Gene F35C8.2 (Nematode worm)

F35C8.2

Species: Nematode worm
Alias: F35C8.2, CE04494, aSWK321
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 5344178-5345129, WormBase Genetic Map location: X:-5.3,

Classification

Group: STE
Family: STE7
Subfamily: STE7-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
F35C8.2.AA Protein Genbank 260 None Fasta, JSON
F35C8.2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 213 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of F35C8.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase F35C8.2.AA STE7-Unclassified 48-260 44 2e-129 436.31 In-house 1-222 (301) Show / Hide 
Range on Protein: 48-260
Range on HMM: 1-222/301
Sequence Identity: 44% (99 aa)

LHGGVRIGSGEGQSAVYRLIYNGMVIARKDVAVRLPQGGDEDSTNKLMAKRLREVNVINGCAPCPFIVHFFGYYVHKYKDCVKIHIFMEEMALSASVLKK
|... ..|.|.....|..|..|||||||.......... ..|..|..|...|||......|.|.|.|||..|.|.|...|| ||||.||.|.......|.
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDC-KIHICMEYMDCGSLDNKI

EVLKRG--------GIVPEFVIGRIACSVIHAMWFLKEKMQIIHRDIKPGNILIDYDGRVKICDFGISGILQDSI--AVSATGCQQYTAPEINELAMVHS
...|..        |..||.|.|.||..|||..|.|.||..||||||||||||....|.|||||||..|.|....  |....|||.|..||...  |.|.
DIYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHR

PGYSIKSDIWSLGITIFELATLT
|.||.||||||||.||.|.||..
PSYSVKSDIWSLGLTIWECATGK
Kinase F35C8.2.AA STE7 48-260 36 1e-102 347.54 In-house 1-211 (288) Show / Hide 
Range on Protein: 48-260
Range on HMM: 1-211/288
Sequence Identity: 36% (81 aa)

LHGGVRIGSGE-GQSAVYRLIYNGMVIARKDVAVRLPQGGDEDSTNKLMAKRLREVNVINGCAPCPFIVHFFGYYVHKYKDCVKIHIFMEEMA-LSASVL
|. . ..|.|. |. . .|. ..|...|.|.. .....       .... . |.|..|.. |..||.||.|.|.......||  |.|.|| |.  .   .
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNND-------PEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDC--IWICMEYMDGGCLDKF

KKEVLKRG-----GIVPEFVIGRIACSVIHAMWFLKEKMQIIHRDIKPGNILIDYDGRVKICDFGISGILQDSI--AVSATGCQQYTAPEINELAMVHSP
 |.|.|..     |..||...|.||..||.....|.||..|||||.||.|||....|.||.|||||.| |.||.  |....|||.| |||  .    ...
YKRVKKVYRGIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDG---NKQ

GYSIKSDIWSLGITI-FELATLT
.|...||.||||||. .|.||..
HYDVRSDVWSLGITMGIEMATGR
Kinase F35C8.2.AA STE 48-258 25 8.8e-57 194.96 In-house 1-263 (359) Show / Hide 
Range on Protein: 48-258
Range on HMM: 1-263/359
Sequence Identity: 25% (69 aa)

LHGGVRIGSGEGQSAVYRLIYN----------------GMVIARKDVAVRLPQGGDED---------STNKLMAKRLREVNVINGCAP-CPFIVHFFGYY
. |  .||.| . . .. .  .                | ..| | . ..  .  | .         . .. | . |.|... . | . .|.||...|.|
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

VHK---YKDCVKIHIFMEEMA-LSASVLKKEVLKRG----------GIVPEFVIGRIACSVIHAMWFLKEKMQIIHRDIKPGNILIDYDGRVKICDFGIS
...    |.. ...|.|| |.  |.. . |.. ..|          . .|| .|..|........  ......||||||||.|||.     ||.||||..
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVC

GILQDSIA----------------V--SATGCQQYTAPEINELAMVH-SPGYSIKSDIWSLGITIFELAT
|.|.||.|                   . .|.. . |||. .    . ..||..|.||||||.|| |.||
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMAT
Kinase F35C8.2.AA MEK7 99-258 41 6.5e-46 153.75 In-house 45-202 (269) Show / Hide 
Range on Protein: 99-258
Range on HMM: 45-202/269
Sequence Identity: 41% (68 aa)

LREVNVINGCAPCPFIVHFFGYYVHKYKDCVKIHIFMEEMALSASVLKKEVLKR-GGIVPEFVIGRIACSVIHAMWFLKEKMQIIHRDIKPGNILIDYDG
|. . |.  |  ||.||  |||..        . | || |.  .  |.| . .     .||..||..  ..| |  .|||| .|.|||.|| |||.|  |
LMDLDVMCMCHDCPYIVQCFGYFMTD----SDVWICMECMSTCCDKLLKRIKHPKLDFIPEQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRG

RVKICDFGISGILQDSIAVS-ATGCQQYTAPEINELAMVHSPGYSIKSDIWSLGITIFELAT
 .| ||||||| . || | .   ||  | |||         | | | .|.||||||..||||
NIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVELAT
Kinase F35C8.2.AA MEK3 147-260 46 1.3e-45 153.05 In-house 89-203 (264) Show / Hide 
Range on Protein: 147-260
Range on HMM: 89-203/264
Sequence Identity: 46% (55 aa)

KEVLK-RGGIVPEFVIGRIACSVIHAMWFLKEKMQIIHRDIKPGNILIDYDGRVKICDFGISGILQDSIA--VSATGCQQYTAPE-INELAMVHSPGYSI
. |.| .|  .|| ..|.|| |.. |  ...|. ..||||.|| |.||   |.||.||||||| | ||.|  . | || .| ||| |.    . . ||..
RHVYKPHGMHIPEDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDA-GCKPYMAPERID--PEMNQKGYDV

KSDIWSLGITIFELATLT
|||.||||||. |.|...
KSDVWSLGITMIEMAIGR
Kinase F35C8.2.AA MEK4 86-258 42 2.1e-45 146.04 In-house 38-207 (275) Show / Hide 
Range on Protein: 86-258
Range on HMM: 38-207/275
Sequence Identity: 42% (74 aa)

GDEDSTNKLMAKRLREVNVINGCAPCPFIVHFFGYYVHKYKDCVKIHIFMEEMALSASVLKKEV-LKRGGIVPEFVIGRIACSVIHAMWFLKEKMQIIHR
. .|. .| . . |.|. |.   . || || |.|  . |  ||    | || | .|   . | |  ..   .|| ..|.|.  .. |  .|||. .||||
DPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYG-ACFKEGDC---WICMELMDISMDKFYKYVYMVQKSRIPENIMGHITVCTVDALNYLKETHKIIHR

DIKPGNILIDYDGRVKICDFGISGILQDSIAVSA-TGCQQYTAPEINELAM-VHSPGYSIKSDIWSLGITIFELAT
|.|| |||.|  | || |||||.| |.|||| .   ||..| |||   ..    ..|| |.||.||||||. |.||
DVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPE--RIDPEQNMDGYDIRSDVWSLGITMYEVAT
Kinase F35C8.2.AA MEK1 99-257 38 2.5e-38 128.31 In-house 45-190 (297) Show / Hide 
Range on Protein: 99-257
Range on HMM: 45-190/297
Sequence Identity: 38% (61 aa)

LREVNVINGCAPCPFIVHFFGYYVHKYKDCVKIHIFMEEMALSASVLKKEVLKRGGIVPEFVIGRIACSVIHAMWFLKEKMQIIHRDIKPGNILIDYDGR
.||..|.  |   |.|| |.| ..    .   | | || |   .  .   |||. | .|| ..|...  |.. . .|..|..|.|||.|| |||.   | 
IRELQVLHECN-SPYIVGFYGAFY----SDGEISICMEYMDGGSLDQ---VLKKAGRIPEKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGE

VKICDFGISGILQDSIAVSATGCQQYTAPEINELAMVHSPGYSIKSDIWSLGITIFELA
.|.||||.|| | ||.| |  |   | .||   |   |   |...|||||.|. . |.|
IKLCDFGVSGQLIDSMANSFVGTRSYMSPE--RLQGTH---YTVQSDIWSMGLSLVEMA
Kinase F35C8.2.AA Pkinase 87-258 24 3.8e-26 93.55 Pfam 35-207 (293) Show / Hide 
Range on Protein: 87-258
Range on HMM: 35-207/293
Sequence Identity: 24% (45 aa)

DEDSTNKLMAKRL-REVNVINGCAPCPFIVHFFGYYVHKYKDCVKIHIFMEEMALS---ASVLKKEVLK--RGGIV--PEFVIGRIACSVIHAMWFLKEK
.... .|....|. .|. . . .  .|.|| .....        .|.. || .      ..    ....  |.| .  .| .. ...  .. .. .. . 
RHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLF--DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-

MQIIHRDIKPGNILIDYDGRV----KICDFGISG---ILQDSIAVSATGCQQYTAPEINELAMVHSPGYSIKSDIWSLGITIFELAT
| |||||.|| ||||| .| .    ||||||..    .  .| . . .|   | |||.      ....|. |.|.||.|....|...
MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV----IRGGQYYGPKVDMWSCGCILYEMLC
Kinase F35C8.2.AA MEK5 156-258 38 2.8e-24 85.85 In-house 90-186 (254) Show / Hide 
Range on Protein: 156-258
Range on HMM: 90-186/254
Sequence Identity: 38% (40 aa)

VPEFVIGRIACSVIHAMWFLKEKMQIIHRDIKPGNILIDYDGRVKICDFGISGILQDSIAVSATGCQQYTAPEINELAMVHSPGYSIKSDIWSLGITIFE
.|| ..||.. ...  . .| . ..|.|||.|| |.|.   |..|.||||.|  | .||.    |   | |||      .    | | ||.||||| ..|
IPEHILGRMTVAIVKGLNYLWN-LKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTYIGTNAYMAPE-----RISGDQYGIHSDVWSLGIFFME

LAT
.||
MAT
Kinase F35C8.2.AA TKL 54-258 22 3.1e-24 84.16 In-house 1-284 (364) Show / Hide 
Range on Protein: 54-258
Range on HMM: 1-284/364
Sequence Identity: 22% (66 aa)

IGSGEGQSAVYRLIYNG------MVIARKDVAVRLPQGGDEDSTNK--------------------LMAKRLREVNVINGCAP--CPFIVHFFGYYVHKY
|||| | . ||. ...|         . |||||      ..|...|                    ..  | .|...|. .    .| ||.| ||     
IGSG-GFGEVYKGKWRGWGGKCPS-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPP

K--DCVK-------IHIFMEEMALSA--SVLKKEVLKRGGIVPEFVIGRIACSVIHAMWFLKE-------KMQIIHRDIKPGNILIDYDGR---------
.   |..       ..| || .      ..|              .. |.| ..  .| .|         |..|||||.|. |||.| ...         
CGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNP

-----VKICDFGISGILQDS---------------------IAVSATGCQQYTAPEINELAMV-----------HSPGYSIKSDIWSLGITIFELAT
     .||||||.|  .. |                        .  |  .. |||. . .|            ..  || |.|..| || ..|..|
NADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILT
Kinase F35C8.2.AA ULK 178-256 33 7.4e-23 76.69 In-house 148-249 (329) Show / Hide 
Range on Protein: 178-256
Range on HMM: 148-249/329
Sequence Identity: 33% (34 aa)

KMQIIHRDIKPGNILIDYD------------GRVKICDFGISGILQDS-----IAVSAT------GCQQYTAPEINELAMVHSPGYSIKSDIWSLGITIF
|..|||||||| ||||. .            |..||.||| .  ....     ......      |   | ||.| .    . | |. |.||||||. ..
KHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFY

EL
|.
EM
Kinase F35C8.2.AA S_TKc 48-260 20 8.3e-14 25.54 SMART 1-220 (231) Show / Hide 
Range on Protein: 48-260
Range on HMM: 1-220/231
Sequence Identity: 20% (53 aa)

LHGGVRIGSGEGQSAVYRLIYNG--MVIARKDVAVRLPQGGDEDSTNKLMAKRLREVNVINGCAPCPFIVHFFGYYVHKYKDCVKIHIFMEEMALSASVL
 . .  ||.| . . ||. . ..   . | | .                  . .||...      .|.||........      .....|| .  ..  |
YEILRKIGKG-AFGKVYKCRHKKTGRIVAIKIIK----------------EHIRREIQILKK--HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDL

KKEVLKRGGI-----VPEFVIGRIACSVIHAMWFLKEKMQIIHRDIKPGNILIDYDGRVKICDFGISGILQDSIAVSATGCQQYTAPEINELAMVHSPGY
..   |||.       || .. .... .. |. .. .. .|||||.|| |||.|   ..||||||.. .|      .  |   | |||.         ||
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL--------GY

SI-KSDIWSLGITIFELAT----------------------------------------LT
.  |.|.||.|....|...                                        |.
GKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQ
Kinase F35C8.2.AA Pkinase_Tyr 177-259 31 9.3e-10 33.67 Pfam 128-210 (270) Show / Hide 
Range on Protein: 177-259
Range on HMM: 128-210/270
Sequence Identity: 31% (28 aa)

EKMQIIHRDIKPGNILIDYDGRVKICDFGISGIL-QDSIA-VSAT---GCQQYTAPE-INELAMVHSPGYSIKSDIWSLGITIFELATL
| ...||||.   |.|.. .. ||||||| .  .  |.   ....        .||| ||.        ...|||.|| |....|. |.
ESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK------FTTKSDVWSFGVLMWEIFTY
Kinase F35C8.2.AA TyrKc 52-259 15 6.4e-05 -143.08 SMART 1-280 (280) Show / Hide 
Range on Protein: 52-259
Range on HMM: 1-280/280
Sequence Identity: 15% (46 aa)

VRIGS--GEGQ-SAVYRLIYNGMVIARKDVAVRLPQGGDEDSTNKLMAKRLREVNVINGC-APCPFIVHFFGYYVHKY------KDCVKIHIFMEEMALS
.. |   |||.   ||. ...       .|||   . .        ..  .|| ..        | || ..|. ...       .    .  .|.  .| 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

ASVLKKEVLKRGGIVPEFVIGRIACSVIHAMWFLKEKMQIIHRDIKPGNILIDYDGRVKICDFGISGILQDS-------IAVSAT---GCQQ-----YTA
    |..       ..      ..  .   | .| .....||||.   |.|.. ...|||.||| |  . |           ...   |.        .|
DYLRKHRPK-----LCMKDLLSFCWQIACGMEYL-HSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEINELAMVHSPGYSIKSDIWSLGITIFELAT--------------------------------------------------------------------
||     .     ...|||.|| |....|. |                                                                    
PECINYGK-----FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

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