Gene chk-1 (Nematode worm)

chk-1

Species: Nematode worm
Alias: CE26076, Y39H10A.7, aSWK038, chk-1, Y39H10A_224.a
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: V: 3759289-3756861, WormBase Genetic Map location: n/a,

Classification

Group: CAMK
Family: CAMKL
Subfamily: CHK1

Sequence

Name Sequence Type Origin Length Description Download
chk-1.AA Protein Genbank 503 None Fasta, JSON
chk-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 263 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of chk-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase chk-1.AA CHK1 24-286 61 1.7e-203 682.29 In-house 1-276 (276) Show / Hide 
Range on Protein: 24-286
Range on HMM: 1-276/276
Sequence Identity: 61% (171 aa)

YRVVQTLGEGAFGEVLLIVNTKNPEVAAAMKKINIANKS-KDFIDN-IRKEYLLQKRVSAVG-HDNVIRMIGMRNDPQFYYLFLEYADGGELFDKIEPDC
|.|||||||||||.|.|..|..|||.|.|||.|.|.... ..|.|| |||||..||..|..| |.|||||.|||.||.|||||.||||||.|||||||||
YEVVQTLGEGAFGQVKLCENQRNPEEAVAMKEIHIKGQHKMCFMDNDIRKEYCIQKMLSKIGKHENVIRMMGMRMDPEFYYLFMEYADGGDLFDKIEPDC

GMSPVFAQFYFKQLICGLKFIHDND-VVHRDIKPENLLLTGTH------VLKISDFGMATLYR-NKGEERLLDLSCGTIPYAAPELCAGKKYRGPPVDVW
||....|..||||||.|||.||... |.|||||||||||....      .|||.|||.||.|| ..||||.|| .|||.||.|||.|.||.|||||||.|
GMPSDEAHRYFKQLISGLKYIHCCGGVTHRDIKPENLLLDKHDSNDMPDNLKIADFGLATWYRRHDGEERMLDKRCGTPPYMAPEVCTGKQYRGPPVDIW

SSGIVLIAMLTGELPWDRAS-DASQSYMGWISNT-SLDERPWKKIDVRALCMLRKIVTDKTDKRATIEQIQADPWY
|.|.||.||||||||||..| ...|.|..|..|. .....||.|||.||.|.||||......||||||||..||||
SCGVVLMAMLTGELPWDQPSHMDCQEYCWWMDNKHWMHWCPWSKIDCRAICLLRKILCENPNKRATIEQIEKDPWY
Kinase chk-1.AA CAMKL 24-286 31 9.5e-127 406.57 In-house 1-297 (297) Show / Hide 
Range on Protein: 24-286
Range on HMM: 1-297/297
Sequence Identity: 31% (96 aa)

YRVVQTLGEGAFGEVLLIVNTKNPEVAAAMKKINIANKS-KDFIDN------------IRKEYLLQKRVSAVG-HDNVIRMIGMRNDPQF------YYLF
||...|||.|.||.| | ........  |.| |..  .. ......            ||.|. ..|... .| | |.|..  .. .|..      .||.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLN-IGKHPNIIKLYEVIETPEHDIETKKIYLV

LEYADGGE--LFDKI--EPDCG--MSPVFAQFYFKQLICGLKFIHDNDVVHRDIKPENLLLTGTH--VLKISDFGMATLYRN--KGEERLLDLSCGTIPY
.||..|||  |||.|  .....  |..  |..||.|........|....|||||||||.||.  .  ..||.|||....||.  .|....|. .||. ||
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

AAPELCAG--KKYRGPPVDVWSSGIVLIAMLTGELPWDRASDA-----SQSYMGWISNTSLDE-RPWKKIDVRALCMLRKIVTDKTDKRATIEQIQADPW
.|||...|  |.|.||.||.|| |..| ||..|.||.| ....      . |. |. ..   . ..|.... ..  ..||. . . .||.||.||  .||
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW

Y
.
M
Kinase chk-1.AA CAMK 29-286 20 2.6e-88 284.6 In-house 1-425 (425) Show / Hide 
Range on Protein: 29-286
Range on HMM: 1-425/425
Sequence Identity: 20% (86 aa)

TLGEGAFGEVLLIVNTKNPE-----------VAAAMKKINIANKSKDF--------------------------IDNIRKEYLLQKRVSAVG----HDNV
|||.|.||.| | ......            .  |.| |.    ...                            .|.|.|. . |.....|    | |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IRMIGMRND-------------------PQFYYLFL---EYADGGEL----FDKI--EPDCG-------------MSPVFAQFYFKQLICGLKFIHDNDV
|... .  |                   ....|...   ||..||||    ||.|   ...|             ..   |..||.|........|....
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDIKPENLLLTGTH-----------------VLKISDFGMATLYRNKGEER---------------------LLDLSCGTIPYAA-PELCAG------
||||.||||.||.  .                  .||.|||.|. .. . ...                     ..  .||| .|.| ||.  |      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------KKYRGPPVDVWSSGIVLIAMLTGELPWDRASDASQS---------YMGWISNTSLDER-PWKKIDV-----------------------RALC
       |.| ||..|.|| |..| .||.|..|..  .| ..          |  .   .. . . |.....                         . .
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

MLRKIVTDKTDKRATIEQIQADPWY
..||. .   .||.||||. ..||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase chk-1.AA S_TKc 24-286 27 3.3e-77 263.72 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-286
Range on HMM: 1-231/231
Sequence Identity: 27% (77 aa)

YRVVQTLGEGAFGEVLLIVNTKNPEVAAAMKKINIANKSKDFIDNIRKEYLLQKRVSAVGHDNVIRMIGMRNDPQFYYLFLEYADG--GELFDKIEPDCG
|......|.||||.| . ...|      |.|.|.         ..||.|  . |.    .|.|.......  | ...|...||.||  |.||| |.   .
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK---------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------MSPVFAQFYFKQLICGLKFIHDNDVVHRDIKPENLLLTGTHVLKISDFGMATLYRNKGEERLLDLSCGTIPYAAPELCAGKKYRGPPVDVWSSG
      ...  |.||..|..|.|...|.. ..|||.||||.||.   ..||.|||.|...         .  |||  | |||..   .| ....|.|| |
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

IVLIAMLTGELPWDRASDASQSYMGWISNTSLDERPWKKIDVRALCMLRKIVTDKTDKRATIEQIQA-------DPWY
..|. ||.|. |..      |  .  |             .  |. ..||. .   .|| |. .. .       .|| 
CILYEMLCGYPPFP----QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase chk-1.AA Pkinase 24-239 29 8.7e-70 242.96 Pfam 1-226 (293) Show / Hide 
Range on Protein: 24-239
Range on HMM: 1-226/293
Sequence Identity: 29% (70 aa)

YRVVQTLGEGAFGEVLLIVNTKNPEVAAAMKKINIANKSKDFIDNIRK--EYLLQKRVSAVGHDNVIRMIGMRNDPQFYYLFLEYADGG----ELFDKIE
|......|.|.||.| . .. ....   |.|.|.  ......  . |.  |  . ||..   |.|..|....  |.. .|. .||..||    .||| |.
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN---HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

--PDCGM--SPVFAQFYFKQLICGLKFIHDNDVVHRDIKPENLLLTGTHVL----KISDFGMATLYRNKGEERLLDLSCGTIPYAAPELCAGKKYRGPPV
   ....  |.  ..||..|...||...|.. ..|||.||||.|.  . ..    ||.||| | ...     . ..  |||..|.|||.. | .| ||.|
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVWSSGIVLIAMLTGELPWDRA----SDASQSYM
|.|| |..|. ||.|..|.. .    . ..| .|
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQM
Kinase chk-1.AA Ciliate-E2 24-286 21 5.7e-54 183.64 In-house 1-365 (365) Show / Hide 
Range on Protein: 24-286
Range on HMM: 1-365/365
Sequence Identity: 21% (82 aa)

YRVVQTLGEGAFGEVLLIVNTKNPEVAA-----------------AMKKINIANKSKDFIDNIRKEYLLQKRVSAVG--------------HDNVIRMIG
| ... .|.|.|| | .  . |...  |                 ..|.... ...|. | .| .|  . ...   .              |.|.|.|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

MRN--DPQFYYLFLEYADGGELFDKIEPDCGMSP-----------VFAQFYFKQLIC---------------GLKFIHDND-VVHRDIKPENLLLTGTHV
     | . .|| .||..||.||| |.  .  ..             .....||..                .|...| .  ..||||||||.|.     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

LKISDFGMATLYRNKGEERL--------LDLS----------------------CGTIPYAAPELCAGKKY--------RGPPVDVWSSGIVLIAMLTGE
.||.|||... | .. ..|.        .. .                      ||| .| |||   ||||         .  .|.|| |..|  ||.|.
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

LPWDRASDASQSYMGWISNTSLDER----------------PWKKIDVRALCMLRK----IVTDKTDKRAT-IEQIQADPWY
.|.          .  | .  .| .                 |||..  .  ...|    .   . .|| | .|||   || 
PPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase chk-1.AA AMPK 101-229 44 2.2e-49 144.82 In-house 76-201 (254) Show / Hide 
Range on Protein: 101-229
Range on HMM: 76-201/254
Sequence Identity: 44% (58 aa)

YLFLEYADGGELFDKIEPDCGMSPVFAQFYFKQLICGLKFIHDNDVVHRDIKPENLLLTGTHVLKISDFGMATLYRNKGEERLLDLSCGTIPYAAPELCA
....||. |||||| |     ..   |. .|.| | |.  .|.. .|||| |||||||   . .|| |||   .. ..|   .|  .||   |||||. .
FMVMEYVSGGELFDYIVKHGRLQEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMM-KDG--EFLKTACGSPCYAAPEMIS

GKKYRGPPVDVWSSGIVLIAMLTGELPWD
||.| || ||.||.|..| ||| | || |
GKLYCGPEVDIWSCGVILYAMLCGYLPFD
Kinase chk-1.AA Ciliate-E2-Unclassified 24-286 21 1.4e-48 166.63 In-house 1-352 (352) Show / Hide 
Range on Protein: 24-286
Range on HMM: 1-352/352
Sequence Identity: 21% (77 aa)

YRVVQTLGEGAFGEVLLIVNTKNPEVAAAMKKINIANKSKDFIDNIRKEYLLQK--RVSAVG-------------------HDNVIRMIGMRNDPQFYYL
|......|.|.||.| . .. |.   ..||| .. ... |. . .  .  ....  ..                       | ....|. . .| |  |.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

FLEYADGGELFDKIEP-----------------DCGMSPVFAQ-----FYFKQLICGLKFIHDND-VVHRDIKPENLLLTGTH---VLKISDFGMATLYR
 .||..||.|.. |.                  ..  .   |.     |||.|...||...| .  ..||||||||.|..  .    .||.||| .  | 
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

NK----GE---------ERLLDLSCGTIPYA----APELCAGKKYRGP---PVDVWSSGIVLIAMLTGELPWDRASDAS--------------QSYMGWI
.     ..         . ...  |||. |     |||.  |..| ..    .|.|| |..| .||.|..| .  .. .              . .  .|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

SN--TSLDERPW----KKIDVRALCMLR----KIVTDKTDKRATIEQIQADPWY
 .  .. .. ||    |...  |  ...    |.   . .|| |.|||   || 
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase chk-1.AA GIN4 82-286 35 2.3e-45 142.58 In-house 91-293 (293) Show / Hide 
Range on Protein: 82-286
Range on HMM: 91-293/293
Sequence Identity: 35% (74 aa)

VGHDNVIRMIGMRNDPQFYYLFLEYADGGELFDKIEPDCGMSPVFAQFYFKQLICGLKFIHDNDVVHRDIKPENLLLTGTHV-LKISDFGMATLYRNKGE
. | ||.|.  .    .  || ||||..||||. .     .    |  ||.|.| |. . |  ...|||.|||||||   .  .|| ||||| |   . .
ISHPNVMRLYDVWETNNDLYLVLEYAEKGELFNYLVDHGPLPEREAIHYFRQIIIGVSYCHAFNICHRDLKPENLLLDHKYNRIKIADFGMAAL---ETD

ERLLDLSCGTIPYAAPELCAGKKYRGPPVDVWSSGIVLIAMLTGELPWDRASDASQSYMGWISNTSLDERPWKKIDVRALCMLRKIVTDKTDKRATIEQI
. ||. |||   |||||. .|  |.| . |||| |..| |.||| ||.|      .  .  .     .    ..|   |  ..|||..   .|| .. .|
NKLLETSCGSPHYAAPEIVMGIPYHGFASDVWSCGVILFALLTGHLPFDEEDGNIRKLLLKVQKGKYEMPSDDEISREAQDLIRKILVVDPEKRIKTRDI

QADPWY
   |  
LKHPLI
Kinase chk-1.AA MARK 84-286 31 2.3e-43 139.69 In-house 58-262 (262) Show / Hide 
Range on Protein: 84-286
Range on HMM: 58-262/262
Sequence Identity: 31% (67 aa)

HDNVIRMIGMRN--DPQF-YYLFLEYADGGELFDKIEPD--CGMSPVFAQFYFKQLICGLKFIHDNDVVHRDIKPENLLLTGTH--VLKISDFGMATLYR
| |.|..  .    ..|   || .||| ||||.| |.      ..   |  .|.|....... |....|||||||||.|.        ||.|||...   
HPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIP

NKGEERLLDLSCGTIPYAAPELCAGKKYRGPPVDVWSSGIVLIAMLTGELPWDRASDASQSYMGWISNTSLDERPWKKIDVRALCMLRKIVTDKTDKRAT
   ....|.  ||| ||.|||.  .|.| ||.||.|| |.|| .|..| .|.| ......  . .  ..   ..| . . . .  ..... |   ..|.|
---PGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGYFPFD-GDTQDYKELYKKILRGKYDIPCH-VSKECRNLIQRLLTVNPEERPT

IEQIQADPWY
||.|  .|| 
IEEIMKHPWM
Kinase chk-1.AA BRSK 84-229 43 4.8e-42 141.02 In-house 59-201 (254) Show / Hide 
Range on Protein: 84-229
Range on HMM: 59-201/254
Sequence Identity: 43% (63 aa)

HDNVIRMIGMRNDPQFYYLFLEYADGGELFDKIEPDCGMSPVFAQFYFKQLICGLKFIHDNDVVHRDIKPENLLLTGTHVLKISDFGMATLYRNKGEERL
| .|..|        . || ||.  ||||||      .. |  | ..|.| | .| | |   . ||| ||||||| .    || ||||| | .   .. .
HPHVMKMYDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHNICHRDLKPENLLLDEKNNIKIADFGMASLQV---KDMM

LDLSCGTIPYAAPELCAGKKYRGPPVDVWSSGIVLIAMLTGELPWD
|. |||   || ||   | || |   |||| |..| |.|.| || |
LHTSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGALPFD
Kinase chk-1.AA ULK 24-228 25 3.3e-41 141.62 In-house 1-259 (329) Show / Hide 
Range on Protein: 24-228
Range on HMM: 1-259/329
Sequence Identity: 25% (66 aa)

YRVVQTLGEGAFGEVLLIVNTKNP---EVAAAMKKIN---IANKSKD-----FIDNIRKEYLLQKRVSAV-GHDN----VIRMIGMRNDPQF--YYLFLE
| . . ||.|.|| |    | |.     .. | |.|    . .|...     ... ...|  ..|.     .| |    ..... . .....  .|...|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YADGGELFDKIEPDCG----------MSPVFAQFYFKQLICGLKFIHDNDVVHRDIKPENLLLTGTH------------VLKISDFGMATL--YRNKGEE
| .|| |.. |. . .           |   |. .|||.. |.|..|.. ..||||||.| |..               ||||.||| |    . |. ..
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

RLLDLS-----CGTIPYAAPELCA----GKKYRGPPVDVWSSGIVLIAMLTGELP---W
 ..  .     |||  | ||..      .|.|    .|.|| |...  ||.|. |   |
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW
Kinase chk-1.AA TyrKc 24-290 19 4.8e-12 -27.99 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-290
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

YRVVQTLGEGAFGEVLLIVNTKNPEVAAAMKKINIANKSKDFIDNIRKEYLLQKRVSAV--GHDNVIRMIGMRNDP-------QFYYLFLEYADGGELFD
 .  ..||||||||| . . .    .  | |...        .  ...|  .    . .   |.|..|..|   ..       . ... .||...| | |
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-----REDFMREARI---MCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

KI-EPDCGMSPVFAQFYFKQLICGLKFIHDNDVVHRDIKPENLLLTGTHVLKISDFGMATLYRNK---GEERLLDLS----CGT--IPYA--APELCAGK
 . ..    ..     .  |  ||  ..|.. ..|||.   | |..  |. ||||||..    ..   ||.     .    .|   .|.   |||    .
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

KYRGPPVDVWSSGIVL--IAMLTGELPWDRAS--DASQSYMGWISNTSLDERPWK--------KIDVRALCMLRKIVTDKTDKRATIEQIQADPWYQHNF
|.  .  |||| |...  |  . .. ... .      |  . .. .    ..|            |     . ..    . ..| | ..|       . |
KF-TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI------HECF
Kinase chk-1.AA BRSK 262-286 40 6e-06 16.16 In-house 230-254 (254) Show / Hide 
Range on Protein: 262-286
Range on HMM: 230-254/254
Sequence Identity: 40% (10 aa)

MLRKIVTDKTDKRATIEQIQADPWY
.||. ..   ||| ....||  |||
LLRGMIEVDPDKRISLKEIQKHPWY
Kinase chk-1.AA MARK 24-40 35 9e-06 15.1 In-house 1-17 (262) Show / Hide 
Range on Protein: 24-40
Range on HMM: 1-17/262
Sequence Identity: 35% (6 aa)

YRVVQTLGEGAFGEVLL
|....|.|.|....| |
YKMLKTIGHGSYAKVKL
Kinase chk-1.AA AMPK 24-38 53 2.1e-05 12.09 In-house 1-15 (254) Show / Hide 
Range on Protein: 24-38
Range on HMM: 1-15/254
Sequence Identity: 53% (8 aa)

YRVVQTLGEGAFGEV
| . .|.|||.|| |
YIIGKTIGEGTFGKV
Kinase chk-1.AA AMPK 273-286 50 7.1e-05 10.48 In-house 241-254 (254) Show / Hide 
Range on Protein: 273-286
Range on HMM: 241-254/254
Sequence Identity: 50% (7 aa)

KRATIEQIQADPWY
||.||..| ..||.
KRITIHDIRNHPWF
Kinase chk-1.AA Pkinase_Tyr 136-172 37 0.0002 15.61 Pfam 122-158 (270) Show / Hide 
Range on Protein: 136-172
Range on HMM: 122-158/270
Sequence Identity: 37% (14 aa)

CGLKFIHDNDVVHRDIKPENLLLTGTHVLKISDFGMA
.|. . ...  .|||.   | |.| ..| ||.|||.|
KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase chk-1.AA Pkinase_Tyr 24-38 60 0.066079 7.08 Pfam 1-15 (270) Show / Hide 
Range on Protein: 24-38
Range on HMM: 1-15/270
Sequence Identity: 60% (9 aa)

YRVVQTLGEGAFGEV
 .  ..|||||||||
ITFGKKLGEGAFGEV
Kinase chk-1.AA BRSK 24-38 53 0.289513 0.04 In-house 1-15 (254) Show / Hide 
Range on Protein: 24-38
Range on HMM: 1-15/254
Sequence Identity: 53% (8 aa)

YRVVQTLGEGAFGEV
||.  ||| |  | |
YRLEKTLGKGQTGLV
Kinase chk-1.AA Pkinase 273-286 57 8.630931 0.34 Pfam 280-293 (293) Show / Hide 
Range on Protein: 273-286
Range on HMM: 280-293/293
Sequence Identity: 57% (8 aa)

KRATIEQIQADPWY
|| |.|||  .|| 
KRPTAEQILQHPWF