Gene C49C8.1 (Nematode worm)

C49C8.1

Species: Nematode worm
Alias: aSWK089, C49C8.1, CE08836
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: IV: 8654592-8656794, WormBase Genetic Map location: IV:3.9,

Classification

Group: CK1
Family: TTBKL

Sequence

Name Sequence Type Origin Length Description Download
C49C8.1.AA Protein Genbank 517 None Fasta, JSON
C49C8.1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 365 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of C49C8.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase C49C8.1.AA TTBKL 27-391 35 8.20000000001e-145 487.39 In-house 1-288 (288) Show / Hide 
Range on Protein: 27-391
Range on HMM: 1-288/288
Sequence Identity: 35% (130 aa)

YEIVSKIDEGGFGQVF--KVTKDHKTFYAMKLESNF-QVGGSAIKLEINVLSQLPKN--TVFPELICGGKRPRYHFLVLELLGDNLKALKAQSPNPSVFS
..|| .|.|||||||.  ...||.|...||| |.|.   |.| .|.|..||..|..|  ..||...|.|||..|.|.|..|.|.||..|....||. .||
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

DGTWSRIGIQCLYAMKMMHDSGFVHRDIKPSNFAIGYSTASESRSRRVLLFDFGLARKFVKKEKNLAPIVTKKESKISKSKTLPSKGPSTKSKDLKPGRS
||||||||||||||.|.||| ||.|||.||.|...||.. |..|.|.|.|.|||.||....|.....                                .
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWN--------------------------------G

KPILNRKAEQMKIKKNFNMLIPPKSIDQSQRTAEEKVDDEEFTFRRARPHTDFRGTFQYASPNAHLQLELGRHDDIWSLMYMVAEFFVELPWTSNEEIA-
 || .... .|. ..||                              |....||||..|.|||.|. .|.|||||.||.|||..|....||||. |.   
-PI-HENKWMMRRPRNF------------------------------RHKAPFRGTTRYCSPNMHDRKEQGRHDDLWSWMYMIIELHCGLPWTNMEDKME

LEELKNQSSILRLFSDGKNIVSSWIHDRIFSDKNPSRLTPEMRGQLDEIDKNLKSCNYYSSPKYDIVYQFF
.|..|....  .||.| ..            |       .... ..... |.|.|..||. | |. .|..|
IEHMKKNMKDEDLFKDMPR------------D-------HDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase C49C8.1.AA CK1 27-387 23 1.4e-96 327.13 In-house 1-339 (339) Show / Hide 
Range on Protein: 27-387
Range on HMM: 1-339/339
Sequence Identity: 23% (98 aa)

YEIVSKIDEGGFG-QVFKV-------TKDHK----TFYAMKLESNFQVGGSAIKLEINVLSQLPKNT---------------------VFPELICGGKRP
...| ||.||||| |..||       .|..|    ..||||.|.. . |..  ..|  .. .....                       .. ....|...
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

RYH-FLVLELLGDNLKALKAQSPNPS-VFSDGTWSRIGIQCLYAMKMMHDSGFVHRDIKPSNFAIGYSTA---------SESRSRRVLLFDFGLAR-KFV
.|. ..|..||| ||  |..|. ..   ||..|| .|.||.|.| . ||| ||.||||||.||..|...          .....|.| ..|||.|| |..
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

KKEKNLAPIVTKKESKISKSKTLPSKGPSTKSKDLKPGRSKPILNRKAEQMKIKKNFNMLIPPKSIDQSQRTAEEKVDDEEFTFRRARP---HTDFRG-T
.| .. .  .                                                          . .       |...  |..|.   .. ||| |
DKDGHNR-WN----------------------------------------------------------G-P------RDKTWQHRPPREHKKKKGFRGCT

FQYASPNAHLQLELGRHDDIWSLMYMVAEFFVE---LPWTSNEEIA------LEELKNQSSILRLFSDGKNIVSSWIHDRIFSDKNPSRLTPEMRGQLDE
. |.|.|.||. |.||.||.||..||..|...    |||.  ..         |. | ..    ..|.  .    . .|            .... .. .
ARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKMSTPFF-LCCPKKD------------HDCPQEF-K

IDKNLKSCNYYSSPKYDIV
| | ..|..||. |.|. .
IMKYIRSLKYYDRPDYEMI
Kinase C49C8.1.AA Worm6 27-186 34 2.7e-43 150.14 In-house 1-168 (279) Show / Hide 
Range on Protein: 27-186
Range on HMM: 1-168/279
Sequence Identity: 34% (58 aa)

YEIVSKIDEGGFGQVFKVT-KDHKT--FYAMKLESN-FQVGGSAIKLEINVLSQLPKNT--VFPELICGGKRPR--YHFLVLELLGDNLKALKAQSPNPS
.... || ||||| |.||. |. |.  ..|||.|.   .   .  |.|..||  . .     |....  || ..  ....|..|.| ||  |.. .|   
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRP-DR

VFSDGTWSRIGIQCLYAMKMMHDSGFVHRDIKPSNFAIG-YSTASESRSRRVLLFDFGLARKFVKKEKN
 || ||  .|.|||| |   .|  ||.|||.||.||.|| |  ..   .... ..|||..|......|.
KFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKG
Kinase C49C8.1.AA TTBK 27-181 35 1.1e-28 98.48 In-house 1-152 (257) Show / Hide 
Range on Protein: 27-181
Range on HMM: 1-152/257
Sequence Identity: 35% (55 aa)

YEIVSKIDEGGFGQVFKVTKDHKT--FYAMKLESNFQVGGSAIKLEINVLSQLPKNTVFPELICGGKRPRYHFLVLELLGDNLKALKAQSPNPSVFSDGT
  .| ||  |||| ..  .         |.|.||  |      |.|. || .|         |  |   .. ..|..|.| ||  |  . |    || .|
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQP-KQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPR-GCFSLST

WSRIGIQCLYAMKMMHDSGFVHRDIKPSNFAIGYSTASESRSRRVLLFDFGLARKFV
  |.|.| | ...  |. || ||||||||||.|      |. |.. . ||||||...
TLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNP---STCRKCYMLDFGLARQYT
Kinase C49C8.1.AA TTBK 266-313 57 2.4e-17 57.88 In-house 159-207 (257) Show / Hide 
Range on Protein: 266-313
Range on HMM: 159-207/257
Sequence Identity: 57% (28 aa)

RRARPHTDFRGTFQYASPNAHLQLELGRHDDIWSLMYMVAEFFV-ELPW
| .|. . ||||  ||| |||.  |.||||| ||| ||  || .  |||
RPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPW
Kinase C49C8.1.AA CK1-Unclassified 27-107 23 4e-16 44.1 In-house 1-90 (244) Show / Hide 
Range on Protein: 27-107
Range on HMM: 1-90/244
Sequence Identity: 23% (21 aa)

YEIVSKIDEGGFGQVFKVT-KDHKTFYAMKLESNFQVGGSAIKLEINVLSQLPKNT-------VFPELICGGKR--PRYHFLVLELLGDNL
|... ||. | ||...|.. .. ....|.|||.. .   . .. |. .. .| ..         .| ... |.    .| ..|..||| .|
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSK-HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSL
Kinase C49C8.1.AA CMGC 27-153 16 1.1e-14 43.73 In-house 1-214 (513) Show / Hide 
Range on Protein: 27-153
Range on HMM: 1-214/513
Sequence Identity: 16% (36 aa)

YEIVSKIDEGGFGQVFKVTK---------------DHKTFYAMK---LESNFQVGGS----------AIKLEINVLSQL------------------PKN
|||..|| || .|.|.| .                . . ..|.|   ..  .. ..            .  ||  | .|                  ..|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

TVFPELICGGKRPR---------------YHFLVLELLGDNLKALKAQSP------NPSVFSDGT------------WSRIG------IQCLYAMK--MM
 |    |.  | ..               . .|| |... .|. .  . .      .|  .|.                 .        | | ..|   .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HDSG--FVHRDIKPSN
|  .  ..|||.||.|
HSHWGNIIHRDLKPEN
Kinase C49C8.1.AA S_TKc 27-403 13 5.3e-14 28.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 27-403
Range on HMM: 1-231/231
Sequence Identity: 13% (55 aa)

YEIVSKIDEGGFGQVFKVTKDH-KTFYAMKLESNFQVGGSAIKLEINVLSQLPKNTVFPELICGGKRPRYHFLVLELLGD---NLKA-LKAQSPNP--SV
|||. || .|.||.|.|... . .  .|.|  .        |. ||..|..  .      |.       . ..|.|...    .|.  .| . ...  ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

FSDGTWSRIGIQCLYAMKMMHDSGFVHRDIKPSNFAIGYSTASESRSRRVLLFDFGLARKFVKKEKNLAPIVTKKESKISKSKTLPSKGPSTKSKDLKPG
|.  .  ..  | . |.. .|. |..|||.||.|  .           .. . ||||||..                                       
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------HIKICDFGLARQL---------------------------------------

RSKPILNRKAEQMKIKKNFNMLIPPKSIDQSQRTAEEKVDDEEFTFRRARPHTDFRGTFQYASPNAHLQLELGR-HDDIWSLMYMVAEFFV-ELPWTSNE
                                                    | | ||  | .|        |.   |.||.  ...|... . |.  ..
----------------------------------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QM

EIALEELKNQSSILRLFSDGKNIVSSWIHDRIFSDKNPSRLTPEMRGQLDEIDKNLKSCNYYSSPKYDIVYQFFK-D-----SMTKAKV--------TWT
.  .. ..                                                      |..  |.. . .. |     .  .|           | 
QMMFKKIG------------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase C49C8.1.AA Worm6 255-313 36 1e-13 45.85 In-house 161-221 (279) Show / Hide 
Range on Protein: 255-313
Range on HMM: 161-221/279
Sequence Identity: 36% (22 aa)

EEKVDDEEFTFRRAR-PHTDFRGTFQYASPNAHLQLELGRHDDIWSLMYMVAEFFVE-LPW
. | .... . |  | ..  ||||..||. ..| . |..| ||. | .||..|..|  |||
RKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCRKDDCESWFYMMVEMIVGCLPW
Kinase C49C8.1.AA CK1-A 27-180 29 1.5e-13 44.11 In-house 1-148 (261) Show / Hide 
Range on Protein: 27-180
Range on HMM: 1-148/261
Sequence Identity: 29% (45 aa)

YEIVSKIDEGGFGQVF-KVTKDHKTFYAMKLESNFQVGGSAIKLEINVLSQLPKNTVFPELICGGKRPRYHFLVLELLGDNLKALKAQSPNPSVFSDGTW
| .| ||  | || ..  ..       |.|.||| ..    .  |  |  .| .   .|..   |.   |  .|..|||  |  |         |.  | 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESN-KARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKR--RFTMKTV

SRIGIQCLYAMKMMHDSGFVHRDIKPSNFAIGYSTASESRSRRVLLFDFGLARKF
  .  | .  . ..|  .|.|||||| || .|          .. | |||||.|.
LMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCN----KLFLIDFGLAKKY
Kinase C49C8.1.AA CK1-Unclassified 139-186 34 1.9e-13 36.09 In-house 120-166 (244) Show / Hide 
Range on Protein: 139-186
Range on HMM: 120-166/244
Sequence Identity: 34% (17 aa)

MHDSGFVHRDIKPSNFAIGYSTASESRSRRVLLFDFGLARKFV--KKEKN
.|  .|.|||||| || .|    .. .. .| . ||||. ...  .|...
LHNKNFIHRDIKPDNFLMGK---LGKNHHQVYIIDFGLSKRYIDMDKTGK
Kinase C49C8.1.AA CK1 27-107 22 1e-12 40.3 In-house 1-91 (271) Show / Hide 
Range on Protein: 27-107
Range on HMM: 1-91/271
Sequence Identity: 22% (21 aa)

YEIVSKIDEGGFGQVFKVTKDHKTF---YAMKLESNFQVGGSAIKLEINVLSQLPK------NTVFPELICGGKR--PRYHFLVLELLGDNL
|... ||..| ||......  ...    .|.|||.| .   . .. |. .. .| .         .| ... |.     | ..|..||| .|
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSK-HPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSL
Kinase C49C8.1.AA Dual 128-181 35 1.3e-12 38.63 In-house 118-167 (282) Show / Hide 
Range on Protein: 128-181
Range on HMM: 118-167/282
Sequence Identity: 35% (19 aa)

IGIQCLYAMKMMHDSGFVHRDIKPSNFAIGYSTASESRSRRVLLFDFGLARKFV
..|| | |..  |  |..||.|||.||..|     . .   | . ||...||..
VAIQMLRAIQDLHSIGYLHRNIKPANFHCGL----GMDETTVYMQDFRIVRKYI
Kinase C49C8.1.AA CK1 128-186 33 2.6e-11 35.41 In-house 110-166 (271) Show / Hide 
Range on Protein: 128-186
Range on HMM: 110-166/271
Sequence Identity: 33% (20 aa)

IGIQCLYAMKMMHDSGFVHRDIKPSNFAIGYSTASESRSRRVLLFDFGLARKFVK-KEKN
|. | .  .  .|  .|.|||||| || .|    .. .. .| . ||||| .... |...
IADQMIQRIEYVHNKNFIHRDIKPDNFLMGR---YGKHCHQVYIIDFGLAKRYRDDKTHQ
Kinase C49C8.1.AA CK1-D 27-180 29 4.5e-10 31.58 In-house 1-148 (261) Show / Hide 
Range on Protein: 27-180
Range on HMM: 1-148/261
Sequence Identity: 29% (45 aa)

YEIVSKIDEGGFGQVFKVTK-DHKTFYAMKLESNFQVGGSAIKLEINVLSQLPKNTVFPELICGGKRPRYHFLVLELLGDNLKALKAQSPNPSVFSDGTW
| |  ||  | ||...  |.       |.|||.  .     ...|  .   .      ||.   |.   |  .|..|||  |  |         ||  | 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLEC-IKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHR--KFSLKTV

SRIGIQCLYAMKMMHDSGFVHRDIKPSNFAIGYSTASESRSRRVLLFDFGLARKF
  .. | .  .. .|   |.|||||| || .|       |   | . |||||...
LMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGK----RGNMVYIIDFGLAKRY
Kinase C49C8.1.AA CK1-A 276-313 48 2.9e-05 14.35 In-house 167-205 (261) Show / Hide 
Range on Protein: 276-313
Range on HMM: 167-205/261
Sequence Identity: 48% (19 aa)

GTFQYASPNAHLQLELGRHDDIWSLMYMVAEF-FVELPW
||  ||| |||| .|  | ||. |. |..  |   .|||
GTARYASINAHLGIEQSRRDDMESMGYVMMYFNRGKLPW
Kinase C49C8.1.AA CK1-D 269-313 41 5.7e-05 13.29 In-house 160-205 (261) Show / Hide 
Range on Protein: 269-313
Range on HMM: 160-205/261
Sequence Identity: 41% (19 aa)

RPHTDFRGTFQYASPNAHLQLELGRHDDIWSLMYMVAEFFV-ELPW
| . .  ||  ||| | |. .|  | ||. || |..  |    |||
RENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPW
Kinase C49C8.1.AA CK1-Unclassified 280-302 60 0.000121 9.65 In-house 182-204 (244) Show / Hide 
Range on Protein: 280-302
Range on HMM: 182-204/244
Sequence Identity: 60% (14 aa)

YASPNAHLQLELGRHDDIWSLMY
||| |||| .| .| ||  ||.|
YASINAHLGIEQSRRDDLESLGY
Kinase C49C8.1.AA Pkinase 139-180 36 0.000641 14.94 Pfam 124-162 (293) Show / Hide 
Range on Protein: 139-180
Range on HMM: 124-162/293
Sequence Identity: 36% (16 aa)

MHDSGFVHRDIKPSNFAIG--YSTASESRSRRVLLFDFGLARKF
.|. |..|||.||.|. |   . ...     .| . |||||..|
CHSMGIIHRDLKPENILIDNNGHIDA-----CVKICDFGLAKQF
Kinase C49C8.1.AA TyrKc 27-319 14 0.000771 -160.55 SMART 1-280 (280) Show / Hide 
Range on Protein: 27-319
Range on HMM: 1-280/280
Sequence Identity: 14% (52 aa)

YEIVSKIDEGGFGQVFKVTKDHKTFYAMKLESNFQVGGSAIKLEINVLSQL--PKNTVFPELICGGKRP------RYHFLVLEL--LGDNLKALKAQSPN
 .   |. || ||.|.| | .  .  | |   .      ..  |......|      .   . .  .          ...|.|.  .|| .. |..  |.
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

PSVFSDGTWSRIGIQCLYAMKMMHDSGFVHRDIKPSNFAIGYSTASESRSRRVLLFDFGLARKFVKK-EKNLAPIVTKK----ESK------------IS
   ..  .   . .|    |   |. ...|||.   |  .|          .|   ||||.|.   . ..  .  . .|     .|            | 
---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

KSKTLPSKGPSTKS----------------KDLKPG---RSKPILNRKAEQMKIKKNFNMLIPPK----SIDQSQRTAEEKVDDEEFTFRRARPHTDFRG
..|       .|||                .   ||   .  .. |. . . ..|. . | .||     |                              
YGKF------TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIE-YVKQGYRMPQPPNDYPMS------------------------------

TFQYASPNAHLQLELGRHDDIWSLMYMVAEF-------FVELPWTSNEEI
               . .|.. ..| .  ..       | |.     |..
------------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEI----HECF
Kinase C49C8.1.AA CK1 280-303 54 0.000971 8.98 In-house 182-205 (271) Show / Hide 
Range on Protein: 280-303
Range on HMM: 182-205/271
Sequence Identity: 54% (13 aa)

YASPNAHLQLELGRHDDIWSLMYM
||| |.|| .| .| ||  ||.|.
YASINTHLGIEQSRRDDMESLGYV
Kinase C49C8.1.AA Dual 27-58 27 0.013563 4.39 In-house 1-37 (282) Show / Hide 
Range on Protein: 27-58
Range on HMM: 1-37/282
Sequence Identity: 27% (10 aa)

YEIVSKIDEGGFGQVFKVTKDHK-----TFYAMKLES
  .|  .  |||. | .| .. .     . |..|.||
WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTES
Kinase C49C8.1.AA Pkinase 27-55 36 0.034959 8.8 Pfam 1-30 (293) Show / Hide 
Range on Protein: 27-55
Range on HMM: 1-30/293
Sequence Identity: 36% (11 aa)

YEIVSKIDEGGFGQVFKVTKDHK-TFYAMK
|.|..|| .|.||.|.| ..      .|.|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVK
Kinase C49C8.1.AA Pkinase 267-313 24 0.617708 4.39 Pfam 165-212 (293) Show / Hide 
Range on Protein: 267-313
Range on HMM: 165-212/293
Sequence Identity: 24% (12 aa)

RARPHTDFRGTFQYASPNAHL-QLELGRHDDIWSLMYMVAEFFV-ELPW
. .  |.| ||  |..|  .. . . |.  |.||.  ...|..  ..|.
NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPF