Gene F22D6.5 (Nematode worm)

F22D6.5

Species: Nematode worm
Alias: F22D6.5, aSWK180, CE05686
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: I: 7102595-7099391, WormBase Genetic Map location: I:1.75,

Classification

Group: CMGC
Family: DYRK
Subfamily: PRP4

Sequence

Name Sequence Type Origin Length Description Download
F22D6.5.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 316 Kinase domain by global Sugen HMM Fasta, JSON
F22D6.5.AA Protein Genbank 775 None Fasta, JSON

Protein domain

Protein domains of F22D6.5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase F22D6.5.AA PRP4 455-770 69 1.5e-252 845.33 In-house 1-320 (320) Show / Hide 
Range on Protein: 455-770
Range on HMM: 1-320/320
Sequence Identity: 69% (222 aa)

YRVVGFTGAGVFGNVCRCNDQTKGN-TVAVKIIRNNEVMYKTGLRELEVLRKLNEA--DKEDKYHCLRLFRTFKHHNHLCLVFENLSMNLRELLKKYGQK
|||.|..|.|||.|||||.|||.|| .||.|||||||.|.||||||||.|.|||.|  ||.||.||.|.||.|.|..|.|||||..||||||.|||||..
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

DGLHLKAVRSYAQQLLLALRLLKKLEFVHADIKPDNILVNESKLTLKLCDFGSAGRVNEQELAPYLVSRFYRAPEIMLGVRHDYAIDLWSVAVTLYEVYT
.||||||||||||||.|||..|||....|||||||||||||||.|||.||||||....|.|..|||||||||||||..|...||.||.|||..||||.||
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNESKNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYT

GKIMFPGRTNNHMLKLFTDVKGKYPNKLVRKSQFKDTHFDVNCNLLYQEVDKVTERNKITVLANLKPTRDLESELIAG-QRLSRDQMDQIQAFRTLLDGM
|||||||.|||||||||.|.|||.|||..||.||||.|||.|||..||||||||||.|.||....|||.|...|||.. ||...|||.....|..|||..
GKIMFPGKTNNHMLKLFMDYKGKMPNKMIRKGQFKDNHFDQNCNFMYQEVDKVTEREKVTVMTYIKPTKDIYQELIECNQRIPEDQMKKVHQFKDLLDKC

LILDPSKRTTCNEALKHPFF
|.|||.||.||||||||||.
LMLDPKKRITCNEALKHPFI
Kinase F22D6.5.AA DYRK 455-770 38 3.7e-164 551.67 In-house 1-320 (320) Show / Hide 
Range on Protein: 455-770
Range on HMM: 1-320/320
Sequence Identity: 38% (126 aa)

YRVVGFTGAGVFGNVCRCNDQTKGN-TVAVKIIRNNEVMYKTGLRELEVLRKLNEADKEDKYHCLRLFRTFKHHNHLCLVFENLSMNLRELLKKYGQKDG
|......| |.||.|..| |. |.|  ||.||||||. .......|.. |..||..|..|||||..... |.|.||||.|||.|||||.|.||..... .
YEILEYIGKGSFGQVVKCWDH-KTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF

LHLKAVRSYAQQLLLALRLLKKL-EFVHADIKPDNILVNE--SKLTLKLCDFGSAGRVNEQELAPYLVSRFYRAPEIMLGVRHDYAIDLWSVAVTLYEVY
..|..||..|||.|..|..|.|. . .|.|.||.||....  .| |.|..||||.. ... .. .|..||||||||..|| ...|||| ||. ..|.| .
FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQ-RIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELF

TGKIMFPGRTNNHMLKLFTDVKGKYPNKLVRKS--QFKDTHFDVNCNLLYQEVDKVTERNKITVLANL---KPTRDLESELIAGQR--LSRDQMDQIQAF
||...||| .....|... .|.|..|.....|.  ..|...||    . |.|.|..|..||||.  .    .||.. ..... |.|   .|.|  . . |
TGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC---FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQF

RTLLDGMLILDPSKRTTCNEALKHPFF
  .....|..||.|| |...||.||.|
KDFIKKCLQWDPHKRITPSQALQHPWF
Kinase F22D6.5.AA CMGC 455-770 18 2.6e-94 310.29 In-house 1-513 (513) Show / Hide 
Range on Protein: 455-770
Range on HMM: 1-513/513
Sequence Identity: 18% (95 aa)

YRVVGFTGAGVFGNVCRCND--------------QTKGNTVAVKIIRNNEVMYKTGL-------------RELEVLRKLN-----------EADKEDKYH
| ...  | | .|.|..| |                 .. ||.|.|.|.. .  ...             ||.. |..||           . |.... .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

CLRLFRTFKHHN-----------------HLCLVFENLSMNLRELLKKYGQ-------------------------KDGLHLKAVRSYAQQLLLALR--L
...|.  |.|.|                 ||.|||| . ..| ...|.. .                         .  . . ..| |..|.| .|    
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

LKKLE--FVHADIKPDNILVNESKLT-------------------LKLCDFGSAGRVNEQ-----------------------ELAPYLVSRFYRAPEIM
. .    ..| |.|| |||.|. .                     ||.||||.|  ...                         . .| |.|.||||||.
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LGVR----------HDYAIDLWSVAVTLYEVYTG--------KIMFPGRTN-----------NHMLKLFTDVKGKYPNKLVRKSQ-------FKDTHFDV
|| .           ...|| |||.  ..| |||        |..|||...            ..|..  .| |. . .. .|..        ... ...
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNM

NCNLLYQE---------------------------VDKVTERNKITVLANLKPTRDLESELIAGQRLSRDQM----------------------DQIQAF
.... |.                              ..  ..   .  ..... | . .          .|                      .. . .
IKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-N-NKK--------AMVFNWIYEEKFKSHKFNHQFKRKCCDPQA

RTLLDGMLILDPSKRTTCNEALKHPFF
. ||..||..||.|| |. .||.||.|
IDLLKKMLQYDPDKRITAEQALQHPYF
Kinase F22D6.5.AA S_TKc 455-770 22 4.5e-68 233.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 455-770
Range on HMM: 1-231/231
Sequence Identity: 22% (73 aa)

YRVVGFTGAGVFGNVCRCNDQTKGNTVAVKIIRNNEVMYKTGLRELEVLRKLNEADKEDKYHCLRLFRTFKHHNHLCLVFENLSM---NLRELLKKYGQK
|...   | | || |..| .   |  ||.|||.      .. .||...|.|       .  .  .|. .| . .||..|.| ..    .|....||.| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

DG---LHLKAVRSYAQQLLLALRLLKKLEFVHADIKPDNILVNESKLTLKLCDFGSAGRVNEQELAPYLVSRFYRAPEIMLGVRHDY-AIDLWSVAVTLY
 .   ..   .|.|..|...||  . .. ..| |.||.|||..|   ..|.||||.| ..       . ....|.|||..    ... ..| ||. ..||
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EVYTGKIMFPGRTNNHMLKLFTDVKGKYPNKLVRKSQFKDTHFDVNCNLLYQEVDKVTERNKITVLANLKPTRDLESELIAGQRLSRDQMDQIQAFRTLL
| ..|.  ||  . . |.|.                                                                         . .. ..
EMLCGYPPFP--QMQMMFKKIG----------------------------------------------------------------------SPEAKDFI

DGMLILDPSKRTTCNEALK-------HPFF
...|  ||.|| |. |||.       ||.|
RKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase F22D6.5.AA DYRK2 455-658 38 2.4e-59 191.5 In-house 1-204 (318) Show / Hide 
Range on Protein: 455-658
Range on HMM: 1-204/318
Sequence Identity: 38% (78 aa)

YRVVGFTGAGVFGNVCRCNDQTKGNTVAVKIIRNNEVMYKTGLRELEVLRKLNEADKEDKYHCLRLFRTFKHHNHLCLVFENLSMNLRELLKKYGQKDGL
| .. . | | || | .| |   .  ||.|.|||     .. ..|...| .. . ||   . | ...  |   ||.|..||.||||| |..||  .. |.
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKN-HFQGF

HLKAVRSYAQQLLLALRLLKKLEFVHADIKPDNILVNES-KLTLKLCDFGSAGRVNEQELAPYLVSRFYRAPEIMLGVRHDYAIDLWSVAVTLYEVYTGK
 |. ||  |...| .||.|.|   .|.| || ||| ..  . ..|. ||||   ...  .  |  ||||||||. || . . |||.||   .. | |||.
SLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGY

IMFPG
..|||
PLFPG
Kinase F22D6.5.AA DYRK1 455-770 33 1.5e-56 194.23 In-house 1-321 (321) Show / Hide 
Range on Protein: 455-770
Range on HMM: 1-321/321
Sequence Identity: 33% (108 aa)

YRVVGFTGAGVFGNVCRCNDQTKGNTVAVKIIRNNEVMYKTGLRELEVLRKLNEADKEDKYHCLRLFRTFKHHNHLCLVFENLSMNLRELLKKYGQKDGL
| .    | | || | .  |. .   ||.|||.|    |   . |. .|  .|..|||.||. ..| | |.. |||||||| || || .||.    . | 
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFR-GV

HLKAVRSYAQQLLLALRLLK--KLEFVHADIKPDNI-LVNESKLTLKLCDFGSAGRVNEQELAPYLVSRFYRAPEIMLGVRHDYAIDLWSVAVTLYEVYT
 |  .| .|||.. ||  .    |. .| |.||.|| |.|  .  .|. ||||. ... | .  |. |||||.||..||.. | |||.||.   | |. |
SLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLG-QRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHT

GKIMFPGRTNNHMLKLFTDVKGKYPNKLVRKSQFKDTHFDV-NCNLLYQEVDKVTER-NKITVLANLKPTRDLESELIAGQRLSRD--QMDQIQAFRTLL
|  .| |      ..   .| |  |.... ..     .|.  . |  |.   .  .. .|      |.     |.    | |.      .   . |. |.
GEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNTWYCKKTRDKKKHYKEPCTRKLHEILGVETGGPGGRRKGEPGHSVEDYLKFKDLI

DGMLILDPSKRTTCNEALKHPFF
  ||. || .| |  .||.|.||
KRMLQYDPKQRITPYYALQHSFF
Kinase F22D6.5.AA HIPK 455-770 31 5.2e-55 171.44 In-house 1-329 (329) Show / Hide 
Range on Protein: 455-770
Range on HMM: 1-329/329
Sequence Identity: 31% (105 aa)

YRVVGFTGAGVFGNVCRCNDQTKGNTVAVKIIRNNEVMYKTGLRELEVLRKLNEADKEDKYHCLRLFRTFKHHNHLCLVFENLSMNLRELLKKYGQKDGL
| |. | | | || | .|  .  .  ||.||..|.    . |  |...|..| . . .. || .| .  |.|.|| ||||| |  || . .|.  .   |
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADE-YHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQN-KFMPL

HLKAVRSYAQQLLLALRLLKKLEFVHADIKPDNI-LVNESK--LTLKLCDFGSAGRVNEQELAPYLVSRFYRAPEIMLGVRHDYAIDLWSVAVTLYEVYT
 ||..|   || | ||  ||.|  .|||.||.|| || ...     |  |||||  | .    .|| ||.||||||.||..   ..| ||    . | . 
PLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFL

GKIMFPGRTNNHMLKLFTDVKGKYPNKLVRKSQFKDTHFDVNCNLLYQEVD-KVTERNKITVLANLKPTR-------DLESELIAGQRLSRDQMD----Q
|   .||  .      .    ..    |. .   |   ||   .. ..    |  |     ... .| .|       |. .| .    . | ..      
GWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRDKQSKFRPWRLKHIEEHEQQTSVKSKEARKYIFNCLDDMPEVNMLVDPERQDYRVEKID

IQAFRTLLDGMLILDPSKRTTCNEALKHPFF
 . |  .|  |. .|. || |  |||.||| 
RREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase F22D6.5.AA Pkinase 455-770 21 1.1e-45 162.65 Pfam 1-293 (293) Show / Hide 
Range on Protein: 455-770
Range on HMM: 1-293/293
Sequence Identity: 21% (73 aa)

YRVVGFTGAGVFGNVCRCNDQTKGNTVAVKIIRNNEVMYKTG---LR--ELEVLRKLNEADKEDKYHC--LRLFRTFKHHNHLCLVFENLSM-----NLR
|....  |.| || |..| ..  | .||||||.  .   .     .|  |......||        |.  .||...|  ..|...|.| . .      | 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

ELLK--KYGQKDGLHLKAVRSYAQQLLLALRLLKKLEFVHADIKPDNILVNESKLTL----KLCDFGSAG---RVNEQELAPYLVSRFYRAPEIML-GVR
....  ..|    .  . ...|. |.| .|  . .  ..| |.||.|||.. .. ..    |.||||.|      | . .  . ....|.|||. . |  
DYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQY

HDYAIDLWSVAVTLYEVYTGKIMFPGR----TNNHMLKLFTDVKG----KYPNKLVRKSQFKDTHFDVNCNLLYQEVDKVTERNKITVLANLKPTRDLES
.....| ||. ..|||...|.  |||.    . . .....  ..|        .. ..| |. . .   .                              
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H------------------------------

ELIAGQRLSRDQMDQIQAFRTLLDGMLILDPSKRTTCNEALKHPFF
     . ...    . .... .....| .||.|| |. ..|.||.|
-----F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase F22D6.5.AA CLK 455-596 31 5.5e-38 110.96 In-house 1-153 (350) Show / Hide 
Range on Protein: 455-596
Range on HMM: 1-153/350
Sequence Identity: 31% (48 aa)

YRVVGFTGAGVFGNVCRCNDQTKG-NTVAVKIIRNNEVMYKTGLRELE-VLRKLNEA-DKEDKYH--CLRLFRTFKH-HNHLCLVFENLSMNLRELLKKY
| .|   | |.|| | .|.|  .| . ||.||||| |        |.. ...|.||. |.. ||   |.... .|.. |.| |.||| .  .. ...|. 
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

G-----QKDGLHLKAVRSYAQQLLLALRLLKKLEFVHADIKPDNILVNESKLT
.     .  .. . ..|. | ||. |.. | ... .| | || ||.   |..|
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRFT
Kinase F22D6.5.AA DyrkP 455-701 30 2.6e-37 119.97 In-house 1-249 (323) Show / Hide 
Range on Protein: 455-701
Range on HMM: 1-249/323
Sequence Identity: 30% (76 aa)

YRVVGFTGAGVFGNVCRCNDQTKGNTVAVKIIRNNEVMYKTGLRELEVLRKLNEADKEDKYHCLRLFRTFKHHNHLCLVFENLSMNLRELLK---KYGQK
| .. . |.  |     | |.  .  . .||| ||   .   . |. .|| .|     |    || .  | |  || .. | |  || |  |      |.
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

DGLHLKAVRSYAQQLLLALRLLKKLEFVHADIKPDNILVN-ESKLTLKLCDFGSAGRVNEQELAPYLVSRFYRAPEIMLGVRHDYAIDLWSVAVTLYEVY
    .  .    ||.|.||  .  |  .| |.||.|||.   .|   |. ||||.  . .  |. |  || |||||...| . || ||.||.   | |..
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDH-LSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELW

TGKIMFPGRTNNHMLKLFTDVKGKYPNKLVRKSQFKDTHFDVNCNLLYQEV
|| ..|   .   .|     . | .|  ...     .  |  .  |||..|
TGNVLFQNDNIQGLLARVIGIIGPFPEWMMQEGRLVQNFF-TRKRLLYMDV
Kinase F22D6.5.AA YAK 455-690 32 7.8e-37 122.41 In-house 1-239 (347) Show / Hide 
Range on Protein: 455-690
Range on HMM: 1-239/347
Sequence Identity: 32% (79 aa)

YRVVGFTGAGVFGNVCRCNDQTKGNTVAVKIIRNNEVMYKTGLRELEVLRKLNE-ADKEDKY---HCLRLFRTFKHHNHLCLVFENLSMNLRELLKKYGQ
| |    | | || |  |        .|||.| |       .  |  .|| ||.  | ..|    | ||.   | | ||.||||| ||.|| |.||    
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

KDGLHLKAVRSYAQQLLLALRLLKKLEFVHADIKPDNILVNE-SKLTLKLCDFGSAGRVNEQELAPYLVSRFYRAPEIMLGVRHDYAIDLWSVAVTLYEV
. |.    .| .  | | ..  |.    .| | || ||.     |  .|. ||||.     . .  |  .|.||.|||....    .|| ||    . | 
C-GFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQ-EKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAEL

YTGKIMFPGRTNNHMLKLFTDVKGKYPNKLVRKSQFKDTHF
. |  .|||      .|   |. |. |. .. . .||   |
FLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYF
Kinase F22D6.5.AA CDK 455-660 25 2.9e-33 103.66 In-house 1-229 (284) Show / Hide 
Range on Protein: 455-660
Range on HMM: 1-229/284
Sequence Identity: 25% (64 aa)

YRVVGFTGAGVFGNVCRCNDQTKG-----NTVAVKIIR---N-----NEVMYKTGLRELEVLRKLNEADKEDKYHCLRLFRTFKHH-----------NHL
|  .   | | .| | .. |.  |     . || | ||   .      | .  | .||   |..|         .  .|.  . ..           | |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-------HPNIVKLHDVCHTKNMDRNNKDKHENKL

CLVFENLSMNLRELLKKYGQKDGLHLKAVRSYAQQLLLALRLLKKLEFVHADIKPDNILVNESKL----TLKLCDFGSAGRVNE--------QELAPYLV
 .||| . . | ....            ...| .||| .|  . .  ..| |.|| |||.|.       .||. ||| |   .         ... .  |
YMVFEYMDHDLKKYMD------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVV

SRFYRAPEIMLGVRHD---YAIDLWSVAVTLYEVYT---GKIMFPGRT
 . |||||. || .|     .||.|||   ..| .|   .| .|||..
TLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDS
Kinase F22D6.5.AA CLK 746-770 64 3.4e-13 35.21 In-house 326-350 (350) Show / Hide 
Range on Protein: 746-770
Range on HMM: 326-350/350
Sequence Identity: 64% (16 aa)

LLDGMLILDPSKRTTCNEALKHPFF
|.  ||. ||||| || .||.||||
LIRKMLEYDPSKRITCKDALQHPFF
Kinase F22D6.5.AA CDK 746-770 52 8.3e-13 37.14 In-house 260-284 (284) Show / Hide 
Range on Protein: 746-770
Range on HMM: 260-284/284
Sequence Identity: 52% (13 aa)

LLDGMLILDPSKRTTCNEALKHPFF
||..|| .||.|| .. .||.||.|
LLNKMLCYDPKKRISAEQALQHPYF
Kinase F22D6.5.AA CLK 598-658 39 6.3e-09 22.14 In-house 187-249 (350) Show / Hide 
Range on Protein: 598-658
Range on HMM: 187-249/350
Sequence Identity: 39% (25 aa)

KLCDFGSAGRVN-EQELAPYLVS-RFYRAPEIMLGVRHDYAIDLWSVAVTLYEVYTGKIMFPG
.. ||||| ... . |  . .|| | |||||. ||    .  | ||..  |.| |||  .|..
CVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQT
Kinase F22D6.5.AA TyrKc 455-770 17 1.1e-08 -82.37 SMART 1-280 (280) Show / Hide 
Range on Protein: 455-770
Range on HMM: 1-280/280
Sequence Identity: 17% (62 aa)

YRVVGFTGAGVFGNVCRCNDQTKGNTVAVKIIRNNEVMYKTGLRELEVLRKL-NEADKEDKYHCLRLFRTFKHH-------NHLCLVFENLSM-NLRELL
 .     | | || |...       .|||| ....    .  .||.....||  . .     . .||.    ..         |..|.|  .  .|.. |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHP-----NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KKYGQKDGLHLKAVRSYAQQLLLALRLLKKLEFVHADIKPDNILVNESKLTLKLCDFGSAGRVNEQ----ELAPYLV------SR-----FYRAPEIMLG
.|.. |  | .|   |.. |     . | .  ..| |.   |.||.| . | | .||| .  . .     |   | .      ..        ||| .  
RKHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

VRHDYAIDLWSVAVTLYEVYT-GKIMFPG-----RTNNHMLKLFTDVKGKYPNKLVR----KSQFKDTHFDVNCNLLYQEVDKVTERNKITVLANLKPTR
 .   . | ||  |...|..| |.   ||      .| .....    .|... .                                              
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEY--VKQGYRMPQPPNDYPMS--------------------------------------

DLESELIAGQRLSRDQMDQIQAFRTLLDGML---ILDPSKRTTCNEALKHPFF
                     .   . . |.     ||..| | .|   | .|
----------------F--VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase F22D6.5.AA DYRK2 754-770 58 7e-06 14.73 In-house 302-318 (318) Show / Hide 
Range on Protein: 754-770
Range on HMM: 302-318/318
Sequence Identity: 58% (10 aa)

DPSKRTTCNEALKHPFF
|||.| |  .|||||..
DPSERMTPSQALKHPWI
Kinase F22D6.5.AA YAK 746-770 32 2.2e-05 13.81 In-house 323-347 (347) Show / Hide 
Range on Protein: 746-770
Range on HMM: 323-347/347
Sequence Identity: 32% (8 aa)

LLDGMLILDPSKRTTCNEALKHPFF
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FINQLLQLNPRERWKPMQAMQHPFI
Kinase F22D6.5.AA DyrkP 750-770 47 0.001571 6.73 In-house 303-323 (323) Show / Hide 
Range on Protein: 750-770
Range on HMM: 303-323/323
Sequence Identity: 47% (10 aa)

MLILDPSKRTTCNEALKHPFF
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CLQIDFTRRPTAKEALQHPWF