Gene gcy-27 (Nematode worm)

gcy-27

Species: Nematode worm
Alias: C06A12.4, gcy-27, aSWK291, CE27797
External Links: Wormbase Link ,
Annotation: WormBase Genetic Map location: n/a, WormBase Physical Map location: IV: 17436591-17432937,

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
gcy-27.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 270 Kinase domain by global Sugen HMM Fasta, JSON
gcy-27.AA Protein Genbank 613 None Fasta, JSON

Protein domain

Protein domains of gcy-27.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase gcy-27.AA RGC 85-346 28 8.3e-102 344.52 In-house 1-300 (300) Show / Hide 
Range on Protein: 85-346
Range on HMM: 1-300/300
Sequence Identity: 28% (86 aa)

T-QRAEFIQFRQI---KHIDITNASLDFLYNLKQLKHDNLANFYGIQLNDDLN----TMTILHALVERGTLEEFCLDRDFGMDETFKSAFMRDILKGLQY
. ... . .. |.   .|.|.| . ...|. ..||.||||..|.|...... .    .|.|.. . .||.|.... ..|..||..||..|.|||.||.||
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHLSPVAYHGHLHAATCLIDINWVLKIALYGVTNFVCDNFDAENITM---------PDRSDYTISYAQYVCFPPEHIREYDATGKLP--TRFVRGSKQGD
|| ||. |||.|. ..|..| .||.||. .|. |..|. |....|..          . .| ...|... ...|||.||.. ... .  ....||...||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

IYCVGMIFYMMIEREDPYRLIHSVERP--GSGLMMEILDHN-----------LMPFISNNET-----QEDTLLDKCKECWNRDPEKRPT-IENLRNAIAI
.|..|.|.|..| |. |..|.. ...|   .  .|||....           ..| |...|.     . ..||  ...||..|||.||. ....|.... 
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase gcy-27.AA RGC 85-346 28 8.3e-102 344.52 In-house 1-300 (300) Show / Hide 
Range on Protein: 85-346
Range on HMM: 1-300/300
Sequence Identity: 28% (86 aa)

T-QRAEFIQFRQI---KHIDITNASLDFLYNLKQLKHDNLANFYGIQLNDDLN----TMTILHALVERGTLEEFCLDRDFGMDETFKSAFMRDILKGLQY
. ... . .. |.   .|.|.| . ...|. ..||.||||..|.|...... .    .|.|.. . .||.|.... ..|..||..||..|.|||.||.||
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHLSPVAYHGHLHAATCLIDINWVLKIALYGVTNFVCDNFDAENITM---------PDRSDYTISYAQYVCFPPEHIREYDATGKLP--TRFVRGSKQGD
|| ||. |||.|. ..|..| .||.||. .|. |..|. |....|..          . .| ...|... ...|||.||.. ... .  ....||...||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

IYCVGMIFYMMIEREDPYRLIHSVERP--GSGLMMEILDHN-----------LMPFISNNET-----QEDTLLDKCKECWNRDPEKRPT-IENLRNAIAI
.|..|.|.|..| |. |..|.. ...|   .  .|||....           ..| |...|.     . ..||  ...||..|||.||. ....|.... 
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
S_TKc gcy-27.AA S_TKc 18-346 14 4.9e-08 -59.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 18-346
Range on HMM: 1-231/231
Sequence Identity: 14% (50 aa)

WCYETVIGENT--RKYKMTWKVPKES--LKIIVNKNADARMQRELENRTAKDEANALTSRRRVFGSYALIGTQRAEFIQFRQIKHIDITNASLDFLYNLK
.    .||. .  . || ..|  ..   .|||                                                . .. |.|            
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------------------------------------EHIRREIQILKK---------

QLKHDNLANFYGIQLNDDLNTMTILHALVER--GTLEEFCLDRDFG-----MDETFKSAFMRDILKGLQYLHLSPVAYHGHLHAATCLIDINWVLKIALY
  .|.|. ..|..  .   . . .   ...   |.| ..  .|  .     ..|     .|. |...|.|.|   .  |  |  .  |.|   ..||.  
--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGII-HRDLKPENILLDE--HIKICDF

GVTNFVCDNFDAENITMPDRSDYTISYAQYVCFPPEHIREYDATGKLPTRFVRGSK-QGDIYCVGMIFYMMIEREDPYRLIHSVERPGSGLMMEILDHNL
|.  ..            .    |  |      .|| .                .|   |.. .| |.| |. .. |..            |...... .
GLARQL------------TTFCGTPWYM-----APEVL--------------GYGKCKCDWWSCGCILYEMLCGYPPFP-----------QMQMMFKKIG

MPFISNNETQEDTLLDKCKECWNRDPEKRPTIENLRN-------AIAI
           . ..|  . |...|||||||.  . .          .
----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase gcy-27.AA TKL 261-344 20 2.4e-07 22.52 In-house 267-364 (364) Show / Hide 
Range on Protein: 261-344
Range on HMM: 267-364/364
Sequence Identity: 20% (20 aa)

SKQGDIYCVGMIFYMMIEREDPYRLIHSVERPGS----GLMMEILDHNLMPFIS----------NNETQEDTLLDKCKECWNRDPEKRPTIENLRNAI
|.. |.|  |.... .. |. ||. ... .. ..      .| . |..| | |           ....  . . . ...||. ||||||. . .   .
SEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase gcy-27.AA TK 317-344 23 3.3e-07 19.4 In-house 445-486 (486) Show / Hide 
Range on Protein: 317-344
Range on HMM: 445-486/486
Sequence Identity: 23% (10 aa)

D-------------TLLDK-CKECWNRDPEKRPTIENLRNAI
|             ....  ...||..|||.||| . |....
DWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase gcy-27.AA MEKK4 111-178 28 6.4e-07 19.95 In-house 51-115 (271) Show / Hide 
Range on Protein: 111-178
Range on HMM: 51-115/271
Sequence Identity: 28% (20 aa)

NLKQLKHDNLANFYGIQLNDDLNTMTILHALVERGTLEEFCLDRDFG--MDETFKSAFMRDILKGLQYLH
.. ..|| ||   ||... .    | |   .  .||||. |     |  |.|   . .   .| . .|||
IFEGIKHPNLVRYYGVEVHRE--EMYIFMEYCSQGTLERVC---HLGGNMQEHMIRQYTKQLLRAVNYLH
Kinase gcy-27.AA TK-Unique 324-344 33 1e-06 19.19 In-house 274-294 (294) Show / Hide 
Range on Protein: 324-344
Range on HMM: 274-294/294
Sequence Identity: 33% (7 aa)

KECWNRDPEKRPTIENLRNAI
|.||...||.||... ... .
KSCWQWEPEERPSFRQIKHRL
Kinase gcy-27.AA Src 324-344 47 1e-06 18.54 In-house 235-255 (255) Show / Hide 
Range on Protein: 324-344
Range on HMM: 235-255/255
Sequence Identity: 47% (10 aa)

KECWNRDPEKRPTIENLRNAI
..||..|||.||| | |..  
LQCWHKDPEQRPTFEYLQWFL
Kinase gcy-27.AA SRM 325-345 52 2e-06 17.13 In-house 233-253 (253) Show / Hide 
Range on Protein: 325-345
Range on HMM: 233-253/253
Sequence Identity: 52% (11 aa)

ECWNRDPEKRPTIENLRNAIA
||| ||||.||.   ||   .
ECWCRDPEQRPCFKDLREKLT
Kinase gcy-27.AA Ciliate-E2 261-346 15 5e-06 16.68 In-house 274-365 (365) Show / Hide 
Range on Protein: 261-346
Range on HMM: 274-365/365
Sequence Identity: 15% (17 aa)

SKQGDIYCVGMIFYMMIEREDPYRLIHSVERPGSGLMMEILDHNLMPFIS----------------NNETQEDTLLDKCKE----CWNRDPEKRPT-IEN
... ||...|.|.|.|.  . |.               ..  ..    ..                ...  ..   | .|     . ..|||||.| .| 
DYKCDIWSLGVILYEMLFGKPPF---------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQ

LRNAIAI
. |   .
ILNHPWF
Kinase gcy-27.AA TKL 112-213 18 1.1e-05 16.4 In-house 79-205 (364) Show / Hide 
Range on Protein: 112-213
Range on HMM: 79-205/364
Sequence Identity: 18% (25 aa)

LKQLKHDNLANFYGIQLNDDLNT-----------MTILHALVERGTLEEFCLDRDFGMDETFKSAFMRDILKGLQYLHL-------SPVAYHGHLHAATC
...|.|.|.  |.|. .. . ..           . |   ....|.|... .          .  ...|| .|..|||         |   |  |  . .
MSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNI

LIDINWV--------------LKIALYGVTNFVC
|.| ||               .||. .|   |..
LVDENWTNVSNYMYNPNADWCCKICDFGLSRFMS
Kinase gcy-27.AA UTK 324-344 38 1.7e-05 14.79 In-house 276-296 (296) Show / Hide 
Range on Protein: 324-344
Range on HMM: 276-296/296
Sequence Identity: 38% (8 aa)

KECWNRDPEKRPTIENLRNAI
..||. ||..||..| |. ..
HRCWHYDPQERPDFEDLVQQM
Kinase gcy-27.AA Pkinase_Tyr 324-344 42 3.9e-05 18.02 Pfam 250-270 (270) Show / Hide 
Range on Protein: 324-344
Range on HMM: 250-270/270
Sequence Identity: 42% (9 aa)

KECWNRDPEKRPTIENLRNAI
|.||. |||.||| . ... .
KQCWHYDPEDRPTFSEIHEQL
Kinase gcy-27.AA Pkinase 265-344 18 5.4e-05 18.74 Pfam 194-293 (293) Show / Hide 
Range on Protein: 265-344
Range on HMM: 194-293/293
Sequence Identity: 18% (19 aa)

DIYCVGMIFYMMIEREDPYRLIHSVERPGSGLMMEILDHNLMPFISNNETQE---------------------DTLLDKCKECWNRDPEKRPTIENLRNA
|.. .| |.| |. .. |..  |    ..   .|.... ...| .. .. ..                     ....| .| |...||.||||.| . . 
DMWSCGCILYEMLCGRPPFP-GHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--I
  .
PWF
Kinase gcy-27.AA TyrKc 91-344 13 0.00041 -156.12 SMART 1-280 (280) Show / Hide 
Range on Protein: 91-344
Range on HMM: 1-280/280
Sequence Identity: 13% (47 aa)

IQFRQ--------------------IKHIDITNASLDFL---YNLKQL--KHDNLANFYGIQLND-----DLNTMTILHALVERGTLEEFCLDRD--FGM
|.. .                    .| .       ||.     ...|  .|.|. ..||. . .         . |.  ... | | ..  ..   . |
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCM

DETFKSAFMRDILKGLQYLHLSPVAYHGHLH---AAT-CLIDINWVLKIALYGVTNFVCDN----FDAENITM----PDR-------------SDY----
..  .  |. .| .| .|||       .  |   ||  ||.. | . ||.  | . .. |        . ...      .              ..    
KDLLS--FCWQIACGMEYLHSK-----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

-------------TISYAQ--YVC-----FPPEHIREYDATGKLPTRFVRG---SKQGDIYCVGMIFYMMIEREDPYRLIHSVERPGSGLMMEILDHNLM
               .| |  |        ......||  .|. . .   .   |                                             
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------------------------------

PFISNNETQEDTLLDKCKECWNRDPEKRPTIENLRNAI
 |     .  | . .  |.||..|||.||| ....  .
-F----VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase gcy-27.AA UTK 112-178 21 0.00253 7.23 In-house 63-135 (296) Show / Hide 
Range on Protein: 112-178
Range on HMM: 63-135/296
Sequence Identity: 21% (16 aa)

LKQLK-HDNLANFYGIQLNDDLNTMTILHALVERGTLEE-------FCLDRDFGMDETFKSAFMRDILKGLQYLH
.||.. | |.....|.....    . |.  . |.| |          . ....  ... .  ...||  |.||||
MKQFHWHPNVLRLVGVCTQEEP--WMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLH
Kinase gcy-27.AA Ciliate-E2 111-178 19 0.007501 5.6 In-house 85-177 (365) Show / Hide 
Range on Protein: 111-178
Range on HMM: 85-177/365
Sequence Identity: 19% (18 aa)

NLKQLKHDNLANFYGIQLNDDLNTMTILHALVERGTLEEFCLDRDF----------GMDETFKSAFMRDILK---------------GLQYLH
.|.||.|.|. ..|    . | |.. .   ... |.|.... ...            ..|   . .|. ||.               .|.|||
ILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLH
Kinase gcy-27.AA TK 112-204 12 0.058152 1.5 In-house 92-293 (486) Show / Hide 
Range on Protein: 112-204
Range on HMM: 92-293/486
Sequence Identity: 12% (25 aa)

LKQLK-----HDNLANFYGIQLNDDL----------NTMTILHALVERGT----LEEFCLD-RDFGMDETFKSA--------------------------
.|...     |.|. ..||. . ..             . |.  ... |     | ..  . |. ...|  ...                          
MKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESN

-----------------------------------------------FMRDILKGLQYLHLSPV-----AYHGHLHAATCLIDINWV-----------LK
                                               ....| .|..|||  ..       |. | |  ||.. | |            |
SPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCK

IA
||
IA
Kinase gcy-27.AA Pkinase 166-178 53 5.296677 1.09 Pfam 113-125 (293) Show / Hide 
Range on Protein: 166-178
Range on HMM: 113-125/293
Sequence Identity: 53% (7 aa)

FMRDILKGLQYLH
.|. ||.||.|.|
YMYQILRGLEYCH
Kinase gcy-27.AA Pkinase_Tyr 112-126 43 5.911139 0.47 Pfam 57-72 (270) Show / Hide 
Range on Protein: 112-126
Range on HMM: 57-72/270
Sequence Identity: 43% (7 aa)

LKQL-KHDNLANFYGI
.||| .|.|. ..||.
MKQLGHHPNIVRLYGV
CYCc gcy-27.AA CYCc 383-574 32 9.1e-72 245.66 SMART 1-231 (231) Show / Hide 
Range on Protein: 383-574
Range on HMM: 1-231/231
Sequence Identity: 32% (74 aa)

LAQMQTMRLLNEMLPASIAKDLKNGV-IAPARSYASATVMFVQICDFIVILKRRPPKEVIGFLNDIFDQFDTVIKRHD--------VETTGETYMVASGV
 ......|||..|||...|..||.|   ... .| ..|..|  |..|  . ... | .|. .|||....||..|.||.        ||| |..|||.||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PNENEG-------------------RHVFEVAEMSLEIRAISLSYTLENDK----NYKLRVRIGFHAGPIAAGVIGIKNPRYCLFGDTVNFASRMQSNCP
| .||                    .|  ..|...|... .. .. ... .    ...||.|||.| ||...||.||. ||||.|||||| ||||.|.. 
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

PLQIQTSEITARML-------LATHEYKLVK
| ||. || | . |        . . . .  
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc gcy-27.AA Guanylate_cyc 410-593 32 2e-45 162.06 Pfam 1-214 (214) Show / Hide 
Range on Protein: 410-593
Range on HMM: 1-214/214
Sequence Identity: 32% (69 aa)

APARSYASATVMFVQICDFIVILKRRP----PKEVIGFLNDIFDQFDTVIKRH--D---VETTGETYMVASGVPNE-----NEGRHVFEVAEMSLEIRAI
 .| .| . |.|| .| .|  .  | .    | ... .|||..  ||... .|  .   |.| | .||..||.|..     .   |   .|.|.|..   
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMM-E

SLSYTLENDKNYK------LRVRIGFHAGPIAAGVIG--IKNPRYCLFGDTVNFASRMQSNCPPL--QIQTSEITARMLLATHEYKLVK----RGIVHVK
....  . ..|.       ...||| | ||  |||||  .. ||||..||||| ||||.|.  |.  .|. || |.| | .  ..  ..    ||...||
YCQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVK

GKGE---VNCYWLNE
|||.   . .|.|. 
GKGKMGEMETYFLHG