Gene D2045.5 (Nematode worm)
D2045.5
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| D2045.5.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 259 | Kinase domain by global Sugen HMM | Fasta, JSON |
| D2045.5.AA | Protein | Genbank | 351 | None | Fasta, JSON |
Protein domains of D2045.5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | D2045.5.AA | TTBKL | 17-282 | 42 | 2e-145 | 489.39 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 17-282 Range on HMM: 1-288/288 Sequence Identity: 42% (123 aa) WKIVEKLGEGGMGAVFKVRDLTRFQTYAAMKVEGDV-SDGG-VLKLEAHVLKSLA--PLPFCARLMDAGDRKSYCFMVMTLLGKDLMAHKRDANTPR-FC |.||...||||.|.|..|.|.......||||.| .. ..|. ..|.|.|||. |. . |........| ||.|.||||||.|..|...... .... |. WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS EQTTLRLAMATLFAIKQIHEVGFTHRDIKPGNCVTGVH---GSDAKNVYLIDYGMVRQFTAKRENG-------ETALRRARS--GEQLFRGTPRYCSMNV ..|..|... .|.|.||.|..|| |||.||.||..|.| ......|||||.||.||. | ... .. .||.|. . ||||.||||.|. DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM HNRKEQGRVDDLWSWLYMLIELHCGLPWRRLTDEKEIMDAKIACSMETLLKG------CPKEFANIHKYLETLEYKSRPDYFGLWSECF |.||||||.||||||.||.|||||||||....|..||. .| ....|.| |. ||.||. ..|.|..|.|..|||| . ||| HDRKEQGRHDDLWSWMYMIIELHCGLPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIY-ECF |
|||||||||
| Kinase | D2045.5.AA | CK1 | 17-277 | 31 | 1.9e-107 | 363.26 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 17-277 Range on HMM: 1-339/339 Sequence Identity: 31% (106 aa) WKIVEKLGEGGMG-AVFKV-----RDLTRFQ----TYAAMKVEGDVSDGG-VLKLEAHVLKSL---------------------APLPFCARLMDAGDRK ||.|.|.|||| | ...|| .|.... . .||||| | |. ...|..... . . |.. .....| .. WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED SYC-FMVMTLLGKDLMAHKR-DAN-TPRFCEQTTLRLAMATLFAIKQIHEVGFTHRDIKPGNCVTGVHGS------------DAKNVYLIDYGMVR-QFT |. .|||||||..|. .. ... . .|. |.|..|. .|.|....|. || ||||||.|.. |...| ....||.||.||.| ... DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR AKRENG--------ETALRRARS--GEQLFRG-TPRYCSMNVHNRKEQGRVDDLWSWLYMLIELHCG---LPWRRLTDEKE-----IMDAKIACSMETLL |.... . .|..|. . ||| |.||||.|.|..|||||.||||||.|||||.. | |||. ..||.. ....| .. .|... DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM KG------------CPKEFANIHKYLETLEYKSRPDYFGL . ||.|| | ||...|.|..|||| . STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
|||||||||
| Kinase | D2045.5.AA | Worm6 | 17-277 | 34 | 1.3e-70 | 240.86 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 17-277 Range on HMM: 1-279/279 Sequence Identity: 34% (98 aa) WKIVEKLGEGGMGAVFKVRDLTRFQT-YAAMKVEG--DVSDGGVLKLEAHVLKSLAPLP---FCARLMDAGDRKS--YCFMVMTLLGKDLMAHKRDANTP ||...|.||||.|||.|| | .. |||.|. . ..||.|. ||| .. . || ...|.| .. . ..||||.||.|. ...... WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFC-KIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDR RFCEQTTLRLAMATLFAIKQIHEVGFTHRDIKPGNCVTGV----HGSDAKNVYLIDYGMVRQFTAKRENGETALRR-ARSGEQLFRGTPRYCSMNVHNRK .| |.|..| .| || . | .|| |||.|||| |. . ...|..|.|| |.. .. ...| .| .. | ||||.||.. . |... KFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACG---FRGTVRYAPLACHKGQ EQGRVDDLWSWLYMLIELHCG-LPWRRLTDEKEIMDAKIAC---S----METLLKGCPK-EFANIHKYLETLEYKSRPDYFGL ||.| ||. ||.||..|. .| |||| ..|... . | .| |. ....||| || | .|. .. | .|||| . EQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
|||||||||
| Kinase | D2045.5.AA | TTBK | 17-277 | 39 | 1.2e-67 | 231.06 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 17-277 Range on HMM: 1-257/257 Sequence Identity: 39% (104 aa) WKIVEKLGEGGMGAVFKVRDLTRFQTYAAMKVEGDVSDGGVLKLEAHVLKSLAPLPFCARLMDAGDRKSYCFMVMTLLGKDLMAHKRDANTPRFCEQTTL ||.| | | || | .. |. . |.||| |||.| ||| | .. | . | . .|||.|.|| | | . | ||| WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL RLAMATLFAIKQIHEVGFTHRDIKPGNCVTGVHGSDAKNVYLIDYGMVRQFTAKRENGETALRRARSGEQLFRGTPRYCSMNVHNRKEQGRVDDLWSWLY || . | .|..||.||| |||||| | | | ...|..|.|. ||.| || |. | |||| || | | | .| || ||||| | RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNAC--GEVRPPREVAG---FRGTVRYASINAHRNREMGRHDDLWSLFY MLIELHCG-LPWRRLTDEKEIMDAKIACSMETLLKGCPKEFANIHKYLETLEYKSRPDYFGL ||.| | ||||.. | .. | . ||| ||.|| . .. |.|. |||| . MLVEFVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
|||||||||
| Kinase | D2045.5.AA | CK1-A | 17-277 | 30 | 4.9e-30 | 103.24 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 17-277 Range on HMM: 1-261/261 Sequence Identity: 30% (82 aa) WKIVEKLGEGGMGAVFKVRDLTRFQTYAAMKVEGDVSDGGVLKLEAHVLKSLAPLPFCARLMDAGDRKSYCFMVMTLLGKDLMAHKRDANTPRFCEQTTL ...| |.| | | .. .| . |.|.| . | || | . |. . .. | | | ||| ||| | . || .| | YRLVRKIGSGSFGDIYLGINITNGEE-VAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSL-EDLFNFCKRRFTMKTVL RLAMATLFAIKQIHEVGFTHRDIKPGNCVTGVHGSDAKNVYLIDYGMVRQFTAKRENGETALRRARSGEQLFRGTPRYCSMNVHNRKEQGRVDDLWSWLY || . | .|| .| |||||| | . |. | ..|||.|. ... .| | . || || |.| | || | ||. | | MLADQMIMRIEYVHEKNFIHRDIKPDNFLMGI-GRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKN----LTGTARYASINAHLGIEQSRRDDMESMGY MLIELHCG-LPWRRLTDEKE------IMDAKIACSMETLLKGCPKEFANIHKYLETLEYKSRPDYFGL ... | ||| .. | . |.. ..| | || | ||. . .| | .. ||| | VMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
|||||||||
| Kinase | D2045.5.AA | CK1-D | 17-277 | 30 | 5.9e-30 | 102.78 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 17-277 Range on HMM: 1-261/261 Sequence Identity: 30% (81 aa) WKIVEKLGEGGMGAVFKVRDLTRFQTYAAMKVEGDVSDGGVLKLEAHVLKSLAPLPFCARLMDAGDRKSYCFMVMTLLGKDLMAHKRDANTPRFCEQTTL ..| |.| | | .. ... |.|.| . |..|... | . .. | | ||| ||| | . .| .| | YRIGRKIGSGSFGDIYHGTNIQT-NEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHR-KFSLKTVL RLAMATLFAIKQIHEVGFTHRDIKPGNCVTGVHGSDAKNVYLIDYGMVRQFTAKRENGETALRRARSGEQLFRGTPRYCSMNVHNRKEQGRVDDLWSWLY || . |. || | |||||| | . |. | . ||.||.|. ... | . | .. || || |.| | || | ||| | | MLADQMICRIEYIHCRNFIHRDIKPDNFLMGL-GKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKN----LTGTARYASINTHQGIEQSRRDDLESLGY MLIELHCG-LPWRRLTDE------KEIMDAKIACSMETLLKGCPKEFANIHKYLETLEYKSRPDYFGL .|. | ||| | |.. |. ...|| || |.||.. | .|.. .||| | VLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
|||||||||
| Kinase | D2045.5.AA | CK1-Unique | 17-221 | 24 | 1e-23 | 79.08 | In-house | 1-223 (337) | Show / Hide |
Range on Protein: 17-221 Range on HMM: 1-223/337 Sequence Identity: 24% (56 aa) WKIVEKLGEGGMGAVFKVRDLTRF------QTYAAMKVEGDVSDGG--VLKLEAHVLKSLAPLP--------FCARLMDAGDRKSYCFMVMTLLGKDLMA |.. ...| || | | .| .. . | .|| | |. | |.|.. . || . | . ... ..|||..|. . WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMY-CMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFC-EVHDFHQHRDWWWIVMTMHGPSMEE HKRDANTPRFCEQ------TTLRLAMATLFAIKQIHEVGFTHRDIKPGNCVTGVHG-SDAKNVYLIDYGMVRQ--FTAKRENGETALRRARSGEQLFRGT .. | . .... ..|..| |..|| ||..||.| ... . . | .||| | | . . . .. |||. CCMMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITP-----FRGC PRYCSMNVHNRKEQGRVDDLWSWLYMLIEL ..||. | .|.|| ||. ||.|||. | KDYCPCSCHQCREHGRRDDMESWFYMLYHL |
|||||||||
| Kinase | D2045.5.AA | Dual | 122-274 | 30 | 1.2e-20 | 65.98 | In-house | 122-275 (282) | Show / Hide |
Range on Protein: 122-274 Range on HMM: 122-275/282 Sequence Identity: 30% (49 aa) TLFAIKQIHEVGFTHRDIKPGNCVTGVHGSDAKNVYLIDYGMVRQFTAKRE--NGETALRRARSGEQLFRGTPRYCSMNVHNRKEQGRVDDLWSWLYM-- .| ||. | .|. ||.||| | |. | | ||. |...|| . . |.. | ||.. . |. || . . |.||| ||| .| || MLRAIQDLHSIGYLHRNIKPANFHCGL-GMDETTVYMQDFRIVRKYI---DPENKK--HRTARKKVKMY-GCGRYACRACMMQKDQGRKDDLECWIYMVF -LIELHCGLPWRRLTDEKEIMDAK---IACSMETLLKGCPKEFANIHKYLETLEYKSRPDY |. |..||.. | .... .| . . |.... . | ..| | ||| DLMDPEHGMSWRKECDCNMMIKQKDNFMYHFDKHQYSHIPRRLKPLVSYVNGYQYDSTPDY |
|||||||||
| Kinase | D2045.5.AA | S_TKc | 17-282 | 19 | 5.3e-14 | 28.45 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 17-282 Range on HMM: 1-231/231 Sequence Identity: 19% (55 aa) WKIVEKLGEGGMGAVFKVRDLTRFQTYAAMKVEGDVSDGGVLKLEAHVLKSLAPLPFCARLMDAGDRKSYCFMVMTLLGK---DLMAHKRDANTPR---- ..|..|.|.|..| |.|.|. . . |.|. .. | .||. |. .| |. . .. .||| ... ||. . .. .... YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP FCEQTTLRLAMATLFAIKQIHEVGFTHRDIKPGNCVTGVHGSDAKNVYLIDYGMVRQFTAKRENGETALRRARSGEQLFRGTPRYCSMNVHNRKEQGR-V | | .. ... .. |.. .|. |. |||.|| | .. ..| |. ||. | ||| |.. | |. FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------------------TTFCGTPWYMAPEVL---GYGKCK DDLWSWLYMLIELHCGLP-WRRLTDEKEIMDAKIACSMETLLKGCPKEFANIHKYLETLEYKSRPDYFGLWS--------ECF | || .|.|. || | .. ....... ..|. .. . . . . . || . . | CDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | D2045.5.AA | Pkinase | 17-238 | 22 | 6.8e-13 | 46.67 | Pfam | 1-228 (293) | Show / Hide |
Range on Protein: 17-238 Range on HMM: 1-228/293 Sequence Identity: 22% (55 aa) WKIVEKLGEGGMGAVFKVRDLTRFQTYAAMKVEGDVSDGGVLKL-----EAHVLKSLAPLPFCARLMDAGDRKSYCFMVMTLLGK-----DLM----AHK ..|..|.|.|..| |.| .. ...| ... . . .... |....|.| |. || |. .|... ||| .... ||. ... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR RDANTPRFCEQTTLRLAMATLFAIKQIHEVGFTHRDIKPGNCVTGVHGSDAKNVYLIDYGMVRQFTAKRENGETALRRARSGEQLFRGTPRYCSMNVHN- . . . | |.. . . .| ... .|. |. |||.|| |. .| . | ..| | .|| | . | |||.|.. |.. HGCFY--FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----------Y-NNS-MTTFCGTPWYMAPEVIRG RKEQGRVDDLWSWLYMLIELHCG-LPWRRL-----TDEKEIMD ... |. | || .|.|. || .|.. |...... GQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMIC |
|||||||||
| Kinase | D2045.5.AA | CK1-Unclassified | 17-98 | 25 | 2.1e-11 | 29.91 | In-house | 1-90 (244) | Show / Hide |
Range on Protein: 17-98 Range on HMM: 1-90/244 Sequence Identity: 25% (23 aa) WKIVEKLGEGGMGAVFKVRDLTRFQTYAAMKVEGDVSDGGVLKLEAHVLKSLAPLP-------FCARLMDAGDR--KSYCFMVMTLLGKDL ...||.| | | ..|. .. . . .|.|.| | |. || ... | ... | | .|||.|||..| YRVIEKIGQGSFGEIYKCINMQTN-EEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSL |
|||||||||
| Kinase | D2045.5.AA | CK1 | 17-98 | 23 | 3.8e-10 | 31.32 | In-house | 1-91 (271) | Show / Hide |
Range on Protein: 17-98 Range on HMM: 1-91/271 Sequence Identity: 23% (22 aa) WKIVEKLGEGGMGAVFKVRDLTRFQTY--AAMKVEGDVSDGGVLKLEAHVLKSLAP------LPFCARLMDAGDR--KSYCFMVMTLLGKDL ....|.|.| | .... .. . . |.|.| | |. || ..| | . ... | . | .|||.|||..| YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSL |
|||||||||
| Kinase | D2045.5.AA | CK1-Unclassified | 128-162 | 45 | 4.5e-10 | 25.95 | In-house | 119-153 (244) | Show / Hide |
Range on Protein: 128-162 Range on HMM: 119-153/244 Sequence Identity: 45% (16 aa) QIHEVGFTHRDIKPGNCVTGVHGSDAKNVYLIDYG ..|. .| |||||| | . | | ...||.||.| YLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFG |
|||||||||
| Kinase | D2045.5.AA | CK1 | 126-163 | 44 | 2.6e-09 | 28.4 | In-house | 118-155 (271) | Show / Hide |
Range on Protein: 126-163 Range on HMM: 118-155/271 Sequence Identity: 44% (17 aa) IKQIHEVGFTHRDIKPGNCVTGVHGSDAKNVYLIDYGM | .|. .| |||||| | . |. | ....||.||.|. IEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGL |
|||||||||
| Kinase | D2045.5.AA | CK1 | 236-275 | 39 | 2.3e-08 | 25.13 | In-house | 231-271 (271) | Show / Hide |
Range on Protein: 236-275 Range on HMM: 231-271/271 Sequence Identity: 39% (16 aa) IMDAKIACSMETLLKG-CPKEFANIHKYLETLEYKSRPDYF ||. |. . |.| || .|.|||. .| |... .||| IMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM |
|||||||||
| Kinase | D2045.5.AA | Dual | 17-51 | 28 | 1e-05 | 15.16 | In-house | 1-38 (282) | Show / Hide |
Range on Protein: 17-51 Range on HMM: 1-38/282 Sequence Identity: 28% (11 aa) WKIVEKLGEGGMGAVFKVRDLTR---FQTYAAMKVEGD ||.| || ||.. | .|.. . ... ..|.| . WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESE |
|||||||||
| Kinase | D2045.5.AA | CK1-Unclassified | 190-211 | 59 | 0.000123 | 9.63 | In-house | 178-199 (244) | Show / Hide |
Range on Protein: 190-211 Range on HMM: 178-199/244 Sequence Identity: 59% (13 aa) GTPRYCSMNVHNRKEQGRVDDL || || | | | .||.| ||| GTARYASINAHLGIEQSRRDDL |
|||||||||
| Kinase | D2045.5.AA | CK1 | 190-219 | 50 | 0.001748 | 8.09 | In-house | 178-207 (271) | Show / Hide |
Range on Protein: 190-219 Range on HMM: 178-207/271 Sequence Identity: 50% (15 aa) GTPRYCSMNVHNRKEQGRVDDLWSWLYMLI || || | | | .||.| ||. | |.|. GTARYASINTHLGIEQSRRDDMESLGYVLM |
|||||||||