Gene cdk-4 (Nematode worm)

cdk-4

Species: Nematode worm
Alias: CE28918, cdk-4, F18H3.5b, F18H3.5a, F18H3.5B, aSWK161
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 13521884-13519580, WormBase Genetic Map location: n/a,

Classification

Group: CMGC
Family: CDK
Subfamily: CDK4

Sequence

Name Sequence Type Origin Length Description Download
cdk-4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 285 Kinase domain by global Sugen HMM Fasta, JSON
cdk-4.AA Protein Genbank 406 None Fasta, JSON

Protein domain

Protein domains of cdk-4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase cdk-4.AA CDK4 104-388 53 6.30000000001e-216 723.63 In-house 3-290 (290) Show / Hide 
Range on Protein: 104-388
Range on HMM: 3-290/290
Sequence Identity: 53% (153 aa)

LFQALGKGAYGNVYRVRSLHDGKDYALKQIMISSKNE--GIPQSVLREITVMKHLARKAHPNIISLKSVFHQLDPVRAILKINMIMERCDWDLHTFLRNI
.....|.||||.|||.|.||.|...||||..|....|  |.|.|..|||.||.||....||||..|..|.|..|..||..||.|..|.|||||||.|...
CVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLDKC

PR-GVPEQQAKHVTAQIVRALDFLHTHSIIHRDLKPQNILLNRDQTVKLADFGLSKEYSNTTAFTTLVVTLWYRSPEVLLQSYYNSTVDMWALGCIVSEI
|. |.|....||...|..|..||||.|.||||||||||||...|..||||||||...||...|.|..|||||||.||||||||||..||||..|||..|.
PPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMALTPVVVTLWYRAPEVLLQSYYNTPVDMWSVGCIFAEM

YCRQPLFVGQNEAEQLTDIFKKMGTPVGKDWPSESVIARDSFPQYRPTNLKDLSPQMSKQAIEFVQQCLRYDHSKRLSARGALSHPFL
|||.|||.||.|..||..||..||.|...|||.......|.|||..|...||..|.|.||.....|..|.|.|.||.||...|.||..
YCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLPWDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase cdk-4.AA CDK 103-388 32 1.7e-121 390.55 In-house 1-284 (284) Show / Hide 
Range on Protein: 103-388
Range on HMM: 1-284/284
Sequence Identity: 32% (103 aa)

FLFQA-LGKGAYGNVYRVRSLHDG-----KDYALKQIMISS-----KNEGIPQSVLREITVMKHLARKAHPNIISLKSVFHQLDPVRA-----ILKINMI
.   . .| |.|| ||. |....|     . .|||.|.. .     . ||.|.. .|||. .|.|    ||||..|. |.|. .. |.     . |. |.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL----HPNIVKLHDVCHTKNMDRNNKDKHENKLYMV

MERCDWDLHTFLRNIPRGVPEQQAKHVTAQIVRALDFLHTHSIIHRDLKPQNILLNRDQT-----VKLADFGLSKEYS-------NTTAFTTLVVTLWYR
.| .|.|| ....           |. . |. |.|...| . |.||||||||||.|.. .     .|.|||||.....       .. ..|  |||||||
FEYMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYR

SPEVLL-QSYYN--STVDMWALGCIVSEIYC---RQPLFVGQNEAEQLTDIFKKMGTPVGKDWPSESVIARDSFPQYRPTNLKDLSPQMSKQAIEFVQQC
.||.|| .. |.   ..|||..||| .|...   |.||| |..| .||  ||. .|||  ..||. .                           .. ...
APELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY----------------------DLLNKM

LRYDHSKRLSARGALSHPFL
| || .||.||  ||.||..
LCYDPKKRISAEQALQHPYF
Kinase cdk-4.AA CMGC 108-388 22 9.20000000001e-108 355.32 In-house 7-513 (513) Show / Hide 
Range on Protein: 108-388
Range on HMM: 7-513/513
Sequence Identity: 22% (112 aa)

LGKGAYGNVYRVRSLHDG--------------KDYALKQIMISSKNE----------GIPQSVLREITVMKHLAR--------------KAHPNIISLKS
.|.|.||.||. |  . .              . .|.| |.    .|          |.|.. ||||  .||| .              | |.||..|. 
IGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYD

VFHQLDPVRA-----------ILKINMIMERCDWDLHTFLRN--------IPRGVPEQQ------------AKHVT------AQIVRALD--FLHTHS--
.|.  .. .              ......| .|.||. ...|        .|.. .| .             |. .       || |.|.  ..| |   
IFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGN

IIHRDLKPQNILLNRDQTV--------------------KLADFGLSKEYSN----------------------TTAFTTLVVTLWYRSPEVLLQSY---
||||||||.|||.| . ..                    |..||||.. |..                      . ..|. |||.|||.||.|| .    
IIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYT

-------YNSTVDMWALGCIVSEIYCR--------QPLFVGQNE-----------AEQLTDIFKKMGTPV---------------GKDWPSESV------
       |....|||..|||  |.| .        .||| |..|            .||  ||| .|||                 ..||. .       
NHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNK

------------IARDS----------FPQYRPTNLKDLSPQ-----------------------------------MSKQAIEFVQQCLRYDHSKRLSA
            .  ..          ||...| ..|.| |                                    ...|||......|.||..||..|
FPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITA

RGALSHPFL
  ||.||..
EQALQHPYF
Kinase cdk-4.AA CDC2 105-388 36 1.7e-100 309.58 In-house 1-301 (301) Show / Hide 
Range on Protein: 105-388
Range on HMM: 1-301/301
Sequence Identity: 36% (113 aa)

FQAL---GKGAYGNVYRVRSLHDGKDYALKQIMISSKNEG--IPQSVLREITVMKHLARKAHPNIISLKSVFHQLDPVRAILKINMIMERCDWDLHTFLR
.| .   |.| || ||. . . ...  |||.| . . .||  .|.. .|||  .| |    ||||..|. |.||        |. |. |..| ||  ...
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELK--DHPNIVKLHDVIHQ-------NKLYMVFEYLDMDLKKYMD

-NIP--RGVPEQQAKHVTAQIVRALDFLHTHSIIHRDLKPQNILLNRDQTVKLADFGLSKEYS-NTTAFTTL--VVTLWYRSPEVLL-QSYYNSTVDMWA
  ||    .|.|  |  . ||.....|.|.. |.||||||||||.... ..|.|||||..  . .  . ||   |||||||.||.|| ...|. .||||.
MSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWS

LGCIVSEI---YCRQPLFVGQNEAEQLTDIFKKMGTPVGKDWPSESVIA--RDSFPQYRPTNLKDLSPQ---------MSKQAIEFVQQCLRYDHSKRLS
.||| .|.     . ||| |. | .||  ||. .|||  ..||. .       .||...|..|... |.         . ...|.  .| |.|| .||.|
IGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRIS

ARGALSHPFL
|. ||.||..
AKEALQHPYF
S_TKc cdk-4.AA S_TKc 102-388 31 3.4e-92 313.52 SMART 1-231 (231) Show / Hide 
Range on Protein: 102-388
Range on HMM: 1-231/231
Sequence Identity: 31% (94 aa)

TFLFQALGKGAYGNVYRVRSLHDGKDYALKQIMISSKNEGIPQSVLREITVMKHLARKAHPNIISLKSVFHQLDPVRAILKINMIMERCDW---DLHTFL
  . . .||||.| ||..|  ..|. .|.|.|          ....||| ..|.     ||||. |. ||.         .. |.|| ||    ||....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK----HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYI

RNIPRG-----VPEQQAKHVTAQIVRALDFLHTHSIIHRDLKPQNILLNRDQTVKLADFGLSKEYSNTTAFTTLVVTLWYRSPEVLLQSYYNS-TVDMWA
.. .|.      || .|.....||..||...| | ||||||||.||||..  ..|..||||....      ||...|.||..||||    |.   .|.|.
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWS

LGCIVSEIYCRQPLFVGQNEAEQLTDIFKKMGTPVGKDWPSESVIARDSFPQYRPTNLKDLSPQMSKQAIEFVQQCLRYDHSKRLSARGALS-------H
.|||. | .|..|.|       |.  .|||.|                                 |..|..|...||..| .||..|  ||        |
CGCILYEMLCGYPPFP------QMQMMFKKIG---------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

PFL
|..
PWF
Kinase cdk-4.AA Pkinase 104-388 32 6.4e-85 293.22 Pfam 3-293 (293) Show / Hide 
Range on Protein: 104-388
Range on HMM: 3-293/293
Sequence Identity: 32% (100 aa)

LFQALGKGAYGNVYRVRSLHDGKDYALKQIMISSKNEGIPQSVLR--EITVMKHLARKAHPNIISLKSVFHQLDPVRAILKINMIMERCDW-----DLHT
. . .|.|..| ||. .   .|| .|.|.|  ...... .|. .|  || .||.| .  ||||. |. .|.         .| |.|| |.      ||..
IGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N--HPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFD

FLR-NIPRGV--PEQQAKHVTAQIVRALDFLHTHSIIHRDLKPQNILLNRDQTV----KLADFGLSKE--YSNTTAFTTLVVTLWYRSPEVLL-QSYYNS
...    ...  .|...|..  ||.|.|...| ..||||||||.|||.... ..    |..||||.|   | | . .||...|.||..|||.. ..|| .
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

TVDMWALGCIVSEIYCRQPLFVGQ----NEAEQLTDIFKKMGTPVGKDWPSESVIARDSFPQYRPTNLKDLSPQMSKQAIEFVQQCLRYDHSKRLSARGA
 ||||..|||. | .|..|.| |.    | ..|.  |...||.|.  ||| .. | ...|... .. .. . . .|. ...|.  ||..| .||..|. .
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHW-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQI

LSHPFL
| ||..
LQHPWF
Kinase cdk-4.AA CDK5 105-388 34 1e-75 238.62 In-house 4-287 (287) Show / Hide 
Range on Protein: 105-388
Range on HMM: 4-287/287
Sequence Identity: 34% (101 aa)

FQALGKGAYGNVYRVRSLHDGKDYALKQIMISSKNEGIPQSVLREITVMKHLARKAHPNIISLKSVFHQLDPVRAILKINMIMERCDWDLHTFLRNIPRG
   .| | || ||. |    .  .|||.. . |  ||.| . .||| ..| |    |.||. |  | |      .  |. .. | || ||  .. ..  .
MEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKEL---KHKNIVRLHDVIH------SEKKLTLVFEFCDQDLKKYMDSCNGE

VPEQQAKHVTAQIVRALDFLHTHSIIHRDLKPQNILLNRDQTVKLADFGLSKEYS-NTTAFTTLVVTLWYRSPEVLLQS-YYNSTVDMWALGCIVSEIY-
.  . .|    |  . | | | | . |||||||| | |.  . |||||||   .      ..  ||||||| | ||. |  |.  .|||  |||  |.  
MDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMAN

CRQPLFVGQNEAEQLTDIFKKMGTPVGKDWPSESVIARDS-----FPQYRPTN-LKDLSPQMSKQAIEFVQQCLRYDHSKRLSARGALSHPFL
  .||| | .. .||  ||| ||||    ||| .           .| | ..  .. . |.....  .. |. |...  .|.||  || ||. 
AGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase cdk-4.AA RCK 104-388 35 3.6e-74 234.66 In-house 3-298 (298) Show / Hide 
Range on Protein: 104-388
Range on HMM: 3-298/298
Sequence Identity: 35% (109 aa)

LFQALGKGAYGNVYRVRSLHDGKDYALKQIMISSKNEGIPQSV-LREITVMKHLARKAHPNIISLKSVFHQLDPVRAILKINMIMERCDWDLHTFLRN--
.   ||.|.|| |   ... .|. .| |. .   | . . .   ||||.... |  ..||||| || |. . |  .  .    ..| .| .|  ....  
IIKQLGDGTYGCVMKAQNKETGEIVAIKKMK--QKFYSWEECMNLREIKSLRKL--NPHPNIIKLKEVIRDNDTYQLYF----VFEYMDMNLYQMMKDFK

-IPRGVPEQQ--AKHVTAQIVRALDFLHTHSIIHRDLKPQNILLNR---------DQTVKLADFGLSKEYSNTTAFTTLVVTLWYRSPEVLLQS-YYNST
   . .||.|   |.   ||  .|...|.| . |||||| ||...          ....|.|||||..|  .   .|  | | |||.||.|| . |||| 
ERRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSP

VDMWALGCIVSEIYCRQPLFVGQNEAEQLTDIFKKMGTPVGKDWPSESVIARD---SFPQYRPTNLKDLSPQMSKQAIEFVQQCLRYDHSKRLSARGALS
.|.||.|||  |.|. .||| |..|  |.  | | ||||  ||||  .  |.     |||. ...|| | |..|...|| .. .|..| .|| .|  || 
MDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQ

HPFL
||. 
HPYF
Kinase cdk-4.AA PITSLRE 105-388 34 3.2e-58 199.74 In-house 1-295 (295) Show / Hide 
Range on Protein: 105-388
Range on HMM: 1-295/295
Sequence Identity: 34% (105 aa)

FQALGK---GAYGNVYRVRSLHDGKDYALKQIMIS--SKNEGIPQSVLREIT-VMKHLARKAHPNIISLKSVFHQLDPVRAILKINMIMERCDWDLHTFL
|| | .   |.|| ||| .    .   ||| . .      ||.|   ||||  . . |   .||||...| .    .    . || |.||  . ||   .
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMAL---QHPNIVNVKEIVMGSN----MDKIYMVMEYVEHDLKSLM

RNIP---RGVPEQQAKHVTAQIVRALDFLHTHSIIHRDLKPQNILLNRDQTVKLADFGLSKEYSNT-TAFTTLVVTLWYRSPEVLL-QSYYNSTVDMWAL
 |.        . . |  . |  |. ...| . |.|||||  |.|..     |..||||  ||     ..| .|||||||.||.|| .  |   ||||  
ENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSV

GCIVSEIYCRQPLFVGQNEAEQLTDIFKKMGTPVGKDWPS----ESVIARDSFPQYRPTNLKDLSP---QMSKQAIEFVQQCLRYDHSKRLSARGALSHP
|||  |.   .||| |..| .|.  ||| ||||  | ||       . .  .||.| . ||. . |     | .. .  .| | |.  .|..|  || ||
GCIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHP

FL
. 
WF
Kinase cdk-4.AA MAPK 104-388 28 3.7e-57 196.17 In-house 3-328 (328) Show / Hide 
Range on Protein: 104-388
Range on HMM: 3-328/328
Sequence Identity: 28% (93 aa)

LFQALGKGAYGNVYRVRSLH------DGKDYALKQIMISSKNEGIPQSVLREITVMKHLARKAHPNIISLKSVFHQL-----DPVRAILKINMIMERCDW
. . .|.|||| |  ..         .||  |.| |.    |.   . ..|||  ..|.  . |.|||.|. .|.       ..      | ..|| ...
ILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHF--HHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLHTFLRNIPRGVPEQQAKHVTAQIVRA--LDFLHTHSIIHRDLKPQNILLNRDQTVKLADFGLSKEYSNT---------------TAFTTLVVTLWYRS
|||  ..  .    ..  .  . || |.  | ..|   .||||||| |||.| . ..|..||||.    ..               .  |  |.| |||.
DLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRA

PEVLLQ---SYYNSTVDMWALGCIVSEIYC-RQPLFVGQNEAEQLTDIFKKMGTPVGKDW---P-SESV--IARDS--FPQYRPTNLKDLSPQ----MSK
||..|      |. .||||..|||  | .  |.||| |..  .|.. |.. .|||   ..   . ||..    .    .|.| . ..... |      . 
PEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANP

QAIEFVQQCLRYDHSKRLSARGALSHPFL
||| .... |  | .||...  ||.||..
QAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase cdk-4.AA ERK7 104-388 32 5.4e-56 189.88 In-house 3-292 (292) Show / Hide 
Range on Protein: 104-388
Range on HMM: 3-292/292
Sequence Identity: 32% (98 aa)

LFQALGKGAYGNVYRVRSLHDGKDYALKQIMISSKNEGIPQSVLREITVMKHLARKAHPNIISLKSVFHQLDPVRAILKINMIMERCDWDLHTFLR--NI
. . ||||||| | ..     ..  ||| |    .|.   |   |||. .. .  . |||||.|  |..        . | .. |  . |||   |  ||
IRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEF--HCHPNIIRLINVIR----ADNDRDIYLVFEFMETDLHAVIRKGNI

PRGVPEQQAKHVTAQIVRALDFLHTHSIIHRDLKPQNILLNRDQTVKLADFGLSKEYSNTT-------AFTTLVVTLWYRSPEVLLQS-YYNSTVDMWAL
 . .  |    .  |..||. ..|   .||||||| ||||. . .||..||||    ...        . |  | | |||.||.|| |  |   |||| .
LKDIHKQ---YIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSI

GCIVSEIYCRQPLFVGQNEAEQLTDIFKKMGTPVGKDWPS-ESVIAR---DSFPQYRPTNLKDLSPQMSKQAIEFVQQCLRYDHSKRLSARGALSHPFL
|||. |.   .|.| |    .|.  | . .. |  .|  . .| .|    .. .| ..  |... || ...||. ... | .   |||.|  ||.||. 
GCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase cdk-4.AA CDK10 105-388 32 1.1e-54 188.05 In-house 4-285 (285) Show / Hide 
Range on Protein: 105-388
Range on HMM: 4-285/285
Sequence Identity: 32% (95 aa)

FQALGKGAYGNVYRVRSLHDGKDYALKQIMISSKNEGIPQSVLREITVMKHLARKAHPNIISLKSVFHQLDPVRAILKINMIMERCDWDLHTFLRNIPRG
   .| |.|| ||| |  .     |||.. .    .|.| | ||||......    |.||. |. |       . .  | ..|. |. ||   | |.|  
LNRVGEGTYGIVYRARDMRSDEIVALKKVRMDKEKDGLPISGLREIMLLIQC---RHENIVELHEVVV----GQHLDSIFLVMQYCEQDLASLLDNMPQP

VPEQQAKHVTAQIVRALDFLHTHSIIHRDLKPQNILLNRDQTVKLADFGLSKEYSN-TTAFTTLVVTLWYRSPEVLLQSYYNST-VDMWALGCIVSEIYC
  | | | .. |..|.| .|| . .||||||  |.|.  .  .|.||||| . |..     |  .|||||| ||.|| .  . | .||||.|||..|.  
FTETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCILGELLV

RQPLFVGQNEAEQLTDIFKKMGTPVGKDWPSES---VIARDSFPQYRPTNLKDLSPQMSKQAIEFVQQCLRYDHSKRLSARGALSHPFL
 .||. |. |  |.  | . .|||  . ||  |   .. . .  .    |||   . .|.   . ..  . |.  ||  |  .|   . 
HKPLMPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKFHWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Pkinase_Tyr cdk-4.AA Pkinase_Tyr 101-256 28 7.4e-15 50.94 Pfam 1-159 (270) Show / Hide 
Range on Protein: 101-256
Range on HMM: 1-159/270
Sequence Identity: 28% (48 aa)

LTFLFQALGKGAYGNVYRVRSL----HDGKDYALKQIMISSKNEG-IPQSVLREITVMKHLARKAHPNIISLKSVFH-QLDPVRAILKINMIMERCDW-D
.||. . ||.||.|.||. .       .. . | | .  ..  |  . .. .||. .||.| .  ||||..|  |   | .|     .| ..|| .   |
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGH--HPNIVRLYGVCTDQGEPN----QIYIVMEYMPHGD

LHTFLRNI---PRGVPEQQAKHVTAQIVRALDFLHTHSIIHRDLKPQNILLNRDQTVKLADFGLSK
|...||.    .. .. ..  .  .|| .....|. . .|||||   |.|.... .|| .||||..
LLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
TyrKc cdk-4.AA TyrKc 102-388 20 1.9e-13 -5.37 SMART 1-280 (280) Show / Hide 
Range on Protein: 102-388
Range on HMM: 1-280/280
Sequence Identity: 20% (65 aa)

TFLFQALGKGAYGNVYRVRSLHDGKDYALKQIMISSKNEGIPQSVLREITVMKHL-ARKAHPNIISLKSVFHQL-------DPVRAILKINMIMERCDW-
  | . || ||.| ||. .      . | | .  ..      .  .||. .|..|  .  ||||. |  |  |        .|.       ..|| ... 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGH--HPNIVRLYGVCTQQGRNFMYIEPLM------IVMEYMPHG

DLHTFLRNIPRGVPEQQAKHVTAQIVRALDFLHTHSIIHRDLKPQNILLNRDQTVKLADFGLSKEYSNT-------TAFTT-----LV--VTLWYRSPEV
||. .||.  . .. ..  .   || .  ..|| . .|||||   |.|.....||| .|||||..  .           ..         . .   .||.
DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

LLQSYYNSTVDMWALGCIVSEI--YCRQPLF------VGQNEAEQLTDIFKKMGTPVG----KDWPSESVIARDSFPQYRPTNLKDLSPQMSKQAIEFVQ
.  . ...  | |. |    ||  |. ||        .   |. .. .  . |  |                               .. ...   .  .
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------FVCCPDEMYQIMK

QCLRYDHSKRLSARGALSHPFL
|| ..| ..| . .    | ..
QCWHEDPEDRPTFSEI--HECF