Gene C25A8.5 (Nematode worm)

C25A8.5

Species: Nematode worm
Alias: aSWK355, C25A8.5, CE08385
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: IV: 6999589-7001483, WormBase Genetic Map location: IV:3.26,

Classification

Group: TK
Family: Fer

Sequence

Name Sequence Type Origin Length Description Download
C25A8.5.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 255 Kinase domain by global Sugen HMM Fasta, JSON
C25A8.5.AA Protein Genbank 416 None Fasta, JSON

Protein domain

Protein domains of C25A8.5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH2 C25A8.5.AA SH2 9-97 32 1.7e-26 95.28 SMART 1-87 (87) Show / Hide 
Range on Protein: 9-97
Range on HMM: 1-87/87
Sequence Identity: 32% (31 aa)

EPWYHGLLPREDIKAMLRKN----GDFLVRSTEPKAGEPRQYVLSAMQSEELEDAGVKHYVMRLNPSNQIFLEA---KGFETIASLVNYYMNSKEP
.||||| ..||.  ..|...    ||||||  |.   .|..|||| .        .||||. | |.... ...    . |...  |||.|.  . .
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSES---NPGDYVLSVRWK-----GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 C25A8.5.AA SH2 11-91 27 9.6e-17 50.98 Pfam 1-81 (81) Show / Hide 
Range on Protein: 11-91
Range on HMM: 1-81/81
Sequence Identity: 27% (24 aa)

WYHGLLPREDIKAMLRK----NGDFLVRSTEPKAGEPRQYVLSAMQSEELEDAGVKHYVMRLNPSN-QIFLEAKGFETIASLVNYY
|||| ..|..   .|..    .|.||||  | . |.   |.|| .   .     ||||. . ..       . . |.... ||..|
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGD---YTLSVRDDGP--GDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
Kinase C25A8.5.AA Fer 120-375 47 5.1e-149 501.37 In-house 1-283 (283) Show / Hide 
Range on Protein: 120-375
Range on HMM: 1-283/283
Sequence Identity: 47% (134 aa)

VELTKKLGEGAFGEVWKG--KLTLKN---GTVENCAIKTAKL--ESLNKEQIKEIMREARLMRN-LDHPNVVKFYGVGASQEPLYVIMELADCGALDSYL
|.|.|||||||||||.||  .|..|.    .|...|.|..|.  |...||||||.|.|||.||| .||||||||||| ....|....||....|.|||||
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

QKNPN-LLPG-KKMEMIYQAACGIAYMHEKKLLHRDIAARNCLYGEGQVK----IADFGLSRE----GNSYVMD-LTKKVPIRWLAPETLKAGIYSPKSD
.||.| ...  .|..|.||||||..|.|.|. .|||||||||||....||    |.|||.||.    |..| |.   .|||||||||||.. ||||||.|
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VFAFGIMAWEITENGKEPYPD----MRVSEV----VGYVRSGHRMRFDPVFVDFRFGEYVTKHCWAENPDDRVNMSDVLRYLQ
|..||.|.||| .||.||||.    |.. .|    .  .. . .| . |  .  .. ....|.||...|.|| .|... . | 
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase C25A8.5.AA TyrKc 120-374 37 2.4e-110 373.79 SMART 1-280 (280) Show / Hide 
Range on Protein: 120-374
Range on HMM: 1-280/280
Sequence Identity: 37% (110 aa)

VELTKKLGEGAFGEVWKGKLTLKNGTVENCAIKTAKLESLNKEQIKEIMREARLMRNL--DHPNVVKFYGVGASQ-------EPLYVIMELADCGALDSY
..| |||||||||||.||...      ...|.|. | ..     ....|||||.|..|  .|||.|..|||  .|       |||...||... |.|..|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LQKNPN-LLPGKKMEMIYQAACGIAYMHEKKLLHRDIAARNCLYGEGQ-VKIADFGLSREGNSY--------VMDL----TKK--VPIRWLAPETLKAGI
|.|. . | . .. .. .|.||| .| |.|.. |||.||||||.||.. |||.||||||.. ..        . .      .|  .||||.|||... |.
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YSPKSDVFAFGIMAWEITENGKEPYPD-----MRVSEVVGYVRSGHRMRFDPV--------FVDFRFGEYVTKHCWAENPDDRVNMSDVLRYL
...||||..||.. |||  .|..|||.     |  .||. ||..|.||.  |           |  .   . | ||.|.|.|| ..|.. ...
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ--IMKQCWHEDPEDRPTFSEIHECF
Kinase C25A8.5.AA Pkinase_Tyr 120-337 40 3.7e-96 326.29 Pfam 1-235 (270) Show / Hide 
Range on Protein: 120-337
Range on HMM: 1-235/270
Sequence Identity: 40% (95 aa)

VELTKKLGEGAFGEVWKGKLT-LKNGTVENCAIKTAKLESLNKEQ--IKEIMREARLMRNL-DHPNVVKFYGVGA-SQEP--LYVIMELADCGALDSYLQ
... |||||||||||.||... .. .|   .|.|.   |.  .||  ... ||||..|..| .|||.|..|||    .||  .|..||.. .| |..||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----NPNLLPGKKMEMIYQAACGIAYMHEKKLLHRDIAARNCLYG-EGQVKIADFGLSREG---NSY-VMDLTKKVPIRWLAPETLKAGIYSPKSDVFA
|    ...| .  . .| .| |.| .| ..|.. |||.|||||| . ...|||.||||.|       | ..    |.||.|.||| .. |... |||| .
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGIMAWEITENGKEP-YPDMRVSEVVGYV-RSGHRM
||.  |||   |..| ||.|  .||. |. ..|.||
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRM
Kinase C25A8.5.AA TK 120-374 21 2.4e-94 316.65 In-house 1-486 (486) Show / Hide 
Range on Protein: 120-374
Range on HMM: 1-486/486
Sequence Identity: 21% (106 aa)

VELTKKLGEGAFG---EVWKGKLTL----------------------KNGTVENCAIKTAKLE-SLNKEQIKE--------------IMREARLMRN--L
..| ||||||.||   ||.||..                        |.|... .|.|. |.. . ..|. ..               ..|. .|..  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DHPNVVKFYG-------------VGASQEPLYVIMELADCGA----LDSYLQKNPN--------------------------------------------
.|||.|..||             |   |||....||....|     |..||.|...                                            
HHPNIVRLYGVCTQGEPKPCFEVV-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

--------------------------------LLPGKKMEMIYQAACGIAYMHEK------KLLHRDIAARNCLYGEGQ------------VKIADFGLS
                                | .  .. | .|.||| .|.|.|      .. |||.|||||| ||.             .||||||||
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

RE----------------------------------GNSYVMDLTK-KVPIRWLAPETLKAGI---------YSPKSDVFAFGIMAWEITENGKEPYPD-
|.                                  . .|... .. |.||||.|||.|. ..         ...||||..||.. |||  .|.|||.  
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

MRV---------SEVVGYVRSG----------------------------HRMRFDPVFVDFRFGEYVTKHCWAENPDDRVNMSDVLRYL
|            ||. |.|.|                            .|| . |  ..  . . . . ||...|.|| ..|.....|
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase C25A8.5.AA UTK 120-338 32 5.9e-71 241.96 In-house 1-262 (296) Show / Hide 
Range on Protein: 120-338
Range on HMM: 1-262/296
Sequence Identity: 32% (86 aa)

VELTKKLGEGAFGEVWKGKLTLKN--GTVENCAIKTAKLESLNKEQIK---EIMREAR---LMRNLD-HPNVVKFYGVGASQEPLYVIMELADCGALDSY
|.| ..||.|||||| |...|  .  ...  .|.|... ..    .     ..|.|||   .| ... ||||....||  ..||.....|..  | |.||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LQKNPN--------LLPGKKMEMIYQAACGIAYMHEKKLLHRDIAARNCLYGEG--------QVKIADFG---LSREGNS-----------YVMDL-TKK
|....         |   ....| .. |.| .|.|.... |||.|||||| ..         ..||||||   .||. |.           |.|    ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

VPIRWLAPETLKAG-IYSPKSDVFAFGIMAWEITENGKEPYPDMRVSEVVGYVRSG--HRMR
.|||| ||| |  .  .. ||||..||.  |||  .|. |||.|   .|.  |. |  .||.
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMP
Kinase C25A8.5.AA TK-Unique 120-337 32 1.5e-64 220.77 In-house 1-258 (294) Show / Hide 
Range on Protein: 120-337
Range on HMM: 1-258/294
Sequence Identity: 32% (85 aa)

VELTKKLGEGAFGEVWKGKLTLKN-GTVEN-CAIKTAKLESLNKEQIKEIMREARLMRNLD-HPNVVKFYGVGASQ-EPLYVIMELADCGALDSYLQKNP
.|. ...||||||.||.|... .. .  .  |.. ..  ....... .. ..|...|..|. |||.|...|.  .  || . ||| . || |..||... 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

----------NLL------PGKKMEM----------IYQAACGIAYMHE--KKLLHRDIAARNCLYGE-GQVKIADFGLSRE---GNSYVMDLT-KKVPI
          ||       | |...           ..| ||| .|...  ||  |||..|||.| .| ...||.|||..|.   .. |.|  . ...||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWLAPETLK--AGIY-SPKSDVFAFGIMAWEITENGKEPYPDMRVSEVVGYVRSGHRM
||.||| ||   |.| ..|||| .||.  |||  .|. |||.|. ....  .| |.||
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRM
Kinase C25A8.5.AA Src 120-337 38 3.6e-56 189.33 In-house 1-219 (255) Show / Hide 
Range on Protein: 120-337
Range on HMM: 1-219/255
Sequence Identity: 38% (87 aa)

VELTKKLGEGAFGEVWKGKLTLKNGTVENCAIKTAKLESLNKEQIKEIMREARLMRNLDHPNVVKFYGVGASQEPLYVIMELADCGALDSYLQ---KNPN
. | .|||.| |||||.|.    ||...  |.|| |  ..  |.     .|| .| .|.|...|. | |    || | . |.   | |  ||.   .  .
IKLCRKLGQGQFGEVWMGYW---NGNTK-VAVKTLKPGTMSPEAFL---QEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRH

LLPGKKMEMIYQAACGIAYMHEKKLLHRDIAARNCLYGEGQ-VKIADFGLSR--E--GNSYVMDLTKKVPIRWLAPETLKAGIYSPKSDVFAFGIMAWEI
|   .  .|  | | | ||. .... ||| |||| | ||.  .|.||||| |  .   . |..    |.||.| ||| .  | .. ||||  |||  .||
LHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEI

TENGKEPYPDMRVSEVVGYVRSGHRM
   |. ||| |.  ||.  |  | ||
VTYGRVPYPGMTNHEVLQQVERGYRM
Kinase C25A8.5.AA TKL 126-374 20 5.9e-54 185.56 In-house 1-364 (364) Show / Hide 
Range on Protein: 126-374
Range on HMM: 1-364/364
Sequence Identity: 20% (78 aa)

LGEGAFGEVWKGKLTLKNGTV------ENCAIKTAKLESLNKEQI-------------------------KEIMREARLMRNLDHPNVVKFYGVGASQEP
.|.|.||||.|||.   .| .      .  |.|. | .. ... .                         ... .|...|..|.|||.|.|.|.  . ..
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

-------------LYVIMELADCGALDSYLQKNPNLLPGKKMEMIYQAACGIAYMHE--------KKLLHRDIAARNCLYGE-GQ--------------V
             |. .||....| | .||.      . ... .....|.|..|.|         ....|||.  .|.|  | ..              .
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIADFGLSREGN-SYVMDLTK------------------KV-PIRWLAPETLK----------------AGIYSPKSDVFAFGIMAWEITENGKEPYPDM
||.||||||. . |  |  |.                  ..  .||.||| |.                 . ||.|.||..|||. |||    . || |.
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-PYYDY

RVSEVV---------GYVRSGHRMRFDP------------VFVDFRFGEYVTKHCWAENPDDRVNMSDVLRYL
  ....          .| .  .    |              .. .. .   ..||...|..| .....| .|
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKK-LMQDCWDHDPEKRPSFQEILKRL
Kinase C25A8.5.AA Abl 120-374 34 2.6e-53 175.98 In-house 1-252 (252) Show / Hide 
Range on Protein: 120-374
Range on HMM: 1-252/252
Sequence Identity: 34% (90 aa)

VELTKKLGEGAFGEVWKGKLTLKNGTVENCAIKTAKLESLNKEQIKEIMREARLMRNLDHPNVVKFYGVGASQEPLYVIMELADCGALDSYLQKN--PNL
. . .||| | .|||..|     . ||   |.|| | ...   ...| ..|| .|... |||.|.  ||     | |.| |    | |  || ..   .|
IMMKHKLGGGQYGEVYEGVWKRHDCTV---AVKTLKEDTM---EVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREEL

LPGKKMEMIYQAACGIAYMHEKKLLHRDIAARNCLYGEGQ-VKIADFGLSR--EGNSYVMDLTKKVPIRWLAPETLKAGIYSPKSDVFAFGIMAWEITEN
 .   . |  | | |. |. ... .|||.|||||| || . ||.|||||.|  ... |      | ||.| ||| |    .| ||||.|||.. |||   
PAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATY

GKEPYPDMRVSEVVGYVRSGHRMRFDPVFVDFRFGEYVTKHCWAENPDDRVNMSDVLRYL
|  ||| . .|.| . .  |.||   .   .  .   . ..||  .. ||    .. . .
GMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVY--ELMRQCWQWSHTDRPSFKEIHHAM
Kinase C25A8.5.AA Frk 120-378 36 2.2e-52 179.74 In-house 1-260 (260) Show / Hide 
Range on Protein: 120-378
Range on HMM: 1-260/260
Sequence Identity: 36% (98 aa)

VELTKKLGEGAFGEVWKGKLTLKNGTVENCAIKTAKLESLNKEQIKEIMREARLMRNLDHPNVVKFYGVGASQEPLYVIMELADCGALDSYLQ----KNP
..| ..|| | ||||| |   | | |.   |.|| |  ...    .. .|||..|..| || ... | | . .||.|.| ||   |.|  |||    |  
IQLIRRLGSGQFGEVWEG---LWNNTTP-VAVKTLKPGTMD---PNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGR

NLLPGKKMEMIYQAACGIAYMHEKKLLHRDIAARNCLYGEGQ-VKIADFGLSR---EGNS--YVMDLTKKVPIRWLAPETLKAGIYSPKSDVFAFGIMAW
..   . ..|  | | |.||. ..  .|||.|||| | ||.. .||||||| |     |   |      ..||.| |||  .   .. ||||..|||.  
QCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLT

EITENGKEPYPDMRVSEVVGYVRSGHRMRFDPVFVDFRFGEYVTKHCWAENPDDRVNMSDVLRYLQTTF
||   |. ||| |   ||.  |  | ||   |   . .. | .  .|| ..|. |     .   |.  |
EIITYGRMPYPGMTNAEVLQMVDHGYRMP-QPPNCPQQLYE-IMLECWHSDPMKRPTFETLQWKLEDYF
Kinase C25A8.5.AA Tec 120-376 35 2.2e-51 177.0 In-house 1-254 (254) Show / Hide 
Range on Protein: 120-376
Range on HMM: 1-254/254
Sequence Identity: 35% (96 aa)

VELTKKLGEGAFGEVWKGKLTLKNGTVENCAIKTAKLESLNKEQIKEIMREARLMRNLDHPNVVKFYGVGASQEPLYVIMELADCGALDSYLQKNPNLLP
  . | || | || |  ||..  .  |   |||. |  |   |   . . ||. | .| ||. |..|||   | |.|.. |    | | .|| ..   . 
LTFMKELGSGQFGVVHLGKWRH-QYDV---AIKMIKEGSMSEE---DFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQ

GKK---MEMIYQAACGIAYMHEKKLLHRDIAARNCLYGEGQ-VKIADFGLSREGNSYVMD------LTKKVPIRWLAPETLKAGIYSPKSDVFAFGIMAW
..    .|| ..   | ||  ... .||| |||||| |. . ||..|||..|    ||.|         | |..| .|| ..   || |||| |||.  |
KNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTR----YVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMW

EITENGKEPYPDMRVSEVVGYVRSGHRMRFDPVFVDFRFGEYVTKHCWAENPDDRVNMSDVLRYLQT
|.   || ||. |  ||||  |  |||.   |     .  . . .||| | |..|   .. || .. 
EVFSCGKMPYENMSNSEVVEHVSQGHRL-YRPHLCSMHIYQ-IMYHCWHEKPEERPTFQQLLRQITE
Kinase C25A8.5.AA Axl 120-373 34 2.8e-50 173.35 In-house 1-267 (267) Show / Hide 
Range on Protein: 120-373
Range on HMM: 1-267/267
Sequence Identity: 34% (93 aa)

VELTKKLGEGAFGEVWKGKLTLKNGTVENCAIKTAKLESLNKEQIKEIMREARLMRNLDHPNVVKFYGVGASQEP------LYVIMELADCGALDSYL--
. | | |||| || |  |.|    |..   |.|. |.. . . .| | ..||  |.. |||||..  ||   .          ||.     | | ..|  
FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLY

---QKNPNLLPGKKM-EMIYQAACGIAYMHEKKLLHRDIAARNCLYGEG-QVKIADFGLSR---EGNSYVMDLTKKVPIRWLAPETLKAGIYSPKSDVFA
   ...|  || . .   .   |||. |. ... .|||.|||||.  |   | .||||||.   .|  |      |.|..|.| | |   .|  ||||.|
SRLGDQPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQGCIAKMPVKWIAIESLADRVYTSKSDVWA

FGIMAWEITENGKEPYPDMRVSEVVGYVRSGHRMRFDPVFVDFRFGEYVTKHCWAENPDDRVNMSDVLRY
||.  |||.  |. ||| .  .|.  |.. |||..  .  .|  .   .  .||  .| ||   | ||| 
FGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCMDELY--DLMYQCWEADPKDRPSFS-VLRE
Kinase C25A8.5.AA S_TKc 120-374 24 3.4e-47 164.01 SMART 1-231 (231) Show / Hide 
Range on Protein: 120-374
Range on HMM: 1-231/231
Sequence Identity: 24% (68 aa)

VELTKKLGEGAFGEVWKGKLTLKNGTVENCAIKTAKLESLNKEQIKEIMREARLMRNLDHPNVVKFYGVGASQEPLYVIMELADC--GALDSYLQKNPN-
 |. .|.|.||||.|.|.. .    | . .|||  |         . |.|| ..... .|||.||.|.|  . . ||..||..|   | | .|..|..  
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LLPGKKMEMIYQAACGIAYMHEKKLLHRDIAARNCLYGEGQVKIADFGLSREGNSYVMDLTKKVPIRWLAPETLKAGIYSP-KSDVFAFGIMAWE
     . .     ..|| .|...|.|... .|||.   | |  | ..||.||||.|.        |  .   ..||| |    |.. |.|. ..|.. .|
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

ITENGKEPYPDMRVSEVVGYVRSGHRMRFDPVFVDFRFGEYVT---KHCWAENPDDRVNMSDVLR---------YL
    |. |.|   . ..   ..                 . .    ..|.  .|..|    ..|.         ..
MLC-GYPPFP--QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase C25A8.5.AA Pkinase 120-374 20 1e-42 152.12 Pfam 1-293 (293) Show / Hide 
Range on Protein: 120-374
Range on HMM: 1-293/293
Sequence Identity: 20% (62 aa)

VELTKKLGEGAFGEVWKGKLTLKNGTVENCAIKTAKLESLNKEQIKEIMR--EARLMRNLDHPNVVKFYGVGASQEPLYVIMELADCG----ALDSYLQ-
 .. .|.|.|.||.|.|..    . .|   |.|. |... .... ..  |  |...|..|.|||.|..|..  .   .|..||....|     | .|.. 
YHIGRKIGSGSFGCVYKCHHKGTGKIV---AVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-KNPNL--LPGKKMEMIYQAACGIAYMHEKKLLHRDIAARNCLYG-EGQV----KIADFGLSRE--GNSYVMDLTKKVPIRWLAPETLK-AGIYSPKSDV
 .. ..   .     ..|| ..|..|.|... .|||.   |.|.  .|..    ||.||||..     ...   |  . ....||| .. .  |.||.|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

FAFGIMAWEITENGKEPYPDM------RVSEVVGYVRSGHRMRFDPVFVDF------------------RFGEYVTKHCWAENPDDRVNMSDVLRY--L
...|.. .|    |. |.|.       .  ...  ....  ..  |   .                   . .  . | |.. .| .| .  ..|    .
WSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase C25A8.5.AA TK-Unique 354-374 28 0.002173 7.69 In-house 274-294 (294) Show / Hide 
Range on Protein: 354-374
Range on HMM: 274-294/294
Sequence Identity: 28% (6 aa)

KHCWAENPDDRVNMSDVLRYL
| || ..|..|.. ....  |
KSCWQWEPEERPSFRQIKHRL
Kinase C25A8.5.AA Pkinase_Tyr 354-374 38 0.002598 11.84 Pfam 250-270 (270) Show / Hide 
Range on Protein: 354-374
Range on HMM: 250-270/270
Sequence Identity: 38% (8 aa)

KHCWAENPDDRVNMSDVLRYL
|.||...|.||  .|.... |
KQCWHYDPEDRPTFSEIHEQL
Kinase C25A8.5.AA UTK 356-374 26 0.010057 5.15 In-house 278-296 (296) Show / Hide 
Range on Protein: 356-374
Range on HMM: 278-296/296
Sequence Identity: 26% (5 aa)

CWAENPDDRVNMSDVLRYL
||. .|..| .. |..  .
CWHYDPQERPDFEDLVQQM