Gene F35C11.3 (Nematode worm)

F35C11.3

Species: Nematode worm
Alias: F35C11.3, CE02210, M05D6.1, aSWK082
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: II: 8246829-8248180, WormBase Genetic Map location: II:0.78,

Classification

Group: CK1
Family: TTBKL

Sequence

Name Sequence Type Origin Length Description Download
F35C11.3.AA Protein Genbank 361 None Fasta, JSON
F35C11.3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 268 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of F35C11.3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase F35C11.3.AA TTBKL 20-282 37 2e-143 482.76 In-house 1-288 (288) Show / Hide 
Range on Protein: 20-282
Range on HMM: 1-288/288
Sequence Identity: 37% (108 aa)

FTVKKKLGEGACGQVFLVDLIQGKGSAAMKVEPLMK-NKEDEILKMEVYVLKKLQ--NSRHVCRLLGSGKTETYTYMVMSVLGKEIGDVRRRLPQRK-MS
....|..|||..|||..|  ...|.. |...|.... ...| ..||||.||.|||  .|.|......|||.. |..|||. .|. ..|.|...|..| .|
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

APSTVRVFIQLVKALQDMHEAGFVHRDVKPSNMALGVK-----NEQVVYIFDFGLSRQIMLPDASG-------KLKLREPRN---KSMFRGTVRYCSLNV
. ...|..||...||..||..||.||||||.|...|..     ....||..|||..||.. .|...       |...|.|||   |..||||.||||.|.
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HLHKEQGRHDDLYGALYAMIETATSTLPWKGKP-KKETSALKEKTTDVQLCKG------CPKSFLEIATTLRKLTYKETPPYGSFMEKL
|..|||||||||. ..| .|| . . |||..   |.|. ..|....| .|.|.      ||..|......|| |.|...|.|....| .
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase F35C11.3.AA CK1 20-278 31 4.2e-101 342.19 In-house 1-339 (339) Show / Hide 
Range on Protein: 20-278
Range on HMM: 1-339/339
Sequence Identity: 31% (107 aa)

FTVKKKLGEGACG-QVFLV------DLIQGK----GSAAMKVEPLMKNKEDEILKMEVYVLKKLQN----------SRHVCR----------LLGSGKTE
..|.||.|||..| |...|      |.  .|      .||||||   .. .  |..|. ..||||.          ..|.|           .  .|...
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

TYT-YMVMSVLGKEIGDVRR--RLPQRKMSAPSTVRVFIQLVKALQDMHEAGFVHRDVKPSNMALGV--------------KNEQVVYIFDFGLSR-QIM
 |  ||||. ||. ..|.|.  |...||.| ...... ||...||..||..||.|||.||.|...|.              ... .||..|||..| . .
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

LPDASG--------KLKLREPRN---KSMFRG-TVRYCSLNVHLHKEQGRHDDLYGALYAMIETATST--LPWKG-------------KPKKETSAL-KE
 .|...        . ..|.||.   |  ||| |.||||.|.||.|||||.|||.  .| .||    |  |||..             | |.|  .  | 
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

KTTDVQLCKG-----CPKSFLEIATTLRKLTYKETPPYGSF
.|..  ||..     ||..| .|.. .|.|.|...|.|  .
STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase F35C11.3.AA TTBK 20-278 39 3.6e-73 249.39 In-house 1-257 (257) Show / Hide 
Range on Protein: 20-278
Range on HMM: 1-257/257
Sequence Identity: 39% (103 aa)

FTVKKKLGEGACGQVFLVDLIQGK-GSAAMKVEPLMKNKEDEILKMEVYVLKKLQNSRHVCRLLGSGKTETYTYMVMSVLGKEIGDVRRRLPQRKMSAPS
 .|.|| | |. | ..    .. .    |.|||   . |   .||||| ||||||   ||||  | |  . . ||||...||   | ||  |. . |  .
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPK--QVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLST

TVRVFIQLVKALQDMHEAGFVHRDVKPSNMALG--VKNEQVVYIFDFGLSRQIMLPDASGKLKLREPRNKSMFRGTVRYCSLNVHLHKEQGRHDDLYGAL
|.|. .|......  |. || |||.|||| |.|   .. . .|. |||| || ..  |.|    | ||.   ||||||| | | |. .| ||||||    
TLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTN--ACG--EVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLF

YAMIETATSTLPW-KGKPKKETSALKEKTTDVQLCKGCPKSFLEIATTLRKLTYKETPPYGSF
| ..| .   ||| | | | .   .|||   . | | ||. |      .. |.|...| |  .
YMLVEFVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase F35C11.3.AA Worm6 20-278 32 4.2e-70 239.22 In-house 1-279 (279) Show / Hide 
Range on Protein: 20-278
Range on HMM: 1-279/279
Sequence Identity: 32% (92 aa)

FTVKKKLGEGACGQVFLVDLIQGKG--SAAMKVEPLMKNKEDEILKMEVYVLKKL--QNSRHVCRLLGSGKTET--YTYMVMSVLGKEIGDVRRRLPQRK
..| ||.|||..| |..|   ..|     |||.|  |.| .   ||||..|||..  ...||.|..   ||..   . |.||  .||  .| |. .|.||
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

MSAPSTVRVFIQLVKALQDMHEAGFVHRDVKPSNMALGV------KNEQVVYIFDFGLSRQIMLPDASGKLKLREPR-NKSMFRGTVRYCSLNVHLHKEQ
.| . . .. ||  .|..|.| .||.||||||.| . |.      ...  .|..|||..|.. . .  ..|.   || ..  |||||||..|. | ..||
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRT--PRWTACGFRGTVRYAPLACHKGQEQ

GRHDDLYGALYAMIETATSTLPWKGKPKKETSA-LKEK---TTD----VQLCKGCPK-SFLEIATTLRKLTYKETPPYGSF
.| ||. . .| |.|  . .|||..  ..   . .|..   .|.     .. ..|||  | .| . . .. | ..| |   
CRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase F35C11.3.AA CK1-D 20-278 29 6e-31 106.35 In-house 1-261 (261) Show / Hide 
Range on Protein: 20-278
Range on HMM: 1-261/261
Sequence Identity: 29% (78 aa)

FTVKKKLGEGACGQVFLVDLIQGKGSAAMKVEPLMKNKEDEILKMEVYVLKKLQNSRHVCRLLGSGKTETYTYMVMSVLGKEIGDVRRRLPQRKMSAPST
. . .|.| |. |....   ||     |.|.|..        |..|  . | .|    . ..   |.   |  ||| .||  . |.     .|| |    
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQ--LHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDL-FNYCHRKFSLKTV

VRVFIQLVKALQDMHEAGFVHRDVKPSNMALGV-KNEQVVYIFDFGLSRQIMLPDASGKLKLREPRNKSMFRGTVRYCSLNVHLHKEQGRHDDLYGALYA
. .  |... .. .|   |.|||.|| |  .|. |  ..||| ||||...   . .   .  ||  ||..  || || |.| |.  || | |||    | 
LMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRE--NKNL-TGTARYASINTHQGIEQSRRDDLESLGYV

MIETATSTLPWKG------KPKKETSALKEKTTDVQ-LCKGCPKSFLEIATTLRKLTYKETPPYGSF
..  .  .|||.|      . | |  . |   | .. |||| |. | .     |.| . . | |  .
LMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase F35C11.3.AA CK1-A 20-278 28 3.6e-30 103.73 In-house 1-261 (261) Show / Hide 
Range on Protein: 20-278
Range on HMM: 1-261/261
Sequence Identity: 28% (77 aa)

FTVKKKLGEGACGQVFLVDLIQGKGSAAMKVEPLMKNKEDEILKMEVYVLKKLQNSRHVCRLLGSGKTETYTYMVMSVLGKEIGDVRRRLPQRKMSAPST
. . .|.| |. | ..|   |.     |.|.|   ..     |  |  | . ||    . ...  |.   |  ||| .||  . |.   . .|. .    
YRLVRKIGSGSFGDIYLGINITNGEEVAIKME--SNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDL-FNFCKRRFTMKTV

VRVFIQLVKALQDMHEAGFVHRDVKPSNMALGVKNE-QVVYIFDFGLSRQIMLPDASGKLKLREPRNKSMFRGTVRYCSLNVHLHKEQGRHDDLYGALYA
. .  |..  .  .|| .|.|||.|| |  .|.      ... ||||...   . .   .. || .|     ||.|| |.| ||  || | ||.    | 
LMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKN---LTGTARYASINAHLGIEQSRRDDMESMGYV

MIETATSTLPWKG------KPKKETSALKEKTTDV-QLCKGCPKSFLEIATTLRKLTYKETPPYGSF
|.     .|||.|      | | |    |  .| . ||||| |  |  . .  |.| ..|.| |   
MMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase F35C11.3.AA CK1-Unclassified 20-166 29 5.7e-27 76.64 In-house 1-155 (244) Show / Hide 
Range on Protein: 20-166
Range on HMM: 1-155/244
Sequence Identity: 29% (47 aa)

FTVKKKLGEGACGQVFLVDLIQGKGSAAMKVEPLMKNKEDEILKMEVYVLKKLQNSR-------HVCRLLGSGKT--ETYTYMVMSVLGKEIGDVRRRLP
. |..|.| |. |.....  .| .  .|.|.|   ||..   |. |..... |||         .. ..  .|.   ..| .|||. ||. . |      
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEK--KNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMC-

QRKMSAPSTVRVFIQLVKALQDMHEAGFVHRDVKPSNMALG--VKNEQVVYIFDFGLS
.|| |   .     |... .. .|. .|.||| || |   |   || ..||| |||||
NRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLS
Kinase F35C11.3.AA CK1 20-166 28 1.5e-24 81.55 In-house 1-156 (271) Show / Hide 
Range on Protein: 20-166
Range on HMM: 1-156/271
Sequence Identity: 28% (46 aa)

FTVKKKLGEGACGQVFLVDLIQGKGSA---AMKVEPLMKNKEDEILKMEVYVLKKLQN------SRHVCRLLGSGKT--ETYTYMVMSVLGKEIGDVRRR
. | .|.|.|. |...|.  .  .| .   |.|.|. .|.|    |. |....| ||.      . .. ..  .|.   . | .|||. ||.   |    
YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEK-NKSKHP-QLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNF

LPQRKMSAPSTVRVFIQLVKALQDMHEAGFVHRDVKPSNMALGV--KNEQVVYIFDFGLS
  .|| |   .. .  |... .. .|. .|.|||.|| |   |.  |....||| ||||.
C-NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLA
Kinase F35C11.3.AA Pkinase 20-232 21 4.4e-24 86.23 Pfam 1-215 (293) Show / Hide 
Range on Protein: 20-232
Range on HMM: 1-215/293
Sequence Identity: 21% (50 aa)

FTVKKKLGEGACGQVFLVDLIQGKGSAAMKVEPLMKNKEDE---ILK-MEVYVLKKLQNSRHVCRLLGSGKTETYTYMVMSVLGKEIG----DVRRRLP-
.....|.|.|. |.|..   .      |.|. .. ..|...    .. .|....|.| |. ...||...  .... ||||  .  | |    |  ...  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYC--EGGLYVMDLFDYIST

--QRKM--SAPSTVRVFIQLVKALQDMHEAGFVHRDVKPSNMALGVKNEQV---VYIFDFGLSRQIMLPDASGKLKLREPRNKSMFRGTVRYCSLNVHL-
  ....  |     ... |....|. .|. |..|||.||.|  .  .| ..   | | ||||..|.          .   .  . | || .|..  |.. 
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD---------Y-NNS-MTTFCGTPWYMAPEVIRG

HKEQGRHDDLYGALYAMIETATSTLPWKGK
... |.  | ...   ..| ..  .|..|.
GQYYGPKVDMWSCGCILYEMLCGRPPFPGH
Kinase F35C11.3.AA CK1-Unique 20-230 23 5.9e-23 76.44 In-house 1-233 (337) Show / Hide 
Range on Protein: 20-230
Range on HMM: 1-233/337
Sequence Identity: 23% (55 aa)

FTVKKKLGEGACGQV-FLVDLIQG-----KGSAAMKVEPLMKNKEDEILKMEVYVLKKL-------QNSRHVCRLLGSGKTETYTYMVMSVLGKEIGDVR
. | |..| |  | | .. ..  |     .   .|| |     | | .|. |  |.| .       . .||.| .  .. .  . ..||  .|. .  ..
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

RRLPQRKMSAP------STVRVFIQLVKALQDMHEAGFVHRDVKPSNMALGVKN---EQVVYIFDFGLSRQIMLPDASGKLKLREPRNKSMFRGTVRYCS
. .   ..           ..   |   ..  ||..|| ||. || |  ..  .   ... |. |.| .| ... . ..   .| || .  |||. .||.
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNH--QIRQPRPITPFRGCKDYCP

LNVHLHKEQGRHDDLYGALYAMIETATST--LPWK
   |. .|.|| ||.   .| .. .   |  | ||
CSCHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK
Kinase F35C11.3.AA Dual 92-212 35 3.2e-21 68.0 In-house 88-206 (282) Show / Hide 
Range on Protein: 92-212
Range on HMM: 88-206/282
Sequence Identity: 35% (43 aa)

YMVMSVLGKEIGDVRRRLPQRKMSAPSTVRVFIQLVKALQDMHEAGFVHRDVKPSNMALGV-KNEQVVYIFDFGLSRQIMLPDASGKLKLREPRNKSMFR
|.|||  |  . ..||      .| .    | || ..|.|| | .|..||..||.| . |.   |  ||  ||.. |    |      | | .| |  . 
YWVMSPYGPSLQEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYMQDFRIVRKYIDPENK---KHRTARKKVKMY

GTVRYCSLNVHLHKEQGRHDDL
|. || .    . |.||| |||
GCGRYACRACMMQKDQGRKDDL
Kinase F35C11.3.AA S_TKc 20-296 18 6e-15 42.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-296
Range on HMM: 1-231/231
Sequence Identity: 18% (57 aa)

FTVKKKLGEGACGQVFLVDLIQGKGSAAMKVEPLMKNKEDEILKMEVYVLKKLQNSRHVCRLLGSGKTETYTYMVMSVLGKEIGDVRRRLPQRK------
... .|.|.|| |.|...  .  .   |.|. .       | .. |. .|||  .  ....|...  . .. ||||  ..   ||..... .|.      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-MSAPSTVRVFIQLVKALQDMHEAGFVHRDVKPSNMALGVKNEQVVYIFDFGLSRQIMLPDASGKLKLREPRNKSMFRGTVRYCSLNVHLHKEQGRHDDL
 ..   . ... |...||. .|. |..|||.||.|  |      .. | ||||.||.                 . | ||  |..  |            
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL-----------------TTFCGTPWYMAPEVL----------G

YGA-----------LYAMIETATSTLPWKGKPKKETSALKEKTTDVQLCKGCPKSFLEIATTLRKLTYKETPPYGSFMEKLKADLPK-----GVKM----
||            || |.   .   |.      .  .. .|                            .|.  .|..|.    |.      .      
YGKCKCDWWSCGCILYEML---CGYPPFP-----QMQMMFKKIG--------------------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWD

---TDPF
      |
IKCHPWF
Kinase F35C11.3.AA CK1-Unclassified 191-212 63 1e-07 18.85 In-house 178-199 (244) Show / Hide 
Range on Protein: 191-212
Range on HMM: 178-199/244
Sequence Identity: 63% (14 aa)

GTVRYCSLNVHLHKEQGRHDDL
|| || |.| || .||.| |||
GTARYASINAHLGIEQSRRDDL
Kinase F35C11.3.AA TyrKc 20-282 17 1e-06 -114.79 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-282
Range on HMM: 1-280/280
Sequence Identity: 17% (53 aa)

FTVKKKLGEGACGQVFLVDLIQGKGSAAMKVEPLMKNKEDEILKMEVYVLKKL-QNSRHVCRLLGSGKTE-------TYTYMVMSVLGKEIGDVRRRLPQ
 | .||||||| |.|..  ..      | |.    .    | .  |  ...||  .  .. ||.|   ..          ..||    .  || . .|  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH--GDLKDYLRK

RK--MSAPSTVRVFIQLVKALQDMHEAGFVHRDVKPSNMALGVKNEQVVYIFDFGLSRQIMLPDASGKLKLREPRNKS----MFR--GTVRYCSLNVHLH
..   . .  .   .|  .  .  |. ...|||    |  .| ..  .| | |||||| |   |..|    ..   ..      .    .| ... .   
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQG---ESKDYYRKKEHKGGKTMLPIRWMAPECI--

KEQGRHDDLYG-------------ALYAMIETATSTLPWKG-----KPKKETSALKEKTTDVQLCKG--------CPKSFLEIATTLRKLTYKETPPYGS
         ||              .. .     .  |. |     .. .|  .. ..       .         ||.   .| ..  .   .. |    
--------NYGKFTTKSDVWSFGVCMWEIFTYGQQ--PYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSE

FMEKL
  |..
IHECF
Kinase F35C11.3.AA CK1 191-212 59 2e-06 18.4 In-house 178-199 (271) Show / Hide 
Range on Protein: 191-212
Range on HMM: 178-199/271
Sequence Identity: 59% (13 aa)

GTVRYCSLNVHLHKEQGRHDDL
||.|| |.| || .||.| ||.
GTARYASINTHLGIEQSRRDDM
Kinase F35C11.3.AA CK1 241-276 37 1.5e-05 15.28 In-house 235-271 (271) Show / Hide 
Range on Protein: 241-276
Range on HMM: 235-271/271
Sequence Identity: 37% (14 aa)

KEKTTDVQLCKG-CPKSFLEIATTLRKLTYKETPPYG
| .|.  ||||| .|. | .  .  |.| ..|.| | 
KMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM