gcy-25

Species: Nematode worm
Alias: gcy-25, Y105C5B.2, Y105C5_11465, aSWK289, CE24069
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: IV: 15872927-15883462, WormBase Genetic Map location: n/a,

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
gcy-25.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 287 Kinase domain by global Sugen HMM Fasta, JSON
gcy-25.AA Protein Genbank 1091 None Fasta, JSON

Protein domain

Protein domains of gcy-25.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor gcy-25.AA ANF_receptor 53-161 17 9.6e-07 24.71 Pfam 33-156 (364) Show / Hide
Range on Protein: 53-161
Range on HMM: 33-156/364
Sequence Identity: 17% (22 aa)

SC---HNFNGLENAANLNYQYSVDLLIGAACDEETQTVSRLALRWHKLYLS----SAPLST--KEKESTTIALKPHSLAGTAEVILAMCKS-MKWKEIGI
.|    . ... .|. . .   |. .||  | ... .|.|.|  |..  .|    .  |.   |..  ... . | ..   ....... .   .||....
CCYCSDC-QAVAAADCCWH-KGVVAIIGPSCSYVCIPVARIANHWNIPMISWGCTCPCLTDKAKNRYPYFFRTVPSDTYQYGWAMVDIIQHHFGWKWVAV

IYSEETK--YT-----AHAIYDMLAE
||.....  .      ..|..| |.|
IYDDDDYYYWRGGCYFMEAFQDELRE

ANF_receptor gcy-25.AA ANF_receptor 351-386 26 0.296803 5.3 Pfam 327-364 (364) Show / Hide
Range on Protein: 351-386
Range on HMM: 327-364/364
Sequence Identity: 26% (10 aa)

LWNHVTN-TETQGYSGPVFIGN-DGVRLPYYEMHMWRD
| ..  | .. .| .|.| .   .| | .|. . |. |
LLHYMWNKVNFEGVTGDVQFDDNGGRRPDYMYWIMNWD

Kinase gcy-25.AA RGC 523-791 27 8.60000000001e-105 354.45 In-house 1-300 (300) Show / Hide
Range on Protein: 523-791
Range on HMM: 1-300/300
Sequence Identity: 27% (82 aa)

NKQKVSVKRHVQR---RAITFSRQEMEMLNQLKYMSHTNINPFTGICFNQGSE-----LIVMWQFTTRYSLEDLIFVKEQKFGRNFQSTFIKHIVHGINY
....| .|.|.||   |...|.|..| .|.|.. . | |.|.| |.|... .|     ....|.. .| ||.|...  . |  ..|.. ||..||.|..|
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

IHNSSIKVHGALYLSNCVVDSYWVVKLTDFGIKGILKERTNHKELAP----SSAFDVD-----AIHYKYLQLAPEHISAILEKLEEP------RGTVEGD
.|.|.|..|| |  .||||||.||||.||||.. .|...  |....|    .......     . ..|.|. ||||. . ...  ..      ||| .||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

IYQLAMCIYQILFYMRPFAERQESIKV--YSGEIFLKLPELAHLLSSQSTAPLHPKVPEGNS-----FTMRLLSIIQQCWLYKPAARPA-LIKITDAVNR
.| .....|.|.. ..|. ..  ....  |. .   .. |...........|..|...|...     . ..||.....||  .|. ||  . .| .....
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT





Kinase gcy-25.AA RGC 523-791 27 8.60000000001e-105 354.45 In-house 1-300 (300) Show / Hide
Range on Protein: 523-791
Range on HMM: 1-300/300
Sequence Identity: 27% (82 aa)

NKQKVSVKRHVQR---RAITFSRQEMEMLNQLKYMSHTNINPFTGICFNQGSE-----LIVMWQFTTRYSLEDLIFVKEQKFGRNFQSTFIKHIVHGINY
....| .|.|.||   |...|.|..| .|.|.. . | |.|.| |.|... .|     ....|.. .| ||.|...  . |  ..|.. ||..||.|..|
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

IHNSSIKVHGALYLSNCVVDSYWVVKLTDFGIKGILKERTNHKELAP----SSAFDVD-----AIHYKYLQLAPEHISAILEKLEEP------RGTVEGD
.|.|.|..|| |  .||||||.||||.||||.. .|...  |....|    .......     . ..|.|. ||||. . ...  ..      ||| .||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

IYQLAMCIYQILFYMRPFAERQESIKV--YSGEIFLKLPELAHLLSSQSTAPLHPKVPEGNS-----FTMRLLSIIQQCWLYKPAARPA-LIKITDAVNR
.| .....|.|.. ..|. ..  ....  |. .   .. |...........|..|...|...     . ..||.....||  .|. ||  . .| .....
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT





S_TKc gcy-25.AA S_TKc 507-794 13 2e-06 -82.27 SMART 11-231 (231) Show / Hide
Range on Protein: 507-794
Range on HMM: 11-231/231
Sequence Identity: 13% (40 aa)

SYSSIFSGNVAEHAIVNKQKVSVKRHVQRRAITFSRQEMEMLNQLKYMSHTNINPFTGICFNQGSELIVMWQFTTR--YSLEDLIFVKEQK-----FGRN
.... . .   .     ...| .|.          |.|...| .     | ||  . ... .  ..| .   .      .| |.|  .  .     |   
AFGKVYKCRHKK----TGRIVAIKIIK-----EHIRREIQILKK----HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-

FQSTFIKHIVHGINYIHNSSIKVHGALYLSNCVVDSYWVVKLTDFGIKGILKERTNHKELAPSSAFDVDAIHYKYLQ----LAPEHISAILEKLEEPRGT
    ... |. ...|.|.    .|  |  .|  .|.  ..|..|||.  .|                     . .      .||| .         . |.
HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL---------------------TTFCGTPWYMAPEVL---------GYGK

VEGDIYQLAMCIYQILFYMRPFAERQESIKVYSGEIFLKLPELAHLLSSQSTAPLHPKVPEGNSFTMRLLSIIQQCWLYKPAARPALIKITD----AVNR
 . |.. .  ..|  |    ||      ...    |                             .  ....|..|. . |. ||   ..      . . 
CKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

EFG
.. 
PWF

Kinase gcy-25.AA RIPK 763-789 22 2e-05 14.38 In-house 264-290 (290) Show / Hide
Range on Protein: 763-789
Range on HMM: 264-290/290
Sequence Identity: 22% (6 aa)

RLLSIIQQCWLYKPAARPALIKITDAV
.. . .|.|| . | .||. . ... .
QMIELMQRCWQQDPNDRPCFQECEEWT

Kinase gcy-25.AA Ciliate-C3 606-644 38 2.7e-05 15.32 In-house 103-140 (140) Show / Hide
Range on Protein: 606-644
Range on HMM: 103-140/140
Sequence Identity: 38% (15 aa)

KHIVHGINYIHNSSIKVHGALYLSNCVVDSYWVVKLTDF
| |.  |.|.|   | ||| . .|| .. |   .|. ||
KQILQAIDYLHEHNI-VHGDIKFSNILINSKDEIKIIDF

Kinase gcy-25.AA PLK1 604-646 37 0.00015 10.58 In-house 104-145 (253) Show / Hide
Range on Protein: 604-646
Range on HMM: 104-145/253
Sequence Identity: 37% (16 aa)

FIKHIVHGINYIHNSSIKVHGALYLSNCVVDSYWVVKLTDFGI
... ||.|. |.||  | .|  | | |  ..    ||. |||.
YMYQIVEGCQYLHNNKI-IHRDLKLGNLFLNDHLQVKIGDFGL

Kinase gcy-25.AA Ciliate-A7 698-723 26 0.000454 10.63 In-house 256-281 (360) Show / Hide
Range on Protein: 698-723
Range on HMM: 256-281/360
Sequence Identity: 26% (7 aa)

GDIYQLAMCIYQILFYMRPFAERQES
.|.... ....||||...||... ..
CDVFAFGVSFFQILFQQNPFCCEACH

Kinase gcy-25.AA SAK 592-651 31 0.000581 9.08 In-house 93-151 (254) Show / Hide
Range on Protein: 592-651
Range on HMM: 93-151/254
Sequence Identity: 31% (19 aa)

KEQKFGRNFQSTFIKHIVHGINYIHNSSIKVHGALYLSNCVVDSYWVVKLTDFGIKGILK
. . |. .    |...|| |. |.|   | .|  | ||| ..     .|. |||.   ||
RMRPFTEEEARHFMHQIVIGMLYLHSHGI-MHRDLTLSNILLTRDMHCKIADFGLATQLK

Kinase gcy-25.AA Musk 767-789 30 0.00085 8.17 In-house 260-282 (282) Show / Hide
Range on Protein: 767-789
Range on HMM: 260-282/282
Sequence Identity: 30% (7 aa)

IIQQCWLYKPAARPALIKITDAV
.  .||  .|| ||   .| . .
LMRRCWQKNPADRPFFCQIHHCI

TyrKc gcy-25.AA TyrKc 511-724 14 0.00086 -161.32 SMART 1-280 (280) Show / Hide
Range on Protein: 511-724
Range on HMM: 1-280/280
Sequence Identity: 14% (42 aa)

IFSGNVA--------EHAIVNKQKVSVKRHVQRRAITFSRQEMEMLNQLKYMSHT-----NINPFTGICFNQG------SELIVMWQFTTRYSLEDLIFV
|  | .          ... . ..| ||             ...... .. |..      ||  . |.|  ||        | .   .    .| | .  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KEQKFGRNFQSTFIKHIVHGINYIHNSSIKVHGALYLSNCVVDSYWVVKLTDFGIKGILKER----TNHKELAPSSAFDVD-----------AIHYK---
.. |.       |   |  | .|.|   . .|  |   || |..  .|| .|||    ...      ...   ...  . .           .| |.   
HRPKLCMKDLLSFCWQIACGMEYLHSKNC-IHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

----------------------YLQ-----LAPEHISAILEKL---EEPRG-------TVEGDIYQLAMCIYQILFYMRP-FAERQESI
                      |       . .... . ...    . |         .   ..||.  .  .    .|| |.|  | .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase gcy-25.AA UTK 762-789 21 0.001549 7.97 In-house 269-296 (296) Show / Hide
Range on Protein: 762-789
Range on HMM: 269-296/296
Sequence Identity: 21% (6 aa)

MRLLSIIQQCWLYKPAARPALIKITDAV
...  . ..|| | |. ||    .....
HPVYRLMHRCWHYDPQERPDFEDLVQQM

Kinase gcy-25.AA UTK 604-645 30 0.002598 7.19 In-house 123-170 (296) Show / Hide
Range on Protein: 604-645
Range on HMM: 123-170/296
Sequence Identity: 30% (15 aa)

FIKHIVHGINYIHNSSIKVHGALYLSNCVVDSY-------WVVKLTDFG
.  .| .| .|.|.  . ||. |   || |..        .|.|. |||
MAWDIARGMQYLHSCGF-VHRDLAARNCLVHMHRMMWHCMMVCKIADFG

Kinase gcy-25.AA TK 767-789 34 0.002964 5.91 In-house 464-486 (486) Show / Hide
Range on Protein: 767-789
Range on HMM: 464-486/486
Sequence Identity: 34% (8 aa)

IIQQCWLYKPAARPALIKITDAV
..|||| |.|. ||    . .. 
LMQQCWHYDPEDRPTFSQLHEQL

Kinase gcy-25.AA TK 604-645 25 0.006892 4.66 In-house 239-296 (486) Show / Hide
Range on Protein: 604-645
Range on HMM: 239-296/486
Sequence Identity: 25% (15 aa)

FIKHIVHGINYIHNSSIK-----VHGALYLSNCVVDSYWV-----------VKLTDFG
.   |  |  |.|   ..     ||. |   || |..  |           .|..|||
MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG

Kinase gcy-25.AA Musk 630-645 43 0.09138 1.35 In-house 156-171 (282) Show / Hide
Range on Protein: 630-645
Range on HMM: 156-171/282
Sequence Identity: 43% (7 aa)

NCVVDSYWVVKLTDFG
|| . .  .||  |||
NCLINEHMDVKIADFG

CYCc gcy-25.AA CYCc 827-1032 32 1.6e-57 198.37 SMART 1-231 (231) Show / Hide
Range on Protein: 827-1032
Range on HMM: 1-231/231
Sequence Identity: 32% (76 aa)

LEQDMSVTENLLYQLLPKSVADSIRSGK-TVVPEQHSSVTLLVVDVCQFTKFCEAFIPVHILETLQELYSSFDNIVQKNK-----AFKVENVGDAYLICS
 |..   .. ||.|.||..||.. ..|. .|.|. ...||.|  |.. ||..|..  |  . . |...|. || |. ...     . ||| .|||| ..|
MEKQK--NDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVS

GIPEMSG-------------------FRHLREICKISLKLQAFMKTFKVRHR----PSHTLQIKMGITSGAVAAGILGSTAPRFCIFGDTVNMACRMAST
|.|.  .                    .| ..|. ..|.   .||||.|.|.    | ..|.. .|| .| |..|  | ..|| |.|||||||| || ||
GCPTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMEST

GNPGSIQLSELTANTLMEKFPSFMLEERGMIDVKG
|.|| |..|| | . |  .. .|.. ..| .....
GDPGQIHVSEETYWCL-CLD-QFERRRCGQFEFEP

Guanylate_cyc gcy-25.AA Guanylate_cyc 856-1043 30 7.2e-47 166.83 Pfam 1-214 (214) Show / Hide
Range on Protein: 856-1043
Range on HMM: 1-214/214
Sequence Identity: 30% (66 aa)

VVPEQHSSVTLLVVDVCQFTKFCEAFI----PVHILETLQELYSSFDNIVQKN--KAFKVENVGDAYLICSGIPEM-----SGFRHLREICKISLKLQAF
|..... .||..  |.  ||.||..      |. ... | ..|..|| .. ..    .||. .||.|...||.|.      ..  |.. .. ..|... .
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

MKTFKVRHRP-SH----TLQIKMGITSGAVAAGILG--STAPRFCIFGDTVNMACRMASTGNPG--SIQLSELTANTLMEKF-PSFML--EERGMIDVKG
.... | | .       ..|. .|| .| | ||..|  .  ||.|..|||||.| || |||.||   |..|| |.  |.... ..| .  ..|| | |||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGA---CLTFWLTG
||      |..|.|
KGKMGEMETYFLHG