Gene F25F2.1 (Nematode worm)

F25F2.1

Species: Nematode worm
Alias: F25F2.1, CE17702, aSWK118
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: III: 4505220-4507631, WormBase Genetic Map location: III:-3.44,

Classification

Group: CK1
Family: Worm10

Sequence

Name Sequence Type Origin Length Description Download
F25F2.1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 262 Kinase domain by global Sugen HMM Fasta, JSON
F25F2.1.AA Protein Genbank 467 None Fasta, JSON

Protein domain

Protein domains of F25F2.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase F25F2.1.AA Worm10 48-337 61 1.1e-232 734.37 In-house 1-295 (295) Show / Hide 
Range on Protein: 48-337
Range on HMM: 1-295/295
Sequence Identity: 61% (183 aa)

LKILTKFDEGRFGAIYMVQNESAVDNDVVSVGNSRFIMKTALRQLSSHQIVYRLSREITVLKTLWGQGNDPPPRVPPILHQGKILGVPFYVTSIFDVNLE
|||||||||||||..||.||...||...|.||...||||....|.|.||..||.....|||||||.|||||||..|||.|||.|.|||.||..|.|||||
LKILTKFDEGRFGKDYMKQNKTKVDQQIVKVGRRMFIMKRIEHQISIHQCFYRVEQKRTVLKTLWKQGNDPPPHIPPIIHQGDIGGVPYYVMPIMDVNLE

KCREQMGGGTFCVQSAFHIAQEIFMALKFMHRRQLVHRDVKPTNIALSYQNRDQWYLIDYGDAISVGKKTPISPPDGVTLPFLSLEAHDLLVTSSYSSFQ
.||.||||..||.|..|||||||.||.||.|.||..|||.|||||||.||||..|.|.||||....|||..|||||.||||.||.||||......||.||
RCRQQMGGHKFCWQDSFHIAQEIMMAIKFCHDRQIIHRDIKPTNIALCYQNRMFWWLCDYGDSCRIGKKKIISPPDAVTLPYLSREAHDATQKPMYSTFQ

QDLESWFYVIVDLLKPLPWKDNNRIDKVALAKRDFMSRLPNNLTN----LPSQILDIGQILKTES---PYSEISKKLVEGLASVKTSSSEKWNPEWY
.|.|||||.||||.||||||..|||||||.|||||.|||||...|    ||.|||||.||.|.||   ||  .   | .|    |      | |.| 
MDIESWFYMIVDLFKPLPWKNMNRIDKVAAAKRDFWSRLPNFFQNRAAKLPPQILDIAQIVKNESIEKPYIQLKTILRDGFD--KNNAKQPWKPDWI
Kinase F25F2.1.AA CK1 48-318 19 1.1e-51 177.97 In-house 1-339 (339) Show / Hide 
Range on Protein: 48-318
Range on HMM: 1-339/339
Sequence Identity: 19% (69 aa)

LKILTKFDEGRFG-AIYMVQNESAVDNDVVSVGNSR----FIMKTALRQLSSHQIVYRLSREITVLKTLWGQ----------------GNDPPPRVPPIL
 |.  | .|| || .||.||.|     |.... |.       .   .   .|   ...| .|. ..| |.|.                 .  |  .. . 
WKVVKKIGEGGFGYQIYKVQKE-----DHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWY

HQGKILGVPFYVTSIFDVNLEKCRE--QMGGGTFCVQSAFHIAQEIFMALKFMHRRQLVHRDVKPTNIALSY--------------QNRDQWYLIDYGDA
|...  .  . | . .  |||..|.  .|... |.. ....||. . .||..||..  .|||.||.|.....              ....|.|.||.| |
HGEEDDYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMA

ISVGKKTP----------------ISPPD--------GVTLPFLSLEAHDLLVTSSYSSFQQDLESWFYVIVDLLKP---LPWKDNNRIDK-----VALA
 .   ...                . |..        | |. . |. .|.        .   ||.||||.....||.   |||.. .. .|     |  .
RR-KYRDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGK----EQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKM

KRDFMSRLPNNLTN----------LPSQILDIGQILKTESPYSEISKKLV
|..|... .....           .|..  .| ..... ..|..   . .
KYEFIDEKKMSTPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase F25F2.1.AA TTBKL 252-312 21 7.8e-09 26.03 In-house 214-278 (288) Show / Hide 
Range on Protein: 252-312
Range on HMM: 214-278/288
Sequence Identity: 21% (14 aa)

SWFYVIVDLLKPLPWKDNNRIDKVALAKRDF-MSRLPNNL---TNLPSQILDIGQILKTESPYSE
||.|.|. |...|||.. .  .... .|..  . .|  ..   . .||. ... . |.. ..|..
SWMYMIIELHCGLPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDR
Kinase F25F2.1.AA S_TKc 48-311 16 1.3e-08 -50.78 SMART 1-231 (231) Show / Hide 
Range on Protein: 48-311
Range on HMM: 1-231/231
Sequence Identity: 16% (48 aa)

LKILTKFDEGRFGAIYMVQNESAVDNDVVSVGNSRFIMKTALRQLSSHQIVYRLSREITVLKTLWGQGNDPPPRVPPILHQGKILGVPFYVTSIFDV---
 .|| |  .| ||  | ... .          . .. .|             .. ||| .||          | .  ..      .  . |.   |    
YEILRKIGKGAFGKVYKCRHKK---------TGRIVAIKIIK---------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLG

NLEKCREQMGGGT----FCVQSAFHIAQEIFMALKFMHRRQLVHRDVKPTNIALSYQNRDQWYLIDYGDAISVGKKTPISPPDGVTLPFLSLEAHDLLVT
.| .  ...|..     |    | .....|. ||...|... .|||.|| || |.     .  ..| | |  .           .|. ... |       
DLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL-------TTFCGTPWYMAPEVL-----

SSYSS---------------------FQQDLESWFYVIVDLLKPLPWKDNNRIDKVALAKRDFMSRLPNNLTNLPSQILDIGQILKTE-----SPYS
 .|.                      |. ...  | .|.                     .||....   |.  |.. . . ..|. |      |. 
-GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------------SPEAKDFIRKC---LQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase F25F2.1.AA CK2 169-208 42 1.5e-08 20.86 In-house 103-141 (288) Show / Hide 
Range on Protein: 169-208
Range on HMM: 103-141/288
Sequence Identity: 42% (17 aa)

EIFMALKFMHRRQLVHRDVKPTNIALSYQNRDQWYLIDYG
|.  || . |    .|||||| ||.   ..| . .||| |
ELLKALDYCHSMGIMHRDVKPHNIMIDHEKR-KLRLIDWG
Kinase F25F2.1.AA CDC7 169-208 35 2.4e-08 19.49 In-house 116-154 (522) Show / Hide 
Range on Protein: 169-208
Range on HMM: 116-154/522
Sequence Identity: 35% (14 aa)

EIFMALKFMHRRQLVHRDVKPTNIALSYQNRDQWYLIDYG
. | ||.. |    .||||||.|.  . ...    |.|.|
NLFYALRHVHQFGIIHRDVKPSNFLYNRRTK-KFLLVDFG
Kinase F25F2.1.AA TTBKL 145-208 34 3.3e-08 23.88 In-house 85-154 (288) Show / Hide 
Range on Protein: 145-208
Range on HMM: 85-154/288
Sequence Identity: 34% (24 aa)

NLEKCREQMGGGT-FCVQSAFHIAQEIFMALKFMHRRQLVHRDVKPTNIALSYQ-----NRDQWYLIDYG
|| . | .|  .  |.....  |.  ...||| ||.   .||||||.|... |      ..   ||||.|
NLQDLRKMMPNKKRFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFG
Kinase F25F2.1.AA NKF1 173-192 70 4.3e-08 24.04 In-house 113-132 (269) Show / Hide 
Range on Protein: 173-192
Range on HMM: 113-132/269
Sequence Identity: 70% (14 aa)

ALKFMHRRQLVHRDVKPTNI
|| ||| |.|||||.|| |.
ALDFMHSRNLVHRDIKPENV
Kinase F25F2.1.AA CMGC 166-199 28 5.4e-08 21.39 In-house 185-222 (513) Show / Hide 
Range on Protein: 166-199
Range on HMM: 185-222/513
Sequence Identity: 28% (11 aa)

IAQEIFMALK--FMHRRQ--LVHRDVKPTNIALSYQNR
... |. .||  ..|..    .||| || || .. ...
YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCE
Kinase F25F2.1.AA Worm6 249-280 38 6.2e-08 24.91 In-house 203-236 (279) Show / Hide 
Range on Protein: 249-280
Range on HMM: 203-236/279
Sequence Identity: 38% (13 aa)

DLESWFYVIVDLLKP-LPWKDNNRIDKVA-LAKR
|.|||||..|..... |||.  .. | |. ..|.
DCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKW
Kinase F25F2.1.AA DAPK 163-208 33 7.4e-08 17.41 In-house 105-152 (264) Show / Hide 
Range on Protein: 163-208
Range on HMM: 105-152/264
Sequence Identity: 33% (16 aa)

AFHIAQEIFMALKFMHRRQLVHRDVKPTNIALSYQNRDQ--WYLIDYG
| .  ..|  .....| |. .| | || || |.  |  |    .|| |
ATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFG
Kinase F25F2.1.AA AGC 166-192 34 1.7e-07 13.89 In-house 152-186 (395) Show / Hide 
Range on Protein: 166-192
Range on HMM: 152-186/395
Sequence Identity: 34% (12 aa)

IAQ------EIFMALKFMHR-RQLVHRD-VKPTNI
.|.      .| .|| ..|. .  .||| .|| ||
AAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENI
Kinase F25F2.1.AA Pkinase 163-192 33 8.9e-05 17.98 Pfam 110-139 (293) Show / Hide 
Range on Protein: 163-192
Range on HMM: 110-139/293
Sequence Identity: 33% (10 aa)

AFHIAQEIFMALKFMHRRQLVHRDVKPTNI
. ... .|. .|...|..  .|||.|| ||
CKFYMYQILRGLEYCHSMGIIHRDLKPENI
Kinase F25F2.1.AA Worm6 49-69 47 0.006274 6.75 In-house 2-22 (279) Show / Hide 
Range on Protein: 49-69
Range on HMM: 2-22/279
Sequence Identity: 47% (10 aa)

KILTKFDEGRFGAIYMVQNES
|.. |  ||.|||.|.|...|
KVTKKIGEGGFGAVYKVEDKS
Kinase F25F2.1.AA Worm6 183-208 31 0.148212 1.77 In-house 126-157 (279) Show / Hide 
Range on Protein: 183-208
Range on HMM: 126-157/279
Sequence Identity: 31% (10 aa)

VHRDVKPTNIALSY------QNRDQWYLIDYG
.|||||| | .          .. . |..|.|
IHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFG