daf-11

Species: Nematode worm
Alias: CE05174, B0240.3, daf-11, aSWK280
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: V: 11728249-11720686, WormBase Genetic Map location: V:3.26343,

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
daf-11.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 287 Kinase domain by global Sugen HMM Fasta, JSON
daf-11.AA Protein Genbank 1093 None Fasta, JSON

Protein domain

Protein domains of daf-11.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase daf-11.AA RGC 433-703 28 9.6e-89 301.14 In-house 1-300 (300) Show / Hide
Range on Protein: 433-703
Range on HMM: 1-300/300
Sequence Identity: 28% (88 aa)

DQVYVLADKYVMR---DKLRYDKIDINLLYQMKSHLQHDNLNSFVGITIDKAS-----HMYIIWNQCFRGSLHDHIFTKERQRGTATRFEGLFLRDILKG
....|.. |...|   ... ... .  .|.||. .||||||| |.|. ||  .     .|.|.|  | ||||.|...   .. .    | . |.|||.||
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMR-QLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILEN--DDIKMDWMFKYSFIRDIVKG

LEYIHASAIDFHGNLTLHNCMLDSHWIVKLSGFGVNRLLVKWKTSGQI----------FTEDHTPVIKSEELHYFDPAMKKIWKNYADRNERALITPQFG
..|.|.| | .||||. .||. ||.| ||...||.|..|..| ..|||          ....|.. .. ...... | . ..|........ . .|... 
MQYLHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGP-HRQTQRGT

KKCDMYSFGVILHEIILKKKFVEQLFD---------SPREEDDSVLIDDENDAIASRFPLPIIIPEG--IEMHNDLIKMLENCFG---SVRPD-IALARK
.|.|.||||.|..|||..| ....  .         ||.|. . |.. .... ... .|. . . ||  ||....|......|.    ..||| .   ||
QKGDVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRK

IIDT
 . |
QLKT

Kinase daf-11.AA RGC 433-703 28 9.6e-89 301.14 In-house 1-300 (300) Show / Hide
Range on Protein: 433-703
Range on HMM: 1-300/300
Sequence Identity: 28% (88 aa)

DQVYVLADKYVMR---DKLRYDKIDINLLYQMKSHLQHDNLNSFVGITIDKAS-----HMYIIWNQCFRGSLHDHIFTKERQRGTATRFEGLFLRDILKG
....|.. |...|   ... ... .  .|.||. .||||||| |.|. ||  .     .|.|.|  | ||||.|...   .. .    | . |.|||.||
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMR-QLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILEN--DDIKMDWMFKYSFIRDIVKG

LEYIHASAIDFHGNLTLHNCMLDSHWIVKLSGFGVNRLLVKWKTSGQI----------FTEDHTPVIKSEELHYFDPAMKKIWKNYADRNERALITPQFG
..|.|.| | .||||. .||. ||.| ||...||.|..|..| ..|||          ....|.. .. ...... | . ..|........ . .|... 
MQYLHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGP-HRQTQRGT

KKCDMYSFGVILHEIILKKKFVEQLFD---------SPREEDDSVLIDDENDAIASRFPLPIIIPEG--IEMHNDLIKMLENCFG---SVRPD-IALARK
.|.|.||||.|..|||..| ....  .         ||.|. . |.. .... ... .|. . . ||  ||....|......|.    ..||| .   ||
QKGDVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRK

IIDT
 . |
QLKT

Kinase daf-11.AA TK-Unique 460-558 18 6.3e-10 30.53 In-house 56-178 (294) Show / Hide
Range on Protein: 460-558
Range on HMM: 56-178/294
Sequence Identity: 18% (23 aa)

QMKSHLQHDNLNSFVGITIDKASHMYIIWNQCFRGSLHDHIFTKERQ--RG-------------TATRFEG-LF-------LRDILKGLEYIHA--SAID
.||.  .| |. ...|.....   ..||. .| .|.| ... |. ..  ..             ... ..  .        . .| .|.||..     | 
MMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI-

FHGNLTLHNCMLDSHWIVKLSGFG
.|..|  .|..| .. ..|...||
VHRDLCARNVLLTEDKVCKICDFG

Kinase daf-11.AA TK 465-566 8 1.3e-08 24.14 In-house 100-351 (486) Show / Hide
Range on Protein: 465-566
Range on HMM: 100-351/486
Sequence Identity: 8% (21 aa)

LQHDNLNSFVGITIDKA-----------SHMYIIWNQCFRGS----LHDHIFTKERQRGTATRFEGL---------------------------------
..|.|. ...|.  ...            ...|.   .  |.    |.|.  .. . . .     .                                  
GHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

---------------------------------------FLRDILKGLEYIHASAID-----FHGNLTLHNCMLDSHWI-----------VKLSGFG---
                                       . ..| .|.||.|.  .       |..|  .||..... .           .|.. ||   
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

--------------------------------------------VNRLLVKW
                                              .| ..|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRW

Kinase daf-11.AA S_TKc 436-705 17 7.1e-07 -76.11 SMART 1-231 (231) Show / Hide
Range on Protein: 436-705
Range on HMM: 1-231/231
Sequence Identity: 17% (52 aa)

YVLADK---------YVMRDKL-----------RYDKIDINLLYQMKSHLQHDNLNSFVGITIDKASHMYIIWNQCFR--GSLHDHIFTKERQRG---TA
| . .|         |  |.|            .  .  |..| .     .|.|.  . ..  |  .|.|..   |    |.|.|.|  . |...     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-----HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

TRFEGLFLRDILKGLEYIHASAIDFHGNLTLHNCMLDSHWIVKLSGFGVNRLLVKWKTSGQIFTEDHTPVIKSEELHYFDPAMKKIWKNYADRNERALIT
      ... |...|||.|   |  |  |   | .||.   .|.. ||. |.|          |   ||   . |.                        
E-HARFYMYQICCALEYCHSHGI-IHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL-----------------------

PQFGK-KCDMYSFGVILHEIILKKKFVEQLFDSPREEDDSVLIDDENDAIASRFPLPIIIPEGIEMHNDLIKMLENCFG---SVRPDIALARK-----II
 ..|| |||..|.|.|| | .  .   .         .. ....                        ... ....|.    . || .  | .      .
-GYGKCKCDWWSCGCILYEMLCGYPPFP---------QMQMMFKKIG-------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKC

DTVL
.  .
HPWF

Kinase daf-11.AA TKL-Unique 463-558 22 1e-06 19.76 In-house 50-162 (290) Show / Hide
Range on Protein: 463-558
Range on HMM: 50-162/290
Sequence Identity: 22% (26 aa)

SHLQ-HDNLNSFVGITID---KASHMYIIWNQCFRGSLHDHIFT--------KERQRGTATRFEGLFLRDILKGLEYIHASA--IDFHGNLTLHNCMLDS
. |. |.|.  ..|...|   ....|.|.   | .|||.|.. .        ..    .  ..  ... || .|..|.| .   |  |..|.  |  .|.
KKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAI-DIAQGMYYLHHCEPPI-IHRDLKSSNFLVDN

H-----WIVKLSGFG
.     | .|...||
NSNIAEWNIKICDFG

Kinase daf-11.AA TKL 461-558 19 4.2e-05 14.32 In-house 78-199 (364) Show / Hide
Range on Protein: 461-558
Range on HMM: 78-199/364
Sequence Identity: 19% (26 aa)

MKSHLQHDNLNSFVGITIDKAS------------HMYIIWNQCFRGS-LHDHIFTKERQRGTATRFE--GLFLRDILKGLEYIHASAI-------DFHGN
|.| |.|.|. .|.|. ..  .            ...|.   | .|| ||...            ..    . .|| .|..| |..           | .
MMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRD

LTLHNCMLDSHWI--------------VKLSGFG
|. .|...|..|               .|.. ||
LKSKNILVDENWTNVSNYMYNPNADWCCKICDFG

Kinase daf-11.AA TKL 612-630 52 8.6e-05 13.19 In-house 265-283 (364) Show / Hide
Range on Protein: 612-630
Range on HMM: 265-283/364
Sequence Identity: 52% (10 aa)

QFGKKCDMYSFGVILHEII
.. .|||.||||..| ||.
EYSEKCDVYSFGIVLWEIL

Kinase daf-11.AA LISK-DD1 617-639 43 9.2e-05 13.42 In-house 212-234 (290) Show / Hide
Range on Protein: 617-639
Range on HMM: 212-234/290
Sequence Identity: 43% (10 aa)

CDMYSFGVILHEIILKKKFVEQL
|| .|||. | |.|. || .. .
CDVFSFGMVLLELITRKKPDKRM

Kinase daf-11.AA MLK 615-630 50 0.00011 12.32 In-house 215-230 (291) Show / Hide
Range on Protein: 615-630
Range on HMM: 215-230/291
Sequence Identity: 50% (8 aa)

KKCDMYSFGVILHEII
.|||..|.||.| |..
EKCDVWSWGVVLWEML

Kinase daf-11.AA Ciliate-E2-Unclassified 430-558 17 0.000493 9.91 In-house 13-192 (352) Show / Hide
Range on Protein: 430-558
Range on HMM: 13-192/352
Sequence Identity: 17% (31 aa)

ATVDQVYVLADKYV------MRDKLRYDKID------INLLYQMKSH----------------LQHDNLNSFVGITID-KASHMYIIWNQCFRGSLHDHI
..| ...   .|..      .  . . .|.       .| . .|...                |.|....  . . .. .  ..||.  .|  |.|...|
GKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYI

-------------FTKERQRGTATRFEGL------FLRDILKGLEYIHASA-IDFHGNLTLHNCMLDSHW---IVKLSGFG
             | . .||   | .. .      ... ||.||||.| .  |  | .... | ..|.      .|...||
KKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNI-IHRDIKPENILFDNNGKNYYIKIIDFG

Kinase daf-11.AA UTK 517-563 24 0.001478 8.04 In-house 123-178 (296) Show / Hide
Range on Protein: 517-563
Range on HMM: 123-178/296
Sequence Identity: 24% (14 aa)

FLRDILKGLEYIHASAIDFHGNLTLHNCMLDSH-------WIVKLSGFG---VNRLL
. .||  |..|.|   .  |..|   || ...|       ...|...||     |..
MAWDIARGMQYLHSCGF-VHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRV

Kinase daf-11.AA TKL-Unique 612-630 52 0.002822 7.62 In-house 204-222 (290) Show / Hide
Range on Protein: 612-630
Range on HMM: 204-222/290
Sequence Identity: 52% (10 aa)

QFGKKCDMYSFGVILHEII
|. .|.| ||||..| ||.
QYSEKSDVYSFGIVLWEIA

Kinase daf-11.AA Ciliate-E2-Unclassified 615-633 47 0.003288 7.01 In-house 249-267 (352) Show / Hide
Range on Protein: 615-633
Range on HMM: 249-267/352
Sequence Identity: 47% (9 aa)

KKCDMYSFGVILHEIILKK
.|||..|.||||.|..  .
YKCDIWSLGVILYEMLFGY

Kinase daf-11.AA UTK 607-629 45 0.020183 4.1 In-house 210-233 (296) Show / Hide
Range on Protein: 607-629
Range on HMM: 210-233/296
Sequence Identity: 45% (11 aa)

ALITP-QFGKKCDMYSFGVILHEI
||.   .|  | |..|||| ..||
ALTHHTRFTTKSDVWSFGVVCWEI

Kinase daf-11.AA TK 610-629 36 0.14858 0.11 In-house 363-387 (486) Show / Hide
Range on Protein: 610-629
Range on HMM: 363-387/486
Sequence Identity: 36% (9 aa)

TPQ-----FGKKCDMYSFGVILHEI
...     |  | |..|||| ..||
SEAEKYGKFTTKSDVWSFGVLMWEI

CYCc daf-11.AA CYCc 739-940 36 4.9e-96 326.27 SMART 1-231 (231) Show / Hide
Range on Protein: 739-940
Range on HMM: 1-231/231
Sequence Identity: 36% (85 aa)

KEQEKGDQLLMELLPKSVANDLKNGI-AVDPKVYENATILYSDIVGFTSLCSQSQPMEVVTLLSGMYQRFDLIISQQGGYKVILNRIMETIGDAYCVAAG
.|..| |.||...||..|||.||.|  .|.|. |...|||..||||||.|||...||.||..| ..| ||| ||.. |.|.. .  ..|||||||.|. |
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHN-YCYKVETIGDAYMVVSG

LPVVME-------------------KDHVKSICMIALLQRDCLHHFEIPHR----PGTFLNCRWGFNSGPVFAGVIGQKAPRYACFGEAVILASKMESSG
.| ..|                    .| . |...||  ..|...|...|.    |.. |..|.|...|||..||.|...||| .||..| .||.|||.|
CPTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTG

VEDRIQMTLASQQLL------EENFPQFVCSN
. ..|... . ...|      . ...||....
DPGQIHVSEETYWCLCLDQFERRRCGQFEFEP

Guanylate_cyc daf-11.AA Guanylate_cyc 766-959 32 1.3e-51 182.57 Pfam 1-214 (214) Show / Hide
Range on Protein: 766-959
Range on HMM: 1-214/214
Sequence Identity: 32% (72 aa)

VDPKVYENATILYSDIVGFTSLCSQSQ----PMEVVTLLSGMYQRFDLIISQQ--GGYKVILNRIMETIGDAYCVAAGLPVV-----MEKDHVKSICMIA
| .. |.. ||. .||||||..||..     ||..|..|  .| .|| ...|   |.|||      .||||.|....|||.         .|   .. .|
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKV------KTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMA

LLQRDCLHHFEIPHRPGTF-----LNCRWGFNSGPVFAGVIG--QKAPRYACFGEAVILASKMESSGVED--RIQMTLASQQLLEENF-PQFVC--SNRG
|   . .. . ..| ...      .. | | ..|||.|||||  |. |||. .|  | .||.||| ||    .|... .  ..|.. . .||.|  ..||
LDMMEYCQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRG

GRTIEGIGR---ILTYWLEG
 . . | |.   . ||.|.|
EIPVKGKGKMGEMETYFLHG

HNOBA daf-11.AA HNOBA 734-760 55 4.9e-07 27.02 Pfam 208-234 (234) Show / Hide
Range on Protein: 734-760
Range on HMM: 208-234/234
Sequence Identity: 55% (15 aa)

TAELEKEQEKGDQLLMELLPKSVANDL
..|||.|  |.|.|| . .|||||| |
HRELEEEKKKTDDLLYSMFPKSVANRL