Gene ULK1 (Mouse)

ULK1

Species: Mouse
Alias: Ulk1, ULK1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: ULK
Subfamily: ULK

Sequence

Name Sequence Type Origin Length Description Download
ULK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 263 Kinase domain by global Sugen HMM Fasta, JSON
ULK1.NA RNA Sugen 5215 None Fasta, JSON
ULK1.AA Protein Sugen 1051 None Fasta, JSON

Protein domain

Protein domains of ULK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ULK1.AA ULK 16-278 34 2.7e-126 425.85 In-house 1-324 (324) Show / Hide 
Range on Protein: 16-278
Range on HMM: 1-324/324
Sequence Identity: 34% (112 aa)

FSRKDLIGHGAFA-VVFKGRHREKH--DLEVAVKCINKKNLAKSQT---------LLGKEIKILKELK---HEN--IVALYDFQEMA--NSVYLVMEYCN
.. .. .|.|.|. .|.|||. ...  .  ||.|.|.||.. |..          || .||.|.|.||   |.|  || |||..| .  | .|..|||||
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLADYLHTMRTLSEDT----------VRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRR----ANPSNIRVKIADFGFARYLQSNMMAATLC
|||| .|... ..|.| |          .. |..||. ... ||...|||||.||||||..|. . .    ..| |...||||||||. ...|.|....|
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNNNMEQQMC

----------GSPMYMAPEVIMSQ-----HYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLR-------------LFYEKNKTLVPAIPR---ETSAPL
          |.|.||||.....|     .|| |.|.||.|.| |..|.|| ||... ..|.              ..|.||. . . .|.     |  .
QTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPEC

RQLLLALLQRNHKDRMDFDEFFHHPFL
..|.  .||.. |||....|.|.||..
KDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase ULK1.AA ULK 16-278 33 1.4e-121 410.25 In-house 1-329 (329) Show / Hide 
Range on Protein: 16-278
Range on HMM: 1-329/329
Sequence Identity: 33% (112 aa)

FSRKDLIGHGAFAVVFKGRHREKH---DLEVAVKCINKKNLAKSQTL---------LGKEIKILKELK--------HENIVALYDFQEMA--NSVYLVME
.. .. .|.|.|..|.|||. ...   .  ||.| | |. . ... .         | .||||.|.||        |.||| |||..| .  | .|..||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCNGGDLADYLHTMRTLSEDT----------VRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRR----ANPSNIRVKIADFGFARYLQSN----
||||||| .|... ..|.|||          .. |..||. ... ||...|||||.||||||..|. . .    ..| |...||||||||. ....    
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDNDNMEQ

--MMAAT----LCGSPMYMAPEVIMSQ-----HYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLR-LFYEKNKTLVPAIP----------------RET
  ||...    |||.|.||||.....|     .|| |.|.||.|.| |..|.|| ||.|. ..|.  ....|.. . | .|                   
QMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQI

SAPLRQLLLALLQRNHKDRMDFDEFFHHPFL
|  ...|.  .||.. |||....|.|.||..
SPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase ULK1.AA S_TKc 16-278 34 4.4e-98 333.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-278
Range on HMM: 1-231/231
Sequence Identity: 34% (95 aa)

FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNG--GDLADYLHTMRT----
.   ..||.|||..|.|.||..  . .||.|.|.          . .||.|||. .|.||| |||. .  ...|.|||||.|  ||| ||.. ...    
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LSEDTVRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDG-KADLWS
  ..| ..| ...||. |.  .||.|||||||||.||||..           ..||.|||.|| |       |.||.| ||||||.   .|.. |.| ||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----------HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWS

IGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPAIPRETSAPLRQLLLALLQRNHKDRMDFDEFFH-------HPFL
.| |.| .|.|. ||.     .. . ..| .          | ......  .||.. ..|.   | ..       ||..
CGCILYEMLCGYPPFP-----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ULK1.AA AGC 16-278 20 2e-84 217.42 In-house 1-395 (395) Show / Hide 
Range on Protein: 16-278
Range on HMM: 1-395/395
Sequence Identity: 20% (85 aa)

FSRKDLIGHGAFAVVFKGRHREKH-----DLEVAVKCINKKN---------LAKSQTL--------LGKEIKILKELK----------HENIVA-LYDFQ
|  . .|| |.|  |.  |.....     .   |.|...||          ... .|         . .| .||....          | .||  |.   
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

EMANS--VYLVMEYCN---------GG-DLADYLHTM-R--TLSEDTVRLFLQQ-------IAGAMRLLHS-KGIIHRD-LKPQNILLSNPGGRRANPSN
.  .   .|.||||..         || .|  .|. . .  ...|...| .. .       |. |.  ||| .|||||| ||| |||| .          
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---------

IRVKIADFGFARYLQSNM---------------------------------------------------MAATLCG--SPMYMAPEVIMSQHYDGKADLW
  .|..|||..  . ...                                                   .. |.||  .| |||||..    |.  .| |
GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWW

S--IGTIVYQCLTGKAPFQASSPQ-------DLRLFYEKNK------TLVPAIP----------RETSAPLRQLLLALLQRNHKDRMD----------FD
|   | . |. |||. ||.. .||       .    ..| .      .  . .|          |. |  .. |.  ||... ..|            ..
SFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAE

EFFHHPFL
|   ||. 
EIKNHPWF
Kinase ULK1.AA CAMK 21-278 22 3.5e-84 271.06 In-house 1-425 (425) Show / Hide 
Range on Protein: 21-278
Range on HMM: 1-425/425
Sequence Identity: 22% (95 aa)

LIGHGAFAVVFKGRHREKHDLE-----------VAVKCINKKNLAK---------------------------SQTLLGKEIKILKE-------LKHENI
 .|.|.|..|....|..   .|           ||.| |.|| | .                           ..  . .||.|.|        |.|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VALYDFQEMANS-------------------VYLVM---EYCNGG----DLADYLHTM---------------RTLSEDTVRLFLQQIAGAMRLLHSKGI
. ||.. | ..                    .|.||   ||| ||    || ||.                  . ..|. .| . .||. |.. .||..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKPQNILLSNPGGRRANPS---------NIRVKIADFGFARYLQS------------------------NMMAATLCGSPMYMA-PEVIMS-----
.|||||| ||||.. .. . . .         |  .||.|||||.....                        . .  | ||.| ||| |||. .     
VHRDLKPENILLDDNNDDSDP-VEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------QHYDGKADLWSIGTIVYQCLTGKAPFQASSPQ----------DLRLFYEKNKTLVPA-IPRETSA-----------------------PLR
         . |. |.| ||.| | | .|.|. ||.... .          ...  .|| ..     .| . |                          .
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

QLLLALLQRNHKDRMDFDEFFHHPFL
.|.  .||.. ..||  ..   ||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase ULK1.AA Pkinase 16-278 32 3.2e-82 284.27 Pfam 1-293 (293) Show / Hide 
Range on Protein: 16-278
Range on HMM: 1-293/293
Sequence Identity: 32% (98 aa)

FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQT-----LLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGG----DLADYLH-
. ..  || |.|..|.|..|.   . .||||.|.|..  ...      |   ||.|.|.|.|.||| |||. |  ...|.|||||.||    ||.||.. 
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-TMRTL--SEDTVRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARY--LQSNMMAATLCGSPMYMAPEVIM-SQHYD
   ...  ||.... .. ||. ..  .||.|||||||||.|||..| |   |     .|||.|||.|.   . .|  . |.||.| |||||||. .|.|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-----CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

GKADLWSIGTIVYQCLTGKAPFQAS----SPQDLRLFYEKNKTLVPAIPRETS---------------------APLRQLLLALLQRNHKDRMDFDEFFH
 |.| ||.| |.|. |.|. ||. .    .  | .  .....   .  .....                      ......  .|... |.|  ... ..
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

HPFL
||..
HPWF
Kinase ULK1.AA CAMKL 16-278 31 4.9e-80 255.08 In-house 1-297 (297) Show / Hide 
Range on Protein: 16-278
Range on HMM: 1-297/297
Sequence Identity: 31% (96 aa)

FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGK--------------EIKILKELK---HENIVALYDFQEMANS------VYLVM
.   . .|.|.|..|  ..|.     .||.| |.|| . . .  . .              ||.|.| |.   |.||. ||.  |  .       .||||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCNGGD--LADYL--HTMRT--LSEDTVRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARYLQS-----NMMAATL
||| ||.  | ||.  |  |   ..|.  | . .||  |.  .||.||.|||.|| ||||.. | .        .||.||||. . .      . .  | 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-------NIKIIDFGFSNMYRPCIFGPGQKLKTF

CGSPMYMAPEVIMS--QHYD-GKADLWSIGTIVYQCLTGKAPFQASSPQ-----DLRLFYEKNKT-LVPAIPRETSAPLRQLLLALLQRNHKDRMDFDEF
|||| |||||.. .  ..||  |.| ||.| | |  ..|. || . . .     .  ..|.|...   | |. . | ..|.|.  .||.| ..|.  .. 
CGSPPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCGYYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQI

FHHPFL
  ||..
MNHPWM
Kinase ULK1.AA Ciliate-E2 16-278 22 5.1e-77 262.19 In-house 1-365 (365) Show / Hide 
Range on Protein: 16-278
Range on HMM: 1-365/365
Sequence Identity: 22% (89 aa)

FSRKDLIGHGAFAVVFKGRHREKHDLE-----------------VAVKCINKKNLAKSQ-TLLGKEIKILKELK----------------HENIVALYDF
.    .|| |.|..|.|......  ..                 |..| ...|.. |.|   . .||.|..|..                | ||. .|..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

QE--MANSVYLVMEYCNGGDLADYLHTMRTLS-----------EDTVRLFLQQIAG---------------AMRLLHSKG-IIHRDLKPQNILLSNPGGR
 .    |..|||||||.|||| ||.  ... .           |  .. . .||.                |.. ||||. |||||.||.|||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

RANPSNIRVKIADFGFARYLQSN--------------------------------MMAATLCGSPMYMAPEVIMSQH---------YDGKADLWSIGTIV
        .||.|||...... .                                .|. |.||.|.|||||.....          || |.|.||.| | 
--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

YQCLTGKAPFQASSPQDLRLFYEKNKTLVPAIPRE------------------TSAPLRQLLLA----LLQRNHKDRMD-FDEFFHHPFL
|..|.|| ||           ....|     .| .                   |    .|.      .||.. . |.. ... . ||..
YEMLFGKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase ULK1.AA CAMK1 14-225 36 1.6e-75 218.96 In-house 1-220 (276) Show / Hide 
Range on Protein: 14-225
Range on HMM: 1-220/276
Sequence Identity: 36% (83 aa)

FEFSRKDLIGHGAFAVVFKGRHREK--HDLEVAVKCIN-KKNLAKSQ----TLLGKEIKILK---ELKHENIVALYDFQEMANSVYLVMEYCNGGDLADY
.||  .. || |||..|... |.|.   . ..|.|||. ||...|.     ..| .|| |.|   ...|.||...|...|  | .|||||...||.| | 
YEF--GKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDR

LHTMRTLSEDTVRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGR----RANPSNIRVKIADFGFARYLQSNM-MAATLCGSPMYMAPEVIMS---
       .|.  |.  .||..|   .||||| ||||||.|.|....       |         ||||| .... ..  .  | ||.| |.||||.     
IVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRS--------IADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKD

QHYDGKADLWSIGTIVYQCLTGKAPFQASS
..|| . |.|||| | |  |.|  ||....
KPYDKACDMWSIGVITYILLCGYPPFYDEN
Kinase ULK1.AA STE 16-278 22 2.4e-71 243.31 In-house 1-359 (359) Show / Hide 
Range on Protein: 16-278
Range on HMM: 1-359/359
Sequence Identity: 22% (85 aa)

FSRKDLIGHGAFAVVFKGRHREKHDLE--------------VAVKCINKKNLA----------------KSQTLLGKEIKILKELK--HENIVALYDFQE
. . . ||.||| .|.|..........              .|.| .|..|                  . .  . |||||.|...  |.|||  |.  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

MA-------NSVYLVMEYCNGGDLADYLH----TMRTLS----------EDTVRLFLQQIAGA-MRLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRV
         ......|||..|| | | ..    . ..|.          |. .. ...||  . . .|||..|||||.||.||||              |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------------V

KIADFGFARYLQSNM-----------------MAATLCGSPMYMAPEVIMS------QHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNK-
|..|||..  |...|                 .  |..|.| .||||||.       ..|| |.| ||.|  .   .||| |.   .|    .   .|. 
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYH

------------TLVPAIPRETS-------------------APLRQLLLALLQRNHKDRMDFDEFFH--HPFL
               | .| ..|                    .... .   ||.. ..| . ..  .  |||.
MQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase ULK1.AA Ciliate-E2-Unclassified 16-278 25 2.3e-68 233.45 In-house 1-352 (352) Show / Hide 
Range on Protein: 16-278
Range on HMM: 1-352/352
Sequence Identity: 25% (91 aa)

FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLG-----------KEIK-------------ILKELKHENIVALYDFQEMANSVYLV
.     ||.|.|..|.| .|...  .  | | ..|..  |..  .            ...|             ||. ..|..|| ...  .  . .|.|
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

MEYCNGGDLADYL--------------HTMRT---LSEDTVR-----LFLQQIAGAMRLLHSKG-IIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGF
||||.|||| .|.              |.|..   ..|  ..      .. ||  .   ||.|. |||||.||.|||..| |.      | ..||.|||.
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK------NYYIKIIDFGI

ARYLQSN----------------MMAATLCGSPMYM----APEVIMSQHYDGK----ADLWSIGTIVYQCLTGKAPFQASSPQD----------------
....|.|                .|. | ||.|.||    ||||...|.||..    .| || | | |..|.|. ||.. .  .                
SKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQ

LRLFYEKNKTLVPA-----IPRETSAPLRQLLL----ALLQRNHKDRMDFDEFFHHPFL
|.    .... .|      ||   |     ..      .|. | . |..|.. . ||..
LYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase ULK1.AA MARK 16-278 33 6.9e-64 207.78 In-house 1-262 (262) Show / Hide 
Range on Protein: 16-278
Range on HMM: 1-262/262
Sequence Identity: 33% (91 aa)

FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAK-SQ-TLLGKEIKILKELKHENIVALYDFQE--MANS-VYLVMEYCNGGDLADYLHTM--R
.  .  ||||..|.| ...|.  .  .||.| ..|..| .  .   .  ||.|.| |.|.||. |..  |    .  .||.|||. ||.| ||.     .
YKMLKTIGHGSYAKVKLACHKHTG-RKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNG

TLSEDTVRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYD-GKADLWSI
 |.|.  | . .||  |.  .|||.|.|||.||.|||.   |       |  .||.||||..  .....  | ||.| |||||.. .. ||  |.| || 
RLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENG-------NHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSL

GTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPAIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFL
| . |  ..|. || ...  .  |. . ..   . ||   |. .|.|.  ||. | ..|.. .|   ||..
GVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYD-IPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase ULK1.AA Pkinase_Tyr 16-206 32 1.8e-39 134.34 Pfam 1-199 (270) Show / Hide 
Range on Protein: 16-206
Range on HMM: 1-199/270
Sequence Identity: 32% (68 aa)

FSRKDLIGHGAFAVVFKGRHR---EKHDLEVAVKCINKKNLAKSQ---TLLGKEIKILKEL-KHENIVALYDFQE-MANS--VYLVMEYCNGGDLADYLH
 .    .|.||| .|.||. .   ......||||.. | .  ..|     . .|.||.|.| .|.||| ||        .  .|.||||. .||| |||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

TM----RTLSEDTVRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARYL----QS-NMMAATLCGSPMYMAPEVIMSQ
.     . |.  .   . .||| .|  |.||..|||||   |.|...         |  |||.||| ||..    .   .   .       ||||.|.  
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---------NNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYG

HYDGKADLWS
 .  | | ||
KFTTKSDVWS
Kinase ULK1.AA TyrKc 16-278 25 5.1e-30 106.96 SMART 1-280 (280) Show / Hide 
Range on Protein: 16-278
Range on HMM: 1-280/280
Sequence Identity: 25% (77 aa)

FSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKEL--KHENIVALYDFQEMA-------NSVYLVMEYCNGGDLADYLHT
 . .. .|.||| .|.||. .    ..||||....      .  . .|..|...|  .|.|||.||               ...||||. .||| |||. 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

MRT-LSEDTVRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARYLQSN--------MMAATLCGSPM------YMAPE
 |  |. ..   |  |||  |. ||||..|||||   |.|.....         .|||.||| .|.. .         .  ..  ..         ||||
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

VIMSQHYDGKADLWSIGTIVYQCLT-GKAPFQA-----SSPQDLRLFYEKNKTLVPAIPRE--------TSAPLRQLLLALLQRNHKDRMDFDEFFHHPF
.|.   .  | | || |   .  .| |. |         |.|... . .. . .   .| .         .. . |. .   ... .||  | |   | .
CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRM--PQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HEC

L
.
F
DUF3543 ULK1.AA DUF3543 834-1050 22 1.2e-78 272.42 Pfam 1-275 (275) Show / Hide 
Range on Protein: 834-1050
Range on HMM: 1-275/275
Sequence Identity: 22% (63 aa)

ETLMEQEHTETLHSLRFTLAFAQQVLEIAALKGSASEAAGG--PEYQLQESVV----------ADQISQLSREWGFAEQLVLYLKVAELLSSGLQTAIDQ
.|.|..|||.|.. |.. ......|...|. |..... ..   ..|.|....|           ....... .|...|.|||| |  .||..... | ..
QTSMDDEHTRTVQKLEECATRSDCVYGFAEVKYKQLIPLMPSVSTYGLGDANVQGRDDSMHQDDGLTPDAIVTWKSEEALVLYVKALSLLAKSMDIASAW

IRA--------------GKLCL-SSTVKQVVRRLNELYKASVVSCQGLSLRL---QRFFLDKQRLLDG-----------------IHGVTAERLILSHAV
..               ..||. |....|||....| .. ... |. . |.|   |... .... ...                 ..|||||.|. ..|.
WYRKNRGEDFNMTRDSSNQLCPTSNRINQVVQWIRERFNECLEKCEFVRLKLQEAQKRLPEDHPSHPKNHSNESSSSGSSNDVVVSSGVTAEKLMYDRAL

QMVQSAALDEMFQ-HREGCVPRYHKALLLLEGLQHTL----------TDQADIENIAKCKLCIERRLSALLSGVY
.|...||..|.|. ...||...||.|. .||.|...            |. |.....|.. .|..|||.| . .|
EMSRTAAINELFGEDLPGCEIAYHTAIWMLEALLENDEDEDKDENDGLDDEDKQMVEKYIVSIRKRLSVLRKKMY