Gene F36H12.8 (Nematode worm)

F36H12.8

Species: Nematode worm
Alias: aSWK126, CE09979, F36H12.8
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: IV:1.75, WormBase Physical Map location: IV: 5258710-5259915,

Classification

Group: CK1
Family: Worm6

Sequence

Name Sequence Type Origin Length Description Download
F36H12.8.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 269 Kinase domain by global Sugen HMM Fasta, JSON
F36H12.8.AA Protein Genbank 311 None Fasta, JSON

Protein domain

Protein domains of F36H12.8.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase F36H12.8.AA Worm6 20-280 48 3.1e-164 551.92 In-house 1-279 (279) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-279/279
Sequence Identity: 48% (134 aa)

WSITKKLGEGGCGAVYLCTDATGK----YALKVEG--ISEAMQVLKMEVLVLGELTKRGSRHFCKIEDKGRYGS--FNYVVMTLVGKSLQDLRKGTAQQC
|..|||.||||.||||...|...|    .|.|.|.   ....|.||||. || .......||||||||.|....  |||.|||||||.|.|||| .....
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

LSLACSLSVGIQSLEALEDLHNIGYLHRDVKPGNYTIGR---AELNELRKVYILDFGMAR--KFTDNNGVIRKPR-AAAGFRGTVRYAPIACHKNQELGR
.|....|...||.|||.|||||.|..||||||||..|||   .|.||....|.|||||.|  |. ......|.|| .|.||||||||||.||||.||..|
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

KDDVEVWLYMQVELTVGRVPWKEITDMNAVG-QAKQAIRNTP---EKMFVFPCPANELKEIMKMVDSWDYFADPNYADC
|||.| |.||.||..||. ||. ..|...|. ..|...|.|    ..|| .|||..|...||...|...|. .|.|...
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase F36H12.8.AA CK1 20-280 31 1.1e-114 387.29 In-house 1-339 (339) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-339/339
Sequence Identity: 31% (109 aa)

WSITKKLGEGGCG-AVYLC-----TDATGK-------YALKVEGISEAMQ-VLKMEVLVLGELTKRG---------SRHFCK----------IEDKGRYG
| ..||.||||.| ..|..     .| ...       ||.||| .... |  ..||. .. .....|         ..||||          ....|. .
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

S-FNYVVMTLVGKSLQDLRK-GTA-QQCLSLACSLSVGIQSLEALEDLHNIGYLHRDVKPGNYTIGRAE-----------LNELRKVYILDFGMAR-KFT
  .||.||||.|..|.|||| ..  ....|. ..| ..|| |||||..|..|..|||.||.|. .||.|            ||.|.||..|||||| |..
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DNNG------------VIRKPRA---AAGFRG-TVRYAPIACHKNQELGRKDDVEVWLYMQVELTVGR--VPWKEITDMNA-----VGQAKQAIRNT---
|..|            ..| ||    ..|||| |.||..|.||...|.||.||.. |.|| .|...|    ||. ..| .      |...|......   
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

PEKMFVFPCPAN------ELKEIMKMVDSWDYFADPNYADC
  ..| ..|| .      |. .|||...|..|.  |.|.  
STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase F36H12.8.AA TTBK 20-280 42 3.3e-89 302.69 In-house 1-257 (257) Show / Hide 
Range on Protein: 20-280
Range on HMM: 1-257/257
Sequence Identity: 42% (112 aa)

WSITKKLGEGGCGAVYLCTDATGK---YALKVEGISEAMQVLKMEVLVLGELTKRGSRHFCKIEDKGRYGSFNYVVMTLVGKSLQDLRKGTAQQCLSLAC
| ..|| | || | .|  .|   .    |.|||      ||||||| ||  |   |  | |.    ||   |||.||.| ||.| |||    ..| ||  
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKL--QGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLST

SLSVGIQSLEALEDLHNIGYLHRDVKPGNYTIGRAELNELRKVYILDFGMARKFTDNNGVIRKPRAAAGFRGTVRYAPIACHKNQELGRKDDVEVWLYMQ
 | .|.| |...|  |..|.||||.|| |. .||.  .  ||.|.||||.||..|   | .| ||..|||||||||| |  |.|.|.||.||     || 
TLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPST-CRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYML

VELTVGRVPWKEITDMNAVGQAKQAIRNTPEKMFVFPCPANELKEIMKMVDSWDYFADPNYADC
||  .|  ||  | | . ||. |.       .| .  ||  |..  |. . | .|.  |.|.  
VEFVQGQLPWRKIKDKDQVGEMKEKYD---HRMLLKHCPH-EFHQFMDHIKSLNYEDRPDYQLI
Kinase F36H12.8.AA TTBKL 20-284 35 1.1e-83 282.33 In-house 1-288 (288) Show / Hide 
Range on Protein: 20-284
Range on HMM: 1-288/288
Sequence Identity: 35% (105 aa)

WSITKKLGEGGCGAVYLCTDAT--GK-YALKVEGIS-EA-MQVLKMEVLVLGELTKRGSRHFCKIEDKGRYGSFNYVVMTLVGKSLQDLRKGTAQQC-LS
| |.|..||||.|.||.  | .  .. .|.|.|  . |  ....|||| || .| ..||.||.|. . |.....|..||||.|..||||||   ... .|
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LACSLSVGIQSLEALEDLHNIGYLHRDVKPGNYTIGRAELN--ELRKVYILDFGMARKFTDNNG-----------VIRKPRA---AAGFRGTVRYAPIAC
   .. .||| |.|| ..| .|..||||||.|. .|  . .  . | ||..||||||.. ...|            .|.||     |.||||.||. .. 
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HKNQELGRKDDVEVWLYMQVELTVGRVPWKEITDMNAVGQAKQAIRNTPEKMFVFP-----CPANELKEIMKMVDSWDYFADPNYADCYRLM
|  .|.||.||   |.|| .|| .|  ||. ..|   ....|..   . |..|  .     ||  |. ..||.. | .|   |.|   | ..
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNM--KDEDLFKDMPRDHDCPS-EFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase F36H12.8.AA Dual 20-284 29 4.9e-49 162.99 In-house 1-282 (282) Show / Hide 
Range on Protein: 20-284
Range on HMM: 1-282/282
Sequence Identity: 29% (85 aa)

WSITKKLGEGGCGAVYLCTDATG------KYALKVEGISEAMQVLKMEVLVLGELTKRG---------SRHFCKIEDKGRYGS--FNYVVMTLVGKSLQD
| . . || || . ||   .         .|.||.|   .    |   |..  . .  .          ..|    | |       .|.|| ..| |||.
WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQE

LRKGTAQQCLSLACSLSVGIQSLEALEDLHNIGYLHRDVKPGNYTIGRAELNEL-RKVYILDFGMARKFTD-NNGVIRKPRAAAGFRGTVRYAPIACHKN
 |. .    ||  ||  |.|| |.|. |||.||||||..|| |. .|   |..   .|| .||...||. |  |.. | .|    . |. ||| .|| . 
IRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCG---LGMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQ

QELGRKDDVEVWLYMQVELT-VGR-VPWKEITDMNAVGQAKQAIRNTPEKMFVFPCPANELKEIMKMVDSWDYFADPNYADCYRLM
.. |||||.| | ||   |   .  ..|.   | | . ..|..   .  |  . . |  .|| .  .|..  |   | |.     .
KDQGRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKDNFMYHFDKHQYSHIP-RRLKPLVSYVNGYQYDSTPDYDYFRNCL
Kinase F36H12.8.AA CK1-Unique 20-219 30 1.8e-42 145.06 In-house 1-223 (337) Show / Hide 
Range on Protein: 20-219
Range on HMM: 1-223/337
Sequence Identity: 30% (68 aa)

WSITKKLGEGGCGAVY-LCTDATG-------KYALKVEGISEAMQ--VLKMEVLVLGELTKRG-----SRHFCKIEDKGRYGSFNYVVMTLVGKSLQDLR
| ..|..| || | |. .   ..|       .|. | | .. .     |. | .|. .. |       .||||...| .  ..  . |||..|.|.  ..
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

KGTAQQCLSLA------CSLSVGIQSLEALEDLHNIGYLHRDVKPGNYTIGRAELNELRKVYILDFGMARK--FTDNNGVIRKPRAAAGFRGTVRYAPIA
   .     |       | .  | | |...|  |  |..||. ||.||  . .   ...  |.||.|  |.  | .||..||.||  . |||. .|.|..
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS

CHKNQELGRKDDVEVWLYMQVEL
||. .|.||.|| | |.|| . |
CHQCREHGRRDDMESWFYMLYHL
Kinase F36H12.8.AA CK1-Unclassified 20-210 30 1.1e-25 72.81 In-house 1-200 (244) Show / Hide 
Range on Protein: 20-210
Range on HMM: 1-200/244
Sequence Identity: 30% (61 aa)

WSITKKLGEGGCGAVYLCTDA--TGKYALKVEGISEAMQVLKMEVLVLGELTKRG-----SRHFCKIEDKGRY--GSFNYVVMTLVGKSLQDLRKGTAQQ
  ...|.| |  | .|.|..     ..|.|.|        |. |. .. .| ..      .... |.   |.   | .|..||.| |.|| || .   ..
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDL-FNMCNR

CLSLACSLSVGIQSLEALEDLHNIGYLHRDVKPGNYTIGRAELNELRKVYILDFGMARKFT--DNNGVIRKPRAAAGFRGTVRYAPIACHKNQELGRKDD
 .||   |  . | .. .| ||| ...||| || |. .|. . |   .||| ||| . ..   |..|     |   .. || ||| |  |.  | .|.||
KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNH-HQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDD

VE
 |
LE
Kinase F36H12.8.AA CK1 20-210 29 2.2e-25 84.49 In-house 1-200 (271) Show / Hide 
Range on Protein: 20-210
Range on HMM: 1-200/271
Sequence Identity: 29% (60 aa)

WSITKKLGEGGCGAVYLCTDATGK----YALKVEGISEAMQVLKMEVLVLGELTK---RG-SRHFCKIEDKGRY--GSFNYVVMTLVGKSLQDLRKGTAQ
  ...|.|.|  | .||... | .    .| |.| .    . |. |. .. .| .    . . .. ..   |.   | .|..||.| |.|| || .   .
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDL-FNFCN

QCLSLACSLSVGIQSLEALEDLHNIGYLHRDVKPGNYTIGRAELNELRKVYILDFGMARKFTD-NNGVIRKPRAAAGFRGTVRYAPIACHKNQELGRKDD
. .||   | .. | .. .| .|| ...|||.|| |. .||   ..  .||| |||.| .. | ...     |   .. ||.||| |  |   | .|.||
RKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGR-YGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDD

VE
 |
ME
Kinase F36H12.8.AA CK1-D 20-227 30 1.1e-23 80.32 In-house 1-206 (261) Show / Hide 
Range on Protein: 20-227
Range on HMM: 1-206/261
Sequence Identity: 30% (65 aa)

WSITKKLGEGGCGAVYLCTD--ATGKYALKVEGISEAMQVLKMEVLVLGELTKRGSRHFCKIEDKGRYGSFNYVVMTLVGKSLQDLRKGTAQQCLSLACS
. | .|.| |  | .|. |.  .    |.|.| |      |..|  .   .  .|     .|   |. | .| .|| |.| || ||     .   ||   
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMM--QGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFN-YCHRKFSLKTV

LSVGIQSLEALEDLHNIGYLHRDVKPGNYTIGRAELNELRKVYILDFGMARKFTDNNGVIRKP-RAAAGFRGTVRYAPIACHKNQELGRKDDVEVWLYMQ
| .. | .  .| .|   ..|||.|| |. .|     ..  |||.|||.|... | .     | |      || ||| |  |.  |  |.||.|   |. 
LMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNM--VYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVL

VELTVGRVPWK
.    | .||.
MYFNRGSLPWQ
Kinase F36H12.8.AA CK1-A 20-233 28 8.1e-22 73.76 In-house 1-212 (261) Show / Hide 
Range on Protein: 20-233
Range on HMM: 1-212/261
Sequence Identity: 28% (62 aa)

WSITKKLGEGGCGAVYLCTDATG--KYALKVEGISEAMQVLKMEVLVLGELTKRGSRHFCKIEDKGRYGSFNYVVMTLVGKSLQDLRKGTAQQCLSLACS
. . .|.| |  | .||    |     |.|.|        |  |  |   |  .|   . ...  |.   .| .|| |.| || ||     .   ..   
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRIL--QGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFN-FCKRRFTMKTV

LSVGIQSLEALEDLHNIGYLHRDVKPGNYTIGRAELNELRKVYILDFGMARKFTDNNGVIRKP-RAAAGFRGTVRYAPIACHKNQELGRKDDVEVWLYMQ
| .  | .  .| .|. ...|||.|| |. .|        |....|||.|.|. |..  .  | |      ||.||| |  |   |  |.||.|   |. 
LMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGR--HCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVM

VELTVGRVPWKEITDMN
.    |..||. .. |.
MYFNRGKLPWQGMKAMT
Kinase F36H12.8.AA S_TKc 20-284 17 2.6e-12 3.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 20-284
Range on HMM: 1-231/231
Sequence Identity: 17% (51 aa)

WSITKKLGEGGCGAVYLCTDAT--GKYALKVEGISEAMQVLKMEVLVLGELTKRGSRHFCKIEDKGRYGSFNYVVMTLVGK---SLQDLRKGTAQ----Q
. | .|.|.|. | ||.|..     ..|.|.       . .. |. .| .    .  . .|. |  .  .. |.|| ...    .| |. |        .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

CLSLACSLSVGIQSLEALEDLHNIGYLHRDVKPGNYTIGRAELNELRKVYILDFGMARKFTDNNGVIRKPRAAAGFRGTVRYAPIACHKNQELGRKDDVE
 ..     ..  | ..||| .|. | .|||.|| |  . .        . | |||.||..               | ||  | .                
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL------------

VWLYMQ------------VELTVGRVPWKEITDMNAVGQAKQAIRNTPEKMFVFPCPANELKEIMKMVDSWDYF--ADPNYADC-------YRLM
   |               |. .|. |.        . .  . |.              |.|....    .|         |            .
--GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase F36H12.8.AA Pkinase 20-194 23 7.3e-08 28.89 Pfam 1-179 (293) Show / Hide 
Range on Protein: 20-194
Range on HMM: 1-179/293
Sequence Identity: 23% (44 aa)

WSITKKLGEGGCGAVYLCTDATGK--YALKVEGISEAMQVLKM------EVLVLGELTKRGSRHFCKIEDKGRYGSFNYVVMTLVGK-----SLQDLRKG
. | .|.|.|. | ||.|..      .|.|.   ...    ..      |. .. .| .  . . ... |  ....  |.|| ....     .| |. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N--HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

TAQQCL--SLACSLSVGIQSLEALEDLHNIGYLHRDVKPGNYTIG-RAELNELRKVYILDFGMARKFTDNNGVIRKPRAAAGFRGTVRYAP
 .. |.  |     ..  | |..|| .|. | .|||.|| |  |  . ....  .| | ||| |..|      . . . . .| || .|..
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMA
Kinase F36H12.8.AA TyrKc 20-284 20 3.1e-05 -137.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 20-284
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

WSITKKLGEGGCGAVYLCT---DATGKYALKVEGISEAMQVLKMEVLVLGEL--------------TKRGSRHFCKIEDKGRYGSFNYVVMTLVGK-SLQ
 .  ||||||  | ||..|   .   |   .       .. .  |  .. .|              |. | . |  ||         ..|| .. . .|.
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPL-------MIVMEYMPHGDLK

DLRKGTAQQCLSLACSLSVGIQSLEALEDLHNIGYLHRDVKPGNYTIGRAELNELRKVYILDFGMARKFTDN-----NGVIRKPRAAAGFR--GTVRYAP
|  . .  . |...  ||  .|  .  | ||  .. |||    |  .|.        | | |||..|. .|      ..   ...   | .    .|  .
DYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

IACHKNQELGRKDDV--------EVWLYMQVELTVGRVPWKE-----ITDMNAVGQAKQAIRNTPEKM-----FVFPCPANELKEIMKMVDSWDYFADPN
. | .  .   | ||        |.       .| |  |. .     ...  .. . ||  |  . .      |  .|   |. .|||.    |    |.
PECINYGKFTTKSDVWSFGVCMWEI-------FTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF--VCCPDEMYQIMKQCWHEDPEDRPT

YADCYRLM
 .......
FSEIHECF