Gene F39H11.3 (Nematode worm)

F39H11.3

Species: Nematode worm
Alias: F39H11.3, aSWK164, CE17815
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: I: 8710534-8713851, WormBase Genetic Map location: I:2.98,

Classification

Group: CMGC
Family: CDK
Subfamily: CDK8

Sequence

Name Sequence Type Origin Length Description Download
F39H11.3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 323 Kinase domain by global Sugen HMM Fasta, JSON
F39H11.3.AA Protein Genbank 622 None Fasta, JSON

Protein domain

Protein domains of F39H11.3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase F39H11.3.AA CDK8 30-348 67 1.3e-270 858.93 In-house 1-329 (329) Show / Hide 
Range on Protein: 30-348
Range on HMM: 1-329/329
Sequence Identity: 67% (226 aa)

KEIGRGTYGLVYKAVPKKQNGQFPNKEYALKMI----------EGQGFSMSACREIALFRELRHPNLICLQRVFLTN-EKKVWLLLDYAEHDLWHVIKHH
|.|||||||.||||..|||. ..||||||||..          ||.|.||||||||||.|||.|||.||||||||.. .|.||.|.|||||||||.||.|
KYIGRGTYGHVYKAKRKKQK-KKPNKEYALKQFRTEKDGVEQLEGTGISMSACREIALCRELHHPNVICLQRVFLNHKDKCVWMLFDYAEHDLWHIIKFH

RTAK-SKKVPIMVPRNMVKNILFQILSGMHYLHSNWVLHRDLKPANILLMGDGPPDMRGRVKIADLGFSRIYANPLKPMAELDPVVVTFWYRAPELLLGA
|..| ..|.|.||||||||.|..|||.|.||||||||||||||||||..|||||.||.|.|||||.||.||..|||||...|||||||||||||||||||
RHNKAHMKDPTMVPRNMVKSIMWQILDGIHYLHSNWVLHRDLKPANIMVMGDGPEDMCGCVKIADMGFARIFHNPLKPLYDLDPVVVTFWYRAPELLLGA

KHYTKAIDVWAIGCIFAELLTAEPLFFCKEE--DIKAQNPYHYDQVKRIFHLLGYPSDADWPDMKKMPDHQRLLSDARNEGTPIQTFPN-SLHRYFDKWK
.|||||||.||||||||||.|.||.|.||||  |||.|||||.||..||||..|.|.|..|||.||||.||||..|.|.    .||.|| |||.|..|.|
RHYTKAIDIWAIGCIFAELITSEPIFHCKEEKLDIKTQNPYHHDQLDRIFHVMGFPQDKMWPDIKKMPEHQRLMKDFRR----MQTYPNCSLHWYMEKHK

INSQSSPYRLLVKLLTVDPTKRVSCEEAMNDIYF
|...|..|.||.|.||.|||||..||.||...||
IKRDSHAYHLLYKMLTMDPTKRITCEQAMEHPYF
Kinase F39H11.3.AA CDK 26-348 34 4.6e-147 473.67 In-house 1-284 (284) Show / Hide 
Range on Protein: 26-348
Range on HMM: 1-284/284
Sequence Identity: 34% (122 aa)

FENSKEIGRGTYGLVYKAVPKKQNGQFPNKEYALKMI---------EGQGFSMSACREIALFRELRHPNLICLQRVFLTN----------EKKVWLLLDY
.|  ..||.|||| ||||  |......... .|||.|         |. ||...|.|||.| .|| ||| ..|  |..|.          |.|...  .|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

AEHDLWHVIKHHRTAKSKKVPIMVPRNMVKNILFQILSGMHYLHSNWVLHRDLKPANILLMGDGPPDMRGRVKIADLGFSRIYANPLK---PMAELDPVV
..|||.....                  .|....|.|.|.||.||||..||||||.|||.. .| .. .||.|||| |..|.. .|..   |. .....|
MDHDLKKYMD------------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVK-CGRLKIADFGLARAFGIPHQMSEPNRTYTHEV

VTFWYRAPELLLGAKHYT--KAIDVWAIGCIFAELLT---AEPLFFCKEEDIKAQNPYHYDQVKRIFHLLGYPSDADWPDMKKMPDHQRLLSDARNEGTP
|| ||||||||||.|||.   .||.|..||||||..|    .||| .. |          || ..|| ..| |.. .||...|.||.             
VTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSE---------IDQLFKIFRICGTPTEDNWPGVTKLPDY-------------

IQTFPNSLHRYFDKWKINSQSSPYRLLVKLLTVDPTKRVSCEEAMNDIYF
                         || |.|. ||.||.|.|.|... ||
------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase F39H11.3.AA CMGC 26-348 24 2.4e-114 377.36 In-house 1-513 (513) Show / Hide 
Range on Protein: 26-348
Range on HMM: 1-513/513
Sequence Identity: 24% (124 aa)

FENSKEIGRGTYGLVYKAVPKKQNGQ---------FPNKEYALKMIE-------------GQGFSMSACREIALFRELR-----------------HPNL
.|. | ||.|||| |||.. |. |..           |...|.| |              . ||...|.||| . ..|.                 |.|.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

ICLQRVFLTNE----------------KKVWLLLDYAEHDLWHVIKHHRT-AKS-KKVPIMVPR----------NMVKNIL------FQILSGMH--YLH
..|. .| ...                ... |  .| .|||...||....  .  ...|               ...|...      .||| |..  |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SNW--VLHRDLKPANILLMGDGPP--------------DMRGRVKIADLGFSRIYANPLKP------------------MAELDPVVVTFWYRAPELLLG
|.|  ..||||||.|||.  ..                . .||.||.| |..|.| .. ..                  .  . . ||| ||||||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

AKHYT---------KAIDVWAIGCIFAELLTA--------EPLFFCKEE----DIKAQNPYHYDQVKRIFHLLGYPS---------------DADWPDMK
.||||         ..||.|..||||||..|         .|||  . |    | | .   |.|| ..|| .|| |.               . .||.|.
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDD-K-NGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

KMPDHQR-------------LLSDARNEGTPIQTFPNSLHRYFDKWKINSQ-----------------------------------SSPYRLLVKLLTVD
|.|...              . ..|||   .  .||.   . . ... ...                                   .    || |.|. |
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PTKRVSCEEAMNDIYF
|.|| ..|.|..  ||
PDKRITAEQALQHPYF
Kinase F39H11.3.AA S_TKc 26-348 23 2.9e-81 277.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 26-348
Range on HMM: 1-231/231
Sequence Identity: 23% (78 aa)

FENSKEIGRGTYGLVYKAVPKKQNGQFPNKEYALKMIEGQGFSMSACREIALFRELRHPNLICLQRVFLTNEKKVWLLLDYAEH---DLWHVIKHHRTAK
.|  ..||.|..| |||.. ||      ....|.|.|       ...|||.. .. .|||.. |  || .  ..... ..|...   || ..||.... .
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHG

SKKVPIMVPRNMVKNILFQILSGMHYLHSNWVLHRDLKPANILLMGDGPPDMRGRVKIADLGFSRIYANPLKPMAELDPVVVTFWYRAPELLLGAKHYTK
    .   |  ... .. ||.... |.||....||||||.||||          ..||.| |..|..          . ...| ||.|||.|    .|.|
---LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GYGK

-AIDVWAIGCIFAELLTAEPLFFCKEEDIKAQNPYHYDQVKRIFHLLGYPSDADWPDMKKMPDHQRLLSDARNEGTPIQTFPNSLHRYFDKWKINSQSSP
 ..|.|..|||..|.|. .|.|                |....|...|                                                 .. 
CKCDWWSCGCILYEMLCGYPPFP---------------QMQMMFKKIG------------------------------------------------SPEA

YRLLVKLLTVDPTKRVSCEEAMN-------DIYF
  .. |.|..||.|| .. ||..       . .|
KDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase F39H11.3.AA CDK7 26-284 37 7.4e-77 204.09 In-house 1-235 (288) Show / Hide 
Range on Protein: 26-284
Range on HMM: 1-235/288
Sequence Identity: 37% (99 aa)

FENSKEIGRGTYGLVYKAVPKKQNGQFPNKEYALKMIE--------GQGFSMSACREIALFRELRHPNLICLQRVFLTNEKKVWLLLDYAEHDLWHVIKH
.|  | || |... ||||  .. . |      | | |           |  ..| ||| . .|..|.| | |  .|      . | .|. . || .||| 
YEKIKHIGEGQFATVYKACDHQTG-QI----VAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIF-MHKSNIQLVFDFMDWDLEVVIKD

HRTAKSKKVPIMVPRNMVKNILFQILSGMHYLHSNWVLHRDLKPANILLMGDGPPDMRGRVKIADLGFSRIYANPLKPMAELDPVVVTFWYRAPELLLGA
      |.. |. | . .|..  ..| |. |.| ||.||||||| | |.      .  |..|||| |  | |  | .    . . ||| |||||||| ||
------KSI-ILTPAH-IKAYMMMTLQGLEYCHRNWILHRDLKPNNLLM------NENGQLKIADFGLARFYGSPNR---IYTHQVVTRWYRAPELLFGA

KHYTKAIDVWAIGCIFAELLTAEPLFFCKEEDIKAQNPYHYDQVKRIFHLLGYPSDADWPDMKKMPD
.||. ..|.|..|||||||.   | ..  . ||        || .|||  || |....||.| .|.|
RHYGTGVDMWSVGCIFAELMLRVP-YLPGDSDI--------DQLTRIFQTLGTPTEEEWPNMCCMMD
Kinase F39H11.3.AA PITSLRE 26-348 32 3.4e-72 246.15 In-house 1-295 (295) Show / Hide 
Range on Protein: 26-348
Range on HMM: 1-295/295
Sequence Identity: 32% (108 aa)

FENSKEIGRGTYGLVYKAVPKKQNGQFPNKEYALKMI---EGQGFSMSACREIA-LFRELRHPNLICLQRVFL-TNEKKVWLLLDYAEHDLWHVIKHHRT
|.    |. |||| ||.|. |. .     |   |||    |  ||   . |||  . ..|.||| . . .. . .|  |... ..| ||||  ..  .. 
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKR--LKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMK-

AKSKKVPIMVPRNMVKNILFQILSGMHYLHSNWVLHRDLKPANILLMGDGPPDMRGRVKIADLGFSRIYANPLKPMAELDPVVVTFWYRAPELLLGAKHY
  ... |   .   .|  . | |.|....|.||..||||| .|.|.         |  ||.| |  | |  |.||     |.||| ||||||||||.| |
--RRNQPFKPGE--IKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYS------HKGILKICDFGLAREYGSPIKPYT---PCVVTLWYRAPELLLGCKKY

TKAIDVWAIGCIFAELLTAEPLFFCKEEDIKAQNPYHYDQVKRIFHLLGYPSDADWPDMKKMPDHQRLLSDARNEGTPIQTFPNSLHRYFD-KWKINSQS
. ..|.| .||||||..| .|||  | |          ||...|| ..| |.   ||. ...|   .. .       | .  .| | . |    .|. . 
STPVDMWSVGCIFAEFITMKPLFQGKSE---------IDQINCIFKEMGTPTEKIWPGWTELPHWKMMNN------FPHYP-YNNLRKRFPAENHISDTG

SPYRLLVKLLTVDPTKRVSCEEAMNDIYF
  . || ..|| .|..| . ..|. . .|
--FDLLNQMLTYNPKNRITASDALKHPWF
Kinase F39H11.3.AA CDC2 26-284 36 1.1e-71 219.46 In-house 1-241 (301) Show / Hide 
Range on Protein: 26-284
Range on HMM: 1-241/301
Sequence Identity: 36% (100 aa)

FENSKEIGRGTYGLVYKAVPKKQNGQFPNKEYALKMI------EGQGFSMSACREIALFRELR-HPNLICLQRVFLTNEKKVWLLLDYAEHDLWHVIK-H
..  . || |||| |||.  ...|        |||.|      || |.  .| ||| .  ||. |||...|. |.    .|. .  .| ..||    .  
YQKIEKIGEGTYGVVYKCKDMQTNQ-----IVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ--NKLYMVFEYLDMDLKKYMDMS

HRTAKSKKVPIMVPRNMVKNILFQILSGMHYLHSNWVLHRDLKPANILLMGDGPPDMRGRVKIADLGFSRIYANPLKPMA---ELDPVVVTFWYRAPELL
  .         .| . ||....|||.|.|..|.. ..|||||| |||.      |  |..|||| | .|    |...     |    ||| ||||||.|
IPKN------KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILI------DKKGNIKIADFGLARAFGIPIRTYTTEHE----VVTLWYRAPEIL

LGAKHYTKAIDVWAIGCIFAEL---LTAEPLFFCKEEDIKAQNPYHYDQVKRIFHLLGYPSDADWPDMKKMPD
||.|.|. ..|.|.|||||||.    | .|||  . | |        ||  .||  || |.. .||.....||
LGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSE-I--------DQLFKIFRILGTPNEQTWPGVTQLPD
Kinase F39H11.3.AA Pkinase 26-348 23 1.3e-69 242.38 Pfam 1-293 (293) Show / Hide 
Range on Protein: 26-348
Range on HMM: 1-293/293
Sequence Identity: 23% (78 aa)

FENSKEIGRGTYGLVYKAVPKKQNGQFPNKEYALKMIEGQGFSMSACR------EIALFRELRHPNLICLQRVFLTNEKKVWLLLDYAEH-----DLWHV
..  . ||.|..| |||.. |. .      ..|.| |. .. ... ..      ||.. ..|.||| . | ..| . ...... ..|.|.     ||...
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDY

IKHHRTAKSKKVPIMVPRNMVKNILFQILSGMHYLHSNWVLHRDLKPANILLMGDGPPDMRGRVKIADLGFSRIYANPLKPMAELDPVVVTFWYRAPELL
|.      ... ... . . .|... |||.|. |.||....||||||.|||.  .| .|   .|||.| |... .   . .   .. ...| ||.|||..
IST-----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVI

LGAKHYTKAIDVWAIGCIFAELLTAEPLFF--CKEEDIKAQNPYHYDQVKR---IFHLLGYPSDADWPDMKKMPDHQRLLSDARNEGTPIQTFPNSLHRY
.|...|....|.|..|||..|.|. .|.|   |  .|  .   . ......    |.     |  . .  .  . |                      . 
RGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----------------------F-

FDKWKINSQSSPYRLLVKLLTVDPTKRVSCEEAMNDIYF
. .  .|  ..   .. ..|..||.|| ..|..... .|
HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase F39H11.3.AA CDK5 26-348 32 9.9e-66 206.5 In-house 1-287 (287) Show / Hide 
Range on Protein: 26-348
Range on HMM: 1-287/287
Sequence Identity: 32% (105 aa)

FENSKEIGRGTYGLVYKAVPKKQNGQFPNKEYALKMI----EGQGFSMSACREIALFRELRHPNLICLQRVFLTNEKKVWLLLDYAEHDLWHVIKHHRTA
.|    || |||| ||||  |.         .||| .    |  |   .| |||.| .||.|.| . |  |  . |||  |   .   ||   .      
YEKMEKIGEGTYGTVYKARNKET-----HEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHS-EKKLTLVFEFCDQDLKKYMDSCNG-

KSKKVPIMVPRNMVKNILFQILSGMHYLHSNWVLHRDLKPANILLMGDGPPDMRGRVKIADLGFSRIYANPLKPMAELDPVVVTFWYRAPELLLGAKHYT
        .  ...| ...| | |. . |.. |||||||| | |         .|  | || |  | .  | .        ||| |||.|  |.|.|||.
-------EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLI------NKNGELKLADFGLARAFGIPVRCYSH---EVVTLWYRPPDVLMGSKHYS

KAIDVWAIGCIFAELL-TAEPLFFCKEEDIKAQNPYHYDQVKRIFHLLGYPSDADWPDMKKMPDHQRLLSDARNEGTPIQTFPNSLHRYFDKWKINSQSS
  ||.| .||||||.  .  |||   ...         || |||| ..| |.   || . |.|| .  . ...    . |.. .  ..  |.   .    
TSIDMWSCGCIFAEMANAGRPLFPGNDVE---------DQLKRIFKIMGTPCEDKWPSITKLPDYK-PNHQQYPMYPAHQSWQQIVPK-LDEKGMD----

PYRLLVKLLTVDPTKRVSCEEAMNDIYF
   || |.| ..| .|.| ..|..  ||
---LLQKMLQCNPNQRISAKAALHHPYF
Kinase F39H11.3.AA CDK10 26-348 36 2e-58 200.44 In-house 1-285 (285) Show / Hide 
Range on Protein: 26-348
Range on HMM: 1-285/285
Sequence Identity: 36% (117 aa)

FENSKEIGRGTYGLVYKAVPKKQNGQFPNKEYALKMIEGQGFSMSACREIALFRELRHPNLICLQRVFLTNE-KKVWLLLDYAEHDLWHVIKHHRTAKSK
||    .| ||||.||.|   . .     |   .   |  |  .|. ||| |  ..||.|.. |. |   ..   ..| ..| | ||  ..         
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRMDK-EKDGLPISGLREIMLLIQCRHENIVELHEVVVGQHLDSIFLVMQYCEQDLASLL--------D

KVPIMVPRNMVKNILFQILSGMHYLHSNWVLHRDLKPANILLMGDGPPDMRGRVKIADLGFSRIYANPLKPMAELDPVVVTFWYRAPELLLGAKHYTKAI
 .|       || |  |.| |..|||.|...||||| .| ||| |     .| .|.|| |  | |..| |||    | .|| ||||||||||..  | ||
NMPQPFTETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSN-LLMTD-----KGCIKVADFGLARMYGVPVKPMT---PKMVTLWYRAPELLLGCRTQTTAI

DVWAIGCIFAELLTAEPLFFCKEEDIKAQNPYHYDQVKRIFHLLGYPSDADWPDMKKMPDHQRLLSDARNEGTPIQTFPNSLHRYFDKWKINSQSSPYRL
|.||.||| .|||   ||.    |           |.  |  ||| ||.. ||   ..|  |.         |  .   | |.    |... |||   ||
DMWAVGCILGELLVHKPLMPGNSE---------IHQIDMIIDLLGTPSENIWPGFSDLPMVQNF--------TLKKQPYNNLKH---KFHWLSQSG-RRL

LVKLLTVDPTKRVSCEEAMNDIYF
|  |.  .| ||   ||...  ||
LNFLFMYNPKKRATAEECLESSYF
Kinase F39H11.3.AA MAPK 26-276 31 1.2e-48 166.28 In-house 1-259 (328) Show / Hide 
Range on Protein: 26-276
Range on HMM: 1-259/328
Sequence Identity: 31% (88 aa)

FENSKEIGRGTYGLVYKAVPKKQNGQ-FPNKEYALKMIE----GQGFSMSACREIALFREL-RHPNLICLQRVFLT------NE----KKVWLLLDYAEH
... | || | ||.| .|. |. |..   .|  |.| |.     . .   . ||| | |.. .|.| |.|. .|        |.    . . .  .. |.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLWHVIKHHRTAKSKKVPIMVPRNMVKNILFQILSG--MHYLHSNWVLHRDLKPANILLMGDGPPDMRGRVKIADLGFSRIYAN-PLKPMAELDP-----
|| ..||  .         .     .. ...||| |  . |.||  |.||||||.|||.      .  . .||.| | .|. ..   ..  . ||     
DLHQIIKSQQ---------PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILV------NENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQK

-----VVVTFWYRAPELLLG--AKHYTKAIDVWAIGCIFAELLT-AEPLFFCKEEDIKAQNPYHYDQVKRIFHLLGYPSDADW
      |.| ||||||..|.  ..|||||.|.|..||||||.||   |||         ..  . || ..|. .|| ||. ..
MHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFP-------GKD--YIDQWNLIMEVLGTPSEEFI
Kinase F39H11.3.AA CRK7 135-283 30 4.9e-39 132.15 In-house 114-284 (343) Show / Hide 
Range on Protein: 135-283
Range on HMM: 114-284/343
Sequence Identity: 30% (57 aa)

VKNILFQILSGMHYLHSNWVLHRDLKPANILLMGDGPPDMRGRVKIADLGFSRIYANPLKPMAELDPVVVTFWYRAPELLLGAKHY--------------
.| .. |.| || |.| . .||||.| .|||.      . .| |||||.|  | | |.    . .   |.| |||.||||||...|              
CKCFMKQLLEGMDYCHKKNFLHRDIKCSNILM------NNQGEVKIADFGLARLY-NSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKELIRNIK

------------------------TKAIDVWAIGCIFAELLTAEPLFFCKEEDIKAQNPYHYDQVKRIFHLLGYPSDADWPDMKKMP
                        ...||.|  |||..||.| .|.|  . |          .|   |. . | |  . ||.  |.|
SIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNE---------MAQLEKIYKICGSPNPNNWPEVMKLP
Kinase F39H11.3.AA TyrKc 26-346 20 2.7e-12 -23.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 26-346
Range on HMM: 1-280/280
Sequence Identity: 20% (71 aa)

FENSKEIGRGTYGLVYKAVPKKQNGQFPNKEYALKMIEGQGFSMSACREIALFREL--RHPNLICLQRVFLTNE------KKVWLLLDYAEH-DLWHVIK
 .  |..|.| .| |||.. |         . | ||.      .  .||. . ..|  .|||...|  | .. .      . ..... |..| || . ..
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

HHRTAKSKKVPIMVPRNMVKNILFQILSGMHYLHSNWVLHRDLKPANILLMGDGPPDMRGRVKIADLGFSRIYANP--------LKPMAE---LDPVVVT
 ||          ..     .. .|| .|| ||||. . ||||   |.|.  ..      .|||.| | ||   .          . ..|    . ..  
KHRPK--------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

FWYRAPELLLGAKHYTKAIDVWAIGCIFAELLTAEPLFFCKEEDIKAQNPYHYDQVKRIFHLLGYPSDADWPDMKKMPDHQRLLSDARNEGTPIQTFPNS
 |. ||| .   . .| . |||. |    |..|        ..  .  |   . .||. . .   |.|   | |                          
RWM-APECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MS-------------------------

LHRYFDKWKINSQSSPYRLLVKLLTVDPTKRVSCEEAMNDI
    |        .  |..  .    || .| . .|   ..
----F----VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase F39H11.3.AA CRK7 26-111 30 1.4e-10 32.47 In-house 1-97 (343) Show / Hide 
Range on Protein: 26-111
Range on HMM: 1-97/343
Sequence Identity: 30% (30 aa)

FENSKEIGRGTYGLVYKAVPKKQNGQFPNKEYALK--MIEGQGFSMSACREIALFRELRHPNLICLQRVFLT-------NEKK--VWLLLDYAEHDL
.|  ..|| |||| ||||. |. . .   |   ..   |   ||   | ||| . |.| |.| . |  . .        ...|  ...  .|. |||
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDL
Kinase F39H11.3.AA Pkinase_Tyr 26-187 26 1.5e-09 32.94 Pfam 1-159 (270) Show / Hide 
Range on Protein: 26-187
Range on HMM: 1-159/270
Sequence Identity: 26% (45 aa)

FENSKEIGRGTYGLVYKAVPKKQNGQFPNKEYALKMIEGQGFSMSA------CREIALFREL-RHPNLICLQRVFLTNEKK--VWLLLDYAEH-DLWHVI
 .  |..|.| .| |||.. |   .. .. . | ||.  .| . ..       ||... ..| .|||...|  | .  ..   ... . |..| || .  
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KHHRTAKSKKVPIMVPRNMVKNILFQILSGMHYLHSNWVLHRDLKPANILLMGDGPPDMRGRVKIADLGFSR
. ||       .  ..  .  .. .|| .|| ||.|.   ||||   |.|.         . |||.| | .|
RKHR-----EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE------NNVVKICDFGLAR
Kinase F39H11.3.AA CDK7 324-348 32 4.5e-09 19.86 In-house 264-288 (288) Show / Hide 
Range on Protein: 324-348
Range on HMM: 264-288/288
Sequence Identity: 32% (8 aa)

LLVKLLTVDPTKRVSCEEAMNDIYF
|. ...| .| ||..| .. .  ||
LMCGMWTMNPCKRWTCTQCLKMPYF
Kinase F39H11.3.AA CDC2 324-348 48 2.7e-08 21.03 In-house 277-301 (301) Show / Hide 
Range on Protein: 324-348
Range on HMM: 277-301/301
Sequence Identity: 48% (12 aa)

LLVKLLTVDPTKRVSCEEAMNDIYF
|| ..|  || ||.| .||..  ||
LLMQMLQYDPQKRISAKEALQHPYF
Kinase F39H11.3.AA CRK7 324-348 44 4.5e-07 20.21 In-house 319-343 (343) Show / Hide 
Range on Protein: 324-348
Range on HMM: 319-343/343
Sequence Identity: 44% (11 aa)

LLVKLLTVDPTKRVSCEEAMNDIYF
|| |.|. ||.||.. ||. .  .|
LLDKMLCLDPKKRFTAEECLQHDWF
Kinase F39H11.3.AA MAPK 324-348 52 5e-05 13.07 In-house 304-328 (328) Show / Hide 
Range on Protein: 324-348
Range on HMM: 304-328/328
Sequence Identity: 52% (13 aa)

LLVKLLTVDPTKRVSCEEAMNDIYF
|| |.|. || || . |||..  ||
LLEKMLVFDPDKRITVEEALQHPYF