Gene F59F5.3 (Nematode worm)

F59F5.3

Species: Nematode worm
Alias: F59F5.3, aSWK410, CE31552
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 10546120-10540875, WormBase Genetic Map location: X:2.06,

Classification

Group: TK
Family: TK-Unique

Sequence

Name Sequence Type Origin Length Description Download
F59F5.3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 294 Kinase domain by global Sugen HMM Fasta, JSON
F59F5.3.AA Protein Genbank 671 None Fasta, JSON

Protein domain

Protein domains of F59F5.3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase F59F5.3.AA TK-Unique 364-652 24 3.6e-98 332.45 In-house 1-294 (294) Show / Hide 
Range on Protein: 364-652
Range on HMM: 1-294/294
Sequence Identity: 24% (73 aa)

LNNKSKLGVGNSSTIYTAEICKTK------KCIVIKESVRKSHCTKELKLLKSLKHPNIITPLGVIVQPEQKTCFNVQIRQHLLLPYYQKTCLETYIHKF
|......| |. ......|.....      ||...|   .....|.. ..|| ..... ...   ||| .. ....  ........|... .|..|....
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD-EPWMIIMEYCPCGNLQHYLRTC

YPPKRGGN------NIFHTNEATVPEEEITMFDLVSIAWQVASALEYLKG--MEITHRDVAMRNVLISNNKVCKITDFERAKKGETTRKISIEKKIKEIL
.|..|...      ..||........|.|...||...|||.|...|||..  ..|.|||...||||....|||||.|| .|....|....| ... ..| 
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

KAHMSKDIPKEYPNECLKGVYYYYSSEVYCFGRLMLCLFSFMKPCDYGRIYPPIQPENCPKAMYDCVLSNHVSINTFRYDLIVDCINENRKSRPSISSCK
...|.....|.|     .|.|... |.|..|| || ..|.... |.|......  ...|....|.. . .|.. ........  |.......|||....|
IRWMAPESLKCY-----HGMYHTTKSDVWSFGVLMWEIFTLGA-CPYPGMPWKD-IMECIRDGYRMPQPEHCCSHEMYNLMKS-CWQWEPEERPSFRQIK

DVL
..|
HRL
Kinase F59F5.3.AA TK 364-652 16 5.5e-41 134.63 In-house 1-486 (486) Show / Hide 
Range on Protein: 364-652
Range on HMM: 1-486/486
Sequence Identity: 16% (80 aa)

LNNKSKLGVGNSS---TIYTAEICK---------------------------TKKCIVIKESVRKSHCTK--------------------ELKLLKS--L
.    ||| |.     ..| .|                              |.  . .. .   .. .                     |.|....  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHPNIITPLGVIVQPEQKTCFN---VQIRQHLLLPYYQKTC----LETYIHKFYPPKRGGNNIFHTNEATVPEE--------------------------
.||||.  .||..|.| |.||.   .|    ... | .. .    | .| .|  |...   .  .......|..                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------EITMFDLVS-------------------IAWQVASALEYLKGM------EITHRDVAMRNVLISNNKV-----------CKITDFERAKK
          ..|. ||..                   ..||.|...|||  .       . |||.| ||.|...|.|           |||.||  ...
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

GE--TTRKISIEK---------------------KIKEILKAHMSKDIPKEYPNECLK---------GVYYYYSSEVYCFGRLMLCLFSFM-KPCDY---
|.   .|.|  ..                     . .. ....  |   . .. |||.            .   | |. || ||  .|..  .|      
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

-------------------------------GRIYPPIQPENCPKAM-YDCVLSNHVSINTFRYDLIVDCINENRKSRPSISSCKDVL
                               |. ... ||..||  | |   .       .. |||. .| ... . ||. | ... |
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase F59F5.3.AA Pkinase_Tyr 403-527 30 9.4e-18 60.75 Pfam 52-155 (270) Show / Hide 
Range on Protein: 403-527
Range on HMM: 52-155/270
Sequence Identity: 30% (39 aa)

KELKLLKSL-KHPNIITPLGVIV-QPEQKTCFNVQIRQHLLLPYYQKTCLETYIHKFYPPKRGGNNIFHTNEATVPEEEITMFDLVSIAWQVASALEYLK
.|.|..|.| .||||.  .||.. | |..       .  . ..| .. .| .| .|                   ... .|| ||....||.|...||| 
REAKIMKQLGHHPNIVRLYGVCTDQGEPN-------QIYIVMEYMPHGDLLDYLRKHR----------------EDKQPLTMKDLLQMCWQIAKGMEYLE

GMEITHRDVAMRNVLISNNKVCKITDF
 . . |||.| ||.|...|.|.||.||
SKNCIHRDLAARNCLVTENNVVKICDF
Kinase F59F5.3.AA Pkinase 364-527 21 7.5e-15 53.59 Pfam 1-156 (293) Show / Hide 
Range on Protein: 364-527
Range on HMM: 1-156/293
Sequence Identity: 21% (39 aa)

LNNKSKLGVGNSSTIYTAEICKTKKCIVIKE-SVRKSHCTK--------ELKLLKSLKHPNIITPLGVIVQPEQKTCFNVQIRQHLL--LPYYQKT----
.  ..|.| |.... | .   .| |  ..|. ..|. .. |        |....|.|.||||.. ...              ..|.   ..| ...    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----------KDHIYMVMEYCEGGLYVM

CLETYIHKFYPPKRGGNNIFHTNEATVPEEEI--TMFDLVSIAWQVASALEYLKGMEITHRDVAMRNVLISNNKVC----KITDF
 | .||.                     .  .  .. .. ....|....|||.  | | |||.   |.||.|| ..    ||.||
DLFDYIST------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF
Kinase F59F5.3.AA FGFR 476-527 45 1.1e-14 46.41 In-house 121-180 (293) Show / Hide 
Range on Protein: 476-527
Range on HMM: 121-180/293
Sequence Identity: 45% (27 aa)

PEEE--------ITMFDLVSIAWQVASALEYLKGMEITHRDVAMRNVLISNNKVCKITDF
||..        .|  ||||.|.|||   |||    . ||| | ||||.. . | || ||
PEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDF
Kinase F59F5.3.AA Src 477-527 43 1.6e-14 45.68 In-house 91-141 (255) Show / Hide 
Range on Protein: 477-527
Range on HMM: 91-141/255
Sequence Identity: 43% (22 aa)

EEEITMFDLVSIAWQVASALEYLKGMEITHRDVAMRNVLISNNKVCKITDF
. .. . .|...|.|||.  .||  | . ||| | ||||...| |||. ||
GRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADF
Kinase F59F5.3.AA RTKL 491-527 51 1.6e-13 31.63 In-house 111-147 (259) Show / Hide 
Range on Protein: 491-527
Range on HMM: 111-147/259
Sequence Identity: 51% (19 aa)

QVASALEYLKGMEITHRDVAMRNVLISNNKVCKITDF
|||.|| |.    . ||| | ||||     |||  ||
QVAQALAYIHQRRMIHRDLASRNVLLVPMMVCKLSDF
Kinase F59F5.3.AA TyrKc 364-652 21 2.7e-13 -7.79 SMART 1-280 (280) Show / Hide 
Range on Protein: 364-652
Range on HMM: 1-280/280
Sequence Identity: 21% (66 aa)

LNNKSKLGVGNSSTIYTAEICKTKKCIV--IKESVRKSHCTKELKLLKSL--KHPNIITPLGVIVQPEQKTCFNVQIRQHLLLPYYQKTCLETYIHKFYP
.  . ||| |.  ..| ..     .. |  .||.  .    .|......|  .||||.  .||..|.. .  |       ... |  . .|  |..|  |
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKDYLRKHRP

PKRGGNNIFHTNEATVPEEEITMFDLVSIAWQVASALEYLKGMEITHRDVAMRNVLISNNKVCKITDFERAKKGETT-RKISIEKKIKEILKAH---MSK
                    ..| ||.|..||.|.  |||  . . ||| | ||.|...|...||.||  .....   ..       |.  ..     .|
K-------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG----ESKDYYRKKEHKGGK

D-IP-KEYPNECLKGVYYYYSSE--VYCFGRLMLCLFSFMKPCDYGRI----YPPIQPENCPKAMYDCVLSNH------VSINTFRYDLIVDCINENRKS
. .| . .. ||.   |. ....  |. || .|  .|.. ..  |  .     ....  .. |. |      .      |   .  |... .| .|. ..
TMLPIRWMAPECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQ-PYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPED

RPSISSCKDVL
||. | ... .
RPTFSEIHECF
Kinase F59F5.3.AA UTK 484-527 35 4.4e-13 41.12 In-house 119-169 (296) Show / Hide 
Range on Protein: 484-527
Range on HMM: 119-169/296
Sequence Identity: 35% (18 aa)

DLVSIAWQVASALEYLKGMEITHRDVAMRNVLISNN-------KVCKITDF
.... ||..|....|| .. . |||.| ||.|.  .        |||| ||
QRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADF
Kinase F59F5.3.AA VEGFR 480-527 45 6.8e-13 45.14 In-house 170-217 (332) Show / Hide 
Range on Protein: 480-527
Range on HMM: 170-217/332
Sequence Identity: 45% (22 aa)

ITMFDLVSIAWQVASALEYLKGMEITHRDVAMRNVLISNNKVCKITDF
.|| ||.. . |||   |.|   ...||| | ||.|.. |.| || ||
LTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDF
Kinase F59F5.3.AA TKL 403-527 19 3.3e-12 40.28 In-house 74-198 (364) Show / Hide 
Range on Protein: 403-527
Range on HMM: 74-198/364
Sequence Identity: 19% (30 aa)

KELKLLKSLKHPNIITPLGVIVQPEQK-TCFN---VQIRQHLLLPYYQKTCLETYIHKFYPPKRGGNNIFHTNEATVPEEEITMFDLVSIAWQVASALEY
.|......|.||||.  .|.  .|..   | .    .   ..   |... .|. |.|                          .  ....| ..|....|
EEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------------------WHQRCRWALDIARGMNY

LKGME--------ITHRDVAMRNVLISNNKV--------------CKITDF
|  |.        | |||   .|.|. .|                |||.||
LHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDF
Kinase F59F5.3.AA S_TKc 364-657 16 7.7e-12 -3.31 SMART 1-231 (231) Show / Hide 
Range on Protein: 364-657
Range on HMM: 1-231/231
Sequence Identity: 16% (50 aa)

LNNKSKLGVGNSSTIYTAEICKTKKCIVIKESVRKSHCTKELKLLKSLKHPNIITPLGVIVQPEQKTCFNVQIRQHLLLPYYQK--TCLETYIHKFYPPK
     |.| |  .. | .   ||..   ||.     |  .|...||. .||||.. ..|..            . .. . |       | .||.|  ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD----------DHLYMVMEYCDGDLGDLFDYIKKRGRHG

RGGNNIFHTNEATVPEEEITMFDLVSIAWQVASALEYLKGMEITHRDVAMRNVLISNNKVCKITDFERAKKGETTRKISIEKKIKEILKAHMSKDIPKEY
..                ..  .  ....|...||||.  . | |||.   |.|...  . ||.||  |..                    ..     .|
LR--------------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------TTFCGTPWY

-PNECLKGVYYYY-SSEVYCFGRLMLCLFSFMKPCDYGRIYPPIQPENCPKAMYDCVLSNHVSINTFRYDLIVDCINENRKSRPSISSCKD----VLSTV
 . | |    | . .. .. .| ..  ...   | .             ...|.. ..           |.|  | . . . ||..  .      . .  
MAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP------------QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP

LK
  
WF
Kinase F59F5.3.AA Abl 477-527 37 1.1e-11 34.69 In-house 91-141 (252) Show / Hide 
Range on Protein: 477-527
Range on HMM: 91-141/252
Sequence Identity: 37% (19 aa)

EEEITMFDLVSIAWQVASALEYLKGMEITHRDVAMRNVLISNNKVCKITDF
.||..   |. .| |.||...||   .  |||.| || |...... |. ||
REELPAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADF
Kinase F59F5.3.AA MLK 485-527 32 2.2e-10 32.39 In-house 126-177 (291) Show / Hide 
Range on Protein: 485-527
Range on HMM: 126-177/291
Sequence Identity: 32% (17 aa)

LVSIAWQVASALEYLKGME---ITHRDVAMRNVLISN------NKVCKITDF
....| |.|....||  |.   | |||   .|.||..      ....||.||
AMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDF
Kinase F59F5.3.AA TKL 629-652 29 0.000191 11.93 In-house 341-364 (364) Show / Hide 
Range on Protein: 629-652
Range on HMM: 341-364/364
Sequence Identity: 29% (7 aa)

DLIVDCINENRKSRPSISSCKDVL
.|. || ... ..||| . ... |
KLMQDCWDHDPEKRPSFQEILKRL
Kinase F59F5.3.AA MLK 364-431 18 0.000239 11.14 In-house 1-86 (291) Show / Hide 
Range on Protein: 364-431
Range on HMM: 1-86/291
Sequence Identity: 18% (16 aa)

LNNKSKLGVGNS----STIYTAEI-----CKTKKCI--VIKESVR----KSHCTKELKLLKSLKHPN----IITPLGVIVQPEQKTC
.... ..|.| .    .. . ...      . |..    . ....    . .  .| ..|. |.|||    ||  .||. ||... |
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFC
Kinase F59F5.3.AA Abl 364-422 26 0.002383 6.47 In-house 1-63 (252) Show / Hide 
Range on Protein: 364-422
Range on HMM: 1-63/252
Sequence Identity: 26% (17 aa)

LNNKSKLGVGNSSTIYTAEICKTKKCIVIK----ESVRKSHCTKELKLLKSLKHPNIITPLGV
.  | ||| |    .| .   . .. . .|    ....     ||  ..| .||||..  |||
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGV
Kinase F59F5.3.AA Pkinase_Tyr 628-652 32 0.009914 9.87 Pfam 246-270 (270) Show / Hide 
Range on Protein: 628-652
Range on HMM: 246-270/270
Sequence Identity: 32% (8 aa)

YDLIVDCINENRKSRPSISSCKDVL
|||. .| ... . ||. | .   |
YDLMKQCWHYDPEDRPTFSEIHEQL
Kinase F59F5.3.AA UTK 628-652 20 0.249368 0.31 In-house 272-296 (296) Show / Hide 
Range on Protein: 628-652
Range on HMM: 272-296/296
Sequence Identity: 20% (5 aa)

YDLIVDCINENRKSRPSISSCKDVL
|.| ..| . .   ||..    ...
YRLMHRCWHYDPQERPDFEDLVQQM
Kinase F59F5.3.AA Pkinase 629-655 24 5.507682 1.03 Pfam 268-293 (293) Show / Hide 
Range on Protein: 629-655
Range on HMM: 268-293/293
Sequence Identity: 24% (7 aa)

DLIVDCINENRKSRPSISSCKDVLST--V
|.| .|.. . |.||.   ....|    .
DFIKWCLCKDPKKRPT---AEQILQHPWF