Gene B0218.5 (Nematode worm)
B0218.5
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| B0218.5.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 289 | Kinase domain by global Sugen HMM | Fasta, JSON |
| B0218.5.AA | Protein | Genbank | 367 | None | Fasta, JSON |
Protein domains of B0218.5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | B0218.5.AA | Worm6 | 24-292 | 47 | 1.4e-160 | 539.72 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 24-292 Range on HMM: 1-279/279 Sequence Identity: 47% (132 aa) YKVLALLGKGGYGAVYSVLRLSDME--KFAIKCEN--AAACRKALYMDCNVLKGAAKIQSRHFCTVIDQAAVKNR-FNFIVMKLIGKNLWDLRMDTAECR .||....|.||.||||.|.. ||.. .||.|||. . ..|. |.|.|.||| ......||||...|.. |.|| ||.|||.|.||||||||....... WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK FTKGTSLKAASQCLISIEELHRFGFLHRDIKPGNFAVGR---KESNEHHTIFMLDFGLCREFVKRGEGR-LRTQR-AKSQFRGTTRYAPINSMLEIDTGR |. ||.|| |.|||..||.||..||.|||.|||||..|| ||.||||||.|||||.||.......| |||.| .. .||||.||||.... .. .| FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR KDDIESWLYMVAEWTSGGLPWRKFKATEREKVLKYKKDVRTDKEIMADLFYNCPLKEFERILKYVDELDFYSEPDYKFV |||.|||.||..|...|.||||..|.. .....|.... ||....|...| .|| .||..|..|.|.......|||||. KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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| Kinase | B0218.5.AA | CK1 | 24-292 | 29 | 1.9e-109 | 369.89 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 24-292 Range on HMM: 1-339/339 Sequence Identity: 29% (100 aa) YKVLALLGKGGYG-AVYSV-----LRLSDM-----EKFAIKCENA-AACRKALYMDCNVLKGAAKIQ---------SRHFCT----------VIDQAAVK .|| ..|.||.| ..| | .... |..|.|.| . ..... . |.. ... . . . ..|||. ... .. WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED NRFNFIVMKLIGKNLWDLRM-DTA-ECRFTKGTSLKAASQCLISIEELHRFGFLHRDIKPGNFAVGRKES-----------NEHHTIFMLDFGLCR-EFV ...|..|| | |.||.|||. .. .|...|.|. | |.| ..|..|. ||.||||||.||..||.|| |||....|.|||..| .. DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR KRGEGR-----------LRTQRA---KSQFRG-TTRYAPINSMLEIDTGRKDDIESWLYMVAEWTSGG--LPWRKFKATER----EKVLKYKKDVRTD-K ...... .|..| | .||| |.||..||..| .. ||.||..||.||..||. |. |||.. |. .. . | | |.. ... | DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQ-VEKMKYEFIDEKK EIMADLFYNCPLK------EFERILKYVDELDFYSEPDYKFV . .. ..||.| || |.||...|..|..|||... MSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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| Kinase | B0218.5.AA | TTBKL | 24-296 | 30 | 5.2e-66 | 221.85 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 24-296 Range on HMM: 1-288/288 Sequence Identity: 30% (91 aa) YKVLALLGKGGYGAVYSVLRLSDMEKFAIKCE--NA-AACRKALYMDCNVLKGAAKIQSRHFCTVIDQAAVKNRFNFIVMKLIGKNLWDLRMDTAECR-F ... ..|.||.|.|| | ..| ...|.. | | . . . | .||. .. |.||...... . ..||.|| | |.|| |||.. . | WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGK-RKDYNFMVMTLCGPNLQDLRKMMPNKKRF TKGTSLKAASQCLISIEELHRFGFLHRDIKPGNFAVGRKESN--EHHTIFMLDFGLCREFV-KRGEG---------RLRTQRA---KSQFRGTTRYAPIN ..||.. . ||| .. ..|. ||.|||.||.|...| .... . .... .|||..| .. | ||. ..|..| |..|||||||. .| SDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPN SMLEIDTGRKDDIESWLYMVAEWTSGGLPWRKFKATEREKVLKYKKDVRTDKEIMADLFYNCP-----LKEFERILKYVDELDFYSEPDYKFVYCCL . . ||.||. ||.||..| | |||. . ..... . ||. .. |||...| .||. . |.. .|..|..||| .| |. MHDRKEQGRHDDLWSWMYMIIELHCG-LPWTNME--DKMEIEHMKKNM-----KDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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| Kinase | B0218.5.AA | TTBK | 24-292 | 39 | 1.8e-64 | 220.52 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 24-292 Range on HMM: 1-257/257 Sequence Identity: 39% (106 aa) YKVLALLGKGGYGAVYSVLRLSDM-EKFAIKCENAAACRKALYMDCNVLKGAAKIQSR-HFCTVIDQAAVKNRFNFIVMKLIGKNLWDLRMDTAECRFTK ||.. | ||.| .|. . . |. ||| | | . . | | ||| | | . | | | ..||..||.| |||| ||| . |. WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLK---KLQGCDHVCRFI-GCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSL GTSLKAASQCLISIEELHRFGFLHRDIKPGNFAVGRKESNEHHTIFMLDFGLCREFVKRGEGRLRTQRAKSQFRGTTRYAPINSMLEIDTGRKDDIESWL .| |. | | |||. | ||||||||| |||.|| |. . .|||||| | .. ..| |. |. |||| ||| ||. . . ||.|| | STTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKC-YMLDFGLARQYTN-ACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLF YMVAEWTSGGLPWRKFKATEREKVLKYKKDVRTDKEIMADLFYNCPLKEFERILKYVDELDFYSEPDYKFV || | | ||||| | . .| | | | .| .|| .||. .. . |.. |||... YMLVEFVQGQLPWRKIKDKDQVGEMKEKYDHR-------MLLKHCP-HEFHQFMDHIKSLNYEDRPDYQLI |
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| Kinase | B0218.5.AA | Dual | 24-296 | 28 | 1.6e-41 | 137.34 | In-house | 1-282 (282) | Show / Hide |
Range on Protein: 24-296 Range on HMM: 1-282/282 Sequence Identity: 28% (81 aa) YKVLALLGKGGYGAVYSVLRLSD----MEKFAIKCENAAACRKALYMD--CNVLKGAAK-------IQSRHFCTVIDQ-AAVKNRFNFIVMKLIGKNLWD || ||| || . || | | | .....| | . | . | . .| ..| .| .. . ...|| . | | . WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQE LRMDTAECRFTKGTSLKAASQCLISIEELHRFGFLHRDIKPGNFAVGRKESNEHHTIFMLDFGLCREFVKRGEGRLRTQRAKSQFRGTTRYAPINSMLEI | . ... .| | | | .| || |.|||.||| ||..| . . |..|.||.. | .. . || | | . |. ||| . |.. IRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGM--DETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQK DTGRKDDIESWLYMVAEW--TSGGLPWRKFKATEREKVLKYKKDVRTDKEIMADLFYNCPLKEFERILKYVDELDFYSEPDYKFVYCCL | |||||.|.| ||| . |..|| | .. ...| | . . | .... .. ||. . . | ||| || DQGRKDDLECWIYMVFDLMDPEHGMSWR--KECDCNMMIKQKDNFMYHFDKHQ---YSHIPRRLKPLVSYVNGYQYDSTPDYDYFRNCL |
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| Kinase | B0218.5.AA | CK1-Unique | 24-223 | 29 | 4.8e-39 | 132.99 | In-house | 1-219 (337) | Show / Hide |
Range on Protein: 24-223 Range on HMM: 1-219/337 Sequence Identity: 29% (66 aa) YKVLALLGKGGYGAVYSVLRLSDM------EKFAIKCENAAACRK--ALYMDCNVLKGAAKIQ-----SRHFCTVIDQAAVKNRFNFIVMKLIGKNLWDL ..| ...|.|||| |. | . . ... | | .. . | ||.|. | .|||| |.| . .||| ..|... . WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHD-FHQHRDWWWIVMTMHGPSMEEC RMDTAECRFTKG------TSLKAASQCLISIEELHRFGFLHRDIKPGNFAVGRKESNEHHTIFMLDFGLCRE--FVKRGEGRLRTQRAKSQFRGTTRYAP .| . ||.. . .. . ||| || | ||.||..||.|. . . |...|||.| || || . .| | . |||. .|.| CMMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNN-HQIRQPRPITPFRGCKDYCP INSMLEIDTGRKDDIESWLYM . . .. . ||.|| |||.|| CSCHQCREHGRRDDMESWFYM |
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| Kinase | B0218.5.AA | CK1-A | 24-292 | 30 | 3.7e-34 | 118.02 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 24-292 Range on HMM: 1-261/261 Sequence Identity: 30% (81 aa) YKVLALLGKGGYGAVYSVLRLSDMEKFAIKCENAAACRKALYMDCNVLKGAAKIQSRHFCTVIDQAAVKNRFNFIVMKLIGKNLWDLRMDTAECRFTKGT |... .| | .| .| . . . | ||| | . | | . | . .| . .| .|| |.| | || . ||| | YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYR---ILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDL-FNFCKRRFTMKT SLKAASQCLISIEELHRFGFLHRDIKPGNFAVGRKESNEHHTIFMLDFGLCREFVKRGEGRLRTQRAKSQFRGTTRYAPINSMLEIDTGRKDDIESWLYM | | | . || .| .|.|||||| || .| . .|..|||| . . . | . || ||| || | |. |.||.|| |. VLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNK--LFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYV VAEWTSGGLPWRKFKATEREKVLKYKKDVRTDKEIMADLFYNCPLKEFERILKYVDELDFYSEPDYKFV . . | ||| .|| | || | . . || ...|. .| | .||| .. MMYFNRGKLPWQGMKAM--TKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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| Kinase | B0218.5.AA | CK1-D | 24-292 | 28 | 4.4e-30 | 103.26 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 24-292 Range on HMM: 1-261/261 Sequence Identity: 28% (77 aa) YKVLALLGKGGYGAVYSVLRLSDMEKFAIKCENAAACRKALYMDCNVLKGAAKIQSRHFCTVIDQAAVKNRFNFIVMKLIGKNLWDLRMDTAECRFTKGT |.. .| | .| .| .. | ||| | . . | .. . | .| | .| .|| |.| | || . .| | YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYK---MMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDL-FNYCHRKFSLKT SLKAASQCLISIEELHRFGFLHRDIKPGNFAVGRKESNEHHTIFMLDFGLCREFVKRGEGRLRTQRAKSQFRGTTRYAPINSMLEIDTGRKDDIESWLYM | | | . || .| |.|||||| || .| ......|||| . . . | . . || ||| || . |. |.||.|| |. VLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGL--GKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYV VAEWTSGGLPWRKFKATEREKVLKYKKDVRTDKEIMADLFYNCPLKEFERILKYVDELDFYSEPDYKFV . . | ||| ||. | || . . .. | . .||.. . |. .| | ||| .. LMYFNRGSLPWQGLKAA--TKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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| Kinase | B0218.5.AA | CK1-G | 95-292 | 31 | 8.9e-27 | 87.71 | In-house | 70-266 (266) | Show / Hide |
Range on Protein: 95-292 Range on HMM: 70-266/266 Sequence Identity: 31% (64 aa) FNFIVMKLIGKNLWDLRMDTAECRFTKGTSLKAASQCLISIEELHRFGFLHRDIKPGNFAVGRKESNEHHTIFMLDFGLCREFVKRGEGRLRTQRAKSQF .| .|| | | | || | . .|. | . | | . .|..| . ||.|| || .||. ....|.|.. |||. .... .. | . YNIMVMDLLGPSLEDL-FDWCDRKFSVKTVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSL RGTTRYAPINSMLEIDTGRKDDIESWLYMVAEWTSGGLPWRKFKATEREKVLKYKKDVRTDKEI-MADLFYN--CPLKEFERILKYVDELDFYSEPDYKF || || || | | ||.|. | | ||| || ..|.| | ... . || | | ..| . |.|| .||| .||| . TGTARYMSINTHLGREQSRRDDMEALGHMFMYFLRGSLPWQGLKADNNK--ERYQKIGDTKRKTNIEDLCQNNAFP-EQFATYLRYVRRLDFFECPDYDY V . L |
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| Kinase | B0218.5.AA | CK1 | 135-219 | 40 | 2.5e-18 | 59.84 | In-house | 118-201 (271) | Show / Hide |
Range on Protein: 135-219 Range on HMM: 118-201/271 Sequence Identity: 40% (34 aa) IEELHRFGFLHRDIKPGNFAVGRKESNEHHTIFMLDFGLCREFVKRGEGRLRTQRAKSQFRGTTRYAPINSMLEIDTGRKDDIES || .| .|.|||||| || .|| ...|.... |||| .... ... .| . . ||.||| ||. | | .|.|| || IEYVHNKNFIHRDIKPDNFLMGR-YGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDMES |
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| Kinase | B0218.5.AA | S_TKc | 24-311 | 15 | 2.3e-12 | 4.38 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 24-311 Range on HMM: 1-231/231 Sequence Identity: 15% (49 aa) YKVLALLGKGGYGAVYSVLRLSDMEKFAIKCENAAACRKALYMDCNVLKGAAKIQSRHFCTVIDQAAVKNRFNFIVMKLIGK---NLWDLRMDTAE---- |..| ..|||..| || . .. ...|||. . . .. ..|| . . .. .| . ..|| ... .| |. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK----HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR CRFTKGTSLKAASQCLISIEELHRFGFLHRDIKPGNFAVGRKESNEHHTIFMLDFGLCREFVKRGEGRLRTQRAKSQFRGTTRYAPINSMLEIDTGRKDD ..|. . . . | . .| .|. |..|||.|| | . . .| ||||.|.. . | || | . . FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---------- IESWLY----------MVAEWTSGGLPWRKFKATEREKVLKYKKDVRTDKEIMADLFYNCPLKEFERILKYVDELDFYSEPDYKFVYCCLQHAAA----A .. . ...| .| |.. . ....| . |.. |. ||| . | --GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG----------------------------------SPEAKDFIRKCLQKDPEKRPTA SKIKD-------TDPL .. . -EALQDEWDIKCHPWF |
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| Kinase | B0218.5.AA | Pkinase | 24-54 | 25 | 6e-06 | 22.03 | Pfam | 1-31 (293) | Show / Hide |
Range on Protein: 24-54 Range on HMM: 1-31/293 Sequence Identity: 25% (8 aa) YKVLALLGKGGYGAVYSVLRLSDMEKFAIKC |... .|.|..| || . .. ...|.|. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKI |
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| Kinase | B0218.5.AA | CK1 | 269-290 | 40 | 0.000356 | 10.5 | In-house | 250-271 (271) | Show / Hide |
Range on Protein: 269-290 Range on HMM: 250-271/271 Sequence Identity: 40% (9 aa) KEFERILKYVDELDFYSEPDYK .|| . |.|. |.|. .|||. NEFAMYLNYCRQLHFEEKPDYM |
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| Kinase | B0218.5.AA | CK1 | 24-59 | 28 | 0.001208 | 8.65 | In-house | 1-38 (271) | Show / Hide |
Range on Protein: 24-59 Range on HMM: 1-38/271 Sequence Identity: 28% (11 aa) YKVLALLGKGGYGAVYSVLRLSDMEK--FAIKCENAAA |.| .| | | .| . .....|. ||| | . . YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKS |
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| Kinase | B0218.5.AA | Pkinase | 138-202 | 26 | 0.002057 | 13.15 | Pfam | 124-179 (293) | Show / Hide |
Range on Protein: 138-202 Range on HMM: 124-179/293 Sequence Identity: 26% (17 aa) LHRFGFLHRDIKPGNFAVGRKESNEHHTIFMLDFGLCREFVKRGEGRLRTQRAKSQFRGTTRYAP .|. |..|||.|| |. . .. .. .. ||||.. | . .. . | || .|.. CHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMA |
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