Gene C03B1.5 (Nematode worm)

C03B1.5

Species: Nematode worm
Alias: aSWK312, C03B1.5, CE03907, YX05_CAEEL
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: X:-3.03, WormBase Physical Map location: X: 6325521-6326522,

Classification

Group: STE
Family: STE20
Subfamily: STLK

Sequence

Name Sequence Type Origin Length Description Download
C03B1.5.AA Protein Genbank 256 None Fasta, JSON
C03B1.5.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 215 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of C03B1.5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase C03B1.5.AA STLK 1-216 25 5.3e-113 381.71 In-house 44-313 (313) Show / Hide 
Range on Protein: 1-216
Range on HMM: 44-313/313
Sequence Identity: 25% (69 aa)

MCLEYAALSDLSLLASSETFESHVAYICKNLISALIHIHNLG--------IVHGDLSVKNILMTHEGVVKLSDFGMANTFEQTRKSKNQSILGTPGFVSV
.||.........|......||.....||||.|....|....|        ..|.....|.|.|.|.||||..|....................|.|.|..
YCLFQKECHNSRLMQHPNIFEYWTCFICKNWIWVIMHFMCYGSCKDLLCTYCHWGMNEKAIAMIHRGVVKALDYIHQMHYIHRSVKAKHILISTDGKVHL

VVFLFEMWKNIVFIFHQNFDKRTNFKTFVKYYTIAPEIIN--LQGYDGKADLWGLGILSLFLLKGENPFKKCTQFDLESYKVSISESFYPDYS-------
..|...||.......|.......||..|...|..|||..|  |.|||.|.|....||.......|..|||..........||..|...|.|.|       
SGFRHCMWMIEHGQRHRCVFDFPNFHSFKQLYWLAPEVLNQNLHGYDAKSDIYSVGITCCEMANGCMPFKDMHPTQMLHEKVNGSVPCYLDCSTLCDNQG

-------------------------------------NYSTPLQEFMSSLKDYNPEFRSSALHASSQTYL
                                     ..||...|||.....||||.|.||.|..|....
MQMQHSHSRVDSGIGDSVGVSNTHPVNSDRPHHPYHRRFSTHFHEFMEQCLQYNPEQRWSASHLMSHSFF
Kinase C03B1.5.AA Ciliate-E2-Unclassified 21-216 16 3.3e-21 70.35 In-house 137-352 (352) Show / Hide 
Range on Protein: 21-216
Range on HMM: 137-352/352
Sequence Identity: 16% (41 aa)

ESHVA-----YICKNLISAL-IHIHNLGIVHGDLSVKNILMTHEG---VVKLSDFGMANTFE--------------QTRKSKNQSILGTPGFVSVVVFLF
| ...     .... ....|   .|...|.| |.   |||.. .|    .|..||| .   .              .... . ... |||.. .      
EQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-Q----

EMWKNIVFIFHQNFDKRTNFKTFVKYYTIAPEIINLQGYDGK----ADLWGLGILSLFLLKGENPFK--KCTQ---------------FDLESYKVSISE
                          || |||..  |.||..    .| |.||..  ..| |. ||.  .|.|                 ..  |  . .
--------------------------YT-APEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQ

SFYPDY----SNYSTPLQEFMS----SLKDYNPEFRSSALHASSQTYL
 .  .      . |   ..| .    .. ..||. | ..  .    ..
FPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase C03B1.5.AA STE20 88-216 18 7.3e-21 73.2 In-house 154-288 (288) Show / Hide 
Range on Protein: 88-216
Range on HMM: 154-288/288
Sequence Identity: 18% (26 aa)

GFVSVVVFLFEMWKNIVFIFHQNFDKRTNFKTFVKYYTIAPEIINL-----QGYDGKADLWGLGILSLFLLKGENPFKKCTQFDLESYKVSISESFYPDY
| |  . | . .. . .. . .  ....        |  |||.|.      .||| |.| | |||  . ...|| |. ..  .    .. . .. . .. 
GEVKLADFGVCAQLTKHG-R-D-TMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLK

S----NYSTPLQEFMSSLKDYNPEFRSSALHASSQTYL
.    ..|. ...|...  ...||.| .| .  .  ..
DDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase C03B1.5.AA MSK 21-160 27 7.7e-21 67.18 In-house 100-211 (277) Show / Hide 
Range on Protein: 21-160
Range on HMM: 100-211/277
Sequence Identity: 27% (42 aa)

ESHVAYICKNLISALIHIHNLGIVHGDLSVKNILMTHE---GVVKLSDFGMANTFEQTRKSKNQSILGTPGFVSVVVFLFEMWKNIVFIFHQNFDKRTNF
|| ...|   |..|. |.| .||.|.||   ||| . |   | |||.||| |  | |  . . .|                                   
ESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKS-----------------------------------

KTFVKY-YTI---APEIIN----LQG-YDGKADLWGLGILSLFLLKGENPFK
     . .|.   |||...     .| ||   |.|.||...  .| |  ||.
-----PCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVILYTMLTGQVPFQ
Kinase C03B1.5.AA CAMK 11-159 18 7e-20 60.09 In-house 168-334 (425) Show / Hide 
Range on Protein: 11-159
Range on HMM: 168-334/425
Sequence Identity: 18% (37 aa)

LSLLASSETF-ESHVAYICKNLISALIHIHNLGIVHGDLSVKNILMTHE-----------------GVVKLSDFGMANTFEQTRKSKNQS----------
. .. ..  | |. .... . ..||. ..|...||| ||   |||...                  . .|..|||.|| |..  .... |          
FDIV-ERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQ

------------ILGTPGFVSVVVFLFEMWKNIVFIFHQNFDKRTNFKTFVKYYTIAPEIIN--------------LQGYDGKADLWGLGILSLFLLKGE
              |||....                                   |||..|               ..|. |.| | .|..  ..| |.
WTTPTEGQKMKTFCGTPEYMA-----------------------------------APEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGY

NPF
 ||
PPF
Kinase C03B1.5.AA STE20 21-87 36 1.5e-18 64.6 In-house 116-186 (288) Show / Hide 
Range on Protein: 21-87
Range on HMM: 116-186/288
Sequence Identity: 36% (26 aa)

ESHVAYICKNLISALIHIHNLGIVHGDLSVKNILMTHEGVVKLSDFGMANTFEQ----TRKSKNQSILGTP
|...||||...  .| ..|. .|.| |.   |||.|..| |||.||| .  ...    |...| ... |||
EEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTP
Kinase C03B1.5.AA STE 21-87 30 2.8e-13 43.34 In-house 150-227 (359) Show / Hide 
Range on Protein: 21-87
Range on HMM: 150-227/359
Sequence Identity: 30% (25 aa)

ESHVAYICKNLISA-LIHIHNLGIVHGDLSVKNILMTHEGVVKLSDFGMANTFEQ---------------TRKSKNQSILGTP
|| .||||. .. . | ..|...|.| |.   |||.     |||.||| .  ...               |...|.... |||
ESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP
Kinase C03B1.5.AA Pkinase 1-91 26 6.1e-13 46.83 Pfam 77-179 (293) Show / Hide 
Range on Protein: 1-91
Range on HMM: 77-179/293
Sequence Identity: 26% (28 aa)

MCLEYAALS----DLS-LLA--SSETF---ESHVAYICKNLISALIHIHNLGIVHGDLSVKNILMTHEGVV----KLSDFGMANTFEQTRKSKNQSILGT
|..||.       ||. ..   .. .|   | ..  ... ....| ..|. ||.| ||   |||. ..|..    |..||| |  |.  ..| .... ||
MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGT

PGFVS
|....
PWYMA
Kinase C03B1.5.AA CAMK-Unique 21-91 24 6.2e-13 38.84 In-house 154-243 (363) Show / Hide 
Range on Protein: 21-91
Range on HMM: 154-243/363
Sequence Identity: 24% (22 aa)

E--SHVAYICKNLISALIHIHNLGIVHGDLSVKNILMTHEGV----------------VKLSDFGMANTFEQTRKSK-NQSILGTPGFVS
|  .... |.  | ||. . |...|||.||   ||.   ..                 .||.|||..  ... ...   |.. ||| ...
ERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMA
Kinase C03B1.5.AA Ciliate-E2 26-91 20 7.4e-13 40.46 In-house 164-255 (365) Show / Hide 
Range on Protein: 26-91
Range on HMM: 164-255/365
Sequence Identity: 20% (20 aa)

YICKNLISALIHIHNLG-IVHGDLSVKNILMTHEGVVKLSDFGMA----------------NTFEQTR--KSKNQS-------------ILGTPGFVS
...  .|.|| ..|. . |.| |.   |||.     .|..|||..                . . . .  .|. ..             |.||||...
FYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMA
Kinase C03B1.5.AA STE 127-216 15 1.7e-12 40.52 In-house 230-359 (359) Show / Hide 
Range on Protein: 127-216
Range on HMM: 230-359/359
Sequence Identity: 15% (20 aa)

APEIINL------QGYDGKADLWGLGILSLFLLKGENPFKKCTQFDLESYKV--SISES----------FYPDYSN--------------------YSTP
|||.|.       .||| |.| | ||.. . .. |. |. . . .    ..   .....            |   .                    .| .
APEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPE

LQEFMSSLKDYNPEFRSSALHASS--QTYL
...|..   ...|. | .|    .     .
FKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase C03B1.5.AA PAKA 21-87 34 2e-12 40.02 In-house 102-167 (260) Show / Hide 
Range on Protein: 21-87
Range on HMM: 102-167/260
Sequence Identity: 34% (23 aa)

ESHVAYICKNLISALIHIHNLGIVHGDLSVKNILMTHEGVVKLSDFGMANTFEQTRKSKNQSILGTP
|...||.|.  ...|  ||. ...| |.   |||.  .| ||. ||| .   .|  ..| ... |||
EGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQ-EQQKRNTMVGTP
Kinase C03B1.5.AA Ciliate-E2 123-216 16 1.1e-11 36.33 In-house 251-365 (365) Show / Hide 
Range on Protein: 123-216
Range on HMM: 251-365/365
Sequence Identity: 16% (21 aa)

YYTIAPEIINLQG---------YDGKADLWGLGILSLFLLKGENPFKKCTQFDLESYKVSIS-ESFYP----------------DYSNYSTPLQEFMSS-
..  ||||.| ..         || |.|.| ||..  ..| |. ||          ..  .  .  .|                .. . |   . ...  
PGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKF

---LKDYNPEFRSS-ALHASSQTYL
   . ...|| | . .  .    ..
GKRMLQKDPEKRITGWEQILNHPWF
Kinase C03B1.5.AA RSK 21-90 28 1.2e-11 39.25 In-house 103-175 (278) Show / Hide 
Range on Protein: 21-90
Range on HMM: 103-175/278
Sequence Identity: 28% (21 aa)

ESHVAYICKNLISALIHIHNLGIVHGDLSVKNILMTH---EGVVKLSDFGMANTFEQTRKSKNQSILGTPGFV
|. ....  ....|. |.| .||.| ||   ||| ..   || .||.||| .  |    ... ..  .|  ..
EDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYM
Kinase C03B1.5.AA S_TKc 1-216 15 4.7e-10 -29.51 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-216
Range on HMM: 1-231/231
Sequence Identity: 15% (46 aa)

M---------------------------------------------------------------CLEYAAL--SDLSLLASSETF--------ESHVAYI
                                                                ..||.     ||  .  .           | |....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY

CKNLISALIHIHNLGIVHGDLSVKNILMTHEGVVKLSDFGMANTFEQTRKSKNQSILGTPGFVSVVVFLFEMWKNIVFIFHQNFDKRTNFKTFVK-YYTI
.. ...|| ..|..||.| ||   |||...  ..|..|||.|  .                                             .||.   . .
MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------------------------------------TTFCGTPWYM

APEIINLQGYDG-KADLWGLGILSLFLLKGENPFKKCTQFDLESYKVSISESFYPDYSNYSTPLQEFMSSLKDYNPEFRSSALHASS-------QTYL
|||..   ||.. |.| | .|..   .| |. ||    | ..   |.             | .. .|.. . ...|| | .|  |           ..
APEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase C03B1.5.AA CAMK-Unique 126-159 30 1e-08 24.71 In-house 242-293 (363) Show / Hide 
Range on Protein: 126-159
Range on HMM: 242-293/363
Sequence Identity: 30% (16 aa)

IAP--------------EIINLQGYDGKA----DLWGLGILSLFLLKGENPF
.||              |.|| |.||..     |.| || .  ..| |. ||
MAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPF
Kinase C03B1.5.AA Pkinase 123-216 17 2.4e-08 30.57 Pfam 175-293 (293) Show / Hide 
Range on Protein: 123-216
Range on HMM: 175-293/293
Sequence Identity: 17% (21 aa)

YYTIAPEIIN-LQGYDGKADLWGLGILSLFLLKGENPFKKC------TQFDLESYKVS--ISESFYPDYSNY----------------STPLQEFMSSLK
.. .|||.|.  |.|. |.| |..|..   .| |. ||. .      .|  .   . .  ...... ..|..                | ....|.... 
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

DYNPEFRSSALHASSQTYL
...|. | .| ..    ..
CKDPKKRPTAEQILQHPWF
Kinase C03B1.5.AA Pkinase_Tyr 37-69 39 1e-06 23.14 Pfam 126-158 (270) Show / Hide 
Range on Protein: 37-69
Range on HMM: 126-158/270
Sequence Identity: 39% (13 aa)

HIHNLGIVHGDLSVKNILMTHEGVVKLSDFGMA
. .. ...| ||  .|.| |...||| .|||.|
YLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase C03B1.5.AA RSK 126-160 35 3e-06 19.22 In-house 175-213 (278) Show / Hide 
Range on Protein: 126-160
Range on HMM: 175-213/278
Sequence Identity: 35% (14 aa)

IAPEIIN----LQGYDGKADLWGLGILSLFLLKGENPFK
.|||...      |.|  .|.| ||.|   .| |  ||.
MAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQ
Kinase C03B1.5.AA PAKA 127-159 45 1.5e-05 15.6 In-house 171-203 (260) Show / Hide 
Range on Protein: 127-159
Range on HMM: 171-203/260
Sequence Identity: 45% (15 aa)

APEIINLQGYDGKADLWGLGILSLFLLKGENPF
|||.|. . || | | | |||. . .. || |.
APEVIRRKQYDEKVDIWSLGIMAIEMIEGEPPY