Gene daf-1 (Nematode worm)

daf-1

Species: Nematode worm
Alias: F29C4.1, aSWK427, CE31492, daf-1
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: IV: 132414-138054, WormBase Genetic Map location: IV:-27.468,

Classification

Group: TKL
Family: STKR
Subfamily: STKR1

Sequence

Name Sequence Type Origin Length Description Download
daf-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 268 Kinase domain by global Sugen HMM Fasta, JSON
daf-1.AA Protein Genbank 669 None Fasta, JSON

Protein domain

Protein domains of daf-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase daf-1.AA Type1 293-586 46 1.3e-208 571.38 In-house 1-290 (290) Show / Hide 
Range on Protein: 293-586
Range on HMM: 1-290/290
Sequence Identity: 46% (136 aa)

IRLTGRVGSGRFGNVSRGDYRGEAVAVKVFNALDEPAFHKETEIFETRMLRHPNVLRYIGSDRVDTGFVTELWLVTEYHPSGSLHDFLLENTVNIETYYN
|... ..|.||.|.|.||..|||.||||.|...||.....||||..|.|.||.|.|..|..|..|.|..|.|||.|.||..|||.|.| ..|........
IQMIECIGKGRYGEVWRGKWRGENVAVKIFFSRDERSWFRETEIYQTVMMRHENILGFIAADMKDNGSWTQLWLITDYHEHGSLYDYLNRHTLDTQQMLR

LMRSTASGLAFLHNQIGGSKESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSLSKPEDAASDIIANENYKCGTVRYLAPEILNSTMQFTVFESYQCADV
|..|.|.|||.||..| |..|..|||.|||||||||||||....|.|.||||......|.....|. .|...||.||.|||.|..||....||||..||.
LAYSCACGLAHLHMEIFGTQEFGKPAIAHRDIKSKNIMVKKNGQCCIADLGLAVRHQQDTDQIDIG-QNPRVGTKRYMAPEVLDETMNMNCFESYKMADI

YSFSLVMWETLCRCEDGDVLPREAATVIPYIEWTDRDPQDAQMFDVVCTRRLRPTENPLWKDHPEMKHIMEIIKTCWNGNPSARFTSYICRKRM
|||.|||||...|||.|.   .......||..|...||....|..|||.|.|||.... |..||.|.|.  . | ||  ||.|| |.    | .
YSFGLVMWEIARRCEVGG---IVEDYQLPYYDWVPNDPSFEDMRKVVCVRKLRPNIPNRWQSHPCMRHMAKLMKECWYQNPHARHTALRIKKTL
Kinase daf-1.AA STKR 293-586 41 1.8e-167 544.97 In-house 1-312 (312) Show / Hide 
Range on Protein: 293-586
Range on HMM: 1-312/312
Sequence Identity: 41% (129 aa)

IRLTGRVGSGRFGNVSRGDYRG----EAVAVKVFNALDEPAFHKETEIFETRMLRHPNVLRYIGSDRVDT-GFVTELWLVTEYHPSGSLHDFLLENTVNI
|.|.. .|.||.|.| .|..||    | ||||.|.  ||  ...||||..| |.||.|.|..|..|. .| |. |..||.||||. |||.|.| ..|...
IQLIECIGKGRYGEVWKGKWRGNGEKETVAVKIFPSRDEQSWFRETEIYQTPMMRHENILQFIAADMKHTEGSWTQYWLITEYHENGSLCDYLKRHTIDW

ETYYNLMRSTASGLAFLHNQIG--GSKESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSLSKPEDAASDIIAN------ENYKCGTVRYLAPEILNSTM
........|.|.|||.||..|   |.....|||.||||||||||.||||.||.|.|.||..  ..|. .. |.|      .|...||.||.|||.|...|
HEMCRMAHSMACGLAHLHMEIWGWGTQQHHKPAIAHRDIKSKNILVKNDGTCCIADFGLAMRHDPDTNQIDIHNTMQDNAQNTQVGTKRYMAPEVLDGAM

QFTVFES-YQCADVYSFSLVMWETLCRCEDGD---VLPREAATVIPYIEWTDRDPQDAQMFDVVCTRRLRPTENPLWK-DHPEMKHIMEIIKTCWNGNPS
.|. ||| ....|.|.. ||||| ..||.||.   | .. .  ..|. .| ...|.  .|..|||..|.||. .  || .|| |... .... ||  .|.
NFQCFESAFKRMDMYAMGLVMWEIARRCTDGGPDLVDQIVPEYQMPFYDWVPNHPSFEDMQKVVCRKRQRPNIPNRWKCNHPAMRSMCKTMEECWDHDPE

ARFTSYICRKRM
|| |.    |.|
ARLTALCVKKTM
Kinase daf-1.AA TKL 299-576 25 4.2e-84 285.72 In-house 1-354 (364) Show / Hide 
Range on Protein: 299-576
Range on HMM: 1-354/364
Sequence Identity: 25% (95 aa)

VGSGRFGNVSRGDYRG----------EAVAVKVFNA-------------------------LDEPAFHKETEIFETRM---LRHPNVLRYIGSDRVDTG-
.|||.|| | .| .||          . ||||.|.                           .|. . ...|..|..|   |||||.....|..   .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-FVTE-------LWLVTEYHPSGSLHDFLLENTVNIETYYNLMRSTASGLAFLHNQI---GGSKESNKPAMAHRDIKSKNIMVKNDLT------------
 .. .       |..|.||.| |||...|.     ..   ......|.|...||...   ..     ||...|||.|||||.|....|            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCT-----KPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--CAIGDLGLSLSKPEDAASDIIA--------------NENYKCGTVRYLAPEILNSTMQFT----------VFESYQCADVYSFSLVMWETLCRCEDGD
  | |.|.||| .. ..  .  ..              . . .||| |..|||.|. .|..|           ||  . .||||| .|.|| |.||.   
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

VLPREAATVIPYIEWTDRDPQDAQMFDVVCTRRLRPTENPLWKD-------HPEMKHIMEIIKTCWNGNPSAR
         .||...  .||   .|| .|| ..|||.  | |..       .. .... .... ||. .|..|
-----PYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKR
Kinase daf-1.AA Type2 293-508 34 1e-73 242.75 In-house 1-235 (315) Show / Hide 
Range on Protein: 293-508
Range on HMM: 1-235/315
Sequence Identity: 34% (82 aa)

IRLTGRVGSGRFGNVSRGDYRGE-----AVAVKVFNALDEPAFHKETEIFETR-MLRHPNVLRYIGSDR--VDTG-FVTELWLVTEYHPSGSLHDFLLEN
|.| . .|.||||.| .. . ..      ||||.|.  |   .  | .|...  ...|.| |..|....  | .|    |.|||||.|. |||.|.| ..
IQLMELIGKGRFGCVWKAQWHNNNGEKRTVAVKIFPEQDKQSWQNEKDIYSLPYHMWHENILQFICAEKRRVHMGDGWMEYWLVTEFHHKGSLCDYLKQH

TVNIETYYNLMRSTASGLAFLHNQIG-GSK-ESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSLSKPEDAASDIIA----NENY---KCGTVRYLAPEI
|.....   . .|.| |||.||  |  ... .  ||. |||||||||. ||||.||.|.|.||..  . .      .     ..      ||.|| ||| 
TIDWHECCRMAMSMARGLAHLHEEIWQWCQTDHHKPPIAHRDIKSKNVLVKNDMTCCIADFGLAMRFCPGKQPYKWEPTMPGDTHNIGQVGTRRYMAPEV

LNSTMQFT-VFESYQCADVYSFSLVMWETLCRCED
| ....|.   .. . .|.|.. ||.|| . || |
LEGAVNFQDCRDAFKQMDMYAMGLVLWEMVSRCTD
Kinase daf-1.AA Pkinase 293-578 19 1.3e-32 116.44 Pfam 1-283 (293) Show / Hide 
Range on Protein: 293-578
Range on HMM: 1-283/293
Sequence Identity: 19% (65 aa)

IRLTGRVGSGRFGNVSRGDYRGEA--VAVKVFNALDEPAFHKET-----EIFETRMLRHPNVLRYIGSDRVDTGFVTELWLVTEYHPSG----SLHDFLL
... ...||| || | ..  .|.   ||||...  .|    ..|     ||   ..|.|||..|.... .      .....|.||.. |    .|.|.. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

---ENTV--NIETYYNLMRSTASGLAFLHNQIGGSKESNKPAMAHRDIKSKNIMVKNDLTC----AIGDLGLS--LSKPEDAASDIIANENYK--CGTVR
   ....    ..  . |. ...||...|..             |||.|. ||...|. ..     |.| ||.  ..        .  |. ..  ||| .
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM----------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--------Y-NNS-MTTFCGTPW

YLAPEILNSTMQFTVFESYQCADVYSFSLVMWETLCRCEDGDVLPREAATVIPYIEWTDRDPQDAQMFDVVCTRRLRPTENPLWKDHPEM----------
|.|||...     .  .  . .|..|. ....| ||.              . . .  . |. . ||. ..| .. .|.. . .......          
YMAPEVIR-----GGQYYGPKVDMWSCGCILYEMLCGR------------PPFPGHC-WHDN-HDQMQ-MICRIMGPPLHFDWPWWCSISYFFFRHWHFH

-------KHIMEIIKTCWNGNPSARFT
       .   ..|| |.. .|. | |
WTFHNWSEECKDFIKWCLCKDPKKRPT
Kinase daf-1.AA TK 293-501 16 2.6e-29 94.79 In-house 1-386 (486) Show / Hide 
Range on Protein: 293-501
Range on HMM: 1-386/486
Sequence Identity: 16% (65 aa)

IRLTGRVGSGRFG---NVSRGDYRG---------------------------EAVAVKVFN---ALDEPAFHK-----------------ETEIFETRML
|.|    |.| ||    | .| .||                           . ||||.     | .. .|.                  | ...  ...
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPNVLRYIG-SDRVDTGFVTE-------LWLVTEYHPSGS----LHDFLLENT----------------------------------------------
.|||..| .| . .... . .|       ...|.|| | |.    |.|.| ..                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VNIETYYNLMRSTASGLAFLHNQ---IGGSKESNKPAMAHRDIKSKNIMVKNDLT-----------CAI
                               .. ..    ..  |.|...|| .            . . |||.   |..| ....           | |
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEF-------IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKI

GDLGLS------LSKPEDAASDIIANENYKCGT-----------------------VRYLAPEILNS--------TMQFTVFESYQCADVYSFSLVMWE
.| |||      |..  .  .|  . ..|. |.                       .|..||| ||.        .  ||        ||.||  .|||
ADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTT-----KSDVWSFGVLMWE
Kinase daf-1.AA TKL-Unique 295-501 26 3.4e-27 93.06 In-house 1-220 (290) Show / Hide 
Range on Protein: 295-501
Range on HMM: 1-220/290
Sequence Identity: 26% (63 aa)

LTGRVGSGRFGNVSRGDYRGEAVAVKVFNALDEPA------FHKETEIFETRMLR-HPNVLRYIGSDRVDTGFVT-------ELWLVTEYHPSGSLHDFL
    .|.| .|.| .| .||. ||.|.|. . ..       |..|  . .  .|. |||...|.       |. .       .. .|.|| | |||.| |
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMK--KLHYHPNIVHYM-------GYCMDHQVYPPNMCIVMEYCPGGSLYDVL

L-----------ENTVNIETYYNLMRSTASGLAFLHNQIGGSKESNKPAMAHRDIKSKNIMVKND-----LTCAIGDLGLSLSKPEDAASDIIAN----E
            ... | . .... .  |.|. .||.       ...| ..|||.||.|. | |.     .   | | ||| ..  . .. .. .    .
HQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHH-------CEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRN

NYKCGTVRYLAPEILNSTMQFTVFESYQC-ADVYSFSLVMWE
  .||. |..|||.|..       . |.. .|||||. |.||
QTRCGSFRWMAPEVLRMNF-----CQYSEKSDVYSFGIVLWE
Kinase daf-1.AA Dicty4 293-501 28 3.4e-25 81.11 In-house 1-209 (277) Show / Hide 
Range on Protein: 293-501
Range on HMM: 1-209/277
Sequence Identity: 28% (66 aa)

IRLTGRVGSGRFGNVSRGDYRGEAVAVKVFNALDEP-------AFHKETEIFETRMLRHPNVLRYIGSDRVDTGFVTELWLVTEYHPSGSLHDFLLE---
|  . | |.| || | .|  || .||||..|.. .        .|.|| .|     .||||..   |.         ..  |||| |.|.|.  |.    
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMC--KIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

---NTVNIE--TYYN---LMRSTASGLAFLHNQIGGSKESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSL-SKPEDAASD-IIANENYKCGTVRYLAP
     . ..  ..     .....| |.. ||. .        |   |||.|| |..|  ...  ..|.|||   |..   .|   .     |||. . ||
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCN--------PVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMT----ACGTPCWMAP

EILNSTMQFTVFESY-QCADVYSFSLVMWE
|..       ....| . ||||||..| ||
EVM-------MHQPYNEKADVYSFGIVLWE
Kinase daf-1.AA MLK 293-501 24 1.3e-24 82.39 In-house 1-228 (291) Show / Hide 
Range on Protein: 293-501
Range on HMM: 1-228/291
Sequence Identity: 24% (62 aa)

IRLTGRVGSGRFGNVSRGDYRGEA-----VAVKVFNA-------LDEPAFHKETEIFETRMLRHPN-----VLRYIGSDRVDTGFVTELWLVTEYHPSGS
|..   .||| || | .| .|..      |||| ..|        .. . ..|.|. . |.|.|||     .  | .. .   .|.    .|.|| . ||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFC----IVMEYCEGGS

LHDFLLENT---------------VNIETYYNLMRSTASGLAFLHNQIGGSKESNKP-AMAHRDIKSKNIMVKN------DLTCAIGDLGLSLSKPEDAA
|...| ...               .  .   | .   |.|...||        |..| .  |||.||.||.. .      ..|. | | |.| .. .   
LYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLH--------SMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-

SDIIANENYKCGTVRYLAPEILNSTMQFTVFESYQC---ADVYSFSLVMWE
.    |    .||... |||..        |.. ..   .||.|. .|.||
TNMMSN----AGTYAWMAPEVIQQ------FRCEKYSEKCDVWSWGVVLWE
Kinase daf-1.AA RAF 293-506 25 6e-18 54.51 In-house 1-218 (282) Show / Hide 
Range on Protein: 293-506
Range on HMM: 1-218/282
Sequence Identity: 25% (61 aa)

IRLTGRVGSGRFGNVSRGDYRGEAVAVKVFNALDEPAFHKET------EIFETRMLRHPNVLRYIGSDRVDTGFVTELWLVTEYHPSGSLHDFLLENTV-
...  |.|||.|| | || . |. ||||. |  |  .           |.   .  || |.| . |  . .      .  ||..    ||   . .    
VMVMTRIGSGSFGTVYRGHWHGD-VAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQ--TNTYAIVTQWCEHSSLYHHIHVQETR

---NIETYYNLMRSTASGLAFLHNQIGGSKESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSLSKPEDA--ASDIIANENYKCGTVRYLAPEILN----
   .. .  .  | .. |. .||               |||.||.||. ..|.|  ||| ||   |       .  .   .   . . ..|||.      
EKFDMHWLIDISRQVCQGMDYLHAK----------NIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPT---HWILWMAPEVIRNLMI

-----STMQFTVFESYQCADVYSFSLVMWETLCRC
       || .   | |  |||||  ||.| . |.
DWRGDVLMQDENPYSFQ-SDVYSFGIVMYELMTRH
Kinase daf-1.AA Pkinase_Tyr 293-507 23 1e-16 57.23 Pfam 1-212 (270) Show / Hide 
Range on Protein: 293-507
Range on HMM: 1-212/270
Sequence Identity: 23% (55 aa)

IRLTGRVGSGRFGNVSRGDYR------GEAVAVKVFNALDEPA------FHKETEIFETRML-RHPNVLRYIGSDRVDTGFVT-E-----LWLVTEYHPS
|..    |.| ||.| .| ..      .  ||||. .    .       | .| .|   . | .|||..|..       | .| .     ...|.|| | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIM--KQLGHHPNIVRLY-------GVCTDQGEPNQIYIVMEYMPH

GSLHDFLLEN-----TVNIETYYNLMRSTASGLAFLHNQIGGSKESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSLSKPEDAASDIIANENYKCGTVR
|.|.|.| ..      .....  .  .  |.|...|...           . |||.  .|..|...... |.| ||.    .|    . . .. |   ..
GDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN----------CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGK-LPIK

YLAPEILNSTMQFTVFESYQCADVYSFSLVMWETLCRCE
 .||| .|              ||.||  .||| . ..|
WMAPECINYGK------FTTKSDVWSFGVLMWEIFTYGE
Kinase daf-1.AA TyrKc 293-586 23 1.6e-16 44.26 SMART 1-280 (280) Show / Hide 
Range on Protein: 293-586
Range on HMM: 1-280/280
Sequence Identity: 23% (77 aa)

IRLTGRVGSGRFGNVSRGDYRGEAVAVKVFN--ALDEPAFHKETEIFETRML--RHPNVLRYIGSDRVD--TGF--VTELWLVTEYHPSGSLHDFLLENT
|.|    |.| || | .| .. . ||||. .  |  . .|..| .|   ..|  .|||..| .|  . .    |  .  |..|.|| | |.|.|.| .. 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--REDFMREARIM--CKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLRKHR

--VNIETYYNLMRSTASGLAFLHNQIGGSKESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSLSKPED-----AASDIIANE--NYKC-GTVRYLAPEI
  .. ..  . .   |.| ..|| .             |||.   |..|....|. |.| |||    .|     . . . . |  . |    .| .||| 
PKLCMKDLLSFCWQIACGMEYLHSK----------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

LNSTMQFTVFESYQCADVYSFSLVMWETLCRCEDGDVLPREAATVIPYIE---WTDRDPQDAQMFDVVCTR-RLRPTENPLWKDHPEM------KHIMEI
.  .  ||        ||.||  .||| . ...             || .       .  .....  | .. |... .|..    | |      . . .|
I-NYGKFTTK-----SDVWSFGVCMWEIFTYGQ------------QPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDY----P-MSFVCCPDEMYQI

IKTCWNGNPSARFTSYICRKRM
.|.||. .|. | |   .....
MKQCWHEDPEDRPTFSEIHECF
Kinase daf-1.AA S_TKc 293-594 17 1.7e-16 62.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 293-594
Range on HMM: 1-231/231
Sequence Identity: 17% (57 aa)

IRLTGRVGSGRFGNVSRGDYRG--EAVAVKVFNALDEPAFHKETEIFETRMLRHPNVLRYIGSDRVDTGFVTELWLVTEYHPS--GSLHDFLLENT----
 ..   .|.| || | ..  ..  . ||.|. .      . .| .| .    .|||. ..... .      ..|..|.|| .   |.|.|.. ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---VNIETYYNLMRSTASGLAFLHNQIGGSKESNKPAMAHRDIKSKNIMVKNDLTCAIGDLGLSLSKPEDAASDIIANENYKCGTVRYLAPEILNSTMQF
    .  .   .|. ....|...|.. |           |||.|  ||.. .  .  |.| ||.               .  |||  |.|||.|      
RFPFPE-HARFYMYQICCALEYCHSH-G---------IIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL------

TVFESYQC--ADVYSFSLVMWETLCRCE--DGDVLPREAATVIPYIEWTDRDPQDAQMFDVVCTRRLRPTENPLWKDHPEMKHIMEIIKTCWNGNPSARF
    .| .  .|..|.  ...| ||..   .                      |...||....                  .   ..|. |.. .|. | 
----GYGKCKCDWWSCGCILYEMLCGYPPFP----------------------QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRP

TSYICRK-RMDERQQLLL
|   . .  .| ..   .
TA-EALQDEWDIKCHPWF
Kinase daf-1.AA Gdt 293-376 28 2.6e-14 45.41 In-house 1-88 (289) Show / Hide 
Range on Protein: 293-376
Range on HMM: 1-88/289
Sequence Identity: 28% (27 aa)

IRLTGRVGSGRFGNVSRGDYRGEAVAVKVFNALDE----------PAFHKETEIFETRMLRHPNVLRYIGSDRVDTGFVTELWLVTEYHPSGSL
| .   .. | || | .| .|. .|||| |   .             . .|. | .   ..|.|....||.    . |   ...||||.| |||
IDFKEYCSQGTFGMVYKGIWRSSQVAVKMFKHHYVNYTKTYSQSCDEIYREMDILS--KIKHQNIVSFIGC----VHFSSHHCIVTEYCPRGSL
GS daf-1.AA GS 265-293 45 6.3e-12 46.86 SMART 1-31 (31) Show / Hide 
Range on Protein: 265-293
Range on HMM: 1-31/31
Sequence Identity: 45% (14 aa)

KDMLDVLEE--TSGSGMGPTTLHKLTIGGQI
|.| |..|.  |||||.|...|...|...||
KTMHDMMEDTCTSGSGSGLPLLVQRTVARQI
TGF_beta_GS daf-1.AA TGF_beta_GS 265-291 44 2.4e-08 30.53 Pfam 1-29 (29) Show / Hide 
Range on Protein: 265-291
Range on HMM: 1-29/29
Sequence Identity: 44% (13 aa)

KDMLDVLE--ETSGSGMGPTTLHKLTIGG
|.| |..|  .|||||.|...|.. ||  
KTMQDMMEDFCTSGSGSGLPLLVQRTIAR
Kinase daf-1.AA Gdt 458-503 34 0.001394 8.15 In-house 189-228 (289) Show / Hide 
Range on Protein: 458-503
Range on HMM: 189-228/289
Sequence Identity: 34% (16 aa)

ANENYKCGTVRYLAPEILNSTMQFTVFESYQ-CADVYSFSLVMWETL
.. | .|||..|. .||.         |.||  .|||||     |..
HCKNTNCGTMNYMSNEIFEG-------ENYQKSTDVYSFGILFYEMM
Kinase daf-1.AA Type2 534-586 35 0.003339 6.19 In-house 262-315 (315) Show / Hide 
Range on Protein: 534-586
Range on HMM: 262-315/315
Sequence Identity: 35% (19 aa)

QMFDVVCTRRLRPTENPLWKDHPEMK-HIMEIIKTCWNGNPSARFTSYICRKRM
.| ..|  .| ||.    || || |   . | |  ||   . || |.     ||
DMQELVVRKRKRPQWPDHWKCHPGMQRMLCETIEDCWDHDAEARLTAQCVQERM
Kinase daf-1.AA TK 561-586 19 0.029018 2.53 In-house 461-486 (486) Show / Hide 
Range on Protein: 561-586
Range on HMM: 461-486/486
Sequence Identity: 19% (5 aa)

IMEIIKTCWNGNPSARFTSYICRKRM
...... ||. .|. | |   .....
YYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase daf-1.AA Gdt 561-576 56 0.099406 1.71 In-house 264-279 (289) Show / Hide 
Range on Protein: 561-576
Range on HMM: 264-279/289
Sequence Identity: 56% (9 aa)

IMEIIKTCWNGNPSAR
|  ||  ||| ||. |
IRNIIECCWNKNPHKR
Kinase daf-1.AA TKL-Unique 559-576 38 0.197602 1.03 In-house 263-280 (290) Show / Hide 
Range on Protein: 559-576
Range on HMM: 263-280/290
Sequence Identity: 38% (7 aa)

KHIMEIIKTCWNGNPSAR
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KEYRDLIQQCWHHDPSQR
Kinase daf-1.AA Pkinase_Tyr 559-576 33 6.115483 0.42 Pfam 243-260 (270) Show / Hide 
Range on Protein: 559-576
Range on HMM: 243-260/270
Sequence Identity: 33% (6 aa)

KHIMEIIKTCWNGNPSAR
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DEIYDLMKQCWHYDPEDR