Gene C39H7.1 (Nematode worm)

C39H7.1

Species: Nematode worm
Alias: aSWK122, C39H7.1, CE06942
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: IV: 5631922-5633312, WormBase Genetic Map location: IV:2.06,

Classification

Group: CK1
Family: Worm6

Sequence

Name Sequence Type Origin Length Description Download
C39H7.1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 260 Kinase domain by global Sugen HMM Fasta, JSON
C39H7.1.AA Protein Genbank 308 None Fasta, JSON

Protein domain

Protein domains of C39H7.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase C39H7.1.AA Worm6 17-276 49 1e-163 550.19 In-house 1-279 (279) Show / Hide 
Range on Protein: 17-276
Range on HMM: 1-279/279
Sequence Identity: 49% (139 aa)

WSIEKKLGEGGFGAVYRVFDATGK----YAMKVEG--ANEQIQVLKLEVSVLNELSKRGNRHFCKIEDKGRFGN--FNYVVMTLVGKSLQDLNKAGVGGH
|...||.||||||||| | |...|    .|||.|.  .|...|.||.|..||... ....||||||||.|...|  |||.|||||||.|.|| |.  ...
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

MSMGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGR---PELNEIRKVYILDFGMCR-KFTGNDGT-IRKPR-QAAGFRGTVKYAPISCHLQRELCR
.|||....|.||.|||.|||||.|..||||||||..|||    |.||....|.||||||| |.. |.|. .|.|| .|.||||||.|||..|| ..|.||
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

KDDLETWMYMQVELSHGTIPWQHISDMNQVG-QAKQAIRNN---LGTLFPPPCPQ-QFQDIMRMVDAMKYYDAPNYQAI
|||.|.|.||.||. .|..||.|..|...|. ..|...|..   . ..|  |||. .|.||| ..| ..|.|.|.|. |
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase C39H7.1.AA CK1 17-276 33 2e-117 396.38 In-house 1-339 (339) Show / Hide 
Range on Protein: 17-276
Range on HMM: 1-339/339
Sequence Identity: 33% (115 aa)

WSIEKKLGEGGFG-AVYRV-----FDATGK-------YAMKVEGANEQIQ-VLKLEVSVLNELSKRG---------NRHFCK----------IEDKGRFG
| ..||.|||||| ..|.|      | ...       |||||| ...  |  ...|.... .. ..|         ..||||          ....|. .
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

N-FNYVVMTLVGKSLQDLNK--AGVGGHMSMGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPE-----------LNEIRKVYILDFGMCR-KFT
. .||.||||.|..|.|| |  .  ....||.... |.|| |||||..|..|..|||.||.|. .|| |            || |.||..||||.| |..
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

GNDGT------------IRKPRQ---AAGFRG-TVKYAPISCHLQRELCRKDDLETWMYMQVELSHGT--IPWQHISDMNQ-----VGQAKQAIRNN---
 .||.            .| ||    ..|||| |..|..|.|||..|..|.|||..|.|| .|.  ||   |||...| ..     |...|......   
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

LGTLFPPPCP-------QQFQDIMRMVDAMKYYDAPNYQAI
. ..|  .||       |.| .|| .....||||.|.|..|
STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase C39H7.1.AA TTBKL 17-280 37 1.6e-88 298.96 In-house 1-288 (288) Show / Hide 
Range on Protein: 17-280
Range on HMM: 1-288/288
Sequence Identity: 37% (109 aa)

WSIEKKLGEGGFGAVYRVFDAT--GK-YAMKVEGAN-EQI-QVLKLEVSVLNELSKRGNRHFCKIEDKGRFGNFNYVVMTLVGKSLQDLNKAGVGGH-MS
| |.|..||||||.||.| | .  .. .|||.|    | . ...|.|| ||..|...| .||.|. . |. ...|..||||.|..|||| |    .. .|
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

MGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELN--EIRKVYILDFGMCRKFTGNDG-----------TIRKPRQ---AAGFRGTVKYAPISC
 | .  |||| |.|| ..| .|..||||||.|. .|  . .  . | ||..||||.|..  .||           ..|.||     |.||||..|. .  
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HLQRELCRKDDLETWMYMQVELSHGTIPWQHISDMNQVGQAKQAIRNNLGTLFP-PP----CPQQFQDIMRMVDAMKYYDAPNYQAIYGMM
|. .|. |.|||  |||| .||  |  ||....|  .....|..   .. .||  .|    ||..| ..|... ...||| |.|. ||  .
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNM--KDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase C39H7.1.AA TTBK 17-276 42 8.1e-86 291.42 In-house 1-257 (257) Show / Hide 
Range on Protein: 17-276
Range on HMM: 1-257/257
Sequence Identity: 42% (111 aa)

WSIEKKLGEGGFGAVYRVFDATGK---YAMKVEGANEQIQVLKLEVSVLNELSKRGNRHFCKIEDKGRFGNFNYVVMTLVGKSLQDLNKAGVGGHMSMGC
| . || | |||| .|   |   .    |.||| |. . ||||.|| ||  |   |  | |.    ||  .|||.||.| ||.| ||  .   |  |.. 
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKL--QGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLST

SIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEIRKVYILDFGMCRKFTGNDGTIRKPRQAAGFRGTVKYAPISCHLQRELCRKDDLETWMYMQ
 . .|.| |...|  |..|.||||.|| |. .||    ..||.|.||||. |..|   | .| ||..||||||| || |  |. ||. |.|||    || 
TLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGR-NPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYML

VELSHGTIPWQHISDMNQVGQAKQAIRNNLGTLFPPPCPQQFQDIMRMVDAMKYYDAPNYQAI
||  .|  ||  | | .|||. |.  . ..  |    ||..|.  |  .  ..| | |.|| |
VEFVQGQLPWRKIKDKDQVGEMKE--KYDHRMLL-KHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase C39H7.1.AA Dual 17-280 28 6.2e-47 155.81 In-house 1-282 (282) Show / Hide 
Range on Protein: 17-280
Range on HMM: 1-282/282
Sequence Identity: 28% (82 aa)

WSIEKKLGEGGFGAVYRVFDATG------KYAMKVEGANEQIQVL--KLEVSVLNELSK-------RGNRHFCKIEDKGRFGN--FNYVVMTLVGKSLQD
| . . || |||. ||.|..         .|..|.|  ...   |  | |. |  . .         |...|    | |       .|.|| ..| |||.
WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQE

LNKAGVGGHMSMGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEI-RKVYILDFGMCRKFTG-NDGTIRKPRQAAGFRGTVKYAPISCHLQ
  .  . | .|| ||  ..|| |.|. |||.||||||..|| |. .|   |..   .|| .||.. ||.     .  | .|    . |.  || . | .|
IRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCG---LGMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQ

RELCRKDDLETWMYMQVELS-HGT-IPWQHISDMNQVGQAKQAIRNNLGTLFPPPCPQQFQDIMRMVDAMKYYDAPNYQAIYGMM
..  ||||||.| ||   |  ..  ..|    | | . ..|..   . .     . |... ..  .|. . |  .| | ..  ..
KDQGRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKDNFMYHFDKHQYSHIPRRLKPLVSYVNGYQYDSTPDYDYFRNCL
Kinase C39H7.1.AA CK1-Unique 17-224 32 1.7e-46 159.18 In-house 1-233 (337) Show / Hide 
Range on Protein: 17-224
Range on HMM: 1-233/337
Sequence Identity: 32% (76 aa)

WSIEKKLGEGGFGAVYRVFD-ATG-------KYAMK--VEGANEQIQVLKLEVSVLNELSKRG-----NRHFCKIEDKGRFGNFNYVVMTLVGKSLQDLN
| . |..| ||.| |.|| . ..|       .|.||  . ..    | |. | .|. ...|        ||||...| .  .   . |||..|.|.  . 
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

KAGVGGHMSMG------CSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEIRKVYILDFGMCRK--FTGNDGTIRKPRQAAGFRGTVKYAPIS
 .  .  .  .      | |  | | |...|  |  |..||. ||.||  . |   . .  |.||.| ||.  |  | . ||.||  . |||. .|.|.|
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS

CHLQRELCRKDDLETWMYMQVELSHGT--IPWQ
||. ||. |.||.|.| || . | |.|  . |.
CHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK
Kinase C39H7.1.AA CK1-Unclassified 17-226 30 3.1e-26 74.43 In-house 1-219 (244) Show / Hide 
Range on Protein: 17-226
Range on HMM: 1-219/244
Sequence Identity: 30% (67 aa)

WSIEKKLGEGGFGAVYRVFDA--TGKYAMKVEGANEQIQVLKLEVSVLNELSKRGNR-----HFCKIEDKGRF--GNFNYVVMTLVGKSLQDLNKAGVGG
  ...|.| | || .| . .     ..|.|.| .|  .  |. |. ....| .. |      .. |.   |.   |..|..||.| |.|| || .   ..
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNM-CNR

HMSMGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIG-RPELNEIRKVYILDFGMCRKFT--GNDGTIRKPRQAAGFRGTVKYAPISCHLQRELCRKD
  |.     |. | .. .| ||| ...||| || |. .| .   ..  .||| |||   ..    ..|.    |   .. ||  || |  ||  |  |.|
KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLG--KNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRD

DLETWMYMQVELSHGTIPWQHI
|||  .|  . .  |. ||| |
DLESLGYVLIYFLKGSLPWQNI
Kinase C39H7.1.AA CK1 17-224 28 4.9e-25 83.25 In-house 1-217 (271) Show / Hide 
Range on Protein: 17-224
Range on HMM: 1-217/271
Sequence Identity: 28% (62 aa)

WSIEKKLGEGGFGAVYRVFDATGK----YAMKVEGANEQIQVLKLEVSVLNELSK---RG-NRHFCKIEDKGRF--GNFNYVVMTLVGKSLQDLNKAGVG
  ...|.|.| || .| . . | .    .|.|.| ..   . |. |. ....| .    .   .. ..   |.   |..|..||.| |.|| || .   .
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDL-FNFCN

GHMSMGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEIRKVYILDFGMCRKFT-GNDGTIRKPRQAAGFRGTVKYAPISCHLQRELCRKDD
.. |.   . |. | .. .| .|| ...|||.|| |. .||   ..  .||| |||.  ..   ....    |   .. ||. || |  || .|  |.||
RKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGR-YGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDD

LETWMYMQVELSHGTIPWQ
.|  .|. . .  |. |||
MESLGYVLMYFLRGSLPWQ
Kinase C39H7.1.AA CK1-D 17-276 26 6.7e-25 84.68 In-house 1-261 (261) Show / Hide 
Range on Protein: 17-276
Range on HMM: 1-261/261
Sequence Identity: 26% (71 aa)

WSIEKKLGEGGFGAVY--RVFDATGKYAMKVEGANEQIQVLKLEVSVLNELSKRGNRHFCKIEDKGRFGNFNYVVMTLVGKSLQDLNKAGVGGHMSMGCS
. | .|.| | || .|      .    |.|.| .  .   |..|  .   ..  |     .|   |. |..| .|| |.| || ||     . . |.   
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQ--GGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNY-CHRKFSLKTV

IGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEIRKVYILDFGMCRKFTGNDGTIRKP-RQAAGFRGTVKYAPISCHLQRELCRKDDLETWMYMQ
. .. | .  .| .|   ..|||.|| |. .|     ..  |||.|||. ...         | |      || .|| |  |.  |  |.||||   |. 
LMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNM--VYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVL

VELSHGTIPWQHISDMNQVGQAKQAIRNNLGTLFPPPC---PQQFQDIMRMVDAMKYYDAPNYQAI
.   .|..||| .  ...  .  . .   . |     |   |..||. |  .  .|. | |.|  .
MYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase C39H7.1.AA CK1-A 17-276 25 7e-24 81.15 In-house 1-261 (261) Show / Hide 
Range on Protein: 17-276
Range on HMM: 1-261/261
Sequence Identity: 25% (68 aa)

WSIEKKLGEGGFGAVYRVFDATG--KYAMKVEGANEQIQVLKLEVSVLNELSKRGNRHFCKIEDKGRFGNFNYVVMTLVGKSLQDLNKAGVGGHMSMGCS
. . .|.| | || .|     |     |.|.| .. .   |  |  | . |.  |   . ...  |.  ..| .|| |.| || ||       . .|   
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQ--GCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNF-CKRRFTMKTV

IGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEIRKVYILDFGMCRKFTGNDGTIRKP-RQAAGFRGTVKYAPISCHLQRELCRKDDLETWMYMQ
. .  | .  .| .|. ...|||.|| |. .|        |....|||. .|.  .   .  | |.     ||..|| |  ||  |  |.||.|   |. 
LMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGR--HCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVM

VELSHGTIPWQHISDMNQVGQAKQAIRNNLGTLFPPPC---PQQFQDIMRMVDAMKYYDAPNYQAI
.    |..||| .  |..  .  .     . |     |   | .|  .|  . .... ..|.|  .
MYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase C39H7.1.AA S_TKc 17-268 16 1.9e-12 5.72 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-268
Range on HMM: 1-231/231
Sequence Identity: 16% (49 aa)

WSIEKKLGEGGFGAVYRVFDAT--GKYAMKVEGANEQIQVLKLEVSVLNELSKRGNRHFCKIEDKGRFGNFNYVVMTLVGK---SLQDLNKAGVGGH---
. | .|.|.|.|| ||.. .     ..|.|.       . .. |...| .    .  . .|. |  .  .. |.|| ...    .| |. |   ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-MSMGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEIRKVYILDFGMCRKFTGNDGTIRKPRQAAGFRGTVKYAPISCHLQRELCRKDDLE
 ..      .  | ..||| .|. | .|||.|| |  . .        . | |||..|..               | ||  | .                
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL------------

TWMYMQ------------VELSHGTIPWQHISDMNQVGQAKQAIRNNLGTLFPPPCPQQFQDIMRMVD------------A-------MKYY
   |               |.  |  |..      |. .  . |.           |.  . |... .            .       . . 
--GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase C39H7.1.AA TyrKc 17-280 17 2.4e-05 -136.19 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-280
Range on HMM: 1-280/280
Sequence Identity: 17% (54 aa)

WSIEKKLGEGGFGAVYR-VFDATGKYAMKVEGANEQIQVLKLEVSVLNEL--SKRGNRHFCK-----IEDKGRF---GNFNYVVMTLVGK-SLQDLNKAG
 . .|||||| || ||. . .   . | |.  ..  .. .  | ... .|  .   . .  .     ......|   .   ..|| .. . .|.|  .. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-REDFMREARIMCKLGGH---HPNIVRLYGVCTQQGRNFMYIEPL-MIVMEYMPHGDLKDYLRKH

VGGHMSMGCSIGIGIQSLEALEDLHNIGYLHRDVKPGNYTIGRPELNEIRKVYILDFGMCRKFTGND--GTIRKPRQAA----GFR--GTVKYAPISCHL
 .   .|   . . .|  .  | ||  .. |||    |  .|..       | | |||..|. .  |  |  .|    .    | .    ..  ..    
RPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAP----

QRELCRKDDLETWMYMQVE---------------LSHGTIPWQH-ISDMNQVGQAKQAIRNNLGTLFPPP--------CPQQFQDIMRMVDAMKYYDAPN
          |...|                   .. |  |.   |  |    .. . ...      ||         ||.   .||..  . .  | |.
----------ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT

YQAIYGMM
 ..|.  .
FSEIHECF
Kinase C39H7.1.AA Pkinase 17-45 32 4.2e-05 19.12 Pfam 1-31 (293) Show / Hide 
Range on Protein: 17-45
Range on HMM: 1-31/293
Sequence Identity: 32% (10 aa)

WSIEKKLGEGGFGAVYRVFDATGK--YAMKV
. |..|.|.|.|| ||.  .      .|.|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKI
Kinase C39H7.1.AA CK1 251-274 16 0.001463 8.36 In-house 248-271 (271) Show / Hide 
Range on Protein: 251-274
Range on HMM: 248-271/271
Sequence Identity: 16% (4 aa)

CPQQFQDIMRMVDAMKYYDAPNYQ
.| .|.. .. .  ......|.|.
FPNEFAMYLNYCRQLHFEEKPDYM
Kinase C39H7.1.AA Pkinase 122-191 30 0.011555 10.5 Pfam 118-179 (293) Show / Hide 
Range on Protein: 122-191
Range on HMM: 118-179/293
Sequence Identity: 30% (22 aa)

LEALEDLHNIGYLHRDVKPGNYTIG-RPELNEIRKVYILDFGMCRKFTGNDGTIRKPRQAAGFRGTVKYAP
|..|| .|. | .|||.|| |  |  ......  .| | ||| ...|      . . . . .| ||  |..
LRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMA