Gene Wnk2 (Mouse)

Wnk2

Species: Mouse
Alias: Wnk2
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: WNK

Sequence

Name Sequence Type Origin Length Description Download
Wnk2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 259 Kinase domain by global Sugen HMM Fasta, JSON
Wnk2.NA RNA Sugen 6882 None Fasta, JSON
Wnk2.AA Protein Sugen 2147 None Fasta, JSON

Protein domain

Protein domains of Wnk2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Wnk2.AA WNK 195-453 85 1e-231 755.98 In-house 1-261 (261) Show / Hide 
Range on Protein: 195-453
Range on HMM: 1-261/261
Sequence Identity: 85% (223 aa)

LKFDIELGRGSFKTVYKGLDTETWVEVAWCELQDRKLTKLERQRFKEEAEMLKGLQHPNIVRFYDFWESSAKGKRCIVLVTELMTSGTLKTYLKRFKVMK
.|||.|.|||||||||.|||||||||||||||||.||.| |||||||||||||.|||||||||||.|||...||.||||||||||||||||||||||.||
MKFDEEVGRGSFKTVYRGLDTETWVEVAWCELQDQKLSKNERQRFKEEAEMLKKLQHPNIVRFYDYWESVLCGKKCIVLVTELMTSGTLKTYLKRFKKMK

PKVLRSWCRQILKGLLFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGDLGLA-TLKRASFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATS
||||||||||||||| |||||.| ||||||||||||||||.|||||||||||| |||..|||||||||||||||||||||||||||||||||||||||||
PKVLRSWCRQILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIGDLGLAVTLKNSSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATS

EYPYSECQNAAQIYRKVTCGIKPASFEKVHDPEIKEIIGECICKNKEERYEIKDLLSHAFF
||||||||||||||||||.||||.||.|...||.|||| .||..|||||..|..||.|.||
EYPYSECQNAAQIYRKVTQGIKPNSFQKIQNPEVKEIIEKCIRHNKEERPSIQQLLNHDFF
Kinase Wnk2.AA S_TKc 195-453 25 5.8e-66 226.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 195-453
Range on HMM: 1-231/231
Sequence Identity: 25% (70 aa)

LKFDIELGRGSFKTVYKGLDTETWVEVAWCELQDRKLTKLERQRFKEEAEMLKGLQHPNIVRFYDFWESSAKGKRCIVLVTELMTS--GTLKTYLKRFKV
 ..  ..|.|.| .|||. ...|  .||  ..          .... | ..||  .|||||..||....      .. .|.|..    |.|..|.|. . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGR

------MKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEHYDE-SVDVYAFGMC
      . . . |....||...| ..| .   ||||||| .||...     .||.| |||..      ....|||..||||.   .|.  ..|....| .
HGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCI

MLEMATSEYPYSECQNAAQIYRKVTCGIKPASFEKVHDPEIKEIIGECICKNKEERYEIKDLLS-------HAFF
. ||.. . |..   . .....|.             .|| |..|  | .|. |.|. . ..|        | .|
LYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Wnk2.AA FRWNK_Wnk1 454-545 78 8.3e-61 208.33 In-house 1-92 (92) Show / Hide 
Range on Protein: 454-545
Range on HMM: 1-92/92
Sequence Identity: 78% (72 aa)

AEDTGVRVELAEEDHGRKSTIALRLWVEDPKKLKGKPKDNGAIEFTFDLEKETPDEVAQEMIDSGFFHESDVKIVAKSIRDRVALIQWRRER
.|||||||||||||.|.||.|.|.||.|||||||||.|||.||||.|||||..|.||||||..||||.|.|.||||||||||||||.|.|||
QEDTGVRVELAEEDDGEKSAIKLWLWMEDPKKLKGKYKDNEAIEFSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSIRDRVALIKWKRER
Kinase Wnk2.AA Pkinase 195-453 26 2.2e-60 211.69 Pfam 1-293 (293) Show / Hide 
Range on Protein: 195-453
Range on HMM: 1-293/293
Sequence Identity: 26% (81 aa)

LKFDIELGRGSFKTVYKGLDTETWVEVAWCELQDRKLTKLERQRFKE--EAEMLKGLQHPNIVRFYDFWESSAKGKRCIVLVTELMTSG----TLKTYLK
...   .|.||| .|||. .  |  .||  ..  |.  . ..|.     |....| |.||||||.||..|.    |. | .|.|..  |     |..|..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

--RFKVM--KPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSV----KIGDLGLAT---LKRASFAKSVIGTPEFMAPEM--YEEHYDE
  | ...   .........|||.|| ..| .   ||||||| .||.|   .| .    ||.| |||    . . | .... |||..||||     ..|. 
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

SVDVYAFGMCMLEMATSEYPYSEC-----QNAAQIYRKVTCGIKPASFEKVHD-------------------PEIKEIIGECICKNKEERYEIKDLLSHA
.||....|  . ||.. . |....      .  |..... ... . .... ..                   .| |..|  |.||. ..|. ....| | 
KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

FF
.|
WF
Kinase Wnk2.AA STE 195-453 20 4e-56 192.76 In-house 1-359 (359) Show / Hide 
Range on Protein: 195-453
Range on HMM: 1-359/359
Sequence Identity: 20% (77 aa)

LKFDIELGRGSFKTVYKGLDT-----------------ETWVEVAWCELQD-------------RKLTKLERQRFKEEAEMLKGLQ--HPNIVRFYDFWE
...  ..|.|.| ||||...                   ... .   .|..             ..  . |.|....| ...| ..  |||||..|.  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SS---AKGKRCIVLVTELMTSGTLKTYLK-RFKVMKP-------------KVLRSWCRQILKG-LLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLG
      | .  . .. |.|  |.|   .| .... ||             ....  ||||||| | .||     |||||.|..||..      ||. | |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL------VKLCDFG

LATLKRAS------------------FAKSVIGTPEFMAPEMYEE-------HYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTCG-------
...    |                    ....||| .||||. .        .||...|.. .| ...|||| ..|... ..   .... . .       
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFE

------IKPASFEKVHD-------------------PEIKEIIGECICKNKEERYEIKDLLS--HAFF
       .| ...   .                   || |. |  |  |. ..|   ..||.  | |.
QLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase Wnk2.AA Ciliate-E2 195-453 20 4.8e-48 163.01 In-house 1-365 (365) Show / Hide 
Range on Protein: 195-453
Range on HMM: 1-365/365
Sequence Identity: 20% (77 aa)

LKFDIELGRGSFKTVYKGLDTETWVEVAWCELQDRK--------------------LTKLERQRFKEEAEM---------------LKGLQHPNIVRFYD
 ||   .|.|.| .|||. . ..  ..|    . .|                      .  .| ..|. .|               |. |.||||...|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

FWESSAKGKRCIVLVTELMTSGTLKTYLKRFKVMKP-----------KVLRSWCRQILK---------------GLLFLHTRTPPIIHRDLKCDNIFITG
....  | . .| ||.|.   |.|. |.| .|  ..           |  .   .|||.               .| .|| . . |||||.| .||..  
CFQE--KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF--

PTGSVKIGDLGLAT-----------------LKRAS-----------------FAKSVIGTPEFMAPEMYE----------EHYDESVDVYAFGMCMLEM
    .|| |.||..                 ..  .                  .....|||..||||...          ..||...|....|... ||
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM

ATSEYPYSECQNAAQIYRKV-TCGIKPASFE---------------KVHDPEIKEIIGE----CICKNKEERYE-IKDLLSHAFF
 . ..|.         ...   | |.  ..|               | ...| | .|      ...|. |.|.  ....| | .|
LFGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase Wnk2.AA CAMK 200-453 16 5.4e-48 152.33 In-house 1-425 (425) Show / Hide 
Range on Protein: 200-453
Range on HMM: 1-425/425
Sequence Identity: 16% (72 aa)

ELGRGSFKTVYKGLDTETW------------VEVAWCELQDRKLT--------------------------KLERQRFKEEAEMLKGLQ-------HPNI
.|||||| .|... ...|             ..||   .  .||.                             |.... | |..| ||       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRFYDFWES-----------SAKG-----KRCIVLVT---ELMTSG----TLKTYLKRF---------------KVMKPKVLRSWCRQILKGLLFLHTRT
...|...|.           . .      ......|.   |... |     |  |...                . .. .  | . |||. .. ..| . 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

PPIIHRDLKCDNIFITGPT----------------GSVKIGDLGLATLKRAS-------------------------FAKSVIGTPEFMA-PEMYE----
  |.|||||..|| ..                   . .|| | |.|. .. .                           | . ||||.|| ||. .    
--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-----------EHYDESVDVYAFGMCMLEMATSEYPYSEC------------QNAAQIYRKVTCGIKPASFEKVHD----------------------PE
           . |....|. . |  .  | . ..|. .             .|  ....|.. |      ... .                      .|
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

IKEIIGECICKNKEERYEIKDLLSHAFF
 |  |  . ... |.|. |.. |.| ..
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Wnk2.AA TKL 201-441 19 1.8e-46 160.68 In-house 1-354 (364) Show / Hide 
Range on Protein: 201-441
Range on HMM: 1-354/364
Sequence Identity: 19% (72 aa)

LGRGSFKTVYKG-LDTET-------WVEVAWCELQDRKLTKLER-------------------------QRFKEEAEMLKGLQHPNIVRFYDFWESSAK-
.|.|.| .|||| .  ..         .||   .  .   . ..                         ....||. |.. |.|||||.|. .  .. . 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

--------GKRCIVLVTELMTSGT-LKTYLKRFKVMKPKVLRSWCRQILKGLLFLHTRT------PPIIHRDLKCDNIFITG-------------PTGSV
        ..  . .|.|..  |. | ...       . .. .|...| .|. .||...      ||||||||| .||..                .. .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIGDLGLATLKRASF---------------------AKSVIGTPEFMAPEMYE-----------------EHYDESVDVYAFGMCMLEMATSEYPYSECQ
||.|.||.. .  |.                       ...||| .||||. .                 . |.|..|||.||... |..| . ||..  
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

NAAQIYR-------KVTC--GIKPASF-----------EKVHDPEIKEIIGECICKNKEER
.  .| .       .. |  | .|              ..  .|..|... .|   . |.|
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKR
Kinase Wnk2.AA NRBP 200-454 33 1.1e-41 144.31 In-house 1-261 (261) Show / Hide 
Range on Protein: 200-454
Range on HMM: 1-261/261
Sequence Identity: 33% (88 aa)

ELGRGSFKTVYKGLDTETWVEVAWCELQ--DRKLTKLERQRFKEEAEMLKGLQHPNIVRFYDFWESSAKGKRCIVLVTELMTSGTLKTYLKRFK----VM
       ...|  .|||. ||| | |.|  .||  |..  . ..  . |  |.|.|||.|  .|  . . |  .. .|| | || .| .||. |     |
QRDVPGIDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQLDHQNIVKFHKYWTDTKEEKPRVIFITEYMSSGSMKQFLKKTKKNHKNM

KPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRA-SFAKSVIGTPEFMAPEMY---EEHYDESVDVYAFGMCMLEM
. |  . || |||  | .||.  |||||  | || |||    | .|||     ....    ..       |.|||      ..    ||.|.|||| |||
NEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQH-NGLIKIGCVWPDAIHHHVRTCREEMRNMHFFAPEYGILEVTDLTTAVDIYSFGMCALEM

ATSEYPYSECQNAAQIYRKVTCGIKPASFEKVHDPEIKEIIGECICKNKEERYEIKDLLSHAFFA
|  |   | |||.   |  ||  .   . . . ||  ...| .|. |. ..|   ..|| |    
AVLEI-QSGCQNGESEY--VTEEAIQRAIHSLEDPMQRDFIRKCLQKDPARRPSARELLFHQILF
Kinase Wnk2.AA ULK 195-453 23 1.2e-39 136.07 In-house 1-329 (329) Show / Hide 
Range on Protein: 195-453
Range on HMM: 1-329/329
Sequence Identity: 23% (77 aa)

LKFDIELGRGSFKTVYKGLDTETW---VEVAWCELQDRKLTKLERQR---------FKEEAEMLKGL--------QHPNIVRFYDFWESSAKGKRCIVLV
   . .|| ||| .|||| . .|    .|.  |   |..  . . .          .| | . .| |        .|||||..||. |.|     .| ..
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH--NNIYII

TELMTSGTLKTYLK----------RFKVMKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGS-----------VKIGDLGLATLKRAS-
.|.   |.|..|.|          . |    .  .. ..||| |. .|| .   |||||.| .|| |. ....           .||.| |.|     . 
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKH--NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDN

----FAKSVI------GTPEFMAPEMYEEH-----YDES-VDVYAFGMCMLEMATSEYPYSECQNAAQI---YRK-----VTCG----IKPASFE-----
     ...        ||| .|||.  ...     |... .|.. .|. . || . ..|.... .  |.   ..|      ...     .|  |.     
MEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGND

KVHDPEIKEIIGECICKNKEERYEIKDLLSHAFF
..  ||.|..|  ..... ..| .. .|..| .|
PQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase Wnk2.AA ULK 195-453 23 3e-39 136.72 In-house 1-324 (324) Show / Hide 
Range on Protein: 195-453
Range on HMM: 1-324/324
Sequence Identity: 23% (77 aa)

LKFDIELGRGSFK-TVYKGLDTET---WVEVAWCELQDRKLTKLERQ--------RFKEEAEMLKGLQ---HPN--IVRFYDFWESSAKGKRCIVLVTEL
   . .|| |||  .|||| . .|    . ||    .  |. | . .         .| | . .| |    |||  ||..||. |.|      | ...|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNH--NNIYIIMEY

MTSGTLKTYLK---------RFKVMKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGS-----------VKIGDLGLATL-----KRAS
   |.|..|.|         . |    .  .. ..||. |. .|| .   |||||.| .|| |. ....           .||.| |.|       . . 
CNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKH--NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQ

FAKSVI------GTPEFMAPEMYEEH-----YDES-VDVYAFGMCMLEMATSEYPYSECQNAAQI------------YRKVTCGIKPASFEKVH-----D
  ..        ||| .|||.  ...     |... .|.. .|. . || . .||.... .  |.            . ...   .|  | |.       
MCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQ-QIYIKNQPIQFPKPPKDPKIS

PEIKEIIGECICKNKEERYEIKDLLSHAFF
||.|..|  ..... ..| .. ....| .|
PECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase Wnk2.AA Ciliate-E2-Unclassified 196-453 20 4.1e-37 126.3 In-house 2-352 (352) Show / Hide 
Range on Protein: 196-453
Range on HMM: 2-352/352
Sequence Identity: 20% (74 aa)

KFDIELGRGSFKTVYKGLDTETWVEV----AWCELQDRK----LTKLERQRFKEEAEMLKG---------------LQHPNIVRFYDFWESSAKGKRCIV
|.   .|.|.| .|||  . ..  ..      .  |..|    ..|  .  ....... |                |.||.... ..|..   | .  | 
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQN--IY

LVTELMTSGTLKTYLKRFKV-----------------MKPKVLR-----SWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTG--SVKIGDLGLAT-
.|.|..  |.|. |.| .|                     .  .      ...|||.|| .||     |||||.|..||...   .   .|| |.|..  
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKK

----------------LKRASFAKSVIGTPEFM----APEMYEE-HYDES----VDVYAFGMCMLEMATSEYPYS-EC------------------QNAA
                  .   .....|||..|    |||.... .||.|    .|....|... || . .||.. ..                  |   
YQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQ

QIYRKVTCGIKPAS--FEKVHDPEIKEIIG----ECICKNKEERYEIKDLLSHAFF
.|. | ..  |     . |  .|| |..|      .. || ..|. ....| | .|
NIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase Wnk2.AA STE11 201-453 24 1.2e-35 124.81 In-house 7-303 (303) Show / Hide 
Range on Protein: 201-453
Range on HMM: 7-303/303
Sequence Identity: 24% (75 aa)

LGRGSFKTVYKGLDTETWVEVAWCELQDRKLTKL------ERQR------FKEEAEMLKGLQHPNIVRFYDFWE-SSAKGKRCIVLVTELMTSGTLKTYL
.|.|.| ||||.... | ...|  . . .. ...      | |       ..|| ...|.|.|.||||.|..    ..... .| .  | .  |.|.  |
IGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFM--EYCPGGSLSSML

K-RFKV--MKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRAS------------FAKSVIGTPE--------FM
. ..    .  .| |   .|||.|| .||     |||||.| .||..    ...|..| | |.   ..            . ||. |||         .|
RHKWGPMKFDEMVIRKYTKQILEGLQYLHSHG--IIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWM

APEMYE-EH---YDESVDVYAFGMCMLEMATSEYPYSECQN--AAQIYRKVTC-GIKPASFEKVHD-----PEIKEIIGECICKNKEERYEIKDLLSHAF
|||..  |    |. ..|. ..| ...||||   |......  .|.... ..  .  |   |..       .| ....  |  .....|.   .|| | |
APEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHPF

F
.
I
Kinase Wnk2.AA Pkinase_Tyr 195-346 34 1.7e-21 73.39 Pfam 1-158 (270) Show / Hide 
Range on Protein: 195-346
Range on HMM: 1-158/270
Sequence Identity: 34% (56 aa)

LKFDIELGRGSFKTVYKGLDT----ETWVEVAWCELQDRKLTKLE--RQRFKEEAEMLKGL-QHPNIVRFYDFWESSAKGKRCIVLVTELMTSGTLKTYL
..|. .||.|.| .||||  .    .| ..||   | . . .. .  |. | .||...| | .||||||.|    .  . .  | .|.|.|  | |..||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYL

KR----FKVMKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA
..     .  ..| | ..|.|| ||. .|. .   .||||| . |. .| .   |||.| |||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENN-VVKICDFGLA
Kinase Wnk2.AA TyrKc 195-453 24 2.1e-19 71.69 SMART 1-280 (280) Show / Hide 
Range on Protein: 195-453
Range on HMM: 1-280/280
Sequence Identity: 24% (74 aa)

LKFDIELGRGSFKTVYKGLDTETWVEVAWCELQDRKLTKLERQRFKEEAEMLKGL--QHPNIVRFYDFWESSAKGK-------RCIVLVTELMTSGTLKT
.... .||.| | .||||  .   ..||   |.. .     |. | .||.... |  .||||||.|      .  .         . .|.|.|  | || 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLY----GVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLKRFKV-MKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLKRAS----FAKSVIGT-----PEF------MAPEMY
||.. .   ..| | |.| || .|  .|| .  ..||||| . |. .. .   |||.| ||.           .|... .       .      ||||  
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

EEH-YDESVDVYAFGMCMLEMATSEYPYSEC-----QNAAQIYRKVTCGIKPASFEKV-------HDPEIKEIIGECICKNKEERYEIKDLLSHAFF
 .. . .  ||..|| || |. |   .  .       ........|  |  .   . .         .|. .|. .|   . |.|   ...  | .|
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase Wnk2.AA OSR1_C 474-511 63 2.5e-19 73.77 Pfam 1-38 (38) Show / Hide 
Range on Protein: 474-511
Range on HMM: 1-38/38
Sequence Identity: 63% (24 aa)

IALRLWVEDPKKLKGKPKDNGAIEFTFDLEKETPDEVA
|.|.|...||||.|||.|.|.||.|.||.||.||.|||
INLWLRMRDPKKRKGKHKENEAIQFEFDIEKDTPEEVA
Kinase Wnk2.AA FRWNK_Wnk2.hmm 498-534 37 0.000377 11.43 In-house 18-54 (63) Show / Hide 
Range on Protein: 498-534
Range on HMM: 18-54/63
Sequence Identity: 37% (14 aa)

FTFDLEKETPDEVAQEMIDSGFFHESDVKIVAKSIRD
| |||. ..|.|.|| |... |  ||. .   . .||
FKFDLDGDNPEEIAQYMVENDFILESEREKFIEQMRD
Kinase Wnk2.AA Pkinase_Tyr 364-409 32 0.504548 4.09 Pfam 181-228 (270) Show / Hide 
Range on Protein: 364-409
Range on HMM: 181-228/270
Sequence Identity: 32% (16 aa)

MAPE--MYEEHYDESVDVYAFGMCMLEMAT-SEYP-YSECQNAAQIYRKV
||||  .| . . .  ||..|| .| |. |  | | | ..   ...|...
MAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYI
FRWNK_Wnk2.hmm Wnk2.AA FRWNK_Wnk2.hmm 1147-1209 77 1.6e-42 140.6 In-house 1-63 (63) Show / Hide 
Range on Protein: 1147-1209
Range on HMM: 1-63/63
Sequence Identity: 77% (49 aa)

DKMVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEHDFILPAERETFIEQMKDVMDKAEDML
|.|||||||||||||||||||||||.|.|||.||||.||||..|||.|||||.|...|||.|.
DRMVECQLETHNHKMVTFKFDLDGDNPEEIAQYMVENDFILESEREKFIEQMRDIIQKAEEMM
FRWNK_Wnk1 Wnk2.AA FRWNK_Wnk1 1164-1211 29 2e-05 16.98 In-house 45-92 (92) Show / Hide 
Range on Protein: 1164-1211
Range on HMM: 45-92/92
Sequence Identity: 29% (14 aa)

FKFDLDGDAPDEIATYMVEHDFILPAERETFIEQMKDVMDKAEDMLSE
| |||. |.|.|.|  |||  |.. |. ..    ..| .   .    .
FSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSIRDRVALIKWKRER
OSR1_C Wnk2.AA OSR1_C 1164-1177 50 0.219478 8.79 Pfam 25-38 (38) Show / Hide 
Range on Protein: 1164-1177
Range on HMM: 25-38/38
Sequence Identity: 50% (7 aa)

FKFDLDGDAPDEIA
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FEFDIEKDTPEEVA
Wnk.CR4 Wnk2.AA Wnk.CR4 1823-1899 65 4.2e-48 166.11 In-house 1-80 (80) Show / Hide 
Range on Protein: 1823-1899
Range on HMM: 1-80/80
Sequence Identity: 65% (52 aa)

SYISSDNDSEFEDADIKKELRSLREKHLKEISELQSQQKQEIEALYRRLGKPLPPNVGFFH---TAPPMGRRRKTSKSKL
||.||||||||||.|..|||..|||||.|||.|||.|||.|||.||.|.|||.||.....|   |||. ||||..||.|.
SYMSSDNDSEFEDEDMWKELQRLREKHMKEIQELQAQQKKEIEELYTRMGKPPPPGIVSPHAMLTAPMSGRRRRPSKHKS