Gene daf-4 (Nematode worm)

daf-4

Species: Nematode worm
Alias: C05D2.1a, CE16827, daf-4, C05D2.1, aSWK428
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: III: 5620504-5627809, WormBase Genetic Map location: III:-1.46069,

Classification

Group: TKL
Family: STKR
Subfamily: STKR2

Sequence

Name Sequence Type Origin Length Description Download
daf-4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 264 Kinase domain by global Sugen HMM Fasta, JSON
daf-4.AA Protein Genbank 744 None Fasta, JSON

Protein domain

Protein domains of daf-4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase daf-4.AA Type2 306-597 46 3.2e-175 583.21 In-house 1-315 (315) Show / Hide 
Range on Protein: 306-597
Range on HMM: 1-315/315
Sequence Identity: 46% (146 aa)

ITDFQLISKGRFGKVFKAQYTPDSGEKRLVAVKKLNEFQKASFLAEKRIFDELNEYPKWYKSIVEFVCAEK----IG---DEYWIVTEFHERLSLYELLK
|....||.|||||.|.|||.....||||.||||...|..|.|...||.|....  |..|...|..|.||||    .|   .|||.|||||...||...||
IQLMELIGKGRFGCVWKAQWHNNNGEKRTVAVKIFPEQDKQSWQNEKDIYSLP--YHMWHENILQFICAEKRRVHMGDGWMEYWLVTEFHHKGSLCDYLK

NNVISITSANRIIMSMIDGLQFLHDDRPYFFG--HPKKPIIHRDIKSKNILVKSDMTTCIADFGLARIYSYDIEQ--------SDLL--GQVGTKRYMSP
...|......|..|||..||..||........  |.|.||.||||||||.|||.|||.||||||||.........        .|.   |||||.|||.|
QHTIDWHECCRMAMSMARGLAHLHEEIWQWCQTDHHKPPIAHRDIKSKNVLVKNDMTCCIADFGLAMRFCPGKQPYKWEPTMPGDTHNIGQVGTRRYMAP

EMLEGATEFT--PTAFKAMDVYSMGLVMWEVISRTKLHQT-DEPPNYQMPF--QVIGFDPTIGLMRNYVVSKKERPQWRDEIIKHEYMS-LLKKVTEEMW
|.||||..|.  ..|||.||.|.||||.||..||...|.. ||.|.|||||  .|...||... |...||.|..||||.|....|..|  .|.   |. |
EVLEGAVNFQDCRDAFKQMDMYAMGLVLWEMVSRCTDHYPDDEVPEYQMPFEEEVGQHDPSFEDMQELVVRKRKRPQWPDHWKCHPGMQRMLCETIEDCW

DPEACARITAGCAFARV
|  | || ||.|.  |.
DHDAEARLTAQCVQERM
Kinase daf-4.AA STKR 306-597 37 5.70000000001e-146 474.4 In-house 1-312 (312) Show / Hide 
Range on Protein: 306-597
Range on HMM: 1-312/312
Sequence Identity: 37% (120 aa)

ITDFQLISKGRFGKVFKAQYTPDSGEKRLVAVKKLNEFQKASFLAEKRIFDELNEYPKWYKSIVEFVCAEKIGD-----EYWIVTEFHERLSLYELLKNN
|. ...| |||.|.|.|...... |||. ||||  ......|. .|..|...   .  ....|..|..|.. ..     .||..||.||. ||.. ||..
IQLIECIGKGRYGEVWKGKWRGN-GEKETVAVKIFPSRDEQSWFRETEIYQT---PMMRHENILQFIAADMKHTEGSWTQYWLITEYHENGSLCDYLKRH

VISITSANRIIMSMIDGLQFLHDDRP--YFFGHPKKPIIHRDIKSKNILVKSDMTTCIADFGLARIYSYDIEQSDLLG---------QVGTKRYMSPEML
.|......|...||..||..||....  ....|.|..|.||||||||||||.|.|.|||||||| ....| .| |. .         ||||||||.||.|
TIDWHEMCRMAHSMACGLAHLHMEIWGWGTQQHHKPAIAHRDIKSKNILVKNDGTCCIADFGLAMRHDPDTNQIDIHNTMQDNAQNTQVGTKRYMAPEVL

EGATEFTP--TAFKAMDVYSMGLVMWEVISRTKLHQTD----EPPNYQMPFQ-VIGFDPTIGLMRNYVVSKKERPQWRDEII-KHEYMSLLKKVTEEMWD
.|| .|..  .||| ||.|.|||||||...|......|    ..|.|||||. ... .|..  |...|. |..||.  ..   .|. |  ..|. || ||
DGAMNFQCFESAFKRMDMYAMGLVMWEIARRCTDGGPDLVDQIVPEYQMPFYDWVPNHPSFEDMQKVVCRKRQRPNIPNRWKCNHPAMRSMCKTMEECWD

PEACARITAGCAFARV
. . || || |   ..
HDPEARLTALCVKKTM
Kinase daf-4.AA TKL 312-584 23 1.2e-71 244.3 In-house 1-351 (364) Show / Hide 
Range on Protein: 312-584
Range on HMM: 1-351/364
Sequence Identity: 23% (86 aa)

ISKGRFGKVFKAQYTPDSGEK------RLVAVKKLNE-------------------------FQKASFLAEKRIFDELNEYPKWYKSIVEFVCAEKIGDE
| .|.||.|.|...   .| |      . |||||...                          ..||.. .....  .         || |. . . .. 
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

-------------YWIVTEFHERLSLYELLKNNVISITSANRIIMSMIDGLQFLHDDRP--YFFGHPKKPIIHRDIKSKNILVKSDMT------------
             ..||.|.... ||...|      .    |.....  |...|| ..|  ..    |.||||||.|||||||....|            
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCT----KPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--TCIADFGLARIYSYDIEQSD-----------------LLGQVGTKRYMSPEMLEGATEFTP-----------TAFKAMDVYSMGLVMWEVISRTKLHQ
   .|.||||.|  | . ...|                 .  |.||.|.|.||.|.|....|            ......||||.|.|.||...| .   
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

TDEPPNYQMP-FQVIGFDPTIGLMRNYVVSKKERPQWRDEIIK-------HEYMSLLKKVTEEMWDPEA
    | |..| ...|..|| . .|  .|..|..||   ..          .  .  .||  .. ||...
----PYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDP
Kinase daf-4.AA Type1 382-590 37 1.1e-66 179.37 In-house 73-283 (290) Show / Hide 
Range on Protein: 382-590
Range on HMM: 73-283/290
Sequence Identity: 37% (82 aa)

WIVTEFHERLSLYELLKNNVISITSANRIIMSMIDGLQFLHDDRPYFFGHP--KKPII-HRDIKSKNILVKSDMTTCIADFGLARIYSYDIEQSDLL--G
| .|..||. |||  |. ..... .. |...|.. || .||..    ||     || | |||||||||.||.. . ||||.|||  .. | .| |.    
WLITDYHEHGSLYDYLNRHTLDTQQMLRLAYSCACGLAHLHME---IFGTQEFGKPAIAHRDIKSKNIMVKKNGQCCIADLGLAVRHQQDTDQIDIGQNP

QVGTKRYMSPEMLEGATEFTP-TAFKAMDVYSMGLVMWEVISRTKLHQTDEPPNYQMPF-QVIGFDPTIGLMRNYVVSKKERPQWRDEIIKHEYMSLLKK
.||||||| ||.|.   ...   ..|  |.||.||||||.  |..  .. |   ||.|.  ..  ||..  ||  |  .| ||.      .|. |. . |
RVGTKRYMAPEVLDETMNMNCFESYKMADIYSFGLVMWEIARRCEVGGIVE--DYQLPYYDWVPNDPSFEDMRKVVCVRKLRPNIPNRWQSHPCMRHMAK

VTEEMWDPEACARITA
. .| | . . || ||
LMKECWYQNPHARHTA
Kinase daf-4.AA Pkinase 306-599 18 7.1e-37 131.47 Pfam 1-293 (293) Show / Hide 
Range on Protein: 306-599
Range on HMM: 1-293/293
Sequence Identity: 18% (60 aa)

ITDFQLISKGRFGKVFKAQYTPDSGEKRLVAVKKLNEFQKASFLA-------EKRIFDELNEYPKWYKSIVEFVCAEKIGDEYWIVTEFHERL----SLY
..  . | .| ||.|.|..   ..    .||||...   . |          | .|  .||      . ||.. ..   .|....|.|..|      .|.
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-----HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

ELLK---NNVI--SITSANRIIMSMIDGLQFLHDDRPYFFGHPKKPIIHRDIKSKNILVKSDMTT----CIADFGLARIYSYDIEQSDLLGQVGTKRYMS
....   ....  |   . ...  .. ||...|.            |||||.|. |||.......    .|.|||||. ..    .| . . .|| .||.
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM----------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMA

PEMLEGATEFTPTAFKAMDVYSMGLVMWEVISRTKLHQTDEPPNYQMPFQVIGFDPTIGLMRNYVVSKKERPQWRDEIIKHEYM----------------
|| .     . .   .. |..|.|....|....              ||.  . ..   .  .... .. .|... .. .   .                
PEVIR----GGQYYGPKVDMWSCGCILYEMLCGR------------PPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHN

--SLLKKVTEEMWDPEACARITAGCAFARVWN
  . .|.. . ....    |.|| ...   | 
WSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase daf-4.AA MLK 306-518 25 1.4e-29 99.83 In-house 1-232 (291) Show / Hide 
Range on Protein: 306-518
Range on HMM: 1-232/291
Sequence Identity: 25% (64 aa)

ITDFQLISKGRFGKVFKAQYTPDSGEKRLVAVKKLN------------EFQKASFLAEKRIFDELNEYPKWYKSIVEFVCA-EKIGDEYWIVTEFHERLS
|.  . | .| ||||.|...    .  . ||||. .              ..  .  . ||.. .|       .|..|. .  . . .. ||.|. |  |
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNN----HPCIIQFYGVCLQPPCHFCIVMEYCEGGS

LYELLKNN---------------VISITSANRIIMSMIDGLQFLHDDRPYFFGHPKKPIIHRDIKSKNILVKS------DMTTCIADFGLARIYSYDIEQ
||..|...               |..  .|... . .  |...|| . |       |||||||.||.|||.        ..|  |.|||..|    |. |
LYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAP-------KPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR----DWHQ

S-D-LLGQVGTKRYMSPEMLEGATEFTPTAFKAMDVYSMGLVMWEVISR
. .   .. || ..|.||... . . . .  .. ||.| |.|.||...|
MCTNMMSNAGTYAWMAPEVIQQFRCEKYS--EKCDVWSWGVVLWEMLTR
Kinase daf-4.AA S_TKc 306-599 20 1.8e-24 88.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 306-599
Range on HMM: 1-231/231
Sequence Identity: 20% (62 aa)

ITDFQLISKGRFGKVFKAQYTPDSGEKRLVAVKKLNEFQKASFLAEKRIFDELNEYPKWYKSIVEFVCAEKIGDEYWIVTEFHER--LSLYELLKNNV--
 .  ..| || ||||.|.. .     .|.||.|...     ... | .|  .        . || .  .    |....|.|. .    .|....|..   
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK----EHIRREIQILKK------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----ISITSANRIIMSMIDGLQFLHDDRPYFFGHPKKPIIHRDIKSKNILVKSDMTTCIADFGLARIYSYDIEQSDLLGQVGTKRYMSPEMLEGATEFT
     ..   | ...  ....|...|. .          |||||.|  |||. .  .  |.||||||..           ..||  ||.||.|       
GLRFPFPE-HARFYMYQICCALEYCHSHG----------IIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL-------

PTAFKAMDVYSMGLVMWEVISRTKLHQTDEPPNYQMPFQVIGFDPTIGLMRNYVVSKKERPQWRDEIIKHEYMSLLKKVTEEMWDPEACARITAGCAFA-
.  ... |..| | ...| ...  . .     ..|| |..||                               . .|   . ... .   |.||  |.. 
GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQD

------RVWN
        | 
EWDIKCHPWF
Kinase daf-4.AA TKL-Unique 380-519 28 1.1e-20 69.75 In-house 74-225 (290) Show / Hide 
Range on Protein: 380-519
Range on HMM: 74-225/290
Sequence Identity: 28% (47 aa)

EYWIVTEFHERLSLYELLK---------NNVISITSANRIIMS--MIDGLQFLHDDRPYFFGHPKKPIIHRDIKSKNILVKSD-----MTTCIADFGLAR
.. ||.|. .. |||..|          || . .. ..|. |   . .|. .||        | ..||||||.||.|.|| ..     .   |.||||..
NMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLH--------HCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSK

IYSYDIEQSDL-------LGQVGTKRYMSPEMLEGA-TEFTPTAFKAMDVYSMGLVMWEVISRT
. | ... .          . .|. |.|.||.|..  . ..    .  |||| | |.|| ..|.
FNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYS----EKSDVYSFGIVLWEIATRK
Kinase daf-4.AA Dicty4 436-514 36 6.2e-19 59.95 In-house 135-209 (277) Show / Hide 
Range on Protein: 436-514
Range on HMM: 135-209/277
Sequence Identity: 36% (29 aa)

IIHRDIKSKNILVKSDMTTCIADFGLARIYSYDIEQSD-LLGQVGTKRYMSPEMLEGATEFTPTAFKAMDVYSMGLVMWE
|||||.|| |.||  ...  ..||||...   .....| . ...||  .|.||.. .  ...  |    |||| |.| ||
IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQ-PYNEKA----DVYSFGIVLWE
Kinase daf-4.AA Ciliate-E2-Unclassified 431-512 29 7.9e-19 61.95 In-house 160-260 (352) Show / Hide 
Range on Protein: 431-512
Range on HMM: 160-260/352
Sequence Identity: 29% (30 aa)

HPKKPIIHRDIKSKNILVKSDM---TTCIADFGLARIYSYD------------IEQSDLL-GQVGTKRYM----SPEMLEGATEFTPTAFKAMDVYSMGL
| |. |||||||  |||.....     .|.|||... | ..            | .....  ..|| .||    .||.|.|    ...| .. |..|.| 
HHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-YKCDIWSLGV

VM
..
IL
Kinase daf-4.AA STE 306-491 19 1.2e-18 62.59 In-house 1-236 (359) Show / Hide 
Range on Protein: 306-491
Range on HMM: 1-236/359
Sequence Identity: 19% (51 aa)

ITDFQLISKGRFGKVFKAQYTP-----DSGEK-------RLVAVKKLN--------------------EFQKASFLAEKRIFDELNEYPKWYKSIVEFVC
 .. . | || ||.|.|| .       ..||.       ...|.|..|                    . .. ..| | .|  ..|      . ||.. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNH--M-HPNIVKYYG

AEKIG-------DEYWIVTEFHERLSLYELLKNN-VISI--------------TSANRIIMSMIDG-LQFLHDDRPYFFGHPKKPIIHRDIKSKNILVKS
..  .       || ||. |. .  || ...|..  .                .   .|. . . | |..||. .          |||||||. |||.  
CYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH----------IIHRDIKPANILL--

DMTTCIADFGLARIYSYDIEQSDLLG----------------QVGTKRYMSPEMLEG
     ..|||.. . . ..  . . .                 |||  .|.||....
---VKLCDFGVCGQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQ
Kinase daf-4.AA RIPK 383-520 30 1.4e-18 59.96 In-house 79-226 (290) Show / Hide 
Range on Protein: 383-520
Range on HMM: 79-226/290
Sequence Identity: 30% (47 aa)

IVTEFHERLSLYELLKNNV------ISITSANRIIMSMIDGLQFLHDDRPYFFGHPKKPIIHRDIKSKNILVKSDMTTCIADFGLARIYSYDIEQSDLL-
||.|. |  || ..|.         .     .|.|  .. | ..||.  |        |||||| |  |||| ...   |||||||        ..|   
IVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEISCGMCYLHSMNP--------PIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCN

---GQV-------GTKRYMSPEMLE-GATEFTPTAFKAMDVYSMGLVMWEVISRTK
   ..        ||  || ||... .    .  . .. |||| . ||||| .. .
QREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKH
Kinase daf-4.AA TyrKc 306-563 20 3.1e-12 -24.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 306-563
Range on HMM: 1-280/280
Sequence Identity: 20% (64 aa)

ITDFQLISKGRFGKVFKAQYTPDSGEKRLVAVKKLNEFQKASFLAEKRIFDEL--NEYPKWYKSIVEFVCAEKIG-------DEYWIVTEFHERLSLYEL
||  . .  | ||.|.|....      . ||||.|.|  .. |. | ||  .|  .      . || .. .   .       . ..||.|. .  .| . 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDAREDFMREARIMCKLGGHH-----PNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LKNNVISITSANRIIMSM--IDGLQFLHDDRPYFFGHPKKPIIHRDIKSKNILVKSDMTTCIADFGLARIYSYD----IEQSDLLGQV--GTK-----RY
|...   .. .  . ..    .| ..||.           ..||||.   |.||... |  |.||||.|    |     ...    .   |.|     | 
LRKHRPKLCMKDLLSFCWQIACGMEYLHSK----------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

MSPEMLEGATEFTPTAFKAMDVYSMGLVMWEVISRTKLHQTDEPPNY-----QMPFQVIGFDPTIGLMRNYVV-----------------------SKKE
|.|| .    .||.    . ||.| | .|||. .. .     .|.         ...|| .  . . |.                             ..
MAPECI-NYGKFTT----KSDVWSFGVCMWEIFTYGQ-----QPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPED

RP---QWRDEI
||   . ....
RPTFSEIHECF
Kinase daf-4.AA Pkinase_Tyr 434-463 50 2.5e-08 28.84 Pfam 130-159 (270) Show / Hide 
Range on Protein: 434-463
Range on HMM: 130-159/270
Sequence Identity: 50% (15 aa)

KPIIHRDIKSKNILVKSDMTTCIADFGLAR
|..||||.  .|.||.....  |.||||||
KNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase daf-4.AA Pkinase_Tyr 314-342 40 5.7e-05 17.45 Pfam 9-38 (270) Show / Hide 
Range on Protein: 314-342
Range on HMM: 9-38/270
Sequence Identity: 40% (12 aa)

KGRFGKVFKAQYT-PDSGEKRLVAVKKLNE
.| ||.|.|. ..  ....|  ||||.|.|
EGAFGEVYKGTWKGDPDNTKIPVAVKMLKE
Kinase daf-4.AA Type1 306-338 39 0.000316 6.92 In-house 1-28 (290) Show / Hide 
Range on Protein: 306-338
Range on HMM: 1-28/290
Sequence Identity: 39% (13 aa)

ITDFQLISKGRFGKVFKAQYTPDSGEKRLVAVK
|.  . | |||.| | ....    ||.  ||||
IQMIECIGKGRYGEVWRGKWR---GEN--VAVK
Kinase daf-4.AA RIPK 312-324 53 0.005457 5.99 In-house 1-13 (290) Show / Hide 
Range on Protein: 312-324
Range on HMM: 1-13/290
Sequence Identity: 53% (7 aa)

ISKGRFGKVFKAQ
...| ||.||||.
VGGGGFGEVFKAR
Kinase daf-4.AA Ciliate-E2-Unclassified 306-324 42 0.100147 1.79 In-house 1-19 (352) Show / Hide 
Range on Protein: 306-324
Range on HMM: 1-19/352
Sequence Identity: 42% (8 aa)

ITDFQLISKGRFGKVFKAQ
 .  . | .| ||||.|.|
YKIIKQIGQGGFGKVYKCQ