gcy-11

Species: Nematode worm
Alias: gcy-11, C30G4.3, aSWK287, CE06899
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 17053135-17045563, WormBase Genetic Map location: n/a,

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
gcy-11.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 269 Kinase domain by global Sugen HMM Fasta, JSON
gcy-11.AA Protein Genbank 1057 None Fasta, JSON

Protein domain

Protein domains of gcy-11.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase gcy-11.AA RGC 505-775 31 9.3e-114 384.22 In-house 1-300 (300) Show / Hide
Range on Protein: 505-775
Range on HMM: 1-300/300
Sequence Identity: 31% (95 aa)

ENTLVTVRKINKT----QLKLTREMKQEIDLLMNETHENLNRFFGLINESD------LIFTIHSYGPRKSLMDLLRNDDLRLDRMFKVSFVEDVVKGLQF
|...| ..|.|..    ....||.|..|. ....  |.|||.|.|.. ...       .. .. | .| ||.|.|.|||. .|.||| ||. |.|||.|.
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHEGSKIGYHGNLKSSNCIVDAYWRIKLSNYGMEQIRVEEPESKPDVFYDLVIFSNKYNSKTKNPIKKFSTDLLWFAPEIIRRYAVKHDLS-----KLEL
||  | |.|||||||.|| ||..| .|....|......... .... ..  .. |......  .. ...  ..||.|||..|... .|. .     ... 
LHH-SPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPP--CK-SDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGT

AKADIYSLAIVLYEIYGRQG-----PFGDD----LLDSDEIIEQLKFP--DGG-ALTRPDIHLITK-----APYPLASVVEKCWVEDPASRPS-IQKVRE
 |.|.||..|..|||..|.|     ||...     |. .|||| .| |  .|| ...||.|| ...     ..  | .....|| |||. ||. ....|.
QKGDVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRK

LLEP
.|. 
QLKT

Kinase gcy-11.AA RGC 505-775 31 9.3e-114 384.22 In-house 1-300 (300) Show / Hide
Range on Protein: 505-775
Range on HMM: 1-300/300
Sequence Identity: 31% (95 aa)

ENTLVTVRKINKT----QLKLTREMKQEIDLLMNETHENLNRFFGLINESD------LIFTIHSYGPRKSLMDLLRNDDLRLDRMFKVSFVEDVVKGLQF
|...| ..|.|..    ....||.|..|. ....  |.|||.|.|.. ...       .. .. | .| ||.|.|.|||. .|.||| ||. |.|||.|.
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHEGSKIGYHGNLKSSNCIVDAYWRIKLSNYGMEQIRVEEPESKPDVFYDLVIFSNKYNSKTKNPIKKFSTDLLWFAPEIIRRYAVKHDLS-----KLEL
||  | |.|||||||.|| ||..| .|....|......... .... ..  .. |......  .. ...  ..||.|||..|... .|. .     ... 
LHH-SPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPP--CK-SDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGT

AKADIYSLAIVLYEIYGRQG-----PFGDD----LLDSDEIIEQLKFP--DGG-ALTRPDIHLITK-----APYPLASVVEKCWVEDPASRPS-IQKVRE
 |.|.||..|..|||..|.|     ||...     |. .|||| .| |  .|| ...||.|| ...     ..  | .....|| |||. ||. ....|.
QKGDVYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRK

LLEP
.|. 
QLKT

Kinase gcy-11.AA TKL 691-773 26 4.4e-14 47.13 In-house 269-364 (364) Show / Hide
Range on Protein: 691-773
Range on HMM: 269-364/364
Sequence Identity: 26% (25 aa)

KADIYSLAIVLYEIYGRQGPFGDDLLDSDE------IIEQLKFPDGGALTRPDI-------HLITKAPYPLASVVEKCWVEDPASRPSIQKVRELL
|.|.|| .|||.||. |. |. |.  .. .      ..  .   .|  ...|.|          . .| ....  ..|| .|| .||| |.. . |
KCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase gcy-11.AA S_TKc 500-777 14 4.6e-12 0.0 SMART 16-231 (231) Show / Hide
Range on Protein: 500-777
Range on HMM: 16-231/231
Sequence Identity: 14% (41 aa)

HLAKYEN--TLVTVRKINKTQLKLTREMKQEIDLLMNETHENLNRFFGLINESDLIFTIHSYGPR--KSLMDLLRNDDLR-----LDRMFKVSFVEDVVK
....  .   .| . .|.       . ...||..|..  |.|. .... . . | .. .  | .    .|.|....   .     ..     ...  ...
YKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICC

GLQFLHEGSKIGYHGNLKSSNCIVDAYWRIKLSNYGMEQIRVEEPESKPDVFYDLVIFSNKYNSKTKNPIKKFSTDLLWFAPEIIRRYAVKHDLSKLELA
.|...|.  .|  |  || .|  .|   .||..  |.  .                              . |   . . |||..          .   .
ALEYCHSH-GI-IHRDLKPENILLDE--HIKICDFGLARQL-----------------------------TTFCGTPWYMAPEVL----------GYGKC

KADIYSLAIVLYEIYGRQGPFGDDLLDSDEIIEQLKFPDGGALTRPDIHLITKAPYPLASVVEKCWVEDPASRPSIQKVRE-----LLEPLS
|.|..|. ..||| . .. ||     . ........                  . .. . ..||.. ||. ||.. .. .      . |  
KCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase gcy-11.AA Pkinase 669-773 15 1e-09 35.44 Pfam 177-293 (293) Show / Hide
Range on Protein: 669-773
Range on HMM: 177-293/293
Sequence Identity: 15% (20 aa)

WFAPEIIRRYAVKHDLSKLELAKADIYSLAIVLYEIYGRQGPFGDDLLDSDEIIEQLKFPDGGALTRPDIHLITKAP-------------------YPLA
. |||.||        ..    |.|..|. ..||| . .. || ..  ..|. ..|..  .    .... .  .. .                    .. 
YMAPEVIR-------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECK

SVVEKCWVEDPASRPSIQKVREL--L
.....|.  ||..||... . .   .
DFIKWCLCKDPKKRPTAEQILQHPWF

Kinase gcy-11.AA LRRK 691-775 25 1.2e-09 30.34 In-house 262-351 (351) Show / Hide
Range on Protein: 691-775
Range on HMM: 262-351/351
Sequence Identity: 25% (25 aa)

KADIYSLAIVLYEIYGRQ-GPFGD---------DLLDSDEIIEQLKFPDGGALTRPDIH----LITKAPYPLASVVEKCWVEDPASRPSIQKVRELLEP
|.|.|| ...|.|.. ||  ||..           ...|.|||.|         || |     . .  .  . .  ..|| .|| .||. ... . |. 
KVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGL---------RPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ

Kinase gcy-11.AA MLK 691-773 21 2.1e-09 28.91 In-house 216-291 (291) Show / Hide
Range on Protein: 691-773
Range on HMM: 216-291/291
Sequence Identity: 21% (18 aa)

KADIYSLAIVLYEIYGRQGPFGDDLLDSDEIIEQLKFPDGGALTRPDIHLITKAPYPLASVVEKCWVEDPASRPSIQKVRELL
|.|..| ..||.|.  |. |.        ......    . |...   ...  .| ....  ..|| .||..||| . . . |
KCDVWSWGVVLWEMLTREVPYK-------QHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL

Kinase gcy-11.AA TKL-ciliate1 691-773 24 4.1e-09 27.34 In-house 199-279 (279) Show / Hide
Range on Protein: 691-773
Range on HMM: 199-279/279
Sequence Identity: 24% (21 aa)

KADIYSLAIVLYEIYGRQGPFGDDLLDSDEIIEQLKFPDGGALTRPDI---HLITKAPYPLASVVEKCWVEDPASRPSIQKVRELL
|.|||...||.|.   |  ||   .   ...     ||      ||      .  . |  .  .  .|| ..|. ||. . . . |
KIDIYAYGIVMYILCFRKTPFQQKMSVINIMCYWCEFP-----GRPNLGPQFIHFDCPQNFHNLMMRCWCQNPNKRPNFNEIIQIL

Kinase gcy-11.AA TyrKc 500-773 20 7.5e-09 -79.56 SMART 16-280 (280) Show / Hide
Range on Protein: 500-773
Range on HMM: 16-280/280
Sequence Identity: 20% (64 aa)

HLAKYENTLVTVRKINKTQLKLTREMKQEIDLLMNE--THENLNRFFGLINES-------DLIFTIHSYGPRKSLMDLLRNDDLRLDRMFKVSFVEDVVK
.....  . | | ....      ... .|. ....    |.|. |..| . ..       . .. .  | |  .| | ||.   .|    ..||  .. .
YKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIAC

GLQFLHEGSKIGYHGNLKSSNCIVDAYWRIKLSNYGM-EQIRVE---EPESKPDVFYDLVIFSNKYNSK-----TK--NPIKKFSTDLLWFAPEIIRRYA
| ..||.   |  |  |   || |..  ..| |  |.   |  .                  | .| .|     .|   ||.       | ||| |    
GMEYLHSKNCI--HRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-------------ESKDYYRKKEHKGGKTMLPIR-------WMAPECI----

VKHDLSKLEL---AKADIYSLAIVLYEI--YGRQGPFGDDL--LDSDEIIEQLKFPDGGALTRPDIHLITK-----APYPLASVVEKCWVEDPASRPSIQ
        .     | |..|  ....||  || | . |. .  .. .|.||..|  .|. . .|. ..        .|  . .. ..|| |||..||. .
-------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK--QGYRMPQPPNDY--PMSFVCCPDEMYQIMKQCWHEDPEDRPTFS

KVRELL
 ..|..
EIHECF

Kinase gcy-11.AA TKL 500-626 15 1.1e-08 27.45 In-house 10-199 (364) Show / Hide
Range on Protein: 500-626
Range on HMM: 10-199/364
Sequence Identity: 15% (30 aa)

HLAKYEN----------TLVTVRKINKTQLKL--------------------------TREMKQEIDLLMNET-HENLNRFFGLINESDL----------
. .|. .          . | | |..... ..                           |. . |  ..|. . |.|. .| |  ....           
YKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGP

---IFTIHSYGPRKSLMDLLRNDDLRLDRMFKVSFVEDVVKGLQFLHEGS------KIGYHGNLKSSNCIVDAYWR--------------IKLSNYG
   .. .  | |. || ..|           ..... |. .|...||         .   | .|||.|. ||  |.              .|.. .|
WGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFG

Kinase gcy-11.AA TKL-Unique 502-626 21 1.2e-08 26.86 In-house 16-162 (290) Show / Hide
Range on Protein: 502-626
Range on HMM: 16-162/290
Sequence Identity: 21% (32 aa)

AKYENTLVTVRKINK---TQLKLTREMKQEIDLLMNET-HENLNRFFG-LI----NESDLIFTIHSYGPRKSLMDLLR---------NDDLRLDRMFKVS
.|.  . |.. ....     .....| . |. .. .   |.|. ...|  .     ...... . .| |. ||.|.|          |. . |.   .|.
GKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCI-VMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVK

FVEDVVKGLQFLHEGSKIGYHGNLKSSNCIVDAY-----WRIKLSNYG
...|...|. .||  ..  .|..|||||  ||       |.||..  |
MAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFG

Kinase gcy-11.AA DRK 519-626 30 1.9e-08 24.76 In-house 38-145 (258) Show / Hide
Range on Protein: 519-626
Range on HMM: 38-145/258
Sequence Identity: 30% (33 aa)

LKLTREMKQEIDLLMNETHENLNRFFGLINESDLIFTIHSYGPRKSLMDLLRNDDLRLDRMFKVSFVEDVVKGLQFLHEGSKIGYHGNLKSSNCIVDAYW
...  |...||.|. .  | |   | |  |..  |  .  | || ||   | .. . .|     .   |. ||. .||    |  |  ||| |  ||  |
ENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHW

RIKLSNYG
..| . .|
QVKVADFG

Kinase gcy-11.AA TKL-Unique 645-713 27 2e-06 18.88 In-house 163-236 (290) Show / Hide
Range on Protein: 645-713
Range on HMM: 163-236/290
Sequence Identity: 27% (22 aa)

LVIFSNKYNSKTKNPI-----KKFSTDLLWFAPEIIRRYAVKHDLSKLELAKADIYSLAIVLYEIYGRQG------PFGD
|..|..| | .|.| .       . . ..| |||..|.        ..   |.|.|| .|||.||. |.       |. .
LSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF------CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQG

Kinase gcy-11.AA TAK1 740-772 25 8e-06 15.6 In-house 249-284 (284) Show / Hide
Range on Protein: 740-772
Range on HMM: 249-284/284
Sequence Identity: 25% (9 aa)

LITK---APYPLASVVEKCWVEDPASRPSIQKVREL
..|    .| .. .  ..|| ..|..||| | . . 
METNRSDCPKRIEQFMKCCWDDNPEKRPSMQECVKY

Kinase gcy-11.AA DRK 755-775 57 5e-05 13.02 In-house 238-258 (258) Show / Hide
Range on Protein: 755-775
Range on HMM: 238-258/258
Sequence Identity: 57% (12 aa)

CWVEDPASRPSIQKVRELLEP
|| |||  ||| | . | || 
CWNEDPQHRPSMQECLERLEA

Kinase gcy-11.AA DRK 691-711 61 7.6e-05 12.38 In-house 182-202 (258) Show / Hide
Range on Protein: 691-711
Range on HMM: 182-202/258
Sequence Identity: 61% (13 aa)

KADIYSLAIVLYEIYGRQGPF
|||.|| |||| |.  || |.
KADVYSFAIVLWECVTRQDPY

Kinase gcy-11.AA TAK1 690-711 40 9.3e-05 11.88 In-house 204-225 (284) Show / Hide
Range on Protein: 690-711
Range on HMM: 204-225/284
Sequence Identity: 40% (9 aa)

AKADIYSLAIVLYEIYGRQGPF
.|.|||| .|.. |.  |. |.
MKCDIYSWGIIMWEVISRKHPY

Kinase gcy-11.AA TKL-Unique 753-773 38 0.000194 11.77 In-house 270-290 (290) Show / Hide
Range on Protein: 753-773
Range on HMM: 270-290/290
Sequence Identity: 38% (8 aa)

EKCWVEDPASRPSIQKVRELL
..||  ||  ||| . ... |
QQCWHHDPSQRPSFDEIIHRL

Kinase gcy-11.AA Dicty4 691-711 61 0.000218 10.74 In-house 197-217 (277) Show / Hide
Range on Protein: 691-711
Range on HMM: 197-217/277
Sequence Identity: 61% (13 aa)

KADIYSLAIVLYEIYGRQGPF
||| || .|||.||  || |.
KADVYSFGIVLWEILTRQEPY

Kinase gcy-11.AA Dicty4 745-775 30 0.000492 9.54 In-house 245-277 (277) Show / Hide
Range on Protein: 745-775
Range on HMM: 245-277/277
Sequence Identity: 30% (10 aa)

PYPLASVVEKCWVEDPASRPSIQKVREL--LEP
| .... ...|| .|| .||| . . .   || 
PPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH

Kinase gcy-11.AA Dicty4 561-621 29 0.011125 4.96 In-house 85-154 (277) Show / Hide
Range on Protein: 561-621
Range on HMM: 85-154/277
Sequence Identity: 29% (21 aa)

PRKSLMDLLRN------DDLRLD--RMFK-VSFVEDVVKGLQFLHE-GSKIGYHGNLKSSNCIVDAYWRIK
|. .|  ||..      .   ||  .. .      |...|.. ||.  . |  |  |||.|  ||. ||.|
PKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVI-IHRDLKSHNLLVDKNWRVK

CYCc gcy-11.AA CYCc 812-1006 47 3.7e-112 379.83 SMART 1-231 (231) Show / Hide
Range on Protein: 812-1006
Range on HMM: 1-231/231
Sequence Identity: 47% (110 aa)

DERKRNESLLLQLLPKSVANSLKNGQ-PVDAEFYDSVSIYFSDIVGFTALSSKSTPLQVVNMLNNLYTNFDTIIDKFD-----CYKVETIGDAYMFVSGL
.|...|..|| |.||..|||.||.|. ||... ||.|.|.|.||||||.|.|..||.|||||||..||.||.|||...     |||||||||||| |||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PEVNS-------------------YLHAGEVASASLELLDSIKTFTVSHC----PDEKLRLRIGNHTGPVVTGVVGIRMPRYCLFGDTVIIANMMESSGE
|..|                    . || ..|. .|. ....||| | |.    |...||.||| |||||| |||||||||||.||||| .|. |||.|.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

PMRIQISSDAYELI-------LKCGGYVTEQ
|..|..|...|...        .||....|.
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP

Guanylate_cyc gcy-11.AA Guanylate_cyc 839-1025 40 1.1e-74 259.23 Pfam 1-214 (214) Show / Hide
Range on Protein: 839-1025
Range on HMM: 1-214/214
Sequence Identity: 40% (88 aa)

VDAEFYDSVSIYFSDIVGFTALSSKST----PLQVVNMLNNLYTNFDTIIDKF--DCYKVETIGDAYMFVSGLPEV-----NSYLHAGEVASASLELLDS
| |. ||.|.|.|.|||||||..|...    |.|.|.||| .||.||...|..  .||||.||||.|| |||||.      ... ||  .|  .|.....
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

IKTFTVSHCPDEK-----LRLRIGNHTGPVVTGVVG--IRMPRYCLFGDTVIIANMMESSGEPM--RIQISSDAYELILKCGGYVTEQ-----REKIVLK
.... | | . |      ...||| |||||| ||.|  .||||||..||||  |. ||| |.|   .|..|  .|. .|||..... .     |  | .|
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYR-CLKCHENFQFECHLQHRGEIPVK

NKLE---VMTYWMND
 | .   . ||. . 
GKGKMGEMETYFLHG

HNOBA gcy-11.AA HNOBA 799-833 42 1e-06 25.29 Pfam 200-234 (234) Show / Hide
Range on Protein: 799-833
Range on HMM: 200-234/234
Sequence Identity: 42% (15 aa)

LEDVIKERTEQLEDERKRNESLLLQLLPKSVANSL
| | ... .. || |.|....|| . .|||||| |
LKDKLEQMHRELEEEKKKTDDLLYSMFPKSVANRL