Gene C34B2.3 (Nematode worm)
C34B2.3
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| C34B2.3.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 255 | Kinase domain by global Sugen HMM | Fasta, JSON |
| C34B2.3.AA | Protein | Genbank | 357 | None | Fasta, JSON |
Protein domains of C34B2.3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | C34B2.3.AA | Worm6 | 48-317 | 39 | 1.3e-142 | 480.09 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 48-317 Range on HMM: 1-279/279 Sequence Identity: 39% (110 aa) WKVVKAIQSDKGFNTIYVAEHVQKKKK-MAAVKVER--KTEAIKMLQFELFVLLTVEKKNQCKQFCKLFEKGNEKE--YNWIAITLCGKSLRALRKNQPT |||.| |... ||...|..|. ..||| . |.|.|. ......||..|..||..|.... |..|||....|. .. .|.| .||.||.|. ||||.|. WKVTKKIGEG-GFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHK-CRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPD GKLTVACGLSVAQQCLKGLEELHRMGFIHRNVAPSVFAIGRYTGDNQSDLRNIYILDFGFAH--QYMIKDGTLKPPSAHPWKYVGSLRHMPRAAYSKVEF .|.....||..|.|||...|.||..|||||.| |. |.||||..... ....||.||||... .|. |...|..| .......| .|..|.|.... |. RKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQ SRMEDLEMWFYMSVELVKGCLPWAHLKKPKEVHDYQKLCRNGLQ---MREMLGGLPP-EFVDIMQIVDKLSFTDTPNYTEI .|..|.|.|||| ||...|||||.|.|....|....| ||. .. ||...|. |. ||.|||...|..|. |.|.|. | CRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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| Kinase | C34B2.3.AA | CK1 | 48-317 | 26 | 3.3e-91 | 309.31 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 48-317 Range on HMM: 1-339/339 Sequence Identity: 26% (92 aa) WKVVKAIQSDKGFN-TIYVA-----EHVQKKK----KMAAVKVERKTEAIK-MLQFELFVLLTVEKKN--------QCKQFCK----------LFEKGNE ||||| | . || .|| . . .. .| . .|.|||.|... . .. |..... ... ..|.||| . .|.| WKVVKKIG-EGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEE KE-YNWIAITLCGKSLRALRK-NQP-TGKLTVACGLSVAQQCLKGLEELHRMGFIHRNVAPSVFAIGRYTG-------DN-QSDLRNIYILDFGFAH-QY .. ||.. .||.|..| ||| |.. ..|... ..| .|.|.|..||..|..|||||.. |. |..||... .. ....|..|..|||.|. .| DDYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKY MIKDGTL------------KPPSAH--PWKYVG-SLRHMPRAAYSKVEFSRMEDLEMWFYMSVELVKGC--LPWAHLKKPKE-----VHDYQKLCRNGLQ . |||. .|| | ...| .|...... .| .| ||..|||| .|..||. ||| ..|.... |.. . ... RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKK MREML--------GGLPPEFVDIMQIVDKLSFTDTPNYTEI | .. ..|.|| .||.....|.. |.|.| .| MSTPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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| Kinase | C34B2.3.AA | TTBK | 48-317 | 34 | 6.5e-42 | 145.56 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 48-317 Range on HMM: 1-257/257 Sequence Identity: 34% (93 aa) WKVVKAIQSDKGFNTIYVAEHVQKKKKMAAVKVERKTEAIKMLQFELFVLLTVEKKNQCKQF-CKLFEKGNEKEYNWIAITLCGKSLRALRKNQPTGKLT ||||| | || || |. .. .. |.||| |. | || || | ... |. . | . ..|.. .| ||.| || .|| |. . WKVVKKI-GGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVL----KKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFS VACGLSVAQQCLKGLEELHRMGFIHRNVAPSVFAIGRYTGDNQSDLRNIYILDFGFAHQYMIKDGTLKPPSAHPWKYVGSLRHMPRAAYSKVEFSRMEDL . | . | |...|. | .|| || . || ||.|| | | |..|.|||| | ||. | || . . | | | | | || LSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGR----NPSTCRKCYMLDFGLARQYTNACGEVRPPREVAG-FRGTVRYASINAHRNREMGRHDDL EMWFYMSVELVKGCLPWAHLKKPKEVHDYQKLCRNGLQMREMLGGLPPEFVDIMQIVDKLSFTDTPNYTEI ||| || |.| ||| .| .| .. .| .| .|.|| |. . | . |.|.| | WSLFYMLVEFVQGQLPWRKIKDKDQVG----EMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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| Kinase | C34B2.3.AA | TTBKL | 48-216 | 32 | 2.1e-33 | 110.17 | In-house | 1-180 (288) | Show / Hide |
Range on Protein: 48-216 Range on HMM: 1-180/288 Sequence Identity: 32% (60 aa) WKVVKAIQSDKG-FNTIYVAEHVQKKKKMAAVKVERKT-EAI-KMLQFELFVLLTVEKKNQCKQFCKLFEKGNEKEYNWIAITLCGKSLRALRKNQPTGK |..|| | ..| | ..| .. .. ||..||.|.| .. | . . ...|. ||. .| .. |.|. . |..| ||... ||||..|..||| |..| WMIVKMI--GEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKL-QPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKK -LTVACGLSVAQQCLKGLEELHRMGFIHRNVAPSVFAIGRYTGDNQSDLRNIYILDFGFAHQYMIKDG-----------TLKPP ... . .. |||..| ..|..||||| | |. ...| |.... .. |..|..|||.| ||. ||| ....| RFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWG-YHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRP |
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| Kinase | C34B2.3.AA | CK1-A | 48-317 | 25 | 2.3e-21 | 72.12 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 48-317 Range on HMM: 1-261/261 Sequence Identity: 25% (69 aa) WKVVKAIQSDKGFNTIYVAEHVQKKKKMAAVKVERKTEAIKMLQFELFVLLTVEKKNQCKQFCKLFEKGNEKEYNWIAITLCGKSLRALRKNQPTGKLTV ...|. | | | ||.. ... . . |.|.|.. | .| | ... | . .. |.||.|| . . | | || | | . . |. YRLVRKIGSG-SFGDIYLGINITNGEEV-AIKMESNKARHPQLIYEAKVYRILQG---CVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLF-NFCKRRFTM ACGLSVAQQCLKGLEELHRMGFIHRNVAPSVFAIGRYTGDNQSDLRNIYILDFGFAHQYMIKDGTLKPPSAHPWKYVGSLRHMPRAAYSKVEFSRMEDLE | .| | . .| .| .|||| . | | .| | ....||| | .| . | . . .| | | .| || .|.| KTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCN-----KLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDME MWFYMSVELVKGCLPWAHLKKPKEVHDYQKLC--RNGLQMREMLGGLPPEFVDIMQIVDKLSFTDTPNYTEI |. . .| ||| .| | |. . . .. | | || .|. . .| | ..|.|. . SMGYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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| Kinase | C34B2.3.AA | TTBKL | 249-321 | 29 | 1.2e-19 | 63.07 | In-house | 215-288 (288) | Show / Hide |
Range on Protein: 249-321 Range on HMM: 215-288/288 Sequence Identity: 29% (22 aa) WFYMSVELVKGCLPWAHLKKPKEVHDYQKLCRNGLQMREML--GGLPPEFVDIMQIVDKLSFTDTPNYTEIYGLL |.|| .||..| ||| ......|.. | . . . .| ..|.|| ..|. . |.. |.|.|. || .. WMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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| Kinase | C34B2.3.AA | CK1-D | 116-317 | 28 | 1.8e-16 | 54.49 | In-house | 64-261 (261) | Show / Hide |
Range on Protein: 116-317 Range on HMM: 64-261/261 Sequence Identity: 28% (59 aa) GNEKEYNWIAITLCGKSLRALRKNQPTGKLTVACGLSVAQQCLKGLEELHRMGFIHRNVAPSVFAIGRYTGDNQSDLRNIYILDFGFAHQYMIKDGTLKP |.| .|| . . | | || | | | . | .|.| .. .| .| |||| . | | .| | .||.||| | .| GQEGDYNVMVMDLLGPSLEDLF-NYCHRKFSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNM-----VYIIDFGLAKRYRDARTHQHI PSAHPWKYVGSLRHMPRAAYSKVEFSRMEDLEMWFYMSVELVKGCLPWAHLKKPKEVHDYQKLCRNGLQMR--EMLGGLPPEFVDIMQIVDKLSFTDTPN | | | .| || .||| |. . .| ||| || |...| .. . .. |.| ||.. | . .| | | |. PYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPD YTEI |. . YCYL |
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| Kinase | C34B2.3.AA | CK1-Unique | 48-263 | 22 | 1.5e-15 | 50.43 | In-house | 1-232 (337) | Show / Hide |
Range on Protein: 48-263 Range on HMM: 1-232/337 Sequence Identity: 22% (54 aa) WKVVKAIQSDKGFNTIYVAEHVQKK-----KKMAAVKVERKTEAIK--MLQFELFVLLTVEKKN-QCK---QFCKLFEKGNEKEYNWIAITLCGKSLRAL |.| | | .. |. . . | ..| . | | . . | |. |.. | ||| ||.. . . . || |. |.|. . WCVIKHIGYG-GYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEEC RKNQPTG-KLTVA------CGLSVAQQCLKGLEELHRMGFIHRNVAPSVFAIGRYTGDNQ-SDLRNIYILDFGFAHQ--YMIKDGTLKPPSAHPWKYVGS . . . . | | . . ||| ..| | ||.||. | . .... ... .|.||.| . . ...| . .. | CM-MMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYC----YMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQP-RPITPFRGC LRHMPRAAYSKVEFSRMEDLEMWFYMSVELVKGC--LPW .. |.. . .| .| |.| |||| . || . | | KDYCPCSCHQCREHGRRDDMESWFYMLYHLVHNTRGLSW |
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| Kinase | C34B2.3.AA | Dual | 48-252 | 26 | 3e-14 | 44.17 | In-house | 1-212 (282) | Show / Hide |
Range on Protein: 48-252 Range on HMM: 1-212/282 Sequence Identity: 26% (59 aa) WKVVKAIQSDKGFNTIY-VAEHVQ--KKKKMAAVKVERKTEAIKMLQFELFVLLTVEKKNQC----------KQFCKLFEKGN--EKEYNWIAITLCGKS ||||. . | || .| | . | |.| ..|.| | . . . | |. .|..| | | . . |. . ... . . | | WKVVNLLGSG-GFRDVYHVHRFSQVNPKNKCYILKTE--SEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPS LRALRKNQPTGKLTVACGLSVAQQCLKGLEELHRMGFIHRNVAPSVFAIGRYTGDNQSDLRNIYILDFGFAHQYMI-KDGTLKPPSAHPWKYVGSLRHMP | |. | |.. | || | |. . || .|..|||. |. |..| | .| .||. . | . . ... |. | .| LQEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGL-----GMDETTVYMQDFRIVRKYIDPENKKHRTARKK-VKMYGCGRYAC RAAYSKVEFSRMEDLEMWFYM || ... | ||| | || RACMMQKDQGRKDDLECWIYM |
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| Kinase | C34B2.3.AA | CK1 | 48-212 | 26 | 2.6e-13 | 42.35 | In-house | 1-166 (271) | Show / Hide |
Range on Protein: 48-212 Range on HMM: 1-166/271 Sequence Identity: 26% (45 aa) WKVVKAIQSDKGFNTIYVAEHVQKKKK-MAAVKVERKTEAIKMLQFELFVLLTVEK---KNQCKQFCKLFEKGNE--KEYNWIAITLCGKSLRALRKNQP .|.. | . | || ......... |.|.|... .|..| .. . |||. . .. | | ..|| . ..| |.|| | .| YRVGRKIGQ-GSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDL-FNFC TGKLTVACGLSVAQQCLKGLEELHRMGFIHRNVAPSVFAIGRYTGDNQSDLRNIYILDFGFAHQYM-IKDGT .|... | .| | .. .| .| .|||| . | | .|| . . ..|| |||.| .| .|... NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGR----YGKHCHQVYIIDFGLAKRYRDDKTHQ |
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| Kinase | C34B2.3.AA | CK1-Unclassified | 63-212 | 27 | 2.9e-13 | 35.51 | In-house | 15-166 (244) | Show / Hide |
Range on Protein: 63-212 Range on HMM: 15-166/244 Sequence Identity: 27% (44 aa) IYVAEHVQKKKKMAAVKVERKTEAIKMLQFELFVLLTVEKKNQC----KQFCKLFEKGNE--KEYNWIAITLCGKSLRALRKNQPTGKLTVACGLSVAQQ || . ..| . . .|.|.|.|. ...|..| .. . . | | . |... | | .|| . .| |.|| | .| .|... | | | IYKCINMQTN-EEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDL-FNMCNRKFSLKTVLMIADQ CLKGLEELHRMGFIHRNVAPSVFAIGRYTGDNQSDLRNIYILDFGFAHQYM-I-KDGT .. .| ||. .|||| | | .|. . ..|| |||.. | . |.|. MIQRIEYLHNKNFIHRDIKPDNFLMGK----LGKNHHQVYIIDFGLSKRYIDMDKTGK |
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| Kinase | C34B2.3.AA | S_TKc | 59-326 | 13 | 4.2e-08 | -58.05 | SMART | 11-231 (231) | Show / Hide |
Range on Protein: 59-326 Range on HMM: 11-231/231 Sequence Identity: 13% (39 aa) GFNTIYVAEHVQKKKKMAAVKVERKTEAIKMLQFELFVLLTVEKKNQCKQFCKLFEKGNEKEYNWIAITLCGK---SLRALRKNQPTGK----LTVACGL .| . | . |. .. |.|. . .... |. .| ... .||.. . .. .. .|. .|. . |...... .. AFGKVYKCRHKK-TGRIVAIKIIK-----EHIRREIQILKK-----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR SVAQQCLKGLEELHRMGFIHRNVAPSVFAIGRYTGDNQSDLRNIYILDFGFAHQYMIKDGTLKPPSAHPWKYVGSLRHM-PRAAYSKVEFSRMEDLEMWF ....| ...|| .|..|.||| . |. . . .| | |||.| |. ..|.. | | FYMYQICCALEYCHSHGIIHRDLKPENILLDE----------HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---------------G YMS------------VELVKGCLPWAHLKKPKEVHDYQKLCRNGLQMREMLGGLPPEFVDIMQIVDKLSFTDTPNYTEIYGLLT-------NAIL | |.. |. |. ..|.. .. . . ....|. | . . .|. . YGKCKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | C34B2.3.AA | CK1 | 287-315 | 26 | 9e-06 | 16.08 | In-house | 242-271 (271) | Show / Hide |
Range on Protein: 287-315 Range on HMM: 242-271/271 Sequence Identity: 26% (8 aa) EMLGG-LPPEFVDIMQIVDKLSFTDTPNYT .. | .| ||.. .... .|.| ..|.|. QLCKGNFPNEFAMYLNYCRQLHFEEKPDYM |
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| Kinase | C34B2.3.AA | Dual | 293-321 | 20 | 0.002935 | 6.66 | In-house | 254-282 (282) | Show / Hide |
Range on Protein: 293-321 Range on HMM: 254-282/282 Sequence Identity: 20% (6 aa) PPEFVDIMQIVDKLSFTDTPNYTEIYGLL | ..... |. .... || | . | PRRLKPLVSYVNGYQYDSTPDYDYFRNCL |
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