Gene D2045.7 (Nematode worm)

D2045.7

Species: Nematode worm
Alias: CE03103, aSWK248, D2045.7
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: III: 10475413-10477512, WormBase Genetic Map location: III:2.53,

Classification

Group: Other
Family: Other-Unique

Sequence

Name Sequence Type Origin Length Description Download
D2045.7.AA Protein Genbank 322 None Fasta, JSON
D2045.7.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 251 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of D2045.7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc D2045.7.AA S_TKc 25-295 21 7.5e-39 136.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 25-295
Range on HMM: 1-231/231
Sequence Identity: 21% (60 aa)

LKVRKTVAVGGSAKIMEVDPGGGKKPMIVKKMVAFSKREEERILLEIDLYKKLENNEFVIDLMAHIVDDITHYLLFDKYSQ---NFLEYIEELKIGGE--
 .. ...  |. .| . .   . .. . .|..        |.|. ||.. ||  . .... |  ...|    |. ..  ..   . ..||.. . .|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-VDELKHLKYFSGIVSAIEQLHGFEFAHLDIKPANILKSGDTIKMIDFGSATKMPIEIKTSADHHRHKEDAEELCSMMYRAPELFNCEIGSTLTT-AVDV
  .|    .|.  |..|.| .|   . | |.||.||| .  .|| .|||.|...                     .  |.|||..        .. ..|.
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL----------------TTFCGTPWYMAPEVL------GYGKCKCDW

WALGVCLYEFLYLENPFNKIYEQGGSIALATQSPHMIKWNENRHISEKSINLIKSILIVDPNQRPTIGELRA-----KVDNLL
|..|..|||.|. . ||              |   |.|       |.  ...|. .| .||..|||. |. .     | .  .
WSCGCILYEMLCGYPPFP-------------QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase D2045.7.AA NAK 126-291 28 2.5e-37 122.1 In-house 122-299 (299) Show / Hide 
Range on Protein: 126-291
Range on HMM: 122-299/299
Sequence Identity: 28% (50 aa)

LKYFSGIVSAIEQLHGFE----FAHLDIKPANILKS----GDTIKMIDFGSATKMPIEIKTSADHHR---HKEDAEELCSMMYRAPELFNCEIGSTLTTA
|. |...  .....|        .| |||. ||| |     ...|  ||||.|   |..... .  .    ...... ...||||||...   . . .. 
LQIFCDVCEGVQAMHQCQPPKPIIHRDIKIENILLSESHHDGNYKLCDFGSMTTAIIQPENRWEAQYRSMVQDWINKYTTPMYRAPEMCDLYSNCPIDEK

VDVWALGVCLYEFLYLENPFNKIYEQGGSIALATQS-PHMIKWNENRHISEKSINLIKSILIVDPNQRPTIGELRAKV
||.||||. ||  .. . || ..|. ..|..|| |.   ...  .|   |.. ..||. .| .||.|||.| ..  ..
VDIWALGCMLYKMCFYTHPFEDCYQRHDSSKLAIQNGNYKYSIPDNSRYSQQMHDLIRYMLTPDPEQRPNIYQVLNQL
Kinase D2045.7.AA Other-Unique 41-286 16 2.8e-29 96.64 In-house 1-249 (249) Show / Hide 
Range on Protein: 41-286
Range on HMM: 1-249/249
Sequence Identity: 16% (42 aa)

EVDPGGGKKPMIVKKMVAFSKREEERILLEIDLYKKLENN---------------EFVIDLMAHIVDDITHYLLFDKYSQNFLEYIEELKIGGEVDELKH
  | | |.   ..|..   .|.... .. .... ... ..               .|... |.|... . .. ..... ... ...  ...  .. ...|
IKDIGKGTYGRVYKQHHNKKKKYCAKKTKHHKI-HCMDMDNNKREQIYHYQIIHCIFYWT-MNHCHLCFCYEHCPNMIFYIMYPWY--HHHCECQCQCEH

LKYFSGIVSAIEQLHGFEFAHLDIKPANILKSGDTIKMIDFGSATKMP-IEIKTSADHHRHKEDAEELCSMMYRAPELFNCEIGSTLTTAVDVWALGVCL
..... .......|| ..  | ||.| ||. . . |.|........ | | | .. .|.....  .. . |||.|||. .|.. |. |. .  ..   ..
WMNCCHMIHNLHHLHNNNHIHCDINPNNIWINQNNIHMCHNCGHNI-PTI-I-IEHQHIKIMDFNNN-N-MMYFAPEF-SCRWCSPETFDYWPLGEKIDQ

YEFLYLENPFNKIYEQGGSIALATQSPHMIKWNENRHISEKSINLIKSILIVDPNQRPTIGE
| | ....  | ....  ....  ..|... .... ||. . ........ |.|.|.|.. .
YHFGCYHFHMNCQHWIFHYHDV-QHWPPHESPKDI-HILICQCECCHQCM-VNPYQNPNCFY
Kinase D2045.7.AA Ciliate-E2 48-287 18 6e-29 96.49 In-house 44-359 (365) Show / Hide 
Range on Protein: 48-287
Range on HMM: 44-359/365
Sequence Identity: 18% (62 aa)

KKPMIVKKMVAFSKREEERILLEIDLYKKLE---------------NNEFVIDLMAHIV--DDITHYLLFDKYSQ-NFLEYIEEL-KIGGEV-------D
|  .  . |  ..|.. | |. ||.......               |. ..| .  .    || . || .. ... . ..||..  |  ..        .
KVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFT

ELKHLKYFSGIVS---------------AIEQLHGFE-FAHLDIKPANILKSGDTIKMIDFGSATKMPIEIKTSADHHRHKEDAEE--------------
| . ....  |..               |.| ||      | |||| |||     || |||| ..|  .. .   .  .. .   .              
EKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQI

---------LCSMMYRAPELFN-CE-----IGSTLTTAVDVWALGVCLYEFLYLENPFNKIYEQGGSIALATQSPHMIKWNEN-----------------
         ... .| ||| .|  .      .   ....|.|.|||.|||.|. . ||                   .. ...                 
IQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-------------------QQQIKQCKIDFPCPEWQKDTQCI

-------RHISEKSINLIKS----ILIVDPNQRPT-IGEL
        ..|.. ..|||     .| .||..|.| . ..
QCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI
Kinase D2045.7.AA MPSK 126-291 32 5e-28 97.66 In-house 113-281 (281) Show / Hide 
Range on Protein: 126-291
Range on HMM: 113-281/281
Sequence Identity: 32% (55 aa)

LKYFSGIVSAIEQLH---GFEFAHLDIKPANILKSGDTIKMI-DFGSATKMPIEIKTSADHHRHKEDAEELCSMMYRAPELFNCEIGSTLTTAVDVWALG
.. | |.   .. .|      .|| |.||.||. . |    | |.|| .   |..| . .  .    |.| |||.|||||||  .   .    .|.| ||
WWIFLGVCEGLKAIHEAMPKPYAHRDMKPTNICLGDDFQPVIMDLGSMNEACIQVKGQRQACALQDWAAERCSMVYRAPELFHVQSHCVIDERTDIWSLG

VCLYEFLYLENPFNKIYEQGGSIALATQSPHMIKWNENRHISEKSINLIKSILIVDPNQRPTIGELRAKV
  ||   |.. |.  ||. | |..|| |.   ..  ||   |.    ||.. . ||| .|| |  .  ..
CVLYAMCYFHSPYDMIYQRGDSVHLAVQN-RNFNIPENSRYSQDMHQLISYMMRVDPMERPHIFWVLNQT
Kinase D2045.7.AA Ciliate-E2-Unclassified 48-287 16 1.4e-23 78.68 In-house 29-346 (352) Show / Hide 
Range on Protein: 48-287
Range on HMM: 29-346/352
Sequence Identity: 16% (54 aa)

KKPMIVKKMVA--FSKREEERILLEIDLYKKLE------------------NNEFVIDLMAHIVDDITHYLLFDKYSQNFLEYIEELKIG----------
.| |.......    .... .|..|..  ....                  ...|.. .. .  |. . |.  ..  .. |... . . .          
MKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFH

-----GEVDELKHL-----KYFSGIVSAIEQLHGFE-FAHLDIKPANILKSGD----TIKMIDFGSAT---KMPIEIKTS----ADHHRHKEDAEELCSM
      ...| . .     .||  |....|.||    . | |||| ||| . .     || ||||..    ... .  |.     .  ....     .. 
NMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTP

MYR----APELF-NCEIGSTLTTAVDVWALGVCLYEFLYLENPFNKIYEQG---------------GSIALATQSPHMIKWNEN----RHISEKSINLIK
.|     |||.. ... . .   ..|.|.|||.|||.|. . ||.   .                   .    | .  ... ..     |.|.. ...|.
NYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN

----SILIVDPNQRPTIGEL
    ..| ..||.|.|. ..
DLLQKMLKKNPNKRITFEQI
Kinase D2045.7.AA Pkinase 127-291 24 6.1e-20 71.6 Pfam 112-293 (293) Show / Hide 
Range on Protein: 127-291
Range on HMM: 112-293/293
Sequence Identity: 24% (48 aa)

KYFSGIVSAIEQLHGFEFAHLDIKPANILKS-GDTI----KMIDFGSATKMPIEIKTSADHHRHKEDAEELC-SMMYRAPELFNCEIGSTLTTAVDVWAL
.|.  |....| .|   . | |.||.||| .  ..|    | .|||.| ..          . ... .  .| .  |.|||. .   |.  ...||.|..
FYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---------Y-NNS-MTTFCGTPWYMAPEVIR--GGQYYGPKVDMWSC

GVCLYEFLYLENPFNKI-----YEQGGSIALATQSPHMIKWNENRHIS-----------------EKSINLIKSILIVDPNQRPTIGELRAK--V
|. |||.|  . ||        ..|   |..  . | .  | . . ||                 |  . .||..| .||..|||. ..     .
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase D2045.7.AA NAK-Unclassified 145-293 19 1e-18 61.75 In-house 196-405 (405) Show / Hide 
Range on Protein: 145-293
Range on HMM: 196-405/405
Sequence Identity: 19% (41 aa)

AHLDIKPANILKS----------------------------------------------------------GD-TIKMIDFGSATKMPIEIKTSADHHRH
.| |||. |.| .                                                           .   |  ||||..   | |... .    
IHRDIKIENVLFCNLRRPSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSEDSEHNGIYKLCDFGSCCECIITIENRQEMQYL

KEDAEELCSMMYRAPELFNCEIGSTLTTAVDVWALGVCLYEFLYLENPFNKIYEQG-GSIALATQS--PHMIKWNENRHISEKSINLIKSILIVDPNQRP
 .. .  .   |||||...   .  .   .|.||||. ||  ..   || .  . . .|....  .  .   .   |   |.. .|||| .| .||.|||
QDWINMHTTPQYRAPEMIDLYRCCPIDEKIDIWALGCFLYKMCFYTTPFEMCGQLHNASVTYKILHGLGKY-EFPSNHNYSNQLHNLIKIMLNEDPIQRP

TIGELRAKVDN
.| ..  ..  
NIYQVLNHICQ
Kinase D2045.7.AA ULK 126-281 21 1.2e-18 61.73 In-house 133-317 (329) Show / Hide 
Range on Protein: 126-281
Range on HMM: 133-317/329
Sequence Identity: 21% (41 aa)

LKYFSGIVSAIEQLHGFEFAHLDIKPANILKSGD-------------TIKMIDFGSATKMPIE------IKTSA-DHHRHKEDAEEL---CSMMYRAPEL
...|  |...   ||     | ||||.||| . .             ..|  ||| | ..  .      ..|   .              .. .| ||..
IQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNE----------KRLCGTPLYMAPQI

FNCE-IGSTLTTA-VDVWALGVCLYEFLYLENPFNK-IYEQG-----GSIALATQSP-----HMIKWN---ENRHISEKSINLIKSILIVDPNQR
.. .  .   ... .|.| ||. .|| || . ||.. ...|        | .   .|     . ....   .. .||.....||.  |..|...|
LQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDR
Kinase D2045.7.AA CMGC 47-228 14 5.6e-17 51.46 In-house 37-329 (513) Show / Hide 
Range on Protein: 47-228
Range on HMM: 37-329/513
Sequence Identity: 14% (44 aa)

GKKPMIVKKMV-AFSKREEER-----------ILLEIDLYKKLE---------------NNEF-VIDLMAHIVDDI-----------------THYLLFD
...   .||.  .| . |...           .| || . |.|                ...  .. |  .....                    || |.
TNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFE

KYSQNFLEYIEELK--IGG-EVDELKHLK---------------YF------SGIVSAIE--QLHGFE--FAHLDIKPANILKSGDT-------------
   .. ..||.. .    |    .|.. .               ..        |  ...   .|     . | |.||.||| . ..             
YMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDW

--------IKMIDFGSATKMPIEIKTSA-------------DHHRHKEDAEELCSMMYRAPELFNCEIGSTL----------TTAVDVWALGVCLYEFL
        .| .|||.|..  .. .  .             | .  .   .. ... |||||.    .|..           ||..|.|..|  ..| .
NPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDD-KPNRPYTHYVVTRWYRAPEIL---LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMY
Kinase D2045.7.AA ULK 126-281 21 1.1e-16 55.78 In-house 129-312 (324) Show / Hide 
Range on Protein: 126-281
Range on HMM: 129-312/324
Sequence Identity: 21% (42 aa)

LKYFSGIVSAIEQLHGFEFAHLDIKPANILKSGDT-------------IKMIDFGSATK-----MPIEIKTSAD-HHRHKEDAEEL---CSMMYRAPELF
...|  |...   ||     | ||||.||| . ..             .|  ||| | .     |   . ...                .. .| ||...
IQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCVNE---------KRIKGTPLYMAPQIL

NCE-IGSTLTTA-VDVWALGVCLYEFLYLENP----FNKIYE-----------QGGSIALATQSPHMIKWN---ENRHISEKSINLIKSILIVDPNQR
. .  .   ... .|.| ||. .|| || . |    ||. |.           |     . .     |...   .. .||.....||.  |..|...|
QGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQ-----QIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDR
Kinase D2045.7.AA PASK 216-287 36 3.4e-13 37.24 In-house 192-254 (260) Show / Hide 
Range on Protein: 216-287
Range on HMM: 192-254/260
Sequence Identity: 36% (26 aa)

DVWALGVCLYEFLYLENPFNKIYEQGGSIALATQSPHMIKWNENRHISEKSINLIKSILIVDPNQRPTIGEL
..||||| ||  .. ||||  | |    .  |      |. ..  |.||  . ||||.|  .|..|.|. ..
EMWALGVTLYTLMFKENPFCNIEE----TLEA-----EIHFPNAEHVSEECMSLIKSMLNRCPEKRCTMHQI
TyrKc D2045.7.AA TyrKc 13-291 17 2.5e-07 -104.26 SMART 1-280 (280) Show / Hide 
Range on Protein: 13-291
Range on HMM: 1-280/280
Sequence Identity: 17% (55 aa)

SKVPDIVGEGYHLKVRKTVAVGGSAKIMEVDPGGGKKPMIVKKMVAFSKREEERILLEIDLYKKL-ENNEFVIDLMAHIVDD-------ITHYLLFDKYS
 .  .. |||   .|.| ..                 .  ||.. . .   .| .. |. . .||  ... .. | . ....         .....   .
ITLGKKLGEGAFGEVYKGTWK---------------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMP

Q-NFLEYIEELKIGGEVDELKHLKYFSGIVSAIEQLHGFEFAHLDIKPANIL-KSGDTIKMIDFGSATKMPIEIKTS------ADHHRHKE--DAEELCS
  . ..|. . .    .   . |..   | .  | ||   . | |.   |.| ... |.|  |||    .  .|.         |  |.||  ..  .  
HGDLKDYLRKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFG----LSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

MMYRAPELFNCEIGSTLTTAVDVWALGVCLYEFL------YLE-----NPFNKIYEQGGSIALATQSPH-----MIKWNENRHISEKSINLIKSILIVDP
    ||| .     .. ||. |||. |||..| .      | .      .   ..|.  .     | |.             . ...  ...|.    ||
IRWMAPECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF------VCCPDEMYQIMKQCWHEDP

NQRPTIGELRAKV
..|||  |.. . 
EDRPTFSEIHECF
Kinase D2045.7.AA PASK 132-170 47 8.1e-07 16.95 In-house 119-158 (260) Show / Hide 
Range on Protein: 132-170
Range on HMM: 119-158/260
Sequence Identity: 47% (19 aa)

IVSAIEQLHGFEFAHLDIKPAN-ILKSGDTIKMIDFGSAT
.|.|.  ||  .  | |||  | |. .  |||.||||||.
VVAAVKYLHEQGIVHRDIKDENVIIDEHFTIKLIDFGSAA
Kinase D2045.7.AA CMGC 259-286 28 0.032803 2.02 In-house 479-506 (513) Show / Hide 
Range on Protein: 259-286
Range on HMM: 479-506/513
Sequence Identity: 28% (8 aa)

NRHISEKSINLIKSILIVDPNQRPTIGE
....... |.|.| .|. ||..|.|. .
RKCCDPQAIDLLKKMLQYDPDKRITAEQ