Gene Wnk3 (Mouse)

Wnk3

Species: Mouse
Alias: Wnk3
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , iHOP
Annotation:

Classification

Group: Other
Family: WNK

Sequence

Name Sequence Type Origin Length Description Download
Wnk3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 259 Kinase domain by global Sugen HMM Fasta, JSON
Wnk3.NA RNA Sugen 10449 None Fasta, JSON
Wnk3.AA Protein Sugen 1794 None Fasta, JSON

Protein domain

Protein domains of Wnk3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Wnk3.AA WNK 146-404 86 7.4e-234 762.97 In-house 1-261 (261) Show / Hide 
Range on Protein: 146-404
Range on HMM: 1-261/261
Sequence Identity: 86% (226 aa)

LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESTLKGKKCIVLVTELMTSGTLKTYLKRFKVMK
.|||.|.|||.|||||.|||||||||||||||||.||.|.|.|||||||||||.|||||||||||.|||.|.|||||||||||||||||||||||||.||
MKFDEEVGRGSFKTVYRGLDTETWVEVAWCELQDQKLSKNERQRFKEEAEMLKKLQHPNIVRFYDYWESVLCGKKCIVLVTELMTSGTLKTYLKRFKKMK

PKVLRSWCRQILKGLQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGDLGLA-TLMRTSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATS
|||||||||||||||.|||||.| ||||||||||||||||.|||||||||||| ||...|||||||||||||||||||||||||||||||||||||||||
PKVLRSWCRQILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIGDLGLAVTLKNSSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATS

EYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIKDLLNHAFF
||||||||||||||||||.||||.||.|...||||||||.|||.||.|| ||..||||.||
EYPYSECQNAAQIYRKVTQGIKPNSFQKIQNPEVKEIIEKCIRHNKEERPSIQQLLNHDFF
Kinase Wnk3.AA S_TKc 146-404 25 2.9e-70 240.64 SMART 1-231 (231) Show / Hide 
Range on Protein: 146-404
Range on HMM: 1-231/231
Sequence Identity: 25% (69 aa)

LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESTLKGKKCIVLVTELMTS--GTLKTYLKRFKV
 ..  ..|.||| .|||. ...|  .||  ..          .... | ..||  .|||||..||....     ... .|.|..    |.|..|.|. . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGR

------MKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPEMYEEHYDE-SVDVYAFGMC
      . . . |....||...|...| .   ||||||| .||...     .||.| |||...     ....|||..||||.   .|.  ..|....| .
HGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCI

MLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIKDLLN-------HAFF
. ||.. . |..   . .....|.             .||.|..|..| . . ..|... ..|.       | .|
LYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Wnk3.AA Pkinase 146-404 25 6.3e-63 220.16 Pfam 1-293 (293) Show / Hide 
Range on Protein: 146-404
Range on HMM: 1-293/293
Sequence Identity: 25% (78 aa)

LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKE--EAEMLKGLQHPNIVRFYDSWESTLKGKKCIVLVTELMTSG----TLKTYLK
...   .|.|.| .|||. .  |  .||  ..  |.  . ..|.     |....| |.||||||.||..|.    |. | .|.|..  |     |..|..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

--RFKVM--KPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSV----KIGDLGLAT---LMRTSFAKSVIGTPEFMAPEM--YEEHYDE
  | ...   .........|||.||...| .   ||||||| .||.|   .| .    ||.| |||    . . | .... |||..||||     ..|. 
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

SVDVYAFGMCMLEMATSEYPYSEC-----QNAAQIYRKVTSGIKPASFNKVTD-------------------PEVKEIIEGCIRQNKSERLSIKDLLNHA
.||....|  . ||.. . |....      .  |..... ... . .. .  .                   .| |..|..|.... ..|......|.| 
KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

FF
.|
WF
Kinase Wnk3.AA STE 146-404 20 7.9e-61 208.4 In-house 1-359 (359) Show / Hide 
Range on Protein: 146-404
Range on HMM: 1-359/359
Sequence Identity: 20% (77 aa)

LKFDIELGRGAFKTVYKGLDT-----------------ETWVEVAWCELQD-------------RKLTKAEQQRFKEEAEMLKGLQ--HPNIVRFYDSWE
...  ..|.||| ||||...                   ... .   .|..             ..  . |.|....| ...| ..  |||||..|.. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ST---LKGKKCIVLVTELMTSGTLKTYLK-RFKVMKP-------------KVLRSWCRQILKG-LQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLG
      | .  . .. |.|  |.|   .| .... ||             ....  ||||||| |..||     |||||.|..||..      ||. | |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL------VKLCDFG

LATLMRTS------------------FAKSVIGTPEFMAPEMYEE-------HYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSG-------
... .  |                    ....||| .||||. .        .||...|.. .| ...|||| ..|... ..   .... ...       
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFE

------IKPASFNKVTD-------------------PEVKEIIEGCIRQNKSERLSIKDLLN--HAFF
       .| ..   ..                   || |. |. | . . ..| . ..||.  | |.
QLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase Wnk3.AA FRWNK_Wnk1 405-496 73 5e-59 202.41 In-house 1-92 (92) Show / Hide 
Range on Protein: 405-496
Range on HMM: 1-92/92
Sequence Identity: 73% (68 aa)

AEDTGLRVELAEEDDCSNSSLALRLWVEDPKKLKGKHKDNEAIEFSFNLEADTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTLIKKIREK
.||||.|||||||||...|...|.||.|||||||||.||||||||||.|| |.|||||.|||.||||.|.|.|.|||||||||.|||. ||.
QEDTGVRVELAEEDDGEKSAIKLWLWMEDPKKLKGKYKDNEAIEFSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSIRDRVALIKWKRER
Kinase Wnk3.AA CAMK 151-404 16 8.1e-54 171.43 In-house 1-425 (425) Show / Hide 
Range on Protein: 151-404
Range on HMM: 1-425/425
Sequence Identity: 16% (72 aa)

ELGRGAFKTVYKGLDTETW------------VEVAWCELQDRKLT--------------------------KAEQQRFKEEAEMLKGLQ-------HPNI
.||||.| .|... ...|             ..||   .  .||.                             ..... | |..| ||       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRFYDSWES-----------TLKG-----KKCIVLVT---ELMTSG----TLKTYLKRF---------------KVMKPKVLRSWCRQILKGLQFLHTRT
...|. .|.           | .      .|....|.   |... |     |  |...                . .. .  | . |||. .....| . 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

PPIIHRDLKCDNIFITGPT----------------GSVKIGDLGLATLMRTS-------------------------FAKSVIGTPEFMA-PEMYE----
  |.|||||..|| ..                   . .|| | |.|. .. .                           | . ||||.|| ||. .    
--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-----------EHYDESVDVYAFGMCMLEMATSEYPYSEC------------QNAAQIYRKVTSGIKPASFNKVTD----------------------PE
           . |....|. . |  .  | . ..|. .             .|  ....|...|       ....                      .|
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

VKEIIEGCIRQNKSERLSIKDLLNHAFF
.|  | .. . . ..|..|.. ||| ..
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Wnk3.AA Ciliate-E2 146-404 19 1e-50 172.28 In-house 1-365 (365) Show / Hide 
Range on Protein: 146-404
Range on HMM: 1-365/365
Sequence Identity: 19% (74 aa)

LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAE---------------------QQRFKEEAEM---------------LKGLQHPNIVRFY
 ||   .|.|.| .|||. . ..  ..|    . .|. .                       .| ..|. .|               |. |.||||...|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

DSWESTLKGKKCIVLVTELMTSGTLKTYLKRFKVMKP-----------KVLRSWCRQILK---------------GLQFLHTRTPPIIHRDLKCDNIFIT
.....  | ...| ||.|.   |.|. |.| .|  ..           |  .   .|||.               .|..|| . . |||||.| .||.. 
ECFQE--KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-

GPTGSVKIGDLGLAT----------------LMRTSF------------------AKSVIGTPEFMAPEMYE----------EHYDESVDVYAFGMCMLE
     .|| |.||..                ..   .                  .....|||..||||...          ..||...|....|... |
-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYE

MATSEYPYSECQNAAQIYRKVTSGIKPASFN-------------KVTDPEVKEIIEG----CIRQNKSERLS-IKDLLNHAFF
| . ..|.       |.  .    . .. ..             |  ..|.| .|      ..  . ..|.. ....||| .|
MLFGKPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase Wnk3.AA TKL 152-402 19 5.1e-49 169.17 In-house 1-364 (364) Show / Hide 
Range on Protein: 152-402
Range on HMM: 1-364/364
Sequence Identity: 19% (73 aa)

LGRGAFKTVYKGLDTE----------TWVEV--------AWCELQDRK---------------LTKAEQQRFKEEAEMLKGLQHPNIVRFYD-SWESTL-
.|.|.| .||||              ..| |          .......                .. ......||. |.. |.|||||.|.  . ...  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------KGKKCIVLVTELMTSGT-LKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRT------PPIIHRDLKCDNIFITG-------------PTGSV
        ... . .|.|..  |. | ...       . .. .|...| .|...||...      ||||||||| .||..                .. .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIGDLGLATLMRTSF---------------------AKSVIGTPEFMAPEMYE-----------------EHYDESVDVYAFGMCMLEMATSEYPYSECQ
||.|.||.. | .|.                       ...||| .||||. .                 . |.|..|||.||... |..| . ||..  
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

NAAQI---------YRKVTSGIKPASF-----------NKVTDPEVKEIIEGCIRQNKSERLSIKDLLNHA
.  .|         .  .  | .|              .. ..|..|.... |  .. ..|.| ...| . 
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Wnk3.AA ULK 146-404 22 1.8e-44 153.15 In-house 1-329 (329) Show / Hide 
Range on Protein: 146-404
Range on HMM: 1-329/329
Sequence Identity: 22% (76 aa)

LKFDIELGRGAFKTVYKGLDTETW---VEVAWCELQDRKLTKAEQQR---------FKEEAEMLKGL--------QHPNIVRFYDSWESTLKGKKCIVLV
   . .|| |.| .|||| . .|    .|.  |   |..  . ...          .| | . .| |        .|||||..||  |..    ..| ..
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH--NNIYII

TELMTSGTLKTYLK----------RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGS-----------VKIGDLGLATLMRTS-
.|.   |.|..|.|          . |    .  .. ..||| |...|| .   |||||.| .|| |. ....           .||.| |.|  .  . 
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKH--NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDN

----FAKSVI------GTPEFMAPEMYEEH-----YDES-VDVYAFGMCMLEMATSEYPYSECQNAAQI----YRKVTSG--------IKPASFN-----
     ...        ||| .|||.  ...     |... .|.. .|. . || . ..|.... .  |.    .. .  .         .|  |.     
MEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGND

KVTDPEVKEIIEGCIRQNKSERLSIKDLLNHAFF
..  ||.|..| ...  . ..| |. .|.|| .|
PQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase Wnk3.AA STE11 152-404 25 1.6e-43 150.94 In-house 7-303 (303) Show / Hide 
Range on Protein: 152-404
Range on HMM: 7-303/303
Sequence Identity: 25% (77 aa)

LGRGAFKTVYKGLDTETWVEVA--WCELQDRK----LTKAEQQR------FKEEAEMLKGLQHPNIVRFYDSWESTLKG-KKCIVLVTELMTSGTLKTYL
.|.||| ||||.... | ...|    |.|. .     .. | |       ..|| ...|.|.|.||||.|..  .  .. ....    | .  |.|.  |
IGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLH--DNQNDHVNIFMEYCPGGSLSSML

K-RFKV--MKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTS------------FAKSVIGTPE--------FM
. ..    .  .| |   .|||.|||.||     |||||.| .||..    ...|..| | |. . ..            . ||. |||         .|
RHKWGPMKFDEMVIRKYTKQILEGLQYLHSHG--IIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWM

APEMYE-EH---YDESVDVYAFGMCMLEMATSEYPYSECQN--AAQIYRKVTS-G--IK-PASFNK--VTDPEVKEIIEGCIRQNKSERLSIKDLLNHAF
|||..  |    |. ..|. ..| ...||||   |......  .|.... ... .  .  | ..    .  .| ....  |  .....| .  .||.| |
APEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHPF

F
.
I
Kinase Wnk3.AA Ciliate-E2-Unclassified 178-404 19 5.8e-43 146.85 In-house 38-352 (352) Show / Hide 
Range on Protein: 178-404
Range on HMM: 38-352/352
Sequence Identity: 19% (63 aa)

QDRKLTKAEQQRFKEEAEMLKGLQ-----------------HPNIVRFYDSWESTLKGKKCIVLVTELMTSGTLKTYLKRFKV-----------------
...|. . .. ... |.. .. ..                 ||.... .. ..   . |..| .|.|..  |.|. |.| .|                  
YKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYC--FQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKI

MKPKVLR-----SWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTG--SVKIGDLGLAT-----------------LMRTSFAKSVIGTPEFM----
   .  .      ...|||.||..||     |||||.|..||...   .   .|| |.|..                    .   .....|||..|    
FTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYT

APEMYEE-HYDES----VDVYAFGMCMLEMATSEYPYS-EC------------------QNAAQIYRKVTSGIKPAS--FNKVTDPEVKEIIE----GCI
|||.... .||.|    .|....|... || . .||.. ..                  |   .|. | ..  |     . |  .||.|..|.     ..
APEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKML

RQNKSERLSIKDLLNHAFF
  | ..|......||| .|
KKNPNKRITFEQILNHPWF
Kinase Wnk3.AA NRBP 151-405 33 8.1e-43 148.33 In-house 1-261 (261) Show / Hide 
Range on Protein: 151-405
Range on HMM: 1-261/261
Sequence Identity: 33% (90 aa)

ELGRGAFKTVYKGLDTETWVEVAWCELQ--DRKLTKAEQQRFKEEAEMLKGLQHPNIVRFYDSWESTLKGKKCIVLVTELMTSGTLKTYLKRFK----VM
       ...|  .|||. ||| | |.|  .||  ||.  . ..  . |  |.|.|||.|   |  | . |  .. .|| | || .| .||. |     |
QRDVPGIDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQLDHQNIVKFHKYWTDTKEEKPRVIFITEYMSSGSMKQFLKKTKKNHKNM

KPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRT-SFAKSVIGTPEFMAPEMY---EEHYDESVDVYAFGMCMLEM
. |  . || |||  | .||.  |||||  | || |||    | .|||     .. .    ..       |.|||      ..    ||.|.|||| |||
NEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQH-NGLIKIGCVWPDAIHHHVRTCREEMRNMHFFAPEYGILEVTDLTTAVDIYSFGMCALEM

ATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIKDLLNHAFFA
|  |   | |||.   |  ||  .   . . . ||  ...|. |....  .| | ..|| |    
AVLEI-QSGCQNGESEY--VTEEAIQRAIHSLEDPMQRDFIRKCLQKDPARRPSARELLFHQILF
Kinase Wnk3.AA ULK 146-404 23 1.8e-42 147.41 In-house 1-324 (324) Show / Hide 
Range on Protein: 146-404
Range on HMM: 1-324/324
Sequence Identity: 23% (78 aa)

LKFDIELGRGAFK-TVYKGLDTET---WVEVAWCELQDRKLTKAEQQ--------RFKEEAEMLKGLQ---HPN--IVRFYDSWESTLKGKKCIVLVTEL
   . .|| |.|  .|||| . .|    . ||    .  |. | ...         .| | . .| |    |||  ||..||  |..    . | ...|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNH--NNIYIIMEY

MTSGTLKTYLK---------RFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGS-----------VKIGDLGLATL-----MRTS
   |.|..|.|         . |    .  .. ..||. |...|| .   |||||.| .|| |. ....           .||.| |.|       |   
CNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKH--NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQ

FAKSVI------GTPEFMAPEMYEEH-----YDES-VDVYAFGMCMLEMATSEYPYSECQNAAQI---YRKVTSG------IKPASFNKV-------TDP
  ..        ||| .|||.  ...     |... .|.. .|. . || . .||.... .  |.   .. .  |      ||   ...          |
MCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISP

EVKEIIEGCIRQNKSERLSIKDLLNHAFF
|.|..| ...  . ..| |. ...|| .|
ECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase Wnk3.AA TyrKc 146-404 25 2.6e-25 91.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 146-404
Range on HMM: 1-280/280
Sequence Identity: 25% (75 aa)

LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGL--QHPNIVRFYDSWESTLKGK-----KCIVLVTELMTSGTLKTYL
.... .||.||| .||||  .   ..||   |.. .     .. | .||.... |  .||||||.|     | .|      . . .|.|.|  | || ||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGV--CTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KRFKV-MKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTS----FAKSVIGT-----PEF------MAPEMYEE
.. .   ..| | |.| || .| ..|| .  ..||||| . |. .. .   |||.| ||.           .|... .       .      ||||   .
RKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

H-YDESVDVYAFGMCMLEMATSEYPYSEC-----QNAAQIYRKVTSGIKPASFNKV-------TDPEVKEIIEGCIRQNKSERLSIKDLLNHAFF
. . .  ||..|| || |. |   .  .       ........| .|  .     .         .|. .|.. | . . ..| . ...  | .|
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase Wnk3.AA OSR1_C 425-462 65 2e-20 77.8 Pfam 1-38 (38) Show / Hide 
Range on Protein: 425-462
Range on HMM: 1-38/38
Sequence Identity: 65% (25 aa)

LALRLWVEDPKKLKGKHKDNEAIEFSFNLEADTPEEVA
..|.|...||||.|||||.||||.|.|..| |||||||
INLWLRMRDPKKRKGKHKENEAIQFEFDIEKDTPEEVA
Kinase Wnk3.AA Pkinase_Tyr 224-297 37 2.5e-12 42.35 Pfam 84-158 (270) Show / Hide 
Range on Protein: 224-297
Range on HMM: 84-158/270
Sequence Identity: 37% (29 aa)

LVTELMTSGTLKTYLKR----FKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLA
.|.|.|  | |..||..     .  ..| | ..|.|| ||...|. .   .||||| . |. .| .   |||.| |||
IVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENN-VVKICDFGLA
Kinase Wnk3.AA Pkinase_Tyr 146-209 36 1.3e-09 33.13 Pfam 1-70 (270) Show / Hide 
Range on Protein: 146-209
Range on HMM: 1-70/270
Sequence Identity: 36% (26 aa)

LKFDIELGRGAFKTVYKGLDT----ETWVEVAWCELQDRKLTKAE--QQRFKEEAEMLKGL-QHPNIVRFY
..|. .||.||| .||||  .    .| ..||   | . . .. .  .. | .||...| | .||||||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase Wnk3.AA FRWNK_Wnk2.hmm 449-494 32 3e-06 18.47 In-house 18-63 (63) Show / Hide 
Range on Protein: 449-494
Range on HMM: 18-63/63
Sequence Identity: 32% (15 aa)

FSFNLEADTPEEVAYEMVKSGFFHESDSKAVAKSIRDRVTLIKKIR
| | |. |.|||.|  ||.. |  ||. ..  . .|| ..  ... 
FKFDLDGDNPEEIAQYMVENDFILESEREKFIEQMRDIIQKAEEMM
Kinase Wnk3.AA Pkinase_Tyr 315-404 22 0.000733 13.7 Pfam 181-270 (270) Show / Hide 
Range on Protein: 315-404
Range on HMM: 181-270/270
Sequence Identity: 22% (21 aa)

MAPE--MYEEHYDESVDVYAFGMCMLEMAT-SEYP-YSECQNAAQIYRKV-TSGIKPASFNKVTDPEVKEIIEGCIRQNKSERLSIKDLLNHAFF
||||  .| . . .  ||..|| .| |. |  | | | ..   ...|...  .|   .   . . .|. ...  | ... ..| . ...  | ..
MAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPC-PENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL
FRWNK_Wnk2.hmm Wnk3.AA FRWNK_Wnk2.hmm 759-821 66 3.5e-40 132.69 In-house 1-63 (63) Show / Hide 
Range on Protein: 759-821
Range on HMM: 1-63/63
Sequence Identity: 66% (42 aa)

DNMVECQLETHNNKMVTFKFDVDGDAPEDIADYMVEDNFVLENEKEKFVEELRAIVGQAQEIL
|.||||||||||.||||||||.|||.||.||.||||..|.||.|.|||.|..|.|. .|.|..
DRMVECQLETHNHKMVTFKFDLDGDNPEEIAQYMVENDFILESEREKFIEQMRDIIQKAEEMM
FRWNK_Wnk1 Wnk3.AA FRWNK_Wnk1 770-823 27 0.00067 11.42 In-house 39-92 (92) Show / Hide 
Range on Protein: 770-823
Range on HMM: 39-92/92
Sequence Identity: 27% (15 aa)

NNKMVTFKFDVDGDAPEDIADYMVEDNFVLENEKEKFVEELRAIVGQAQEILHV
.|  . | || . |.||..|  ||| .|..| . .      |. |   ..  . 
DNEAIEFSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSIRDRVALIKWKRER
OSR1_C Wnk3.AA OSR1_C 776-789 50 0.393861 7.87 Pfam 25-38 (38) Show / Hide 
Range on Protein: 776-789
Range on HMM: 25-38/38
Sequence Identity: 50% (7 aa)

FKFDVDGDAPEDIA
|.||.  |.||..|
FEFDIEKDTPEEVA
Wnk.CR4 Wnk3.AA Wnk.CR4 1523-1599 47 8.6e-39 135.2 In-house 1-80 (80) Show / Hide 
Range on Protein: 1523-1599
Range on HMM: 1-80/80
Sequence Identity: 47% (38 aa)

SPMSSDNESEIEDEDLKVELQRLREKHIQEVVSLQTQQNKELQELYERLRATKDNKAQS-SEVP--LSPASPRRPRSFKS
|.|||||.||.||||...|||||||||..|...||.||.||..|||.|.. ... ...| ....  . ....|||...||
SYMSSDNDSEFEDEDMWKELQRLREKHMKEIQELQAQQKKEIEELYTRMGKPPPPGIVSPHAMLTAPMSGRRRRPSKHKS