Gene B0414.7 (Nematode worm)

B0414.7

Species: Nematode worm
Alias: B0414.7, aSWK302, CE07737, B0414.7A, B0414.7a
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: I: 5809422-5803603, WormBase Genetic Map location: I:0.43,

Classification

Group: STE
Family: STE11
Subfamily: MEKK4

Sequence

Name Sequence Type Origin Length Description Download
B0414.7.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 264 Kinase domain by global Sugen HMM Fasta, JSON
B0414.7.AA Protein Genbank 1418 None Fasta, JSON

Protein domain

Protein domains of B0414.7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase B0414.7.AA MEKK4 1125-1388 58 6.9e-221 740.11 In-house 1-271 (271) Show / Hide 
Range on Protein: 1125-1388
Range on HMM: 1-271/271
Sequence Identity: 58% (159 aa)

WALLDHIASGSFGSVHRAMDIDSHRVIAAKVMRIQRENHKAIES---EINIFRQLIHENLVKYYGVQVEDSDVIIFMEYCSQGTLERICHGK--MDLKMV
|...|||..|.||.|...|..|.|.|.|.|.||.||..||||..   ||.||....|.|||.||||.|......|||||||||||||.||..  |...|.
WQRGDHIGEGQFGKVYTCMNMDTHEVMAMKEMRFQRNDHKAIKNIADEIKIFEGIKHPNLVRYYGVEVHREEMYIFMEYCSQGTLERVCHLGGNMQEHMI

RQYTNSLLRAVQYLHSHKIIHRDIKPANIFLDKCTVLKLGDFGCSSRLVESS-TVYGEFQTTAGTPQFMAPEIYSYGEKDETTGSYSGYGRSVDIWALGA
||||..|||||.|||.|.|.|||||||||||||||||||||||||..|...| |..||||.|.||...||||.|.|.|||||||||||.||..|||.||.
RQYTKQLLRAVNYLHQHGIVHRDIKPANIFLDKCTVLKLGDFGCSVKLQNHSQTMPGEFQSTMGTAAYMAPEVYTYTEKDETTGSYSGHGRAADIWSLGC

TVVNMMTGKVPFEGQTRHQIAFALCFRKQKPTYPDIADKR-PDVKRFFDNCFEFLPNDRPTAAELLQTTFA
.||.|||||.|..|||.....|..........||.|.||. |..|.|||.|.|..|.||.||.|||..||.
VVVEMMTGKRPWHGQTQYDHNFQIMYKVGMGHYPHIPDKMSPEGKDFFDHCLEHDPKDRWTANELLDHTFC
Kinase B0414.7.AA STE11 1125-1388 35 7e-132 444.44 In-house 1-303 (303) Show / Hide 
Range on Protein: 1125-1388
Range on HMM: 1-303/303
Sequence Identity: 35% (111 aa)

WALLDHIASGSFGSVHRAMDIDSHRVIAAKVMRIQREN---------------HKAIESEINIFRQLIHENLVKYYGVQV---EDSDVIIFMEYCSQGTL
| . ..| .|.||.|...|..| ....| | ..||..|               ||||..||.....| |.|.|.|||...   ... | ||||||..|.|
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

ERICHGK-----MDLKMVRQYTNSLLRAVQYLHSHKIIHRDIKPANIFLDK-CTVLKLGDFGCSSRLVESS--------------TVYGEFQ-TTAGTPQ
......|     .| ...|.||. .|...||||||.|||||||.|||.||. ..|.||.||||. ||...               ...|... ...|||.
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

FMAPEIYSYGEKDETTGSYSGYGRSVDIWALGATVVNMMTGKVPFEGQTR-HQIAFALCFRKQKPTYPDIADKR------PDVKRFFDNCFEFLPNDRPT
.||||..... .|       ||||..|||.||.||..|.||| |...... |. |.. .....||..|   . .      .. ..|...|||. |..|||
WMAPEVIKQEGRD-------GYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPT

AAELLQTTFA
|..|||. | 
ANQLLQHPFI
Kinase B0414.7.AA STE 1125-1388 25 2.2e-85 289.94 In-house 1-359 (359) Show / Hide 
Range on Protein: 1125-1388
Range on HMM: 1-359/359
Sequence Identity: 25% (94 aa)

WALLDHIASGSFGSVHRAMDID---------------SHRVIAAKVMRIQR------------------ENHKAIESEINIFRQLI--HENLVKYYGVQV
| ... | .|.||.|..||...               .....| |.|....                  |... |. ||.| ...   |.| |||||  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ED-------SDVIIFMEYCSQGTLERICH----------------GKMDLKMVRQYTNSLLRA-VQYLHSHKIIHRDIKPANIFLDKCTVLKLGDFGCSS
 .       ... |.|||.. |.|. | .                .... . .. .. ..|..  .|||||.|||||||||||.|      || |||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

RLVESST------------VYG-EFQTTAGTPQFMAPEIYSYGEKDETTGSYSGYGRSVDIWALGATVVNMMTGKVPFEGQTRHQIAFALCFR-------
.|..|..              . . .| .||| .||||. . .... .    .||....||| || |.. | |||.|.   . ..  |.  |        
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R---DKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQF

-------KQKPTYPDI-----------------ADKRPDVKRFFDNCFEFLPNDRPTAAELLQ--TTFA
       .. |. ||                      |. | | ..|..  ||.|||| .||.    | 
EQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase B0414.7.AA S_TKc 1125-1388 27 3.1e-82 280.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 1125-1388
Range on HMM: 1-231/231
Sequence Identity: 27% (78 aa)

WALLDHIASGSFGSVHRAMDIDSHRVIAAKVMRIQRENHKAIESEINIFRQLIHENLVKYYGVQVEDSDVIIFMEYCSQ--GTLERICHGK--------M
. .|..| .|.||.|... .....|. | |...      . |..||.| ..  |.|.||.|.| .. ... ..||||..  |.| .. . .        .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

DLKMVRQYTNSLLRAVQYLHSHKIIHRDIKPANIFLDKCTVLKLGDFGCSSRLVESSTVYGEFQTTAGTPQFMAPEIYSYGEKDETTGSYSGYGR-SVDI
.  ..| |.  ...|..|.|||.|||||.||.||.||.  ..|..||| . .|           |  ||| .||||.              |||. ..|.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL-------------GYGKCKCDW

WALGATVVNMMTGKVPFEGQTRHQIAFALCFRKQKPTYPDIADKRPDVKRFFDNCFEFLPNDRPTAAELLQ-------TTFA
|..| ..  |..|. ||.  . ...   ..               |..| | ..|... |..|||| |.||         . 
WSCGCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase B0414.7.AA Pkinase 1125-1388 26 1.8e-66 231.92 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1125-1388
Range on HMM: 1-293/293
Sequence Identity: 26% (80 aa)

WALLDHIASGSFGSVHRAMDIDSHRVIAAKVMRIQRENHKAIES-----EINIFRQLIHENLVKYYGVQVEDSDVIIFMEYCSQG----TLE-RIC---H
. ..  | |||||.| ....... .. | |... ..|...  ..     || | . | |.| |..|..  ..... . ||||  |     |  .|    |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GKM--DLKMVRQYTNSLLRAVQYLHSHKIIHRDIKPANIFLD-KCTV---LKLGDFGCSSRLVESSTVYGEFQTTAGTPQFMAPEIYSYGEKDETTGSYS
|..  . . .. |   .||...|.||..|||||.||.||..| ....   .|..|||..  .      .. ..| .||| .||||.           ...
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIR---------GGQ

GYGRSVDIWALGATVVNMMTGKVPFEGQ----TRHQIAFALCFRKQKPTYPDIADKR--------------------PDVKRFFDNCFEFLPNDRPTAAE
.||..||.|..| ..  |..|. || |.    . |   . .| ....|.  |.  ..                    .. | | ..|... |..||||..
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

LLQTTFA
.||  . 
ILQHPWF
Kinase B0414.7.AA CAMK 1130-1388 17 1.1e-59 190.67 In-house 1-425 (425) Show / Hide 
Range on Protein: 1130-1388
Range on HMM: 1-425/425
Sequence Identity: 17% (76 aa)

HIASGSFGSVHRAMDIDSH------------RVIAAKVMRIQ-----------------------------RENHKAIESEINIFRQ-------LIHENL
 . .|||| |...... .             .  |.|..  .                              .. | ...||.| ..       | |.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKYYGVQVE-------------------DSDVIIFM---EYCSQG----T-LERIC-H---------------GKMDLKMVRQYTNSLLRAVQYLHSHKI
.| | |                      |......|   |||| |      ...|. |               |... . .|.|   .. ||.|.|||.|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDIKPANIFLDKCT-----------------VLKLGDFGCSSRLVESSTVYGE--------------------FQTTAGTPQFMA-PEIYSYGEKDET
.|||.|| || ||.                    .|. ||| . .. ...  . .                    ..|  ||| .|| ||. ..  ... 
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

TGSY------SGYGRSVDIWALGATVVNMMTGKVPFEGQTRHQIA---------FALCFRKQKPTYPDIADKRPD------------------------V
.  .       .||...|.|..|     | .|. ||.| .. .|            |. . .|  |  . .. ..                        .
Q--NATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

KRFFDNCFEFLPNDRPTAAELLQTTFA
| .  .. .  |..|.|... |.  . 
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase B0414.7.AA STE11-Unclassified 1125-1388 29 3e-51 176.57 In-house 1-308 (308) Show / Hide 
Range on Protein: 1125-1388
Range on HMM: 1-308/308
Sequence Identity: 29% (94 aa)

WALLDHIASGSFGSVHRAMDIDSHRVIAAKVMRIQREN------HKA----IESEINIFRQLIHENLVKYYGVQ--VEDSDVIIFMEYCSQGTLERICH-
|   . | .||||.|  .|...   ..| | ..|.  |      .|     |..|... .|| |.| |.|||..  .. . . |||||.. | . .    
WQKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNK

-GKMDLKMVRQYTNSLLRAVQYLHSHKIIHRDIKPANIFLDKCTVLKLGDFGCSS-------------------RLVESSTVY---GEFQTTAGTPQ---
 |. | .  . ||. .|  ..|||||.|||||||.||| .|.  . || ||||.                       ......   .  ..  |||.   
YGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQPF

FMAPEIYSYGEKDETTGSYS-GYGRSVDIWALGATVVNMMTGKVPFEGQTR---HQIAFALCFRKQKPTYPDIAD---------KRPDVKRFFDNCFEFL
 ||||.         ..| . |..|..|||.|| ||. | ||| |... .     ....     .| |  |               .. | | . ||.. 
WMAPEV--------IKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQID

PNDRPTAAELLQTTFA
|..|||| .|||. | 
PKKRPTANQLLQHPFI
Kinase B0414.7.AA Ciliate-E2 1125-1388 20 3.6e-49 166.93 In-house 1-365 (365) Show / Hide 
Range on Protein: 1125-1388
Range on HMM: 1-365/365
Sequence Identity: 20% (80 aa)

WALLDHIASGSFGSVHRAMDIDSHRVIAAK---------------------VMRIQRENHKAIESEINIFR----------------QLIHENLVKYYGV
  ..  | .|.|||| .. ..   . .| |                     . ...  . ..|..||.|.|                || | |..|.| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

QV--EDSDVIIFMEYCSQGTLERICH-------------GKMDLKMVRQYTNSLLR---------------AVQYLHSHK-IIHRDIKPANIFLDKCTVL
     |. . . ||||..|.|. ..              .....| .....  .|.               |..|||| . |||||||| ||..     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLGDFGCSSRLVESSTVYGE----------------------------FQTTAGTPQFMAPEIYSYGEKDETTGSYSGYGRSVDIWALGATVVNMMTGKV
|. ||| | .. ...  . .                            |.|..||| .|||||..... |       ||. ..|||.|| .   |..|| 
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ-QKQKGYDYKCDIWSLGVILYEMLFGKP

PFEGQTRHQIAFALCFRKQ-KPTYP----------------DIADKRPDVKRFFDN----CFEFLPNDRPT-AAELLQTTFA
||           .   || |  .|                .  .  ...| .. .    ...  |. |.| . ..|.  . 
PF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase B0414.7.AA MEKK2 1125-1388 33 4.2e-49 169.45 In-house 1-262 (262) Show / Hide 
Range on Protein: 1125-1388
Range on HMM: 1-262/262
Sequence Identity: 33% (92 aa)

WALLDHIASGSFGSVHRAMDIDSHRVIAAKVMRIQRENH------KAIESEINIFRQLIHENLVKYYGVQVEDS--DVIIFMEYCSQGTL--ERICHGKM
| .   .  | || |    |.|  | .|.| .... .|       .|.| ||.. . | || .|.|||   .     . ||||| . | .  .    | .
WRRGKLLGQGAFGRVYVCYDVDTGRELAVKQVQFDPDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKAYGAL

DLKMVRQYTNSLLRAVQYLHSHKIIHRDIKPANIFLDKCTVLKLGDFGCSSRLVESSTVYGEFQTTAGTPQFMAPEIYSYGEKDETTGSYSGYGRSVDIW
  .. |.||  .|  ..|||.| |.||||| |||  |    .|||||| | ||          ..  ||| .|.||. . ||         ||||  |.|
TETVTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICMHITGMKSVTGTPYWMSPEVIN-GE---------GYGRKADVW

ALGATVVNMMTGKVPFEGQTRHQIAFALCFRKQKPTYPDIADKRPDVKRFFDNCFEFLPNDRPTAAELLQTTFA
..| ||| |.| | |.         | .  .. .|  |.   .  . . |   ||     ||| |.|||.  |.
SIGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPQHVSQ--HARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase B0414.7.AA ASK 1131-1388 32 3e-46 151.73 In-house 2-254 (254) Show / Hide 
Range on Protein: 1131-1388
Range on HMM: 2-254/254
Sequence Identity: 32% (87 aa)

IASGSFGSVHRAMDIDSHRVIAAK-VMRIQRENHKAIESEINIFRQLIHENLVKYYGVQVEDSDVIIFMEYCSQGTLERICHGKMD-LK----MVRQYTN
.  |..| |. . | . .. || | .   . .. . .  ||.. .|| |.|.|.| | . |.. . ||||    | |  . . |   .|     .. || 
LGKGTYGIVYAGRDMHTQVRIAIKEIPERDSRYVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENTMNFYTK

SLLRAVQYLHSHKIIHRDIKPANIFLDK-CTVLKLGDFGCSSRLVESSTVYGEFQTTAGTPQFMAPEIYSYGEKDETTGSYSGYGRSVDIWALGATVVNM
 .|  ..||| ..|.|||||  |. .     |.|. ||| . ||     .   |.   || |.||||.   |..        |||.. |||..| |.| |
QILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRLAGINPCTETFT---GTLQYMAPEVIDQGQR--------GYGKPADIWSFGCTMVEM

MTGKVPFEGQTRHQIA-FALCFRKQKPTYPDIADKRPDVKRFFDNCFEFLPNDRPTAAELLQTTFA
 ||| ||      | | |   . |. |  |.   .  . | |   |||  |..|..|..|||  | 
ATGKPPFHELGEPQAAMFKVGMYKKHPEIPEELSA--ECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase B0414.7.AA ULK 1125-1333 26 5.6e-45 154.97 In-house 1-259 (329) Show / Hide 
Range on Protein: 1125-1333
Range on HMM: 1-259/329
Sequence Identity: 26% (71 aa)

WALLDHIASGSFGSVHRAMDIDSH----RVIAAKVMRIQRENHKA-----------IESEINIFRQLI--------HENLVKYYGVQVEDSD--VIIFME
. | . . .|||| |... .....     ..|.|.. .| .| |            ...|| | ..|         |.| ||.| .. .. .  . |.||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCSQGTLERICH--GKMDLKM----------VRQYTNSLLRAVQYLHSHKIIHRDIKPANIFLDKCT------------VLKLGDFGCSSRLVESSTVYG
|| .|.|| . .  .|. ..           ..|.   .| . ..||.|.||||||||.|| ... .            |||..|||  .. |.....  
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGF-AKHVDNDNMEQ

E-FQTTA------GTPQFMAPEIYSYG--EKDETTGSYSGYGRS-VDIWALGATVVNMMTGKVPFEGQ
. ..|.       ||| .|||.| .    .|.        |. . .||| ||     | .||.||...
QMMMTCVNEKRLCGTPLYMAPQILQGQGEQKP--------YYDYKCDIWSLGCIFYEMLYGKPPFYAW
Kinase B0414.7.AA TKL 1131-1386 20 3.7e-44 153.02 In-house 1-364 (364) Show / Hide 
Range on Protein: 1131-1386
Range on HMM: 1-364/364
Sequence Identity: 20% (75 aa)

IASGSFGSVHRA--MDID------SHRVIAAKVMRIQRE----------------------------NHKAIESEINIFRQLIHENLVKYYGVQVEDSD-
| ||.|| |...  . ..      . ...| |..... .                            . . .| ||.. ..| |.|.|...|.  . .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------VIIFMEYCSQGTLERICHGKMDLKMVRQYTNSLLRAVQYLHSHK--------IIHRDIKPANIFLDKCTV--------------LKLG
              | ||||. |.|. . |    .    .   .  |...||||..        |||||.|..||..|.                 .|..
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKIC

DFGCSSRLVES-STVYGE---------------FQTTAGTPQFMAPEIYS----YGEK---DETTGSYSGYGRSVDIWALGATVVNMMTGKVPFEGQTRH
||| | .. .| .   ..                 |  |||..||||.      | ||   ||     . |  ..|... |     ..|...|....   
DFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE-FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYM

QIA---------FALCFRKQKPTYPDI----------ADKRPDVKRFFDNCFEFLPNDRPTAAELLQTT
..             | ....|. |.|           |  |..|.    | .  |..||.. |.|.. 
PMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase B0414.7.AA TyrKc 1125-1386 21 1e-13 -0.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 1125-1386
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

WALLDHIASGSFGSVHRAMDIDSHRVIAAKVMRIQRENHKAIESEINIFRQL--IHENLVKYYGVQVED-------SDVIIFMEYCSQGTLE---RICHG
  |.. . .| || |.... .   .  | |...     .... .|..| ..|   |.|.|. ||| ...         . | |||.. | |    | ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

KMDLKMVRQYTNSLLRAVQYLHSHKIIHRDIKPANIFLDKCTVLKLGDFGCSSRLVES-----STVYGEFQTTAGTPQ-----FMAPEIYSYGEKDETTG
|  .|   ..     .  .||||...||||.   |. ...  . | .||| |  . .      |. |   ... |.        ||||   ||.      
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK------

SYSGYGRSVDIWALGATVVNMMT-GKVPFEG-----QTRHQIAFAL--CFRKQKPTY--PDI--ADKRPDVKRFFDNCFEFLPNDRPTAAELLQTT
    .    |.|. | .   ..| |. | .|      .  ..   .   .|  .| .  | .      ... .    | .. |.|||| .|. .  
----FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase B0414.7.AA Pkinase_Tyr 1125-1206 24 3.4e-09 31.76 Pfam 1-94 (270) Show / Hide 
Range on Protein: 1125-1206
Range on HMM: 1-94/270
Sequence Identity: 24% (23 aa)

WALLDHIASGSFGSVHRAMDI----DSHRVIAAKVM--RIQREN--HKAIESEINIFRQL-IHENLVKYYGVQV-EDSD--VIIFMEYCSQGTL
  ..  . .|.||.|...       . .   | |..      |.  ...  .|..| .||  |.|.|..||| . ..    ..| |||.  | |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL
Kinase B0414.7.AA Pkinase_Tyr 1231-1262 40 0.00202 12.21 Pfam 125-156 (270) Show / Hide 
Range on Protein: 1231-1262
Range on HMM: 125-156/270
Sequence Identity: 40% (13 aa)

QYLHSHKIIHRDIKPANIFLDKCTVLKLGDFG
.||.|...||||.   |. ...  | | .|||
EYLESKNCIHRDLAARNCLVTENNVVKICDFG