Gene C44C10.7 (Nematode worm)

C44C10.7

Species: Nematode worm
Alias: aSWK271, C44C10.7, CE05414
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: X:5.8, WormBase Physical Map location: X: 11691999-11690730,

Classification

Group: Other
Family: Worm5

Sequence

Name Sequence Type Origin Length Description Download
C44C10.7.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON
C44C10.7.AA Protein Genbank 341 None Fasta, JSON

Protein domain

Protein domains of C44C10.7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase C44C10.7.AA Worm5 51-308 57 1.4e-225 683.86 In-house 1-260 (260) Show / Hide 
Range on Protein: 51-308
Range on HMM: 1-260/260
Sequence Identity: 57% (150 aa)

YEIISVLGGGAFGTVYSCVDVDDRLNQLAIKAMDLST-VTRENSYKLELMVLQRVETLSEVEQTRFSKLIGNFIQDSSLGFFVMHKEGECVDEVWMRNKS
|.||.|||.|..||.|.|||.|||.||||||||.... ...||..||||||.||..||...|..||.....||..||....|||||||.|...||||||.
YYIIYVLGEGEYGTIYACVDMDDRHNQLAIKAMNFEHGIQCENCFKLELMVFQRIDTLGNNERNRFPQFCDNFQVDSTYYCFVMHKEGDCLNDVWMRNKN

GRFSASNVLKIVHCMAHGLRSLHKIGFIHRDCHAGNILFASRLTPTAPVKIVDFGIGRRFANRRGHPIPS-PSRDIDFLGCEHCSVNVHVGGIPGPKDDF
.|||..|||||..||.|.|..||.|||||||||..||.||.|.||..|.|..|||||.||.|||||.... |.||..|..|.|||.|||.||||..||||
KRFSRKNVLKIMCCMSHSLQTLHSIGFIHRDCHWQNIMFAKRITPINPCKLIDFGIGKRFKNRRGHYCKDRPQRDVNFKDCRHCSWNVHCGGIPRKKDDF

LSMVLLAIRMSGIHAISYENSETNLCQKKSFESNPAQFLMRCPWLVPVSVAIIKNDPNRF
.||..||.||||||...|||.|...|||..|..||.||||.|||...|.....|.....|
ESMMYLALRMSGIHCYRYENKEQRFCQKMKFHFNPEQFLMNCPWMTIVFKSMRKQNDDDF
Kinase C44C10.7.AA CK1 51-247 19 1.3e-22 75.75 In-house 1-253 (339) Show / Hide 
Range on Protein: 51-247
Range on HMM: 1-253/339
Sequence Identity: 19% (50 aa)

YEIISVLGGGAFG-TVYSC-----VDVDDRL----NQLAIKAMDLSTVTRENSYKLELMVLQRVE--------TLSEVEQTRFSK----------LIGNF
....  .|.|.|| ..| .     .|...       . |.|.   ..  .  . . |  ...  .         |   .   |.|          ..  .
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASIL---KHKHFCKKHCGCPHPCMYWYHG

IQDSSLGFFVMHKEGECVDEVWM--RNKSGRFSASNVLKIVHCMAHGLRSLHKIGFIHRDCHAGNILFAS------RLTPT-------APVKIVDFGIGR
 .|    . ||   |.  ... .  |.  ..|| . .|.|  .|  .|. .| .||||||  ..|...            .         | ..|||. |
EEDDYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKH-HHEWNNEHRQVYMIDFGMAR

-RFANRRGHP----------IPSPSRD----IDFLG--CEHCSVNVHVGGIPGPKDD
 ......||.          .. | |.      | |  ...||.|.| |  .|..||
RKYRDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDD
Kinase C44C10.7.AA Worm7 132-260 32 1.2e-13 42.0 In-house 79-206 (263) Show / Hide 
Range on Protein: 132-260
Range on HMM: 79-206/263
Sequence Identity: 32% (42 aa)

VMHKEGECVDEVWMRNKSGRFSASNVLKIVHCMAHGLRSLHKIGFIHRDCHAGNILFASRLTPTAPVKIVDFGIGRRFANRRGHPIPSPSRD-IDFLGCE
||  ||    .|  ||    ||  ||. |   .   |   |  .||||| |. |.|  .     . . ..|||   ||    |  .|    |  ..  | 
VMSEEGQNLRDVVKRNNNKPFSTNNVIRIAWQIGSTLCFIHNKSFIHRDVHSQNVLV-TLKNKVCKMVLIDFGNAVRFKDVNGNELPQ-FNDGYQYHHCV

HCSVNVHVGGIPGPKDDFLSMVLLAIRMSG
| |.||  |     .||  |.. | . | |
HKSINVMKGNPHTCRDDWISLIYLCVEMHG
Kinase C44C10.7.AA SLK 51-205 28 1.9e-13 41.64 In-house 1-143 (259) Show / Hide 
Range on Protein: 51-205
Range on HMM: 1-143/259
Sequence Identity: 28% (44 aa)

YEIISVLGGGAFGTVYSCVDVDDRLNQLAIKAMDLSTVTRENSYKLELMVLQRVETLSEVEQTRFSKLIGNFIQDSSLGFFVMHKEGECVDEVWMRNKSG
.|||  || |||| ||  ..  ..    | | ...     ..  .||  .   .. |||..     ||.. .  |  |  .. . .|  ||.. | .   
WEIIGELGDGAFGKVYKAQHK-EQKVFAAAKMIEI-----KDEEELEDYMVE-IDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNI-MVELEH

RFSASNVLKIVHCMAHGLRSLHKIGFIHRDCHAGNILFASRLTPTAPVKIVDFGI
    . .  . . |  .|. ||.   ||||  |||||    .|    |.. |||.
PLTEDQIQYVCKHMCEALNWLHSNKVIHRDLKAGNIL----MTMDGDVRLADFGV
Kinase C44C10.7.AA CAMK 56-209 14 1.4e-11 32.88 In-house 1-246 (425) Show / Hide 
Range on Protein: 56-209
Range on HMM: 1-246/425
Sequence Identity: 14% (37 aa)

VLGGGAFGTVYSCVDVDDR-----------LNQLAIKAMDLSTVTREN----------------------SYKLELMVLQRVETLSEVEQTRF---SKLI
.|| |.||.|. |..  .              . ||| .| . ..  .                      . | . .|.. .| .. . ...     . |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

GNFIQ---------------DSSL--------GFFVM-----HKEGECVDEVWMRNKS----------------GRFSASNVLKIVHCMAHGLRSLHKIG
 ....                 |          ..||        ||  |..  . ..                |||. . . .... .. ... .|. .
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

FIHRDCHAGNILFASRLTPT-------------APVKIVDFGIGRRF
 .|||    |||. .. . .             ...||.|||  ..|
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKF
Kinase C44C10.7.AA S_TKc 51-323 17 3.7e-11 -13.33 SMART 1-231 (231) Show / Hide 
Range on Protein: 51-323
Range on HMM: 1-231/231
Sequence Identity: 17% (52 aa)

YEIISVLGGGAFGTVYSCVDVDDRLNQLAIKAMDLSTVTRENSYKLELMVLQRVETLSEVEQTRFSKLIGNFIQDSSLGFFVMHKEG--ECVDEVWMRNK
|||. ..| ||||.|| |....    . ||| ..       .. . |. .|..             ||.. |   ..| ..  . .|    . ..  ...
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

SGR----FSASNVLKIVHCMAHGLRSLHKIGFIHRDCHAGNILFASRLTPTAPVKIVDFGIGRRFANRRGHPIPSPSRDIDFLGCEH------CSVNVHV
...    |.   . .... .. .|  .|. |.||||    |||. .       .|| |||. |..                | |  .      .      
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL--------------TTFCGTPWYMAPEVL------

GGIPGPKDDFLSM-VLLAIRMSGIHAISYENSETNLCQKKSFESNPAQFLMRCPWLVPVSVA-----IIKNDPN-RFNYDCVIH---AIENASLF
 |  ..| |  |  ..|.. ..|    .    .  . .|                  . ..      . . ||. |     . .   .| .   |
-GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase C44C10.7.AA MLCK 51-70 45 1.6e-10 23.42 In-house 1-20 (257) Show / Hide 
Range on Protein: 51-70
Range on HMM: 1-20/257
Sequence Identity: 45% (9 aa)

YEIISVLGGGAFGTVYSCVD
|.|...||.|.||.|. |..
YQIHEELGRGKFGIVHRCIE
Kinase C44C10.7.AA STE20 51-103 20 1.1e-08 28.16 In-house 1-60 (288) Show / Hide 
Range on Protein: 51-103
Range on HMM: 1-60/288
Sequence Identity: 20% (13 aa)

YEIISVLGGGAFGTVYSCVDVDDRLNQL-----AIKAMDLSTV----TRENSYKLELMVLQR
||.. ..| |..|.|| .   . . ...     ||| |.|..      .... . |  ....
YELLEKIGQGSYGKVYKA--YHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQ
Kinase C44C10.7.AA STE 51-103 19 1.1e-08 26.87 In-house 1-84 (359) Show / Hide 
Range on Protein: 51-103
Range on HMM: 1-84/359
Sequence Identity: 19% (16 aa)

YEIISVLGGGAFGTVYSCVDVD-----DRLNQ---------LAIKAMDLSTV-----------------TRENSYKLELMVLQR
.|.|...| ||||||| .....     .  ..          ||| |.|..                  . ..... |. ....
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKK
Kinase C44C10.7.AA STE 140-205 28 5.1e-08 24.55 In-house 128-193 (359) Show / Hide 
Range on Protein: 140-205
Range on HMM: 128-193/359
Sequence Identity: 28% (21 aa)

VDEVWMRNKS--------GRFSASNVLKIVHCMAHG-LRSLHKIGFIHRDCHAGNILFASRLTPTAPVKIVDFGI
........|.        .||. | . .|..   .| |  ||. . ||||  ..|||.         ||..|||.
IKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCDFGV
Kinase C44C10.7.AA Pkinase 51-104 22 1.2e-07 28.18 Pfam 1-57 (293) Show / Hide 
Range on Protein: 51-104
Range on HMM: 1-57/293
Sequence Identity: 22% (13 aa)

YEIISVLGGGAFGTVYSCVDVDDRLNQLAIKAMDLSTVTRENSYKL----ELMVLQRV
|.|....| |.||.|| |......  . |.| .....   .  . .    |. ...|.
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL
Kinase C44C10.7.AA AGC 51-84 30 1.2e-07 14.3 In-house 1-39 (395) Show / Hide 
Range on Protein: 51-84
Range on HMM: 1-39/395
Sequence Identity: 30% (12 aa)

YEIISVLGGGAFGTVYSCVDVD-----DRLNQLAIKAMD
.|.. |.| |.||.|| . ..|     |   . |.| ..
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLK
Kinase C44C10.7.AA AGC 163-204 36 6.5e-07 12.36 In-house 161-200 (395) Show / Hide 
Range on Protein: 163-204
Range on HMM: 161-200/395
Sequence Identity: 36% (16 aa)

CMAHGLRSLHK-IGFIHRD-CHAGNILFASRLTPTAPVKIVDFG
|.. .| .||.  |.||||     |||. ..      .|..|||
CIVLALEYLHSHMGIIHRDYLKPENILLDED----GHIKLTDFG
Kinase C44C10.7.AA Worm6 51-82 33 1e-06 20.38 In-house 1-33 (279) Show / Hide 
Range on Protein: 51-82
Range on HMM: 1-33/279
Sequence Identity: 33% (11 aa)

YEIISVLGGGAFGTVYSCVDVDDRLN-QLAIKA
...   .| |.||.||.. | .|  . | |.|.
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKC
Kinase C44C10.7.AA Worm6 150-185 41 4.1e-05 14.67 In-house 99-134 (279) Show / Hide 
Range on Protein: 150-185
Range on HMM: 99-134/279
Sequence Identity: 41% (15 aa)

GRFSASNVLKIVHCMAHGLRSLHKIGFIHRDCHAGN
..|| .  |||   .  ... ||..||||||  .||
RKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGN
Kinase C44C10.7.AA Pkinase 148-209 34 4.5e-05 19.03 Pfam 99-162 (293) Show / Hide 
Range on Protein: 148-209
Range on HMM: 99-162/293
Sequence Identity: 34% (22 aa)

KSGRF--SASNVLKIVHCMAHGLRSLHKIGFIHRDCHAGNILFASRLTPTAPVKIVDFGIGRRF
..|.|  |   . ...  .. ||  .|. |.||||    |||. .. .. |.||| |||. . |
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQF
Kinase C44C10.7.AA TyrKc 51-258 14 0.000126 -147.85 SMART 1-280 (280) Show / Hide 
Range on Protein: 51-258
Range on HMM: 1-280/280
Sequence Identity: 14% (43 aa)

YEIISVLGGGAFGTVYSCVDVDDRLNQLAIKAMDLSTVTRENSYKLELMVLQRV--ETLSEVEQTRFSKLIGNFIQDS------SLGFFVM-HKEGECVD
 . . .|| ||||.|| ..       | |.| .  ..   .     |. .. ..  .    |      .|.|  .|..         . || . .. . .
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIV------RLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

EVWMRNKSGRFSASNVLKIVHCMAHGLRSLHKIGFIHRDCHAGNILFASRLTPTAPVKIVDFGIGRRFANR----------R-----GHP--IP------
.   ...   .. .  |.. .  | | . ||. ..||||  | |.| ....     ||| |||  |   .           |     |    .|      
DYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

-----------------------------SPSRD---IDFLGCEHCSVNVHVGGIPGPKDD----------------------F-----LSMVLLAIRM
                             .|  .     ..  ..   .|  |. . . ..                      .      ..  .  ..
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase C44C10.7.AA STE20 171-204 50 0.00052 10.89 In-house 133-162 (288) Show / Hide 
Range on Protein: 171-204
Range on HMM: 133-162/288
Sequence Identity: 50% (17 aa)

LHKIGFIHRDCHAGNILFASRLTPTAPVKIVDFG
||. . ||||  |.|||    ||  . ||..|||
LHSNHIIHRDIKADNIL----LTEDGEVKLADFG
Kinase C44C10.7.AA Worm7 51-70 40 0.121512 1.11 In-house 1-20 (263) Show / Hide 
Range on Protein: 51-70
Range on HMM: 1-20/263
Sequence Identity: 40% (8 aa)

YEIISVLGGGAFGTVYSCVD
|  |   | | || |   .|
YKLIHKIGNGQFGEVWQVID