
Sequence Identity: 24% (13 aa)

HG----DLHSLVR--SRRGI--PESEAAGLFRQMASAVAHCHKHGLVLRDLKL
.|    ||.....  .....  .| |.   ..|.......||..| . ||||.
GGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKP

Kinase Trb3.AA RSK 150-185 30 0.000187 12.62 In-house 93-132 (278) Show / Hide
Range on Protein: 150-185
Range on HMM: 93-132/278
Sequence Identity: 30% (12 aa)

SRRGI----PESEAAGLFRQMASAVAHCHKHGLVLRDLKL
.....     |.||.  ... ..|| | |..| . ||||.
QKEKHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKP