Gene F19C6.1 (Nematode worm)

F19C6.1

Species: Nematode worm
Alias: YQR1_CAEEL, CE01554, aSWK006, F19C6.1
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 10002916-9995752, WormBase Genetic Map location: X:1.55,

Classification

Group: AGC
Family: GRK
Subfamily: GRK

Sequence

Name Sequence Type Origin Length Description Download
F19C6.1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 268 Kinase domain by global Sugen HMM Fasta, JSON
F19C6.1.AA Protein Genbank 642 None Fasta, JSON

Protein domain

Protein domains of F19C6.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RGS F19C6.1.AA RGS 51-188 21 7.2e-26 93.18 SMART 1-121 (121) Show / Hide 
Range on Protein: 51-188
Range on HMM: 1-121/121
Sequence Identity: 21% (29 aa)

TYAFVVEKQPIGKLLFHEFCQATNSQYHQCCQFLTKVEEYETSDDDGQSRRDLASSIVSLLHSKPEDNPSGSQDEQEFWCSFLSDEVISTCITTADSATH
... . ...|||...| ||.. ....|... .|.  .||.....|  ..||  |  | .   |..  ..         .| .........| .. ..   
SFHHLCDNDPIGRRYFREFLKQEFCEYKENLEFWLACEEFKKMED--EERRQKAREIYDKYISPNAPCE---------HCVNIDHHTREQCQQCLCN---

DDEPRSDIFTEPYRLTCQYLTDAPFKEFAESMYFHRFL
   |  |.| | .| ..|.. . ....| .|.|..|.|
---PHPDCFDEAQRHVYQLMEKDSYPRFLRSDYYKRYL
RGS F19C6.1.AA RGS 53-96 27 7.3e-07 24.67 Pfam 1-47 (124) Show / Hide 
Range on Protein: 53-96
Range on HMM: 1-47/124
Sequence Identity: 27% (13 aa)

AF--VVEKQPIGKLLFHEFCQATNSQYHQCCQFLTKVEEYETS--DDD
 |  . ..||||..||..|.. ... |  . .|.  .|.....  |.|
SFHHLCNDQPIGRRLFRQFLESEFCEY-ENIEFWLACEDFKKMFSDSD
RGS F19C6.1.AA RGS 136-187 23 0.073766 8.18 Pfam 80-124 (124) Show / Hide 
Range on Protein: 136-187
Range on HMM: 80-124/124
Sequence Identity: 23% (12 aa)

EVISTCITTADSATHDDEPRSDIFTEPYRLTCQYLTDAPFKEFAESMYFHRF
|..  ....|       .|  |.| |  | .....   .. .| .|.|..||
EHCQDNLEQA-------QPTPDCFDEAQRHIYTLMEKDSYPRFLKSDYYQRF
Kinase F19C6.1.AA GRK 203-470 66 2.4e-221 704.95 In-house 1-272 (272) Show / Hide 
Range on Protein: 203-470
Range on HMM: 1-272/272
Sequence Identity: 66% (182 aa)

FRLYRVLGKGGFGEVCACQVRASGKMYALKKLEKKRVKKRHAETLSLNEKQILQRINSP---FVVSLAYAYETKDALCLVLTLMNGGDLKFHLYNLMP--
|| |||||||||||||||||||.|||||.|.|.|||.|||..||..|||||||....|.   |.|..|||||||||||||.|.||||||..|.||...  
FRQYRVLGKGGFGEVCACQVRATGKMYACKCLDKKRIKKRKGETMALNEKQILEKVHSRDCPFIVCMAYAYETKDALCLVMTIMNGGDLHYHIYNMGNNE

GGFDEKRVQFYAAEITLGLQHLHSERILYRDLKPENILLDDFGHVRISDLGLAVEIKDNE-PIKGRVGTVGYMAPEIVKNER-YSYGVDWWGVGCLIYEM
.||||.|..||||||..||.|.|..||.|||||||||||||.|||||||||||.||.... .|.|||||.||||||...||| |....|||..||.||||
PGFDEERMRFYAAEICCGLEHMHRRRIVYRDLKPENILLDDHGHVRISDLGLACEIPEGQPMIHGRVGTHGYMAPEVLQNERAYDFSPDWWSLGCMIYEM

IEGKAPFRQRKEKVKREEVERRVREDQEKYSEKFSEAARTLCRGLLHKEPGFRLGCRRVGRPEDGAEEIRAHPFF
|||..||||.|||||||||.|||.||..||..||||.|...|..||.|.|  |||||. ..   ||.|...||||
IEGHSPFRQHKEKVKREEVDRRVKEDPVKYPDKFSEEAKDICEMLLQKDPEQRLGCRGGTC---GAQEVKEHPFF
Kinase F19C6.1.AA GRK 203-470 74 1.6e-218 732.28 In-house 1-265 (265) Show / Hide 
Range on Protein: 203-470
Range on HMM: 1-265/265
Sequence Identity: 74% (200 aa)

FRLYRVLGKGGFGEVCACQVRASGKMYALKKLEKKRVKKRHAETLSLNEKQILQRINSPFVVSLAYAYETKDALCLVLTLMNGGDLKFHLYNLM-PGGFD
|| |||||||||||||||||||.|||||.|||||||.|||..|...|||||||....|.||||||||||||||||||.|.|||||||||.||.. ..|||
FRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEQMALNEKQILEKVHSRFVVSLAYAYETKDALCLVMTIMNGGDLKFHIYNMGENPGFD

EKRVQFYAAEITLGLQHLHSERILYRDLKPENILLDDFGHVRISDLGLAVEIKDNEPIKGRVGTVGYMAPEIVKNERYSYGVDWWGVGCLIYEMIEGKAP
|.|..||||||..||.|||.|||.|||.|||||||||.||.|||||||||||.....|.||||||||||||.||||||....||||.||||||||||..|
EERAIFYAAEICCGLEHLHRERIVYRDMKPENILLDDHGHIRISDLGLAVEIPEGQMIRGRVGTVGYMAPEVVKNERYTFSPDWWGLGCLIYEMIEGRSP

FRQRKEKVKREEVERRVREDQEKYS-EKFSEAARTLCRGLLHKEPGFRLGCRRVGRPEDGAEEIRAHPFF
|||||||||||||.|||.||.|||| |||||.|...|| ||||.| .|||||.      |..|.|.||||
FRQRKEKVKREEVDRRVKEDPEKYSHEKFSEEAKDICRMLLHKDPEQRLGCREE-----GCDEVRQHPFF
Kinase F19C6.1.AA AGC 203-470 28 2.5e-150 391.77 In-house 1-395 (395) Show / Hide 
Range on Protein: 203-470
Range on HMM: 1-395/395
Sequence Identity: 28% (116 aa)

FRLYRVLGKGGFGEVCACQVR------ASGKMYALKKLEKKR---VKKRHAETLSLNE------------KQILQRIN----------SPFVVS-LAYAY
|....|.|||.||.|. .. .      ..||.||.|.|.||.    ||.. .   ..|            ..||...|          .||.|. | |..
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETKDA--LCLVLTLMN---------GG-DLKFHLYNL-MPGGFDEKRVQFYAAE-------ITLGLQHLHS-ERILYRD-LKPENILLDDFGHVRISDLG
..||   |..|. .|.         || .| .||..    | |||.|..|||||       |.|.|..|||   | .|| |||||||||. ||....| |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LAVEIKDNE---------------------------------------------------PIKGRVG--TVGYMAPEIVKNERYSYGVDWWG--VGCLIY
|. |.....                                                     .  .|  |  ||||||.    |.. .|||.  .|||.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMIEG-------------KAPFRQRKEKVKREEVERRVREDQEKYS----------EKFSEAARTLCRGLLHKEPGFRLGCRRVGRPEDGAEEIRAHPFF
||. |             . |||...|. .. .  |.. ....|.           ..||. |. |...||.|.|  ||||.. .... |||||..||.|
EMLTGYPPFYGDNPQENRH-PFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase F19C6.1.AA BARK 203-470 47 9.2e-91 307.84 In-house 1-264 (264) Show / Hide 
Range on Protein: 203-470
Range on HMM: 1-264/264
Sequence Identity: 47% (130 aa)

FRLYRVLGKGGFGEVCACQVRASGKMYALKKLEKKRVKKRHAETLSLNEKQILQRI----NSPFVVSLAYAYETKDALCLVLTLMNGGDLKFHLYNLMPG
|   |..|.||||||  |     |||||.| |.|||.| .  ||| |||. .|. .      ||.| ..||..| | || .| ||||||| .||     |
FSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGQDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQH--G

GFDEKRVQFYAAEITLGLQHLHSERILYRDLKPENILLDDFGHVRISDLGLAVEIKDNEPIKGRVGTVGYMAPEIV-KNERYSYGVDWWGVGCLIYEMIE
 | |. ..|||||| ||| |.|   . |||||| |||||. ||||||||||| .     |    ||| ||||||.. |   |    ||. .||..| .. 
VFSEQEMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDENGHVRISDLGLACDFSKKKP-HASVGTHGYMAPEVLQKGTAYDSSADWFSLGCMLYKLLR

GKAPFRQRKEKVKREEVERRVREDQEKYSEKFSEAARTLCRGLLHKEPGFRLGCRRVGRPEDGAEEIRAHPFF
| .|||| | | | .|..|     . .  ..||.  | |  |||...   ||||.  ||   ||.|.. ||||
GHSPFRQHKTKDK-HEIDRMTLTMNVELPDSFSKEMRDLLEGLLQRDVSKRLGCM--GR---GAQEVKEHPFF
Kinase F19C6.1.AA S_TKc 203-470 30 4.2e-87 296.59 SMART 1-231 (231) Show / Hide 
Range on Protein: 203-470
Range on HMM: 1-231/231
Sequence Identity: 30% (83 aa)

FRLYRVLGKGGFGEVCACQVRASGKMYALKKLEKKRVKKRHAETLSLNEKQILQRINSPFVVSLAYAYETKDALCLVLTLMNG--GDLKFHLYNLMPGG-
... |..|||.||.|. |. . .|. .|.|..              ..| |||.. . |..| | ..... | |..|. ...|  |||. .. .  ..| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FDEKRVQFYAAEITLGLQHLHSERILYRDLKPENILLDDFGHVRISDLGLAVEIKDNEPIKGRVGTVGYMAPEIVKNERYSY-GVDWWGVGCLIYEM
   |.| ...||...| ..|...|| .|..|||||||||||.  |. |.| ||| ..      .  .||  |||||..    |..  .||| .||..|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

IEGKAPFRQRKEKVKREEVERRVREDQEKYSEKFSEAARTLCRGLLHKEPGFRLGCRRVGRPEDGAEEIRAHPFF
. |. ||.        ... ....          |. |. . |..|.|.|  |...  . . |   ..|..||.|
LCGYPPFP------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDE---WDIKCHPWF
Kinase F19C6.1.AA RSK 206-470 35 9.1e-82 277.96 In-house 1-278 (278) Show / Hide 
Range on Protein: 206-470
Range on HMM: 1-278/278
Sequence Identity: 35% (102 aa)

YRVLGKGGFGEVCACQVR---ASGKMYALKKLEKKRVKKRHAETLSLN-EKQILQRIN-SPFVVSLAYAYETKDALCLVLTLMNGGDLKFHLYNLMP-GG
 .|||.||.|.|  |.     ..|. || | |.|. ...|   |     | .||.|.. .||.|.| ||..|.. | |.. ...||.|  ||..    | 
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDEKRVQFYAAEITLGLQHLHSERILYRDLKPENILLDD---FGHVRISDLGLAVE--IKDNEPIKGRVGTVGYMAPEIVK---NER-YSYGVDWWGVGC
|.|....||.|||.| ..|||.  | .|||||||||.||    ||....| |.. .  ...|.. .  ..|. |||||..|    .. ..  .|||  |.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LIYEMIEGKAPFRQRKEKVKREEVERRVREDQ--EKYS--EKFSEAARTLCRGLLHKEPGFRLGCRRVGRPEDGAEEIRAHPFF
|.|||  |. ||..  ..  |.|. .|... .   .    .. |..|. | |..||..|  |||| .     ..||||..||.|
LMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGP-----QDAEEIKQHPWF
Kinase F19C6.1.AA SGK 203-470 35 9.5e-82 252.15 In-house 1-283 (283) Show / Hide 
Range on Protein: 203-470
Range on HMM: 1-283/283
Sequence Identity: 35% (104 aa)

FRLYRVLGKGGFGEVCACQVRAS------------------GKMYALKKLEKKRVK-------KRHAETLSLNEK-QILQRINSPFVVSLAYAYETKDAL
|..  |.|||.||.|   .  .                   .|.||.| | |. .        |.  . . . |.  ||. ...|| |.| ||  ||. |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CLVLTLMNGGDLKFHLYNLMPGGFDEKRVQFYAAEITLGLQHLHSERILYRDLKPENILLDDFGHVRISDLGLAV-EIKDNEPIKGRVGTVGYMAPEIVK
 .|.  .|||.. .||     . | | |. |||||| . | .|||  | ||||||||||||. ||... | ||.  .||.|.  .   ||. |.|||. .
YFVMDYVNGGEMFYHLQRE--KHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLR

NERYSYGVDWWGVGCLIYEMIEGKAPFRQRKEKVKREEVERRVREDQEKYSEKFSEAARTLCRGLLHKEPGFRLGCRRVGRPEDGAEEIRAHPFF
 . ..  ||||  ||. |||. |. ||  |     ...     .    .    .| .|. |  |||.|.|  ||| .|      ...||. ||||
KQPHDRTVDWWCLGCVLYEMMYGLPPFYSR----NKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKR------DFMEIKNHPFF
Kinase F19C6.1.AA AktR 203-470 36 1.5e-79 270.56 In-house 1-268 (268) Show / Hide 
Range on Protein: 203-470
Range on HMM: 1-268/268
Sequence Identity: 36% (102 aa)

FRLYRVLGKGGFGEVCACQVR-ASGKMYALKKLEKKRVKKRHAETLSLNEKQILQ-RINSPFVVSLAYAYETKDALCLVLTLMNGGDLKFHLYNLMPGGF
|..|..||||.||.|  .| .  ..|.||.| . ||  ..| ..   ..|..|..  .| || | | |. .||. | ...  . ||.| .|| .   . |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKK--KKF

DEKRVQFYAAEITLGLQHLHSE-RILYRDLKPENILLDDFGHVRISDLGLAV-EIK--DNEPIKGRVGTVGYMAPEIVKN-ERYSYGVDWWGVGCLIYEM
.|....||.|.| |.|..||..  | ||||||||||||  |||.|.| ||.  ...  ..|. .  .||. |||||.... . . . |||| .|..||||
SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM

IEGKAPFRQRKEKVKREEVERRVRED--QEKYSEKFSEAARTLCR-GLLHKEPGFRLG--CRRVGRPEDGAEEIRAHPFF
. |  || . .   .......   ..  . .|...||.... |.  .|| | |  |||  |        |.|||. ||.|
VTGCPPFYHKN---QNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCN-------GWEEIKSHPWF
Kinase F19C6.1.AA Pkinase 203-470 29 1.7e-76 265.27 Pfam 1-293 (293) Show / Hide 
Range on Protein: 203-470
Range on HMM: 1-293/293
Sequence Identity: 29% (90 aa)

FRLYRVLGKGGFGEVCACQVRASGKMYALKKLEKKRVKKRHAETLSL-NEKQILQRINSPFVVSLAYAYETKDALCLVLTLMNGG----DLKFHLYNLMP
... |..|.|.||.|. |. . .||..|.|...|.. |.   .|. . .| ||..|.|.|..| | ...|.|| ...|. ...||    ||. ..   . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GGF--DEKRVQFYAAEITLGLQHLHSERILYRDLKPENILLDDFGHV----RISDLGLAVE--IKDNEPIKGRVGTVGYMAPEIVK-NERYSYGVDWWGV
|.|  .|. ..||. .|  ||...||..|..|||||||||.|. ||.    .|.| |||    .  |.  ....|| .|||||... .. |.. ||.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCLIYEMIEGKAPFRQR---KEKVKREEVERRVREDQEKYSEKFS---------------------EAARTLCRGLLHKEPGFRLGCRRVGRPEDGAEEI
||..|||. |. ||...   .. .   .. .|... . ....  .                     |... .....|.| |  |..          ||.|
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT----------AEQI

RAHPFF
  ||.|
LQHPWF
Kinase F19C6.1.AA Ciliate-E2 203-470 22 9.7e-69 234.68 In-house 1-365 (365) Show / Hide 
Range on Protein: 203-470
Range on HMM: 1-365/365
Sequence Identity: 22% (87 aa)

FRLYRVLGKGGFGEVCACQVRASGKM-----------------------YALKKLEKKRVKKRHAETLSL----------NEKQILQRINSPFVVSLAYA
. . ...|.|.|| |. |.|.  .|.                       ||.| ..|. ..    |   .          |||.||...|.|... . ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YE--TKDALCLVLTLMNGGDLKFHLYNL----------MPGGFDEKRVQ---------------FYAAEITLGLQHLHSER-ILYRDLKPENILLDDFGH
..  ... . ||. . .||||. ...|             . |.|| ..               ||.|.| |.|..|||.  |..||.||||||.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VRISDLGLAVEIKDN--------------------------------EPIKGRVGTVGYMAPEIVKNER---------YSYGVDWWGVGCLIYEMIEGKA
. |.|.||. ...|.                                . ..  .|| |||||||....          |.| .|.| .|...|||. || 
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFRQRKEKVKREEVERRVREDQEKYS------------------EKFSEAARTLCRG----LLHKEPGFRLGCRRVGRPEDGAEEIRAHPFF
||            ..   . . ...                  .| |. .  |..     .| |.|  |..         |.|.|  ||.|
PF------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT---------GWEQILNHPWF
Kinase F19C6.1.AA Akt 203-402 43 1.1e-68 218.62 In-house 1-203 (264) Show / Hide 
Range on Protein: 203-402
Range on HMM: 1-203/264
Sequence Identity: 43% (89 aa)

FRLYRVLGKGGFGEVCACQVRASGKMY-ALKKLEKKRVKKRHAETLSLNEKQILQRINSPFVVSLAYAYETKDALCLVLTLMNGGDLKFHLYNLMPGGFD
|.. .||||| || |  ..  ...|.| |.| | |..  ..      . |. |||..|.||.|.| |.  |.| |..|.  .|||.| .||.    . |.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRK--RRFS

EKRVQFYAAEITLGLQHLHSERILYRD-LKPENILLDDFGHVRISDLGLAV-E-IKDNEPIKGRVGTVGYMAPEIVKNERYSYGVDWWG-VGCLIYEMIE
|.|  ||.||| |...||||  | ||| |||||||.|  ||... | ||.  . |||..  |   ||  |.|||| ..  ..  ||||| .||..|||. 
EDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMC

GKAPF
|  ||
GRPPF
Kinase F19C6.1.AA Ciliate-E2-Unclassified 203-470 22 8.5e-66 224.9 In-house 1-352 (352) Show / Hide 
Range on Protein: 203-470
Range on HMM: 1-352/352
Sequence Identity: 22% (82 aa)

FRLYRVLGKGGFGEVCACQVRASGKMYALKKLEKKRVKKRHAETLS---------LNEKQ-------------ILQRINSPFVVSLAYAYETKDALCLVL
... ...|.||||.|. || .  .. ||.| . |....|..    .         .|.|.             ||. ...||.| . |. ..|. ...|.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

TLMNGGDLKFHLYNLMP---------------GGFDEKRVQ-----FYAAEITLGLQHLHSE-RILYRDLKPENILLDDFG---HVRISDLGLAVEIKDN
 ...||||.... . .                  |.|. ..     ||.|.| .||..||..  |..||.||||||.|. |   ...|.|.|.. ....|
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

----------------EPIKGRVGTVGYM----APEIVKNERYS----YGVDWWGVGCLIYEMIEGKAPFRQRKEKV------------KREEVERRVRE
                . .. ..|| .||    |||. ... |.    | .|.|..|...|||. |. || .....              |.....   .
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

DQEKYSE--------KFSEAARTLCRGLLHKEPGFRLGCRRVGRPEDGAEEIRAHPFF
 . ....        . |. |  ... ||.| .  ... |       ..|.|  ||.|
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRI------TFEQILNHPWF
Kinase F19C6.1.AA TyrKc 203-464 20 2.6e-14 8.6 SMART 1-280 (280) Show / Hide 
Range on Protein: 203-464
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

FRLYRVLGKGGFGEVCACQVRASGKMYALKKLEKKRVKKRHAETLSLNEKQILQRI--NSPFVVSLAYAYETK-------DALCLVLTLMNGGDLKFHLY
 .| ..|| | ||||. .. .    . | |.| .        .   ..| .|. ..  . | .| |  .  ..       . |..|. .| .|||| .| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

NLMPGGFDEKRVQFYAAEITLGLQHLHSERILYRDLKPENILLDDFGHVRISDLGLAVEIKDN-------EPIK------GR-VGTVGYMAPEIVKNERY
.  |  .  |    ..  |  | ..||| ..  |||   |.|... ..|.||| ||. .|.|        . ..      |. .  .  ||||  .  ..
KHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SYGVDWWGVGCLIYEMIEGKAPFRQRKEK--VKREEVERRVRED--QEKYSE--------KFSEAARTLCRGLLHKEPGFRLGCRRVGRPEDGAEEI
.   | |  | ...|.    ..     ..  .. .|| ..|..    ..  .          .|  . . .   | .|  |   . .       |..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI------HECF
Kinase F19C6.1.AA Akt 427-470 36 1.8e-10 29.58 In-house 226-264 (264) Show / Hide 
Range on Protein: 427-470
Range on HMM: 226-264/264
Sequence Identity: 36% (16 aa)

EKFSEAARTLCRGLLHKEPGFRLGCRRVGRPEDGAEEIRAHPFF
...| ....| .|||.| |  |||       ...|.||..||.|
DWISPECKDLISGLLNKDPKKRLGGG-----PNDAQEIKRHPWF
Kinase F19C6.1.AA Pkinase_Tyr 203-402 23 1e-07 26.76 Pfam 1-216 (270) Show / Hide 
Range on Protein: 203-402
Range on HMM: 1-216/270
Sequence Identity: 23% (52 aa)

FRLYRVLGKGGFGEVCACQVR----ASGKMYALKKLEKKRVKKR---HAETLSLNEKQILQRI-NSPFVVSLAYAYE-TKDA--LCLVLTLMNGGDLKFH
 .. ..||.| ||||. .  .      .   | |.| |    ..   ... ..  | .|.  . . | .|.|  .    ..   ...|. .| .|||. .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR--EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LYNL--MPGGFDEKRVQFYAAEITLGLQHLHSERILYRDLKPENILLDDFGHVRISDLGLAVEI--KDNE--PIKGRVGTVGYMAPEIVKNERYSYGVDW
| .    .. .. |.   ....|  |...|.| ..  |||   |.|... ..|.|.| |||  |  .|.     .|    .  ||||  .. ...   | 
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

WGVGCLIYEMIE-GKAP-F
|  | |..|..  |. | .
WSFGVLMWEIFTYGEQPTY
S_TK_X F19C6.1.AA S_TK_X 480-559 20 3e-06 27.95 SMART 1-79 (79) Show / Hide 
Range on Protein: 480-559
Range on HMM: 1-79/79
Sequence Identity: 20% (18 aa)

EPVPWKKMEA--GKVTPPFCPDPRAVYAKDVLDIEQFS--TVKGVRLDATDTQFYGKFNTGCVSIPWQSEMIETE----CFAELNTFH
  . |.| ..  ....||| |....||| .  |...|     ...         .  .... ... ||.| .|||    .|.... ..
RGIDWDKLYNQQKEIEPPFKPKIKEVYA-SPTDTSNFDPEFTEETPM-------LTPDDPPLSNSMWQNE-METEIPPDPFRGFTYVF