Gene gcy-22 (Nematode worm)

gcy-22

Species: Nematode worm
Alias: aSWK298, CE18923, gcy-22, T03D8.5
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: V: 20817183-20812521, WormBase Genetic Map location: n/a,

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
gcy-22.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 252 Kinase domain by global Sugen HMM Fasta, JSON
gcy-22.AA Protein Genbank 1012 None Fasta, JSON

Protein domain

Protein domains of gcy-22.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor gcy-22.AA ANF_receptor 48-175 18 5.1e-12 43.34 Pfam 1-133 (364) Show / Hide 
Range on Protein: 48-175
Range on HMM: 1-133/364
Sequence Identity: 18% (25 aa)

QVAGALGVAWSRIVEYGL-LPGYETMNLTWVLTN---CREADAVGSVINYAEGHAHVVLGPPCVRPAQVAGSVAKYLDFPLILW--GPPFDSSLLNQFEY
|.|.|.  | ..|   .  |    | .. .  ..   .  . ..  .  ..   . ...|| |   .  ....| ... |.| |    |  .. .   .|
QCAPAMRMAIEDINADPGILLPGITLGYHDDDCCYCSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPCLTDKA-KNRY

PTIASTTSSTLYQ-ATSLIRLLEY-YKWTEIALIYY
|... |. | .|| .  ....... ..|...|.||.
PYFFRTVPSDTYQYGWAMVDIIQHHFGWKWVAVIYD
ANF_receptor gcy-22.AA ANF_receptor 183-355 18 1.4e-12 45.38 Pfam 192-364 (364) Show / Hide 
Range on Protein: 183-355
Range on HMM: 192-364/364
Sequence Identity: 18% (36 aa)

PRFVIVCLESDEA---RRNLMISISENGMDGDEYVYIMAESRRAGF-ASSFWNGTDGKNDLALRAARKFLVMDNQKYNDT--TTFVQEVRAAFSRPPFSC
.| ...| ..|..   .| .|. . | ||....||.|....   ..  . .|. .|  || ...|.  .|..  .   ..    |.|....         
ARVIVMCCYPDDMGLLQRQIMQQAHELGMMSGGYVWIYTDWWMHSYDMQ-WWYDDDMDNDKFREAMKGVLGFTMH-P-SPEFQEFMQRWKK---------

PNCTNIDPTVSQVGPLGDALLLYAYALNRS------IATGN----PNPTGTEFCEVAKG-MEFLGFTGKVIINQNSTRTPLFVVYNLDST
    . ..  . .. . || .|||.||..       . .|.    .   |. . .  .  ..| |.|| | .. |  | | . .. .. .
----TDTEMNYYAAYAYDAVYLYAHALHNMLRCDPNHWNGGCDIMKW-HGWQLLHYMWNKVNFEGVTGDVQFDDNGGRRPDYMYWIMNWD
Kinase gcy-22.AA RGC 511-748 36 2.1e-123 416.25 In-house 1-300 (300) Show / Hide 
Range on Protein: 511-748
Range on HMM: 1-300/300
Sequence Identity: 36% (110 aa)

NNDSVVARKHNFRATFTKNDR--AMFRK---MRNVDNDNLCKFIGLSLDSP------TLISIWRYCSRGSLQDVIAKGSLQMDWFFKYSLMRDVADAIYY
..| |...|||.|..| . |   .|.|.   ||....|||.||||...|.|      .....|.|||||||||........|||.||||..||..  ..|
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHHSPIGPHGWLSSSTCLVDERWQVKVSFFGLS----------------------AIK-QYEVKEQRDFLHTAPEHIRDTNLPITKE-----------MD
||||||. ||.|.|..|.|| ||.||.. |||.                       .. . | ......|.|||||.|....| ...            |
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

IYSFAIICSELITKKSAWDLE-----------NETFDIEELVYKIKKGGRSPPRPSLETE-----DEHNGSMSLLVRDCWNENPDQRPT-SEQIKTLMKS
.|||.||..|.||.|..||||           .   .|||..| .||||. |.|||....     .|.|  .  |.||||.|.|..||.  .||....|.
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase gcy-22.AA RGC 511-748 36 2.1e-123 416.25 In-house 1-300 (300) Show / Hide 
Range on Protein: 511-748
Range on HMM: 1-300/300
Sequence Identity: 36% (110 aa)

NNDSVVARKHNFRATFTKNDR--AMFRK---MRNVDNDNLCKFIGLSLDSP------TLISIWRYCSRGSLQDVIAKGSLQMDWFFKYSLMRDVADAIYY
..| |...|||.|..| . |   .|.|.   ||....|||.||||...|.|      .....|.|||||||||........|||.||||..||..  ..|
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHHSPIGPHGWLSSSTCLVDERWQVKVSFFGLS----------------------AIK-QYEVKEQRDFLHTAPEHIRDTNLPITKE-----------MD
||||||. ||.|.|..|.|| ||.||.. |||.                       .. . | ......|.|||||.|....| ...            |
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

IYSFAIICSELITKKSAWDLE-----------NETFDIEELVYKIKKGGRSPPRPSLETE-----DEHNGSMSLLVRDCWNENPDQRPT-SEQIKTLMKS
.|||.||..|.||.|..||||           .   .|||..| .||||. |.|||....     .|.|  .  |.||||.|.|..||.  .||....|.
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase gcy-22.AA TKL 535-746 19 8.4e-31 108.14 In-house 77-364 (364) Show / Hide 
Range on Protein: 535-746
Range on HMM: 77-364/364
Sequence Identity: 19% (58 aa)

RKMRNVDNDNLCKFIGLSLDSPT-------------LISIWRYCSRGSLQDVIAKGSLQMDWFFKYSLMRDVADAIYYLHH-------SPIGPHGWLSSS
. |.. . .|...|.| ....|              |  .  ||..||| ...        |  . ....|.| ...|||         |   |  | |.
MMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSK

TCLVDERWQ--------------VKVSFFGLSAIKQYE----------------------VKEQR-DFLHTAPEHIRDT--------------NLPITKE
 .|||| |.              .|.. ||||  .. .                         |.  . . ||| .|..              ... .. 
NILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEK

MDIYSFAIICSELITKKSAWD-LENETFDIE-----ELVYKIKKGGRSPPRPSLET----EDEHNG--SMSLLVRDCWNENPDQRPTSEQIKTLM
.|.|||.|.  |..| .  .. . ... ..      .... ..|| | |. |  ..     ....   ||. |  |||...|..||. ..|.  .
CDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase gcy-22.AA TKL-Unique 543-680 26 2.1e-17 58.09 In-house 56-225 (290) Show / Hide 
Range on Protein: 543-680
Range on HMM: 56-225/290
Sequence Identity: 26% (45 aa)

DNLCKFIGLSL----DSPTLISIWRYCSRGSLQDVIA---------KGSLQMDWFFKYSLMRDVADAIYYLHHSP--IGPHGWLSSSTCLVDER-----W
.|. ...| .     . | .. .  ||..||| ||..         . .. ...  .... .|.|.. |||||.   |  |. | ||  |||..     |
PNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPI-IHRDLKSSNFLVDNNSNIAEW

QVKVSFFGLSAIKQYEVKEQRD-------------FLHTAPEHIRDTNLPITKEMDIYSFAIICSELITKK
..|.. |||| ..  . |.                |.  ||| .|. .  ...  |.|||.|.  |..| |
NIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIATRK
Kinase gcy-22.AA DRK 544-636 40 1.4e-15 49.26 In-house 58-155 (258) Show / Hide 
Range on Protein: 544-636
Range on HMM: 58-155/258
Sequence Identity: 40% (40 aa)

NLCKFIGLSLDSPTLISIWRYCSRGSLQDVIAKGSLQMDWFFKYSLMRDVADAIYYLHHS-PIGPHGWLSSSTCLVDERWQVKVSFFGLSA----IKQ
| | |.|  . .|    .  | .||||  .    |..|||    ..| |.|  . ||| . ||  |  | |   |||| |||||. ||||     .||
NICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQ
Kinase gcy-22.AA RIPK 617-746 25 2.9e-13 41.53 In-house 141-290 (290) Show / Hide 
Range on Protein: 617-746
Range on HMM: 141-290/290
Sequence Identity: 25% (39 aa)

LVDERWQVKVSFFGLSAIKQYEVKEQ-RD----------------FLHTAPEHIRDTNLPI----TKEMDIYSFAIICSELITKKSAWDLENETFDIEEL
|||    ||.. |||.. ..     | |.                  . .|||.|. |       |.. |.|||||.  |. |.| .   . ... .. .
LVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHP---YEDRKCMMMI

VYKIKKGGRSPPRPSLETEDE--HNGSMSLLVRDCWNENPDQRPTSEQIKTLM
....|.| | .  |  |  .|  |  .|  | ..||  .|..||.   ..   
MMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase gcy-22.AA TK 532-746 12 1.9e-12 37.3 In-house 89-486 (486) Show / Hide 
Range on Protein: 532-746
Range on HMM: 89-486/486
Sequence Identity: 12% (51 aa)

AMFRKMRN---VDNDNLCKFIGLSLDSPT------------LISIWRYCSRGS----LQDVIAKGSL---------------------------------
|. .|| .    . .|. ...| .... .            .. .  |.. |.    |.|   | .                                  
AEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSH

------------------------------------------QMDWFFKYSLMRDVADAIYYLHHSPI-----GPHGWLSSSTCLVDERWQ---------
                                          |..   .   ....|..  |||  ..       |. |    |||.|. .         
ESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCG

--VKVSFFGLS------------AIKQYEVKEQRDFLH--------------------------TAPEHIRDT-------NLPITKEMDIYSFAIICSEL
  .|.. ||||              . | .|....                             .||| ..|        .   | . |..|| . . |.
PVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEI

IT---KKSAWDLENETFDI----EELVYKIKKG-------------GRSPPRPSLETE---------DEHNGSMSLLVRDCWNENPDQRPTSEQIKTLM
 |   .  .... |.   .    .|.. ....|             .  .|.| . ..          ..   . .| ..||...|..||| .|..  .
FTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase gcy-22.AA TAK1 665-745 26 9e-11 32.51 In-house 207-284 (284) Show / Hide 
Range on Protein: 665-745
Range on HMM: 207-284/284
Sequence Identity: 26% (22 aa)

DIYSFAIICSELITKKSAWDLENETFDIEELVYKIKKGGRSPPRPSLETE-DEHNGSMSLLVRDCWNENPDQRPTSEQIKTL
||||..||  |.|. |   |  .    . .. ..| .| | |    .||.  . .   . .   ||..||..||... .   
DIYSWGIIMWEVISRKHPYDHIMNPNSAYRIMWAIHNGNRPP----METNRSDCPKRIEQFMKCCWDDNPEKRPSMQECVKY
TyrKc gcy-22.AA TyrKc 510-746 16 9.6e-10 -65.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 510-746
Range on HMM: 1-280/280
Sequence Identity: 16% (52 aa)

LNNDSV---------------------VARKHNFRATFTKNDRAMFRK----MRNV--DNDNLCKFIGLSLDS-------PTLISIWRYCSRGSLQDVIA
.  . .                     . ...          |..|..    |...  ...|. ...|  ...       . |  .  |.. |.|.| . 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KGSLQMDWFFKYSLMRDVADAIYYLHHSPIGPHGWLSSST----------CLVDERWQVKVSFFGLS-AIKQY-------EVKEQRD--FLH-------T
|   .  .  . | . ..|.   |||.                       |||.|. .||.| |||| .|. .       ... ..     .       .
KHRPKLCMKDLLSFCWQIACGMEYLHSK-----------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

APEHIRDTNLPITKEMDIYSFAIICSELIT--KKSAWDLENETFDIEELVYKIKKGGRSPPRPSLETEDE------HNGSMSLLVRDCWNENPDQRPTSE
||| |       | . |..|| . . |. |  ..  .. . .  . .|.. ..|.|.| |. |. .   .      .    . . ..||.|.|..||| .
APECI--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---PMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFS

QIKTLM
.|. ..
EIHECF
Kinase gcy-22.AA LRRK 649-748 27 1.2e-09 30.27 In-house 247-351 (351) Show / Hide 
Range on Protein: 649-748
Range on HMM: 247-351/351
Sequence Identity: 27% (31 aa)

APEHIRDT-NLPITKEMDIYSFAIICSELITKK-SAWDLENETFD----IEELVYKIKKGGRSPPRPSLETEDEHNG-----SMSLLVRDCWNENPDQRP
||| .|.. .   | . |.|||..|  ||.| .  . | | . ||    .|..  ||..|     ||..  .   ..     ... |  .||...|..||
APEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFD-EHDFFDHMQWMEQIEDKIIEGL----RPTIPQH-YCPPCQPWHMYQDLIQHCWQHDPKKRP

TSEQIKTLMKS
...||   ...
HFSQIVKRLSQ
S_TKc gcy-22.AA S_TKc 435-749 14 2.5e-09 -40.12 SMART 1-231 (231) Show / Hide 
Range on Protein: 435-749
Range on HMM: 1-231/231
Sequence Identity: 14% (49 aa)

VLIIAVIST----IVFLVRSKR-QEEERLNQLWQVHFSSLVKPPQKNTMHSSRSLQSTVTTSTKVTINSKKDTERHSFYFLNNDSVVARKHNFRATFTKN
  |. .|       |...| |. ...  . ..                                                                 ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------------------------------------------------------EHIRR

DRAMFRKMRNVDNDNLCKFIGLSLDSPTLISIWRYCSR--GSLQDVIAKGSLQ-----MDWFFKYSLMRDVADAIYYLHHSPIGPHGWLSSSTCLVDERW
 ... .|    . .|..|...   |   |  .  ||.   |.| |.| |   .     ..     ..|. ...|. |.|   |  |  |  .  |.||  
EIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGII-HRDLKPENILLDE--

QVKVSFFGLSAIKQYEVKEQRDFLHT----APEHIRDTNLPITK-EMDIYSFAIICSELITKKSAWDLENETFDIEELVYKIKKGGRSPPRPSLETEDEH
..|.. |||...        . |  |    ||| .     . .| . |..|. .|  |... .  ..      .....  ||.                 
HIKICDFGLARQL-------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG-----------------

NGSMSLLVRDCWNENPDQRPTSEQIKT------LMKSM
  ..  ..| |.. .|..|||  .. .      ..  .
SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase gcy-22.AA Pkinase 649-746 16 2.2e-08 30.71 Pfam 179-293 (293) Show / Hide 
Range on Protein: 649-746
Range on HMM: 179-293/293
Sequence Identity: 16% (20 aa)

APEHIRDTNLPITKEMDIYSFAIICSELITKKSAWDLEN----ETFDIEELVYKIKKGGRSPPRPSLETED--------------EHNGSMSLLVRDCWN
||| || .. ..... |..|. .|. |.....  .. .     .  |  .....|...  . ..| . ..               . . ..  ....|..
APEVIR-GGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC

ENPDQRPTSEQIKTL--M
 .| .||| |||.    .
KDPKKRPTAEQILQHPWF
Kinase gcy-22.AA DRK 724-748 36 1.5e-07 21.71 In-house 234-258 (258) Show / Hide 
Range on Protein: 724-748
Range on HMM: 234-258/258
Sequence Identity: 36% (9 aa)

LVRDCWNENPDQRPTSEQIKTLMKS
|  |||||.| .||. ...   . .
LMNDCWNEDPQHRPSMQECLERLEA
Kinase gcy-22.AA Dicty4 544-636 27 5.4e-07 19.55 In-house 59-165 (277) Show / Hide 
Range on Protein: 544-636
Range on HMM: 59-165/277
Sequence Identity: 27% (29 aa)

NLCKFIGLSL----DSPTLISIWRYCSRGSLQDVIAK------GSLQMDWFFKYS---LMRDVADAIYYLHH-SPIGPHGWLSSSTCLVDERWQVKVSFF
|.|.| | ..     ....     |...|.|  .. .       | ..||    .   ...|.|  . .||   |.  |  | |.  |||. |.|||. |
NICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDF

GLSAIKQ
|||....
GLSQYMK
Kinase gcy-22.AA Dicty4 724-751 30 9e-06 15.48 In-house 251-277 (277) Show / Hide 
Range on Protein: 724-751
Range on HMM: 251-277/277
Sequence Identity: 30% (9 aa)

LVRDCWNENPDQRPTSEQIKTLMKS--MNH
|. .||...| .||. |.|    .   ..|
LIQWCWDHDPQHRPSFEEI---IQRRILEH
Kinase gcy-22.AA TKL-Unique 724-746 34 0.000123 12.48 In-house 268-290 (290) Show / Hide 
Range on Protein: 724-746
Range on HMM: 268-290/290
Sequence Identity: 34% (8 aa)

LVRDCWNENPDQRPTSEQIKTLM
| ..||. .|.|||. ..| .  
LIQQCWHHDPSQRPSFDEIIHRL
Kinase gcy-22.AA Pkinase_Tyr 726-746 33 0.003649 11.34 Pfam 250-270 (270) Show / Hide 
Range on Protein: 726-746
Range on HMM: 250-270/270
Sequence Identity: 33% (7 aa)

RDCWNENPDQRPTSEQIKTLM
..||...|..||| ..|   .
KQCWHYDPEDRPTFSEIHEQL
Kinase gcy-22.AA LRRK 568-601 19 0.007959 5.81 In-house 140-181 (351) Show / Hide 
Range on Protein: 568-601
Range on HMM: 140-181/351
Sequence Identity: 19% (8 aa)

GSLQDVIA---KGSL-----QMDWFFKYSLMRDVADAIYYLH
|.|....    . ..      ..| .|. .. ..|... |||
GDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH
Kinase gcy-22.AA Pkinase_Tyr 616-632 52 0.723419 3.56 Pfam 142-158 (270) Show / Hide 
Range on Protein: 616-632
Range on HMM: 142-158/270
Sequence Identity: 52% (9 aa)

CLVDERWQVKVSFFGLS
|||.|  .||.. |||.
CLVTENNVVKICDFGLA
CYCc gcy-22.AA CYCc 785-980 45 2.8e-102 347.01 SMART 1-231 (231) Show / Hide 
Range on Protein: 785-980
Range on HMM: 1-231/231
Sequence Identity: 45% (106 aa)

EEKKRSDVLLYRMLPKQVAEKLKLGQ-SVEPETFDCVTIFFSDVVSFTTLASRCTPLQVVNLLNDLYTTFDAIIEQHD-----VYKVETIGDGYLCVSGL
.||.. | ||..|||. ||. || |. .|.|...||||| |.|.|.||.|.|.|||.||||.|||.|| || ||..|.     .||||||||.| .|||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PHRNG-------------------NEHAKEISSMSFSLLKAIKTFRVPHL----PKERINIRVGLHTGPVVTGVVGMTMPRYCLFGDSVNTASRMESNGK
|.||.                    .||..|.....  ....||| |.|     | . ...|.|.|||||| |||| .|||||.||| ||.||||||.|.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

PGRVHISTECMKFL------TEVIGGYQTEP
||..|.| |  . |      .   |....||
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc gcy-22.AA Guanylate_cyc 812-999 42 1e-89 309.18 Pfam 1-214 (214) Show / Hide 
Range on Protein: 812-999
Range on HMM: 1-214/214
Sequence Identity: 42% (90 aa)

VEPETFDCVTIFFSDVVSFTTLASRCT----PLQVVNLLNDLYTTFDAIIEQH--DVYKVETIGDGYLCVSGLPHR-----NGNEHAKEISSMSFSLLKA
|... .|||||.|.|.| || ..|||.    |.|.|..|||.||.|| ...||  ..|||.|||| |.|||||| .     ..  ||  .  |.. ....
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

IKTFRVPHLPKER-----INIRVGLHTGPVVTGVVG--MTMPRYCLFGDSVNTASRMESNGKPG--RVHISTECMKFLTEVIG-GYQT--EPRGEVIVKG
.....|.|.. |.     |..|.|.|||||| ||.|  . |||||..|| ||.||||||.|.||  ..|.|.| .. |..  .  ...  ..|||. |||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGA---VQTHWLLT
||    ..|..|  
KGKMGEMETYFLHG
HNOBA gcy-22.AA HNOBA 780-806 59 2.2e-09 35.48 Pfam 208-234 (234) Show / Hide 
Range on Protein: 780-806
Range on HMM: 208-234/234
Sequence Identity: 59% (16 aa)

MKELTEEKKRSDVLLYRMLPKQVAEKL
..|| ||||..| ||| |.||.||..|
HRELEEEKKKTDDLLYSMFPKSVANRL