Gene C08F8.6 (Nematode worm)
C08F8.6
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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C08F8.6.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 254 | Kinase domain by global Sugen HMM | Fasta, JSON |
C08F8.6.AA | Protein | Genbank | 380 | None | Fasta, JSON |
Protein domains of C08F8.6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | C08F8.6.AA | Worm6 | 16-278 | 49 | 2.8e-163 | 548.73 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 16-278 Range on HMM: 1-279/279 Sequence Identity: 49% (139 aa) WQIDKKLGEGAFGAVYKCSNPKGD---LFALKVEG--KDEKIQLLKMEVYVLNELKKAGGRHFCNIEDKGQVDN--FNYVVMTFVGLSLADLRAISPTKK |...||.|||.||||||... .. ||.|.|. . .|.| ||||..||...|. ..||||.|||.|.||| |||.|||.|| .|.|||. .|..| WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK FSMGTAISIARQSLEALEDMHNIGYLHRDVKPGNYTIGR---AEVNELRKVYVLDFGMAR-KFAHEDGT-IKKPR-NVAGFRGTVKYAPVSCHAGRELCR |||||...||.|.|||.||.||.|..||||||||..||| .| ||....| |||||.| |.....|. ...|| ...||||||.|||..|| |.|.|| FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR QDDCETWLYMVVELTKGSLPWRNMTEIQDVG-NEKRAIRRDPIVKKKMFGG-CPR-EYLDILEAIDKGQFFDEPNYERI .||||.|.||.||...| ||||.|.. ..|. . |...|| . ..|| | ||. |. ||.. ||.....|.|.|. | KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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Kinase | C08F8.6.AA | CK1 | 16-278 | 33 | 1.6e-116 | 393.43 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 16-278 Range on HMM: 1-339/339 Sequence Identity: 33% (114 aa) WQIDKKLGEGAFG-AVYKC-----SNPKG------DLFALKVEGKDEKIQ-LLKMEVYVLNELKKAG---------GRHFCN----------IEDKGQVD |.. ||.|||.|| ..||. .. |. . .|.||| |... | ..||.|.. .....| ..|||. ....| .| WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED N-FNYVVMTFVGLSLADLRA--ISPTKKFSMGTAISIARQSLEALEDMHNIGYLHRDVKPGNYTIGRAE-----------VNELRKVYVLDFGMAR-KFA . .||.||| .| .| |||. ...||||.|.. || | |||||.||..|..|||.||.|. .||.| ||.|.||..|||||| |.. DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR HEDGT------------IKKPRN---VAGFRG-TVKYAPVSCHAGRELCRQDDCETWLYMVVELTKGS--LPWRNMTEIQD-----VGNEKRAIRRDPIV ||. .. ||. .|||| |..|....|| |.|..| ||...|.||..|..||. |||.||.. |. .|....... DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM KKKMFGG--------CPREYLDILEAIDKGQFFDEPNYERI . ..| . ||.|. .|.. |.. ...|.|.|| | STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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Kinase | C08F8.6.AA | TTBKL | 16-282 | 37 | 3.6e-87 | 294.31 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 16-282 Range on HMM: 1-288/288 Sequence Identity: 37% (108 aa) WQIDKKLGEGAFGAVY--KCSNPKGDLFALKVEGKD-EKI-QLLKMEVYVLNELKKAGGRHFCNIEDKGQVDNFNYVVMTFVGLSLADLRAISPTKK-FS |.| |..|||.||.|| . .. |.| .|.|.| . |.. . .||||.||..| . | .||... . |. ...|..||| .| .| |||. .|.|| || WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS MGTAISIARQSLEALEDMHNIGYLHRDVKPGNYTIGRAE--VNELRKVYVLDFGMARKFAHEDG-----------TIKKPRN---VAGFRGTVKYAPVSC ||. |. | |.|| .|| .|..||||||.|. .| . . | ||..||||||..| .|| ....||| |.||||..|. . DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM HAGRELCRQDDCETWLYMVVELTKGSLPWRNMTEIQDVGNEKRAIRRDPIVKKKMF--GGCPREYLDILEAIDKGQFFDEPNYERIYYLL |...|. | || |.||..|| .| |||.||.. ... |.. . . |. |. .||.| ... ... .. |.|.|| || .. HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKD-MPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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Kinase | C08F8.6.AA | TTBK | 16-278 | 39 | 5.3e-79 | 268.77 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 16-278 Range on HMM: 1-257/257 Sequence Identity: 39% (104 aa) WQIDKKLGEGAFGAVYKCSNPKGD--LFALKVEGKDEKIQLLKMEVYVLNELKKAGGRHFCNIEDKGQVDNFNYVVMTFVGLSLADLRAISPTKKFSMGT |.. || | |.|| .| . . |.||| . . | ||||| || | | | | | |.|||.||. | .||||| | .||..| WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQ--GCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLST AISIARQSLEALEDMHNIGYLHRDVKPGNYTIGRAEVNELRKVYVLDFGMARKFAHEDGTIKKPRNVAGFRGTVKYAPVSCHAGRELCRQDDCETWLYMV .. . | |...| |..|.||||.|| |. .||. . ||.| ||||.||.. | . ||.|||||||| || . | ||. |.|| || TLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPST-CRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYML VELTKGSLPWRNMTEIQDVGNEKRAIRRDPIVKKKMFGGCPREYLDILEAIDKGQFFDEPNYERI || .| |||| . .||. | ..| || | .. | ...| |.| | VEFVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKH-----CPHEFHQFMDHIKSLNYEDRPDYQLI |
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Kinase | C08F8.6.AA | CK1-Unique | 16-224 | 30 | 2.3e-41 | 141.13 | In-house | 1-233 (337) | Show / Hide |
Range on Protein: 16-224 Range on HMM: 1-233/337 Sequence Identity: 30% (71 aa) WQIDKKLGEGAFGAVYK-CSNPKG------DLFALKVEGKD-EKI-QLLKMEVYVLNELKKAG-----GRHFCNIEDKGQVDNFNYVVMTFVGLSLADLR |.. |..| | .| |.. . | | .. | | . |. |.|. | |. .. | .|||| ..| .| . . |||..| |. .. WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC AISPTKKFSMG------TAISIARQSLEALEDMHNIGYLHRDVKPGNYTIGRAEVNELRKVYVLDFGMARK--FAHEDGTIKKPRNVAGFRGTVKYAPVS .| . .|| . | |...| || |..||. ||.|| . . ... |.||.| |. | . |..|| . |||. .|.| | MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS CHAGRELCRQDDCETWLYMVVELTKGS--LPWR || ||. | || |.|.|| . | . | |. CHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK |
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Kinase | C08F8.6.AA | CK1-Unclassified | 16-225 | 32 | 1.7e-36 | 105.25 | In-house | 1-218 (244) | Show / Hide |
Range on Protein: 16-225 Range on HMM: 1-218/244 Sequence Identity: 32% (72 aa) WQIDKKLGEGAFGAVYKCSNP-KGDLFALKVEGKDEKIQLLKMEVYVLNELKKAG--G---RHFCNIEDKGQVDN--FNYVVMTFVGLSLADLRAISPTK .. .|.| |.|| .||| | ....|.|.| |. |. .|. |......|.. . ... .. || .. .|..||.. | || || . . YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMC-NR KFSMGTAISIARQSLEALEDMHNIGYLHRDVKPGNYTIGRAEVNELRKVYVLDFGMARKFA--HEDGT-IKKPRNVAGFRGTVKYAPVSCHAGRELCRQD |||. | || | .. .| .|| ...||| || |. .|. . | .|| ||| . .. ..|. | .| .. || || . | | | | | KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNH-HQVYIIDFGLSKRYIDMDKTGKHIPYRENK-NLTGTARYASINAHLGIEQSRRD DCETWLYMVVELTKGSLPWRN | | | . . |||||| | DLESLGYVLIYFLKGSLPWQN |
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Kinase | C08F8.6.AA | Dual | 16-282 | 26 | 2.6e-36 | 119.55 | In-house | 1-282 (282) | Show / Hide |
Range on Protein: 16-282 Range on HMM: 1-282/282 Sequence Identity: 26% (77 aa) WQIDKKLGEGAFGAVYKC-----SNPKGDLFALKVEGKDEKIQLLKMEVYVLNELKKAG---------GRHFCNIEDKGQV--DNFNYVVMTFVGLSLAD | . . || | |. ||. ||| ..||.| ... | | . . | |. ..| | |.. | .|.|| .|.|| . WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQE LRAISPTKKFSMGTAISIARQSLEALEDMHNIGYLHRDVKPGNYTIGRAEVNELRKVYVLDFGMARKFAH-EDGTIKKPRNVAGFRGTVKYAPVSCHAGR | . .|| .. .| | |.|. | |.||||||..|| |. .| . . .|| .||...||. | . . .| . |. || | . IRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGM--DETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQK ELCRQDDCETWLYMVVELT-KGS-LPWRNMTEIQDVGNEKRAIRRDPIVKKKMFGGCPREYLDILEAIDKGQFFDEPNYERIYYLL . | || |.| ||| | .. ..||. . . . .| . . |. . ||. ... .. |. | |. . | DQGRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKDNFMYH--FDKHQYSHIPRRLKPLVSYVNGYQYDSTPDYDYFRNCL |
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Kinase | C08F8.6.AA | CK1 | 16-227 | 29 | 3.9e-33 | 111.5 | In-house | 1-220 (271) | Show / Hide |
Range on Protein: 16-227 Range on HMM: 1-220/271 Sequence Identity: 29% (66 aa) WQIDKKLGEGAFGAVYKCSNPKGDLF---ALKVEGKDEKIQLLKMEVYVLNELKK---AG-GRHFCNIEDKGQV--DNFNYVVMTFVGLSLADLRAISPT .. .|.|.|.|| .|.. | . . | |.| .. | ..|. |......|.. . . .. .. || ..|..||.. | || || . YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFC-N KKFSMGTAISIARQSLEALEDMHNIGYLHRDVKPGNYTIGRAEVNELRKVYVLDFGMARKFA-HEDGTIKKPRNVAGFRGTVKYAPVSCHAGRELCRQDD .|||. | . || | .. .| .|| ...|||.|| |. .|| .. .||. |||.| .. .... |. .. ||. || . | |.| | || RKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGR-YGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDD CETWLYMVVELTKGSLPWRNMT | |. . . .||||| ... MESLGYVLMYFLRGSLPWQGLK |
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Kinase | C08F8.6.AA | CK1-A | 16-278 | 26 | 5.9e-31 | 106.53 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 16-278 Range on HMM: 1-261/261 Sequence Identity: 26% (71 aa) WQIDKKLGEGAFGAVY-KCSNPKGDLFALKVEGKDEKIQLLKMEVYVLNELKKAGGRHFCNIEDKGQVDNFNYVVMTFVGLSLADLRAISPTKKFSMGTA ... .|.| |.|| .| . .|. |.|.| .. . | | | . |... | . ... |. ..| .|| .| || || . ...|.| | YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVG--IPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFC-KRRFTMKTV ISIARQSLEALEDMHNIGYLHRDVKPGNYTIGRAEVNELRKVYVLDFGMARKFAHEDGTIKKP-RNVAGFRGTVKYAPVSCHAGRELCRQDDCETWLYMV . .| | . .| .|. ...|||.|| |. .| |....|||.|.|. . . | |. ||..|| . | | | | || | |.. LMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGR--HCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVM VELTKGSLPWRNMTEIQDVGN-EKRAIRRDPIVKKKMFGGCPREYLDILEAIDKGQFFDEPNYERI . .|.||| |. || .. . ... | | |. ... . . .| ..|.| . MYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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Kinase | C08F8.6.AA | CK1-D | 16-278 | 28 | 5.2e-29 | 99.39 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 16-278 Range on HMM: 1-261/261 Sequence Identity: 28% (76 aa) WQIDKKLGEGAFGAVYKCSN-PKGDLFALKVEGKDEKIQLLKMEVYVLNELKKAGGRHFCNIEDKGQVDNFNYVVMTFVGLSLADLRAISPTKKFSMGTA . | .|.| |.|| .| | .. |.|.| | |..| . .. || .| || ..| .|| .| || || .|||. | YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQ--GGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYC-HRKFSLKTV ISIARQSLEALEDMHNIGYLHRDVKPGNYTIGRAEVNELRKVYVLDFGMARKFAHEDGTIKKP-RNVAGFRGTVKYAPVSCHAGRELCRQDDCETWLYMV . .| | . .| .| ..|||.|| |. .| .. ||..|||.|... | | || .|| . | | | | || | |.. LMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNM--VYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVL VELTKGSLPWRNMTEIQDVGNEKRAIRRDPIVK-KKMFGGCPREYLDILEAIDKGQFFDEPNYERI . .||||| . . | . . .| ... | | |. . .. . .| | |.| . MYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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Kinase | C08F8.6.AA | Pkinase | 16-191 | 26 | 1.5e-16 | 59.6 | Pfam | 1-179 (293) | Show / Hide |
Range on Protein: 16-191 Range on HMM: 1-179/293 Sequence Identity: 26% (50 aa) WQIDKKLGEGAFGAVYKCSNPKG-DLFALKVEGKDEKIQLLKM------EVYVLNELKKAGGRHFCNIEDKGQVDNFNYVVMTFV--GLSLADLR-AIS- ..| .|.|.|.|| |||| . . ...|.|. |... .. |......|. . . . | . .. |.|| .. ||...|| || YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST -PTKKF--SMGTAISIARQSLEALEDMHNIGYLHRDVKPGNYTIG-RAEVNELRKVYVLDFGMARKFAHEDGTIKKPRNVAGFRGTVKYAP ..| |. .......| |..|| .|. | .|||.|| | | . .... .| . ||| |..| . . . .| || |.. WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMA |
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Kinase | C08F8.6.AA | S_TKc | 16-270 | 20 | 2.9e-13 | 17.63 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 16-270 Range on HMM: 1-231/231 Sequence Identity: 20% (57 aa) WQIDKKLGEGAFGAVYKCSNPK-GDLFALKVEGKDEKIQLLKMEVYVLNELKKAGGRHFCNIEDKGQVDNFNYVVMTFVGL---SLADLRAISPTKK--- ..| .|.|.|||| |||| . | | ..|.|. . .. |. .| . . . ... | | .. |.|| ... .| |. .... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF -FSMGTAISIARQSLEALEDMHNIGYLHRDVKPGNYTIGRAEVNELRKVYVLDFGMARKFAHEDGTIKKPRNVAGFRGTVKYAPVSCHAGRELCRQDDCE |. .| ....| ..||| .|. | .|||.|| | . . . . |||.||.. | || | . PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL------------ TWLY----------MVVELTKGSLPWRNMTEIQDVGNEKRAIRRDPIVKKKMFGGCPR-------EYLDILE---AIDKGQFF . . .. |. | |.. .. . |. .| .| . .| . ..|. .| . ..| GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG-SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | C08F8.6.AA | TyrKc | 16-282 | 18 | 4.1e-05 | -140.02 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 16-282 Range on HMM: 1-280/280 Sequence Identity: 18% (58 aa) WQIDKKLGEGAFGAVYKCSNPKGDLFALKVEGKDEKIQLLKMEVYVLNEL--------------KKAG------GRHFCNIE--DKGQVDNFN-YVVMTF . .||||||||| |||. | |. .| .. . | .. .| . | . .. | ..| ... . . ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK- VGLSLADLRAISPTKKFSMGTAISIARQSLEALEDMHNIGYLHRDVKPGNYTIGRAEVNELRKVYVLDFGMARKFAHED--GTIKKPRNVA----GFR-- ..| . .|.. | . | | .. ||| | .|. | . |||..|. ..| | | .. | . ----------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTM GTVKYAPVSCHAGRELCRQDDCETWLYM------------VV--EL-TKGSLPWRNM----TEIQDVGNEKRAIRRDPIVKKKMFGG-----CPREYLDI .. . |.. | |. |. | | |. .| . |.| . .. .| |. . || | .| LPIRWMAP--------------ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMSFVCCPDEMYQI LEAIDKGQFFDEPNYERIYYLL . . . | |. . |. .. MKQCWHEDPEDRPTFSEIHECF |
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Kinase | C08F8.6.AA | CK1 | 252-276 | 26 | 0.12857 | 1.58 | In-house | 246-271 (271) | Show / Hide |
Range on Protein: 252-276 Range on HMM: 246-271/271 Sequence Identity: 26% (7 aa) G-CPREYLDILEAIDKGQFFDEPNYE | .| | . |. . . .|...|.|. GNFPNEFAMYLNYCRQLHFEEKPDYM |