Gene Wnk4 (Mouse)

Wnk4

Species: Mouse
Alias: 2010002J11Rik, Wnk4
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: WNK

Sequence

Name Sequence Type Origin Length Description Download
Wnk4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 259 Kinase domain by global Sugen HMM Fasta, JSON
Wnk4.AA Protein Sugen 1222 None Fasta, JSON
Wnk4.NA RNA Sugen 4148 None Fasta, JSON

Protein domain

Protein domains of Wnk4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Wnk4.AA WNK 171-429 80 8.20000000001e-228 743.13 In-house 1-261 (261) Show / Hide 
Range on Protein: 171-429
Range on HMM: 1-261/261
Sequence Identity: 80% (209 aa)

LKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMK
.|||.|.||||||||||||||.|.|||||||||..|||..|||||.||.||||.|||||||||||.|.|||.|..||||||||||||||||||.||..||
MKFDEEVGRGSFKTVYRGLDTETWVEVAWCELQDQKLSKNERQRFKEEAEMLKKLQHPNIVRFYDYWESVLCGKKCIVLVTELMTSGTLKTYLKRFKKMK

PRVLQRWSRQILRGLHFLHSRVP-PILHRDLKCDNVFITGPSGSVKIGDLGLA-TLKRASFAKSVIGTPEFMAPEMYEEKYDEAVDVYAFGMCMLEMATS
|.||..|.||||.||||||.|.| ||.||||||||.||||..||||||||||| |||..||||||||||||||||||||.|||.||||||||||||||||
PKVLRSWCRQILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIGDLGLAVTLKNSSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATS

EYPYSECQNAAQIYRKVTSGTKPNSFYKVKMPEVKEIIEGCIRTDKNERFTIQDLLAHAFF
||||||||||||||||||.| ||||| |...||||||||.|||..|.||..||.||.|.||
EYPYSECQNAAQIYRKVTQGIKPNSFQKIQNPEVKEIIEKCIRHNKEERPSIQQLLNHDFF
Kinase Wnk4.AA S_TKc 171-429 24 4e-66 226.9 SMART 1-231 (231) Show / Hide 
Range on Protein: 171-429
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

LKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTS--GTLKTYLRRFRE
 ..  .||.|.| .||.. ...|  .||  ..          ...  |...||  .|||||..||.. .      .. .|.|..    |.|..|... . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGR

------MKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPSGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEKYDE-AVDVYAFGMC
      . . . ... .||...| ..||.   |.||||| .|....     .||.| |||..      ....|||..||||.   .|.  ..|....| .
HGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCI

MLEMATSEYPYSECQNAAQIYRKVTSGTKPNSFYKVKMPEVKEIIEGCIRTDKNERFTIQDLLA-------HAFF
. ||.. . |..   . .....|.              ||.|..|..| . | ..| |. ..|.       | .|
LYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Wnk4.AA Pkinase 171-429 25 5.1e-59 207.18 Pfam 1-293 (293) Show / Hide 
Range on Protein: 171-429
Range on HMM: 1-293/293
Sequence Identity: 25% (78 aa)

LKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSE--EVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSG----TLKTYLR
...   ||.||| .||.. . .|  .||  ..  |. .  ..|.     |....| |.||||||.||.. .  .. ..  .|.|..  |     |..|..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIY--MVMEYCEGGLYVMDLFDYIS

--RFREM--KPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPSGSV----KIGDLGLAT---LKRASFAKSVIGTPEFMAPEM--YEEKYDE
  | . .   ....... .|||||| ..||.   |.||||| .|..|    | .    ||.| |||    . . | .... |||..||||     ..|. 
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

AVDVYAFGMCMLEMATSEYPYSEC-----QNAAQIYRKVTSGTKPNSFYKV--KM-----------------PEVKEIIEGCIRTDKNERFTIQDLLAHA
.||....|  . ||.. . |....      .  |..... ..  . ....   ..                 .| |..|..|.. | ..| |....| | 
KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

FF
.|
WF
Kinase Wnk4.AA STE 171-429 20 2.6e-53 183.44 In-house 1-359 (359) Show / Hide 
Range on Protein: 171-429
Range on HMM: 1-359/359
Sequence Identity: 20% (75 aa)

LKFDIEIGRGSFKTVYRGLDTDTT-----------------VEVAWCELQT--------RKLSRA-------ERQRFSEEVEMLKGLQ--HPNIVRFYDS
...  .||.|.| |||.... ...                 . .   .|..         . .         |.|.. .|....| ..  |||||..|..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQEN-Q-ELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC

WKSVL--RGQ-VCIVLVTELMTSGTLKTYLR-RFREMKP-------------RVLQRWSRQILRG-LHFLHSRVPPILHRDLKCDNVFITGPSGSVKIGD
        ..   . .. |.|  |.|   .. ..   ||              .. .  ||||.| |..|||    | |||.|..|...      ||. |
YFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL------VKLCD

LGLATLKRAS------------------FAKSVIGTPEFMAPEMYEE-------KYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTS------
 |...    |                    ....||| .||||. .        .||. .|.. .| ...|||| ..|... ..   .... ..      
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQ

--------GTKPNSFYKVKM------------------PEVKEIIEGCIRTDKNERFTIQDLLA--HAFF
        |. |    ....                  || |. |. | . | |.| | ..||   | |.
FEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase Wnk4.AA CAMK 176-429 17 8.9e-53 168.01 In-house 1-425 (425) Show / Hide 
Range on Protein: 176-429
Range on HMM: 1-425/425
Sequence Identity: 17% (75 aa)

EIGRGSFKTVYRGLDTDTT------------VEVAWCELQTRKLS--------------------------RAERQRFSEEVEMLKGLQ-------HPNI
..||||| .|... .. ||            ..||   . ..||.                             |...  |.|..| ||       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRFYDSWKS-----------VLRG-------QVCIVL-VTELMTSG----TLKTYLRRF---------------REMKPRVLQRWSRQILRGLHFLHSRV
...|. . .             .        ....|. ..|... |     |  |...                . .. |  .|. |||. ..|..||. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

PPILHRDLKCDNVFITGPS----------------GSVKIGDLGLATLKRAS-------------------------FAKSVIGTPEFMA-PEMYEEK--
  | |||||..|. ..  .                . .|| | |.|. .. .                           | . ||||.|| ||. . |  
--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-------------YDEAVDVYAFGMCMLEMATSEYPYSEC------------QNAAQIYRKVTSGTKPNSFYKVKM----------------------PE
             |....|. . |  .  | . ..|. .             .|  ....|...|      ....                       .|
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

VKEIIEGCIRTDKNERFTIQDLLAHAFF
.|  | .. ..| ..|.||.. |.| ..
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Wnk4.AA FRWNK_Wnk1 430-520 59 4.8e-50 172.57 In-house 1-92 (92) Show / Hide 
Range on Protein: 430-520
Range on HMM: 1-92/92
Sequence Identity: 59% (55 aa)

REERGVHVELAEEDDGEKPGLKLWLRMEDARR-GGRPRDNQAIEFLFQLGRDAAEEVAQEMVALGLVCEADYQPVARAVRERVAAIQRKREK
.|..||.|||||||||||...||||.|||... .|...||.||||.|.| .|..||||||||..|..|||||. ||...|.|||.|..|||.
QEDTGVRVELAEEDDGEKSAIKLWLWMEDPKKLKGKYKDNEAIEFSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSIRDRVALIKWKRER
Kinase Wnk4.AA STE11 177-429 25 1.9e-48 167.28 In-house 7-303 (303) Show / Hide 
Range on Protein: 177-429
Range on HMM: 7-303/303
Sequence Identity: 25% (77 aa)

IGRGSFKTVYRGLDTDTTVEVAWCELQTRKLS------RAERQR------FSEEVEMLKGLQHPNIVRFYDSWKSV-LRGQVCIVLVTELMTSGTLKTYL
||.|.| |||.....|| ...|  . .... .      . | |       . ||....|.|.|.||||.|..  .   .. |.| .  | .  |.|.  |
IGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFM--EYCPGGSLSSML

R-RFRE--MKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPSGSVKIGDLGLATLKRAS------------FAKSVIGTPE--------FM
| ..    .   | ..  .|||.||..|||    | |||.| .|...   ....|..| | |.   ..            . ||. |||         .|
RHKWGPMKFDEMVIRKYTKQILEGLQYLHSHG--IIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWM

APEMYE-EK---YDEAVDVYAFGMCMLEMATSEYPYSECQN--AAQIYRKVTS-GTKPN---SFYK--VKMPEVKEIIEGCIRTDKNERFTIQDLLAHAF
|||..  |.   |. ..|. ..| ...||||   |......  .|.... ... .. |.   ..    .  .| ....  |   |...| | ..|| | |
APEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHPF

F
.
I
Kinase Wnk4.AA TKL 177-427 21 1.2e-44 154.68 In-house 1-364 (364) Show / Hide 
Range on Protein: 177-427
Range on HMM: 1-364/364
Sequence Identity: 21% (78 aa)

IGRGSFKTVYRGLDTDTT--------VEVAWCELQTRK-------------------------LSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRG
||.|.| .||.|    ..         .||   . ..                           .. .|... ||. |.. |.|||||.|. . ..   |
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

QVCI---------VLVTELMTSGT-LKTYLRRFREMKPRVLQRWSRQILRGLHFLHSRV------PPILHRDLKCDNVFITGPSG-------------SV
.||.          .|.|..  |. | ...       . .. ||...| ||...|||.       |||.||||| .|...                   .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIGDLGLATLKRASF---------------------AKSVIGTPEFMAPEMYE-----------------EKYDEAVDVYAFGMCMLEMATSEYPYSECQ
||.|.||.. .  |.                       ...||| .||||. .                 ..|.|..|||.||... |..| . ||..  
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

NAAQI---------YRKVTSGTKPNSF----Y-------KVKMPEVKEIIEGCIRTDKNERFTIQDLLAHA
.  .|         .  .  | .|       .       .  .|..|.... |  .| ..| . |..| . 
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase Wnk4.AA Ciliate-E2 171-429 16 1.5e-43 147.36 In-house 1-365 (365) Show / Hide 
Range on Protein: 171-429
Range on HMM: 1-365/365
Sequence Identity: 16% (66 aa)

LKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRK-------------------LSRAERQRFSEEVEMLK----------------GLQHPNIVRFYD
 ||   ||.|.| .||.. .  .  ..|    . .|                   ..  . . .. |  ...                 |.||||...|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

SWKSVLRGQVCIVLVTELMTSGTLKTYLRRFREMKP-----------RVLQRWSRQILR---------------GLHFLHSRVPPILHRDLKCDNVFITG
....    . .| ||.|.   |.|. |.. ..  ..           .  .. ..|||.               .|..|||. . |.|||.| .|...  
CFQE--KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF--

PSGSVKIGDLGLAT-----------------LKRAS-----------------FAKSVIGTPEFMAPEMYEEK----------YDEAVDVYAFGMCMLEM
    .|| |.||..                 ..  .                  .....|||..||||... |          ||...|....|... ||
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM

ATSEYPYSECQNAAQIYRKVTSGTKPNSFYKVKM-----------------------------PEVKEIIEG----CIRTDKNERFT-IQDLLAHAFF
 . ..|.                      .. ..                             .|.| .|      ..  | ..|.| ....| | .|
LFGKPPF----------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase Wnk4.AA NRBP 176-430 30 1.5e-39 136.61 In-house 1-261 (261) Show / Hide 
Range on Protein: 176-430
Range on HMM: 1-261/261
Sequence Identity: 30% (82 aa)

EIGRGSFKTVYRGLDTDTTVEVAWCELQ--TRKLSRAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVLRGQVCIVLVTELMTSGTLKTYLRRFR----EM
       ...|  .||.. ||| | |.|   ||  .|.  .  .  . |  |.|.|||.|   |  . . .. .. .|| | || .| .|.. .    .|
QRDVPGIDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQLDHQNIVKFHKYWTDTKEEKPRVIFITEYMSSGSMKQFLKKTKKNHKNM

KPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPSGSVKIGDLGLATLKRA-SFAKSVIGTPEFMAPEMY---EEKYDEAVDVYAFGMCMLEM
. .  .||  |||  | .|||  |||.|  | || .||    | .|||     ....    ..       |.|||      ..   |||.|.|||| |||
NEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQH-NGLIKIGCVWPDAIHHHVRTCREEMRNMHFFAPEYGILEVTDLTTAVDIYSFGMCALEM

ATSEYPYSECQNAAQIYRKVTSGTKPNSFYKVKMPEVKEIIEGCIRTDKNERFTIQDLLAHAFFR
|  |   | |||.   |  ||  .   .   .. |  ...|. |.. |  .| . ..|| |    
AVLEI-QSGCQNGESEY--VTEEAIQRAIHSLEDPMQRDFIRKCLQKDPARRPSARELLFHQILF
Kinase Wnk4.AA Ciliate-E2-Unclassified 172-429 18 2.1e-36 123.8 In-house 2-352 (352) Show / Hide 
Range on Protein: 172-429
Range on HMM: 2-352/352
Sequence Identity: 18% (65 aa)

KFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQR-------FSEEVEMLKG---------------LQHPNIVRFYDSWKSVLRGQVCIVL
|.   ||.|.| .||.  . ..  ...  .    . ... .|        .... .. |                |.||.... .. .  . . . .| .
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFY--CFQDKQNIYI

VTELMTSGTLKTYLRRF-----------------REMKPRVLQ-----RWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPSG--SVKIGDLGLAT--
|.|..  |.|. |.. .                 ..   .  .     .. .||| || .||.    |.|||.|..|....   .   .|| |.|..   
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

---------------LKRASFAKSVIGTPEFM----APEMYEE-KYD----EAVDVYAFGMCMLEMATSEYPYS-EC------------------QNAAQ
                 .   .....|||..|    |||.... .||    ...|....|... || . .||.. ..                  |   .
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

IYRKVTSGTKPNS--FYKVKMPEVKEIIE----GCIRTDKNERFTIQDLLAHAFF
|. | ..  | .   . |   ||.|..|.     ..  . |.| |....| | .|
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase Wnk4.AA ULK 171-429 20 5.3e-36 123.2 In-house 1-329 (329) Show / Hide 
Range on Protein: 171-429
Range on HMM: 1-329/329
Sequence Identity: 20% (70 aa)

LKFDIEIGRGSFKTVYRGLDTDTT----VEVAWCELQTRKLSRAERQR--------FSEEVEMLKGL--------QHPNIVRFYDSWKSVLRGQ--VCIV
   . ..| ||| .||.| . .|     . ||   ..  |... . ..        .  |.. .| |        .|||||..||    ... .   .| 
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYD----WFETSNHNNIY

LVTELMTSGTLKTYLR-------------RFREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGP-----------SGSVKIGDLGLATL
...|.   |.|..|.              |. |.. .      .||| |. .||..   | |||.| .|. |. .           .| .||.| |.|  
IIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQF---FKQILNGFKELHKH--NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKH

KRAS-----FAKSVI------GTPEFMAPEMYEEK-----YDEA-VDVYAFGMCMLEMATSEYPYSECQNAAQI----YRKVTSGTKPN--------SFY
   .      ...        ||| .|||.  ...     |... .|.. .|. . || . ..|.... .  |.    .. .  . ...         |.
VDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFP

-----KVKMPEVKEIIEGCIRTDKNERFTIQDLLAHAFF
     ..  ||.|..| ...  | ..|.....|..| .|
KDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase Wnk4.AA MLK 171-391 28 8.5e-36 121.7 In-house 1-256 (291) Show / Hide 
Range on Protein: 171-391
Range on HMM: 1-256/291
Sequence Identity: 28% (74 aa)

LKFDIEIGRGSFKTVYRGLDTDTT-----VEVAWCELQTRKLSRAE--RQRFSEEVEMLKGLQHPN----IVRFYDSWKSVLRGQVCIVLVTELMTSGTL
..|   || |||  |..|    ..     | |  ..  ..  |...  .. | .|.. |. |.|||    |..||      |. . . ..|.| .  | |
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFY---GVCLQPPCHFCIVMEYCEGGSL

KTYL---R-----------RFREMKPRVLQRWSRQILRGLHFLHS-RVPPILHRDLKCDNVFITG-----PSGSVKIGDLGLATLKRASFAK---SVIGT
 ..|   |           . | ... .. .|. |. ||.|.|||  ..|| |||||  |. |.        | .|| | |... .  .  .   | .||
YNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGT

PEFMAPEMY----EEKYDEAVDVYAFGMCMLEMATSEYPYS-ECQNAAQIYRKVTSGTKP
. .||||.     .|||.|..||. .|... || | | ||. .  ..| ..  .  |. |
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRP
Kinase Wnk4.AA TyrKc 171-429 24 7.4e-18 66.05 SMART 1-280 (280) Show / Hide 
Range on Protein: 171-429
Range on HMM: 1-280/280
Sequence Identity: 24% (73 aa)

LKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKLSRAERQRFSEEVEMLKGL--QHPNIVRFYDSWKSVLRGQ-------VCIVLVTELMTSGTLKT
.... ..|.| | .||.|  .   ..||   |.  .     |. | .| .... |  .||||||.|     | . |         . .|.|.|  | || 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLY----GVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLRRFRE-MKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPSGSVKIGDLGLATLKRAS----FAKSVIGT-----PEF------MAPEMY
|||. |.  ... |  .. || .|  .|||.  .. |||| . |. .. .   |||.| ||.           .|... .       .      ||||  
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

EEK-YDEAVDVYAFGMCMLEMATSEYPYSEC-----QNAAQIYRKVTSGTKPNSFYKV-------KMPEVKEIIEGCIRTDKNERFTIQDLLAHAFF
 .. . .. ||..|| || |. |   .  .       ........| .|  .     .         .|. .|.. | . | ..| | ...  | .|
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase Wnk4.AA OSR1_C 450-486 44 1.1e-16 64.25 Pfam 1-38 (38) Show / Hide 
Range on Protein: 450-486
Range on HMM: 1-38/38
Sequence Identity: 44% (17 aa)

LKLWLRMEDARR-GGRPRDNQAIEFLFQLGRDAAEEVA
..|||||.|...  |....|.||.| |....|..||||
INLWLRMRDPKKRKGKHKENEAIQFEFDIEKDTPEEVA
Kinase Wnk4.AA Pkinase_Tyr 249-322 34 1.2e-09 33.24 Pfam 84-158 (270) Show / Hide 
Range on Protein: 249-322
Range on HMM: 84-158/270
Sequence Identity: 34% (27 aa)

LVTELMTSGTLKTYLRR----FREMKPRVLQRWSRQILRGLHFLHSRVPPILHRDLKCDNVFITGPSGSVKIGDLGLA
.|.|.|  | |..|||.     .  ..  |  ...|| .|. .|.|.   . |||| . |. .| .   |||.| |||
IVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENN-VVKICDFGLA
Kinase Wnk4.AA Pkinase_Tyr 171-234 32 1.2e-08 29.97 Pfam 1-70 (270) Show / Hide 
Range on Protein: 171-234
Range on HMM: 1-70/270
Sequence Identity: 32% (23 aa)

LKFDIEIGRGSFKTVYRGLDT----DTTVEVAWCELQTRKLSRAE--RQRFSEEVEMLKGL-QHPNIVRFY
..|. ..|.|.| .||.|  .    .|...||   |   . .  .  |. | .|....| | .||||||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase Wnk4.AA FRWNK_Fray 471-504 50 6e-06 17.83 In-house 20-53 (97) Show / Hide 
Range on Protein: 471-504
Range on HMM: 20-53/97
Sequence Identity: 50% (17 aa)

IEFLFQLGRDAAEEVAQEMVALGLVCEADYQPVA
| | | .|.| || .||| |. ||| . |.. ||
IRFEFTPGKDTAEGIAQELVSAGLVDGRDLVIVA
Kinase Wnk4.AA Pkinase_Tyr 340-388 32 0.00278 11.74 Pfam 181-232 (270) Show / Hide 
Range on Protein: 340-388
Range on HMM: 181-232/270
Sequence Identity: 32% (17 aa)

MAPE-MYEEKYDEAVDVYAFGMCMLEMAT-SEYP-YSECQNAAQIYRKV-TSG
|||| . . |. .. ||..|| .| |. |  | | | ..   ...|...  .|
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDG
Kinase Wnk4.AA FRWNK_Wnk2.hmm 467-518 23 0.013124 6.24 In-house 12-63 (63) Show / Hide 
Range on Protein: 467-518
Range on HMM: 12-63/63
Sequence Identity: 23% (12 aa)

DNQAIEFLFQLGRDAAEEVAQEMVALGLVCEADYQPVARAVRERVAAIQRKR
... . | | |  |. ||.|| ||    . |.. .   . .|. .   . . 
NHKMVTFKFDLDGDNPEEIAQYMVENDFILESEREKFIEQMRDIIQKAEEMM
FRWNK_Wnk2.hmm Wnk4.AA FRWNK_Wnk2.hmm 682-744 65 9.7e-41 134.57 In-house 1-63 (63) Show / Hide 
Range on Protein: 682-744
Range on HMM: 1-63/63
Sequence Identity: 65% (41 aa)

DRVVECQLQTHNSKMVTFRFDLDGDSPEEIAAAMVYNEFILPSERDGFLSRIREIIQRVETLL
||.|||||.|||.|||||.||||||.|||||..|| |.|||.|||..|. ..|.|||..|...
DRMVECQLETHNHKMVTFKFDLDGDNPEEIAQYMVENDFILESEREKFIEQMRDIIQKAEEMM
FRWNK_Wnk1 Wnk4.AA FRWNK_Wnk1 699-746 31 9e-06 18.2 In-house 45-92 (92) Show / Hide 
Range on Protein: 699-746
Range on HMM: 45-92/92
Sequence Identity: 31% (15 aa)

FRFDLDGDSPEEIAAAMVYNEFILPSERDGFLSRIREIIQRVETLLKR
| |||. | |||.|  || . |.. ..       ||. .....   .|
FSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSIRDRVALIKWKRER
OSR1_C Wnk4.AA OSR1_C 699-712 57 0.093056 10.14 Pfam 25-38 (38) Show / Hide 
Range on Protein: 699-712
Range on HMM: 25-38/38
Sequence Identity: 57% (8 aa)

FRFDLDGDSPEEIA
| ||.  |.|||.|
FEFDIEKDTPEEVA
Wnk.CR4 Wnk4.AA Wnk.CR4 1098-1172 55 6.1e-42 145.65 In-house 1-80 (80) Show / Hide 
Range on Protein: 1098-1172
Range on HMM: 1-80/80
Sequence Identity: 55% (44 aa)

CLSSEESESSGEDEEFWAELQNLRQKHLSEVEALQTLQKKEIEDLYSRLGKQPPPGIVAPAAML----SCRQRRLSK-GS
  .|....|..|||..|.|||.||.||..|...||. ||||||.||.|.||.||||||.|.|||    |.|.||.|| .|
SYMSSDNDSEFEDEDMWKELQRLREKHMKEIQELQAQQKKEIEELYTRMGKPPPPGIVSPHAMLTAPMSGRRRRPSKHKS