Gene C49C3.2 (Nematode worm)
C49C3.2
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| C49C3.2.AA | Protein | Genbank | 330 | None | Fasta, JSON |
| C49C3.2.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 266 | Kinase domain by global Sugen HMM | Fasta, JSON |
Protein domains of C49C3.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | C49C3.2.AA | Worm6 | 26-285 | 33 | 6.4e-133 | 447.88 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 26-285 Range on HMM: 1-279/279 Sequence Identity: 33% (93 aa) YKLSAPIATGPFSSVFLVEE--DGV--PYAMKVEAE-KSCVRPVLKLDHAVLTALGNQT--GFPSLMDSGRTDS--FKYIVMQLVGPDLSTLLEFAPQNR .|....|..|.|..|..||. |. ..|||.|.. ... |..||....||.|.... .|....| |..|. |.||||.|||..|. | ...|... WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK FSQSTIYKIALQTLDRLRVLHHAGWLNRDVKAQNFAVGF-----GEESNIVYMLDFGLTR--RFLELDGSRHLLR-PWGPSVGTFPYAPLSSLGFLDQTP || .| .|||.|.|.....||..|...||||..||..| .|. ..||||||..| .... ..... | .. ...||..||||.. . .| . FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR ADDVEGWLYMIIHLLNG-LPWHNSKRSLSLAKVREWKMYCRRAGGRTQLFRDIPD-GWSDVFDIILKTSYQEYPDYTKI ||.|.|.||..... | |||...|.. . .|...|.....||......|. .| ...|..|.|...||...|||..| KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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| Kinase | C49C3.2.AA | CK1 | 26-285 | 23 | 8e-82 | 278.15 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 26-285 Range on HMM: 1-339/339 Sequence Identity: 23% (79 aa) YKLSAPIATGPFS-SVFLV-----EEDGVP-------YAMKVEAEKSCVRPVLKLDHAVLTALGNQT-----------GFPS----------LMDSGRTD .|. .|..| | ...| . . |||||| .|| .. .... ... .. .. .|.. ....|..| WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED S-FKYIVMQLVGPDLSTLLE--FAPQNRFSQSTIYKIALQTLDRLRVLHHAGWLNRDVKAQNFAVGF-------------GEESNIVYMLDFGLTR-RFL ..|.||.|.||.|. |.. . ....|| .|...||.|.|..|...| .|.. ||.|..||..| ..|...|||.|||. | ... DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR ELDGSR------------HLLRP---WGPSVG-TFPYAPLSSLGFLDQTPADDVEGWLYMIIHLLNG---LPWHNSKRSLS---LAKVREWKMYCRRAGG . ||.. |. . .| |. |..... .|.. ||.. |.||.|..| | |||.| |. .. |...|. ... DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQ-VEKMKYEFIDEKK RTQLF--------RDIPDGWSDVFDIILKTSYQEYPDYTKI ..| .|.|. . .....| . .|.. ||| .| MSTPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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| Kinase | C49C3.2.AA | TTBKL | 26-179 | 29 | 8e-40 | 132.17 | In-house | 1-165 (288) | Show / Hide |
Range on Protein: 26-179 Range on HMM: 1-165/288 Sequence Identity: 29% (48 aa) YKLSAPIATGPFSSVF--LVEED-GVPYAMKVEAEK-SCVRPVLKLDHAVLTALG--NQTGFPSLMDSGRTDSFKYIVMQLVGPDLSTLLEFAPQNR-FS .. |. | | .|. . .| . .|||.| . . ..|. . ||..| ... || ...||..... ..||.|.||.|. | |... || WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS QSTIYKIALQTLDRLRVLHHAGWLNRDVKAQNFAVGFGEE----SNIVYMLDFGLTRRFLELDGS ..|.. |. |.|. |. .| .|.. |||| .|...|. .. . .|| .|||..|.... ||. DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGE |
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| Kinase | C49C3.2.AA | Dual | 81-289 | 26 | 2.2e-28 | 92.44 | In-house | 72-282 (282) | Show / Hide |
Range on Protein: 81-289 Range on HMM: 72-282/282 Sequence Identity: 26% (56 aa) FPSLMDSGR--TDSFKYIVMQLVGPDLSTLLEFAPQNRFSQSTIYKIALQTLDRLRVLHHAGWLNRDVKAQNFAVGFGEESNIVYMLDFGLTRRFLE-LD |... | | .| ||.|| ..|| | . . . .| .. . .|.|.|. .. || .|.|.|..| ||..| |.. |||.||.. | ... FIEFVDYGKCEQDKCKYWVMSPYGPSLQEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYMQDFRIVRKYIDPEN GSRHLLRPWGPSVGTFPYAPLSSLGFLDQTPADDVEGWLYMIIHLL---NGLPWHNSKRSLSLAKVREWKMYCRRAGGRTQLFRDIPDGWSDVFDIILKT . | |. || .. || ||.| | ||. |. .|..| .. ... | . || . . . || . . . . KKHRTARKKVKMYGCGRYACRACMMQKDQGRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKDNFMY----HFDKHQYSHIPRRLKPLVSYVNGY SYQEYPDYTKILNKV .|. ||| ..| QYDSTPDYDYFRNCL |
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| Kinase | C49C3.2.AA | TTBK | 51-178 | 37 | 5.1e-25 | 85.39 | In-house | 29-156 (257) | Show / Hide |
Range on Protein: 51-178 Range on HMM: 29-156/257 Sequence Identity: 37% (49 aa) AMKVEAEKSCVRPVLKLDHAVLTALGNQTGFPSLMDSGRTDSFKYIVMQLVGPDLSTLLEFAPQNRFSQSTIYKIALQTLDRLRVLHHAGWLNRDVKAQN |.||| . . |||. ||| | . . || | | |.|||| | |. | .|. || || .. .| |. .. | |.| ||.| | AIKVESAQQ-PKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSN FAVG-FGEESNIVYMLDFGLTRRFLELDG ||.| . .. ...||||||| |... | FAMGRNPSTCRKCYMLDFGLARQYTNACG |
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| Kinase | C49C3.2.AA | CK1-Unique | 81-228 | 25 | 9.6e-25 | 82.72 | In-house | 72-232 (337) | Show / Hide |
Range on Protein: 81-228 Range on HMM: 72-232/337 Sequence Identity: 25% (42 aa) FPSLMDSGRTDSFKYIVMQLVGPDLSTLLEFAPQN-RFSQS------TIYKIALQTLDRLRVLHHAGWLNRDVKAQNFAVGFGE--ESNIVYMLDFGLTR |. . |.. ... ..|||...|| . . ... | | . .. . ..|.|. ... |..| ..|. | |. . . ||||.| | FCEVHDFHQHRDWWWIVMTMHGPSMEE-CCMMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICR R--FLELDGSRHLLRPWGPSVGTFPYAPLSSLGFLDQTPADDVEGWLYMIIHLLN---GLPW | |.. .. || | |. .|.| |. . ... || | |.||..||. || | RVFFVSNNHQIRQPRPITPFRGCKDYCPCSCHQCREHGRRDDMESWFYMLYHLVHNTRGLSW |
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| Kinase | C49C3.2.AA | CK1-A | 26-285 | 26 | 1e-24 | 84.13 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 26-285 Range on HMM: 1-261/261 Sequence Identity: 26% (70 aa) YKLSAPIATGPFSSVFLV--EEDGVPYAMKVEAEKSCVRPVLKLDHAVLTALGNQTGFPSLMDSGRTDSFKYIVMQLVGPDLSTLLEFAPQNRFSQSTIY |.| .| | | ..| ..| |.|.| .| | | . | . | |.| . |. . .||.|.|| | | | . ||. |. YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNK-ARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFC-KRRFTMKTVL KIALQTLDRLRVLHHAGWLNRDVKAQNFAVGFGEESNIVYMLDFGLTRRFLELDGSRHLL-RPWGPSVGTFPYAPLSSLGFLDQTPADDVEGWLYMIIHL .| | . |. .|. ... ||.| || .| | | ....||||.... . .|. | .|| || . ..|. ||.| |... MLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYF -LNGLPW---HNSKRSLSLAKVREWKMYCRRAGGRTQLFRDIPDGWSDVFDIILKTSYQEYPDYTKI . ||| . . |. | || . || . | .. . . . ..| |||. . NRGKLPWQGMKAMTKKQKYEKISEKKMSTPIE----QLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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| Kinase | C49C3.2.AA | CK1-D | 26-228 | 27 | 5.1e-23 | 77.95 | In-house | 1-205 (261) | Show / Hide |
Range on Protein: 26-228 Range on HMM: 1-205/261 Sequence Identity: 27% (57 aa) YKLSAPIATGPFSSVFLVEE--DGVPYAMKVEAEKSCVRPVLKLDHAVLTALGNQTGFPSLMDSGRTDSFKYIVMQLVGPDLSTLLEFAPQNRFSQSTIY |... | | | ... .. . |.|.|. |. | |... . . | |.. |. . .||.|.|| | | . . .|| |. YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKT-KHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYC-HRKFSLKTVL KIALQTLDRLRVLHHAGWLNRDVKAQNFAVGFGEESNIVYMLDFGLTRRFLELDGSRHL-LRPWGPSVGTFPYAPLSSLGFLDQTPADDVEGWLYMIIHL .|.| . |. .| .. ||.| || .| | |.||..||||..|. . .|. | || || . ..| ||.| |... MLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYF LNG-LPW | ||| NRGSLPW |
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| Kinase | C49C3.2.AA | CK1 | 26-181 | 28 | 3.2e-18 | 59.51 | In-house | 1-167 (271) | Show / Hide |
Range on Protein: 26-181 Range on HMM: 1-167/271 Sequence Identity: 28% (48 aa) YKLSAPIATGPFSSVFLVE--EDGVP--YAMKVEAEKSCVRPVLKLDHAVLTALGN------QTGFPSLMDSGRT--DSFKYIVMQLVGPDLSTLLEFAP |.. | .| | ..|.. .|. .|.|.| .|| | |. ... | . |.| . .|. . ..|| | ||.| |. | YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSK-HPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFC- QNRFSQSTIYKIALQTLDRLRVLHHAGWLNRDVKAQNFAVGF-GEESNIVYMLDFGLTRRFLELDGSRH . .|| |. || | ..|. ..|. . . ||.| || .| | ....||. |||| |.. . .| NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQH |
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| Kinase | C49C3.2.AA | CK1-Unclassified | 26-179 | 27 | 1.5e-17 | 48.38 | In-house | 1-166 (244) | Show / Hide |
Range on Protein: 26-179 Range on HMM: 1-166/244 Sequence Identity: 27% (47 aa) YKLSAPIATGPFSSVFLVE--EDGVPYAMKVEAEKSCVRPVLKLDHAVLTALGNQT-------GFPSLMDSGRTDS--FKYIVMQLVGPDLSTLLEFAPQ |.. | .| | .... ... .|.|.| ..| | |. ....| | |.| . .|. . . ..|| | ||.| |. . YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSK-HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMC-- N-RFSQSTIYKIALQTLDRLRVLHHAGWLNRDVKAQNFAVG-FGEESNIVYMLDFGLTRRFLEL--DGS | .|| |. || | ..|. .||. . . || | || .| | ....||. |||| |.. .|. NRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGK |
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| Kinase | C49C3.2.AA | S_TKc | 26-293 | 15 | 4.3e-10 | -28.93 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 26-293 Range on HMM: 1-231/231 Sequence Identity: 15% (45 aa) YKLSAPIATGPFSSVFLVEE--DGVPYAMKVEAEKSCVRPVLKLDHAVLTALGNQTGFPSLMDSGRTDSFKYIVMQLVGP---DLSTLLEFAPQNR---- |.. .| | |..|... . .| .|.|. .. ..| . | |. .. .. |.|| ... || .... . .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP FSQSTIYKIALQTLDRLRVLHHAGWLNRDVKAQNFAVGFGEESNIVYMLDFGLTRRFLELDGSRHLLRPWGPSVGTFPYAPLSSLGFLDQTPADDVEGWL |. .. ... |... | .| | . ||.| .| . . |||| |.. .|| | . | |. FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL------------GYG Y----------MIIHLLNGLP-WHNSKRSLSLAKVREWKMYCRRAGGRTQLFRDIPDGWSDVFDIILKTSYQEYPDYTKILN-----KVMSML . ... .| | | .. . .| .. | .. | . .|. .. | ..|. | . . KCKCDWWSCGCILYEMLCGYPPFP------------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | C49C3.2.AA | TTBKL | 204-289 | 26 | 2e-08 | 24.65 | In-house | 204-288 (288) | Show / Hide |
Range on Protein: 204-289 Range on HMM: 204-288/288 Sequence Identity: 26% (24 aa) LDQTPADDVEGWLYMIIHLLNGLPWHNSKRSLSLAKVREWKMYCRRAGGRTQLFRD------IPDGWSDVFDIILKTSYQEYPDYTKILNKV ..|.. || |.|||| |. ||||.|.. .. . |. . ..|| | .|. ... . .|.. |||..|.. KEQGRHDDLWSWMYMIIELHCGLPWTNMEDK---MEIEHMKKNMK----DEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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