Gene F35C8.1 (Nematode worm)

F35C8.1

Species: Nematode worm
Alias: CE04493, F35C8.1, aSWK323
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 5345177-5348151, WormBase Genetic Map location: X:-5.3,

Classification

Group: STE
Family: STE7
Subfamily: STE7-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
F35C8.1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 246 Kinase domain by global Sugen HMM Fasta, JSON
F35C8.1.AA Protein Genbank 294 None Fasta, JSON

Protein domain

Protein domains of F35C8.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase F35C8.1.AA STE7-Unclassified 49-294 39 3.1e-141 475.51 In-house 1-273 (301) Show / Hide 
Range on Protein: 49-294
Range on HMM: 1-273/301
Sequence Identity: 39% (109 aa)

LYGGERIGNGEGQSAVYRLIYNGKLIARKDVAVRLPKGVDQDSTNKLMAKKLREVNVINGCAPCPFIVHFFGYYVHKYRDCVKIHIFMEEMALSASVLKT
|......|.|.....|..|..||..|||.......... ..|..|..|...|||......|.|.|.|||..|.|.|...|| ||||.||.|.......|.
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDC-KIHICMEYMDCGSLDNKI

EALKQG--------GAIPEFVIGRIVCSVIHAMWFLKDRLQIIHRDIKPGNILIDYDGRVKICDFGICGILENSI--AVSDTGCQQYTAPEILVKGVSNS
. .|..        |.|||.|.|.|...|||..|.|.....||||||||||||....|.|||||||.||.|||..  |.. .|||.|..||.. . ....
DIYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHR

PGYSIKSDIWSLGITIFELATLRYPYPV--------------GFSEFTLLSAIVTTPAPYLERVT----FSNNY
|.||.||||||||.||.|.||..|||..              ..|...|||.||..|.|.|....    .|...
PSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEF
Kinase F35C8.1.AA STE7 49-291 34 4.7e-118 398.49 In-house 1-257 (288) Show / Hide 
Range on Protein: 49-291
Range on HMM: 1-257/288
Sequence Identity: 34% (93 aa)

LYGGERIGNGE-GQSAVYRLIYNGKLIARKDVAVRLPKGVDQDSTNKLMAKKLREVNVINGCAPCPFIVHFFGYYVHKYRDCVKIHIFMEEMA-LSASVL
|  ....|.|. |. . .|. ..||..|.|.. .....       .... . |.|..|.. |..||.||.|.|.......||  |.|.|| |.  .   .
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNND-------PEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDC--IWICMEYMDGGCLDKF

KTEALK-----QGGAIPEFVIGRIVCSVIHAMWFLKDRLQIIHRDIKPGNILIDYDGRVKICDFGICGILENSI--AVSDTGCQQYTAPEILVKGVSNSP
  ...|     ..| |||...|.|...||.....|.....|||||.||.|||....|.||.||||||| |..|.  |....|||.| ||| .     |..
YKRVKKVYRGIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDG---NKQ

GYSIKSDIWSLGITI-FELATLRYPYPVGFS-----------------EFTLLSAIVTT-PAPYLERVTFS
.|...||.||||||. .|.||.|||||  ..                 .|..|. ||.  |.| |.  .||
HYDVRSDVWSLGITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP--KFS
Kinase F35C8.1.AA STE 49-286 24 3.3e-60 206.34 In-house 1-304 (359) Show / Hide 
Range on Protein: 49-286
Range on HMM: 1-304/359
Sequence Identity: 24% (76 aa)

LYGGERIGNGEGQSAVYRLIYN----------------GKLIARKDVAVRLPKGVDQD---------STNKLMAKKLREVNVINGCAP-CPFIVHFFGYY
. | |.||.| . . .. .  .                |...| | . ..  .  | .         . .. | . |.|... . | . .|.||...|.|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

VHKYRD---CVKIHIFMEEMA-LSASVLKTEALKQG----------GAIPEFVIGRIVCSVIHAMWFLKDRLQIIHRDIKPGNILIDYDGRVKICDFGIC
... ..   . ...|.|| |.  |.. .  .  . |          . .|| .|..|........  .. ...||||||||.|||.     ||.||||.|
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

GILENSIA----------------V--SDTGCQQYTAPEILVKGVSN-SPGYSIKSDIWSLGITIFELATLRYPYPVGFSE---------------FTLL
|.|..|.|                   ...|.. . |||.. .. .. ..||..|.||||||.|| |.|| ..|.  .                  | .|
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

SAIVTTPAPYLE
 .||  | | |.
-CIVNGPPPPLP
Kinase F35C8.1.AA MEK7 100-291 39 1.2e-51 173.45 In-house 45-239 (269) Show / Hide 
Range on Protein: 100-291
Range on HMM: 45-239/269
Sequence Identity: 39% (78 aa)

LREVNVINGCAPCPFIVHFFGYYVHKYRDCVKIHIFMEEMALSASVLKTEALKQG--GAIPEFVIGRIVCSVIHAMWFLKDRLQIIHRDIKPGNILIDYD
|. . |.  |  ||.||  |||..        . | || |.  .  |.   .|.     |||..||..| ..| |  .||.  .|.|||.|| |||.|  
LMDLDVMCMCHDCPYIVQCFGYFMTD----SDVWICMECMSTCCDKLL-KRIKHPKLDFIPEQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWR

GRVKICDFGICGILENSIAVS-DTGCQQYTAPEILVKGVSNSPGYSIKSDIWSLGITIFELATLRYPYPVGFSEFTLLSAIVTT--PAPYLERVT---FS
| .| ||||| | .  | | .   ||  | ||| .     | | | | .|.||||||..|||| .||||    ||. .. |     . | |.  .   ||
GNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVELATGQYPYPGCDMEFEMMTKILNDNLEPPCLPEHMKYNFS
Kinase F35C8.1.AA MEK4 157-265 51 5.2e-50 161.32 In-house 105-213 (275) Show / Hide 
Range on Protein: 157-265
Range on HMM: 105-213/275
Sequence Identity: 51% (57 aa)

IPEFVIGRIVCSVIHAMWFLKDRLQIIHRDIKPGNILIDYDGRVKICDFGICGILENSIAVS-DTGCQQYTAPEILVKGVSNSPGYSIKSDIWSLGITIF
||| ..|.|   .. |  .||  ..|||||.|| |||.|  | || ||||||| |..||| . | ||..| ||| .     |..|| |.||.||||||. 
IPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDP-EQNMDGYDIRSDVWSLGITMY

ELATLRYPYP
|.|| ..||.
EVATGKFPYR
Kinase F35C8.1.AA MEK3 150-264 47 5.3e-49 164.79 In-house 91-206 (264) Show / Hide 
Range on Protein: 150-264
Range on HMM: 91-206/264
Sequence Identity: 47% (56 aa)

ALK-QGGAIPEFVIGRIVCSVIHAMWFLKDRLQIIHRDIKPGNILIDYDGRVKICDFGICGILENSIA-VSDTGCQQYTAPEILVKGVSNSPGYSIKSDI
..| .|  ||| ..|.|  |.. |  ... .|..||||.|| |.||   |.||.||||| | | .|.|   | || .| |||  . .  |. ||..|||.
VYKPHGMHIPEDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPE-RIDPEMNQKGYDVKSDV

WSLGITIFELATLRYPY
||||||. |.|..||||
WSLGITMIEMAIGRYPY
Kinase F35C8.1.AA MEK1 100-265 38 2.5e-37 124.79 In-house 45-197 (297) Show / Hide 
Range on Protein: 100-265
Range on HMM: 45-197/297
Sequence Identity: 38% (64 aa)

LREVNVINGCAPCPFIVHFFGYYVHKYRDCVKIHIFMEEM-ALSASVLKTEALKQGGAIPEFVIGRIVCSVIHAMWFLKDRLQIIHRDIKPGNILIDYDG
.||..|.  |   |.|| |.| ..    .   | | || |  .|  ..    ||. | ||| ..|..   |.. . .|.|. .|.|||.|| |||.   |
IRELQVLHECN-SPYIVGFYGAFY----SDGEISICMEYMDGGSLDQV----LKKAGRIPEKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRG

RVKICDFGICGILENSIAVSDTGCQQYTAPEILVKGVSNSPGYSIKSDIWSLGITIFELATLRYPYP
 .|.||||. | |  |.| |  |   | .|| | .|      |...|||||.|. . |.|  ||| |
EIKLCDFGVSGQLIDSMANSFVGTRSYMSPERL-QGTH----YTVQSDIWSMGLSLVEMAIGRYPIP
Kinase F35C8.1.AA MEK5 157-265 43 1.6e-27 97.76 In-house 90-192 (254) Show / Hide 
Range on Protein: 157-265
Range on HMM: 90-192/254
Sequence Identity: 43% (47 aa)

IPEFVIGRIVCSVIHAMWFLKDRLQIIHRDIKPGNILIDYDGRVKICDFGICGILENSIAVSDTGCQQYTAPEILVKGVSNSPGYSIKSDIWSLGITIFE
||| ..||.  ...  . .| . |.|.|||.|| |.|.   |..|.||||.   | |||.    |   | |||  . |      | | ||.||||| ..|
IPEHILGRMTVAIVKGLNYLWN-LKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTYIGTNAYMAPER-ISGDQ----YGIHSDVWSLGIFFME

LATLRYPYP
.|| |.|||
MATGRFPYP
Kinase F35C8.1.AA Pkinase 87-265 23 6.4e-26 92.73 Pfam 32-213 (293) Show / Hide 
Range on Protein: 87-265
Range on HMM: 32-213/293
Sequence Identity: 23% (46 aa)

VDQDSTNKLMAKKLR---EVNVINGCAPCPFIVHFFGYYVHKYRDCVKIHIFMEEMALS---ASVLKTEALK--QGGAI--PEFVIGRIVCSVIHAMWFL
.. ..... . . .|   |. . . .  .|.|| .....        .|.. || .      ..    . ..  ..|..  .| .. ...  .. .. ..
IKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLF--DYISTWRHGCFYFSEWECKFYMYQILRGLEYC

KDRLQIIHRDIKPGNILIDYDGRV----KICDFGICG---ILENSIAVSDTGCQQYTAPEILVKGVSNSPGYSIKSDIWSLGITIFELATLRYPYP
 .   |||||.|| ||||| .| .    ||||||..    .  || . . .|   | |||..      ...|. |.|.||.|....|... | |.|
HS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPKVDMWSCGCILYEMLCGRPPFP
Kinase F35C8.1.AA ULK 181-264 33 2.2e-25 85.62 In-house 150-256 (329) Show / Hide 
Range on Protein: 181-264
Range on HMM: 150-256/329
Sequence Identity: 33% (36 aa)

QIIHRDIKPGNILIDYD------------GRVKICDFGICGILENS-----IAVSDT------GCQQYTAPEILVKGVSNSPGYSIKSDIWSLGITIFEL
.|||||||| ||||. .            |..||.||| .  ..|.     .... .      |   | ||.|| .   . | |. |.||||||. ..|.
NIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEM

ATLRYPY
 . ..|.
LYGKPPF
Kinase F35C8.1.AA STE20 179-264 40 1.1e-23 83.61 In-house 135-227 (288) Show / Hide 
Range on Protein: 179-264
Range on HMM: 135-227/288
Sequence Identity: 40% (38 aa)

RLQIIHRDIKPGNILIDYDGRVKICDFGICGILEN----SIA---VSDTGCQQYTAPEILVKGVSNSPGYSIKSDIWSLGITIFELATLRYPY
. .||||||| .|||.. ||.||..||| |. |..    ...    .  |   . |||.. .  ..  ||  |.||||||||. |.|. . ||
SNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPY
Kinase F35C8.1.AA S_TKc 49-290 21 5.2e-21 77.05 SMART 1-231 (231) Show / Hide 
Range on Protein: 49-290
Range on HMM: 1-231/231
Sequence Identity: 21% (58 aa)

LYGGERIGNGEGQSAVYRLIYNG--KLIARKDVAVRLPKGVDQDSTNKLMAKKLREVNVINGCAPCPFIVHFFGYYVHKYRDCVKIHIFMEEMALSASVL
   .. || | . . ||. . ..  .. | | .                  . .||...      .|.||........      .....|| .  ..  |
YEILRKIGKG-AFGKVYKCRHKKTGRIVAIKIIK----------------EHIRREIQILKK--HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDL

KTEALKQGGA-----IPEFVIGRIVCSVIHAMWFLKDRLQIIHRDIKPGNILIDYDGRVKICDFGICGILENSIAVSDTGCQQYTAPEILVKGVSNSPGY
..   |.|.      .|| .. .... .. |. .. .. .|||||.|| |||.|   ..||||||.. .|      .  |   | |||.|        ||
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL--------GY

SI-KSDIWSLGITIFELATLRYPYPVGFSEFTLLSAIVTTPAPY-------------------LE-------RVTF
.  |.|.||.|....|... . |.|    .....  |. .|                      |.          |
GKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase F35C8.1.AA Pkinase_Tyr 191-260 28 3.6e-11 38.45 Pfam 141-210 (270) Show / Hide 
Range on Protein: 191-260
Range on HMM: 141-210/270
Sequence Identity: 28% (21 aa)

NILIDYDGRVKICDFGICGIL-ENSIA-VSDT---GCQQYTAPEILVKGVSNSPGYSIKSDIWSLGITIFELATL
|.|.. .. ||||||| .  . . .   .. .        .||| .  |.     ...|||.|| |....|. |.
NCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK-----FTTKSDVWSFGVLMWEIFTY
Kinase F35C8.1.AA TyrKc 49-292 17 1.8e-08 -85.75 SMART 1-275 (280) Show / Hide 
Range on Protein: 49-292
Range on HMM: 1-275/280
Sequence Identity: 17% (52 aa)

LYGGERIGNGEGQSAVYRLIYNGKLIARKDVAVRLPKGVDQDSTNKLMAKKLREVNVINGC-APCPFIVHFFGYYVHKY------RDCVKIHIFMEEMAL
.  |. .|.|.     .  .| |...   .|||   |          ..  .|| ..        | || ..|. ...            .  .|.  .|
ITLGKKLGEGA-----FGEVYKGTWK--IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

SASVLKTEALKQGGAIPEFVIGRIVCSVIHAMWFLKDRLQIIHRDIKPGNILIDYDGRVKICDFGICGILENS--------IAVSDT--GCQQ-----YT
     |..       ..      .   .   | .| .. ..||||.   |.|.. ...|||.||| .  ...           .. .  |.        .
KDYLRKHRPK-----LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

APEILVKGVSNSPGYSIKSDIWSLGITIFELATLRYPYPVG-----FSEFTLLSAIVTT-----PAP------------------------YLERVTFSN
||| . .|.     ...|||.|| |....|. |.  . . |      | . ..  . .      |.                           .| |||.
APECINYGK-----FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSE
Kinase F35C8.1.AA MEK4 87-120 37 0.018743 3.62 In-house 37-71 (275) Show / Hide 
Range on Protein: 87-120
Range on HMM: 37-71/275
Sequence Identity: 37% (13 aa)

VD-QDSTNKLMAKKLREVNVINGCAPCPFIVHFFG
||  |. .| . . |.|. |.   . || || |.|
VDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYG