Gene H05L14.1 (Nematode worm)

H05L14.1

Species: Nematode worm
Alias: CE16168, aSWK078, H05L14.1
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: I: 7985110-7980530, WormBase Genetic Map location: No interpolated position., Secondary Group: CK1, Secondary Family: Dual

Classification

Group: CK1
Family: Dual

Sequence

Name Sequence Type Origin Length Description Download
H05L14.1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 256 Kinase domain by global Sugen HMM Fasta, JSON
H05L14.1.AA Protein Genbank 794 None Fasta, JSON
H05L14.1.kin_dom2 Protein Kinase Domain Sugen global kinase HMM prediction 276 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of H05L14.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase H05L14.1.AA Dual 130-389 43 5.70000000001e-173 580.94 In-house 12-282 (282) Show / Hide 
Range on Protein: 130-389
Range on HMM: 12-282/282
Sequence Identity: 43% (119 aa)

LRNPVHLGEFNAVNEKNEKFIVRLEPSNRGKLKFGSDVVAEVEKLFAG---------QEKVPVLRNIEFCQTQHLNYWIISPFSLQILEILR--IVKALT
.|...|...|..||.||...|...|.....|......|...|...||.         ............|......||..||......||.|  |...|.
FRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQEIRRKYIMGQLS

VPCAFNVALQTLDAIQYLHQAGFLNRNIKPASFSVGLNEEETKIYMTDYRLVRTHIDPSTKKVRPARTGLKYGGTARYASIAGLKKKDQGRKDDVEAWIY
..|.||||.|.|.|||.||..|.|.||||||.|..||...||..||.|.|.||..|||..||.|.||...|..|..|||..|....||||||||.|.|||
MHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQKDQGRKDDLECWIY

MIYDLIDPENGLSWRKSPRCNMMIKEKENFKYHVLPHTYDKVPEEFKKLVDLVHGYSYDSLPDYAAFKEIV
|..||.|||.|.||||...||||||.|.||.||...|.|...|...|.||..|.||.|||.|||..|    
MVFDLMDPEHGMSWRKECDCNMMIKQKDNFMYHFDKHQYSHIPRRLKPLVSYVNGYQYDSTPDYDYFRNCL
Kinase H05L14.1.AA CK1 141-385 20 2.3e-67 230.11 In-house 24-339 (339) Show / Hide 
Range on Protein: 141-385
Range on HMM: 24-339/339
Sequence Identity: 20% (66 aa)

AVNEKN------EKFIVRLEPSNRGKLKFGSDVVAEVEKLFAGQ-------------------EKVPVLRNIEFCQTQHLNYWIISPFSLQILEILR---
....||      |.. . .|| .  . ..   ..... |.. |.                   .. |... . ... .. || ... .   . ....   
HKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEEDDYYNYMVMTLLGPNLEDLRKQNR

I-VKALTVPCAFNVALQTLDAIQYLHQAGFLNRNIKPASFSVGL-------------NEEETKIYMTDYRLVR-THIDP-----------STKKVRPART
   . .........|.|.|.|..|.| .||. |.|||. | .|.             |.|. ..|| |. ..|   .|.           .|.. ||.|.
MCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYRDKDGHNRWNGPRDKTWQHRPPRE

---GLKYGG-TARYASIAGLKKKDQGRKDDVEAWIYMIYDLIDPENGLSWRKSPRCNM-----MIKEKENFKYHVLPHTYDK---------VPEEFKKLV
     .. | ||||.||.  . |.|||.||...|.||. .......|| |..  . ..     ..|.|..|.   ...| ..         .|.|| |..
HKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKMSTPFFLCCPKKDHDCPQEF-KIM

DLVHGYSYDSLPDYAAF
. .....|.. |||...
KYIRSLKYYDRPDYEMI
Kinase H05L14.1.AA Worm6 215-385 30 7.1e-34 118.87 In-house 99-279 (279) Show / Hide 
Range on Protein: 215-385
Range on HMM: 99-279/279
Sequence Identity: 30% (55 aa)

KALTVPCAFNVALQTLDAIQYLHQAGFLNRNIKPASFSVGL-----NEEETKIYMTDYRLVR-THIDPSTKKVRPAR-TGLKYGGTARYASIAGLKKKDQ
........  .|.|.|.||. ||..||..|..||. | .|      ..|. .||| |. . |    .   ...|. | |  .. || |||..|  |...|
RKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQ

GRKDDVEAWIYMIYDLIDPENGLSWRKSPRCNMMIKEKENFKYHV----LPHTYDKVPE-EFKKLVDLVHGYSYDSLPDYAAF
.||||.| | ||. ..| .  .| ||.. . .   |.|.   ..         . ..|  ||..  | . .||| . |||.  
CRKDDCESWFYMMVEMIVG--CLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase H05L14.1.AA CK1-Unique 221-333 29 6.8e-27 90.27 In-house 118-233 (337) Show / Hide 
Range on Protein: 221-333
Range on HMM: 118-233/337
Sequence Identity: 29% (34 aa)

CAFNVALQTLDAIQYLHQAGFLNRNIKPASFSVGLNE--EETKIYMTDYRLVRT--HIDPSTKKVRPARTGLKYGGTARYASIAGLKKKDQGRKDDVEAW
|| . ..|.|..|   |..||..|..||.... . .   ..  .|| ||   |    ....   .|. |   .. |. .|....  . ...||.|| | |
CAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNN-HQIRQPRPITPFRGCKDYCPCSCHQCREHGRRDDMESW

IYMIYDLIDPENGLSWR
 ||.|.|.. . ||||.
FYMLYHLVHNTRGLSWK
Kinase H05L14.1.AA TTBK 227-385 32 4.5e-22 74.82 In-house 104-257 (257) Show / Hide 
Range on Protein: 227-385
Range on HMM: 104-257/257
Sequence Identity: 32% (52 aa)

LQTLDAIQYLHQAGFLNRNIKPASFSVGLNEEET-KIYMTDYRLVRTHIDPSTKKVRPARTGLKYGGTARYASIAGLKKKDQGRKDDVEAWIYMIYDLID
.| |..|.  |. ||| | |||  |..|.| ... |.|| |. | |  .  ..  |||.|    . ||.|||||   . .. ||.||     ||    . 
VQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTN-ACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFV-

PENGLSWRKSPRCNMMIKEKENFKYHVLPHTYDKVPEEFKKLVDLVHGYSYDSLPDYAAF
 .  | |||    .   . || .   .|    . .|.||.  .| ..   |   |||. .
-QGQLPWRKIKDKDQVGEMKEKYDHRML---LKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase H05L14.1.AA TTBKL 225-389 24 4.7e-19 61.03 In-house 107-288 (288) Show / Hide 
Range on Protein: 225-389
Range on HMM: 107-288/288
Sequence Identity: 24% (46 aa)

VALQTLDAIQYLHQAGFLNRNIKPASFSVGLNEE----ETKIYMTDYRLVRTHIDP----------STKKVRPART---GLKYGGTARYASIAGLKKKDQ
.. |.|.|....| .||. | .||. . .|....    .  .|  |. ..|  ...          .....|..|.        || ||.|..    |.|
IGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNMHDRKEQ

GRKDDVEAWIYMIYDLIDPENGLSWRKSPRCNMMIKEKENFKYHVLPHTYDK---VPEEFKKLVDLVHGYSYDSLPDYAAFKEIV
||.||  .|.|||. | ..   | |. .     ... |.| |  .|    ..    | || | .  ..  .| . |||  . |. 
GRHDDLWSWMYMIIELHCG---LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase H05L14.1.AA CK1-D 225-385 29 2.3e-16 54.08 In-house 100-261 (261) Show / Hide 
Range on Protein: 225-385
Range on HMM: 100-261/261
Sequence Identity: 29% (49 aa)

VALQTLDAIQYLHQAGFLNRNIKPASFSVGLNEEETKIYMTDYRLVRTHIDPSTKKVRPARTGLKYGGTARYASIAGLKKKDQGRKDDVEAWIYMIYDLI
.|.| .  |.|.|   |. | |||  | .||      .|. |. | . . |. |..  | |      ||||||||   .  .| |.||.|.  |..    
LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN

D---PENGL-SWRKSPRCNMMIKEKENFKYHVLPHTYDKVPEEFKKLVDLVHGYSYDSLPDYAAF
    |  ||    |  . . ..  | . | ..| . |   |.||.. .. ..   .|  |||. .
RGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGY---PSEFQQYMNYCRNLKFDDKPDYCYL
Kinase H05L14.1.AA CK1-Unclassified 226-315 39 1e-15 42.86 In-house 110-201 (244) Show / Hide 
Range on Protein: 226-315
Range on HMM: 110-201/244
Sequence Identity: 39% (36 aa)

ALQTLDAIQYLHQAGFLNRNIKPASFSVG-LNEEETKIYMTDYRLVRTHIDP-STKKVRPARTGLKYGGTARYASIAGLKKKDQGRKDDVEA
| | .. |.|||  .|. | |||  | .| |. . ...|. |. |    ||. .|.|  | | . .  ||||||||   . . |.|.|| |.
ADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLES
Kinase H05L14.1.AA CK1-A 228-320 34 1.2e-14 48.09 In-house 103-195 (261) Show / Hide 
Range on Protein: 228-320
Range on HMM: 103-195/261
Sequence Identity: 34% (32 aa)

QTLDAIQYLHQAGFLNRNIKPASFSVGLNEEETKIYMTDYRLVRTHIDPSTKKVRPARTGLKYGGTARYASIAGLKKKDQGRKDDVEAWIYMI
| .  | |.|. .|. | |||  | .|..    |... |. | . . |. |..  | |.  .  ||||||||      .| |.||.|.  |..
QMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVM
Kinase H05L14.1.AA CK1 224-315 34 5.8e-13 41.16 In-house 109-201 (271) Show / Hide 
Range on Protein: 224-315
Range on HMM: 109-201/271
Sequence Identity: 34% (32 aa)

NVALQTLDAIQYLHQAGFLNRNIKPASFSVGL-NEEETKIYMTDYRLVRTHIDPSTKKVRPARTGLKYGGTARYASIAGLKKKDQGRKDDVEA
..| | .. |.|.|  .|. | |||  | .|. . .....|. |. |    .|..|..  | |.. .  ||||||||     . |.|.|| |.
MIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDMES
Kinase H05L14.1.AA Pkinase 222-242 23 0.535259 4.61 Pfam 110-130 (293) Show / Hide 
Range on Protein: 222-242
Range on HMM: 110-130/293
Sequence Identity: 23% (5 aa)

AFNVALQTLDAIQYLHQAGFL
. ....|.| ...|.|. |..
CKFYMYQILRGLEYCHSMGII
Kinase H05L14.1.AA Dual 461-740 51 1e-199 669.75 In-house 1-282 (282) Show / Hide 
Range on Protein: 461-740
Range on HMM: 1-282/282
Sequence Identity: 51% (146 aa)

WKVVRLLGSGGFGDVYKVFDDKAKGPKKTHYALKTESEGGKKAMLRLKVEMQVMITISDARKKSKGDVNRHFVDFIDRGKSEELKCKYIVMSLVGPSLDD
||||.|||||||.|||.|.......||...|.||||||.|.|.|||||||||||......|||.|......|..|.|.||.|..||||.|||..||||..
WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQE

CRRKFGVNLSNTSTPYIIAIQTLESIRDLHNLGYLHRDIKPANFAVGVGAKESTVFMLDFGIGRSYLDPKTKQHRAPRKKVKFLGTLRYASRACMLEVDQ
.|||..............|||.|..|.|||..|||||.||||||..|.|..|.||.|.||.|.|.|.||..|.||..|||||..|..|||.||||...||
IRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQKDQ

GRKDDLECWIYMVFDIFDPKNGVSWKKQRDRVKIREAKQLFFDGKAQYDYAPIS--LRPIIIYINSLQFQTTPEYANLVKTL
|||||||||||||||..||..|.||.|..|.......|..|........|..|.  |.|...|.|..|...||.|....  |
GRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKDNFMYHFDKHQYSHIPRRLKPLVSYVNGYQYDSTPDYDYFRNCL
Kinase H05L14.1.AA CK1 461-736 28 2.3e-104 353.01 In-house 1-339 (339) Show / Hide 
Range on Protein: 461-736
Range on HMM: 1-339/339
Sequence Identity: 28% (98 aa)

WKVVRLLGSGGFG-DVYKV-----FDDKAKGP-KKTHYALKTESE-GGKKAMLRLKVEMQVMITISD---------ARKKSKGDVNRHFVDFIDRGKSEE
||||...|.|||| ..|||      | | ..| |...||.|.|..   .. .......  ....            .....|.. .....  .. .. |.
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

LKCKYIVMSLVGPSLDDCRR--KFGVNLSNTSTPYIIAIQTLESIRDLHNLGYLHRDIKPANFAVGV-------------GAKESTVFMLDFGIGR-SYL
 ...|.||.|.||.|.|.|.  ... .  . .| . ||||.||.....|. |..||||||.||..|.             . .. .|.|.|||. |  |.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DP-----------KTKQHRAPRK---KVKFLG-TLRYASRACMLEVDQGRKDDLECWIYMVFDIFDPKNGVSWKKQRDRVK-----IREAKQLFFDGKAQ
|.           ||.||| ||.   |..| | |.||.|..|.| ..|||.|||..|.||... .....|  |.. .|  |     ....|. |.| |  
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

YDY-----------APISLRPIIIYINSLQFQTTPEYANL
..             | .. .|. ||.||.....|.|...
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase H05L14.1.AA Worm6 461-673 41 8.9e-75 254.74 In-house 1-211 (279) Show / Hide 
Range on Protein: 461-673
Range on HMM: 1-211/279
Sequence Identity: 41% (92 aa)

WKVVRLLGSGGFGDVYKVFDDKAKGPKKTHYALKTES--EGGKKAMLRLKVEMQVMITISDARKKSKGDVNRHFVDFIDRGKSEELKCKYIVMSLVGPSL
|||....|.||||.|||| |.. | .   ..|.| |.  |. |. |  ||.|. |. ..    |..|   .|||....|||| ..   .|||| |||..|
WKVTKKIGEGGFGAVYKVEDKSDKKK--KQFAMKCEKQMENMKRQM--LKMECMVLKAV----KHHK---CRHFCKIEDRGKVDNRGFNYIVMTLVGKNL

DDCRRKFGVNLSNTSTPYIIAIQTLESIRDLHNLGYLHRDIKPANFAVGV-----GAKESTVFMLDFGIGR-SYLDPKTKQHRAPR-KKVKFLGTLRYAS
 | |. .  .    .| . ||||.||.|.|||| |..|||.||.||..|.       ...|..|||||. |  ... | .. | || ....| ||.|||.
WDLRKNRPDRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAP

RACMLEVDQGRKDDLECWIYMV
.||.   .|.||||.|.| ||.
LACHKGQEQCRKDDCESWFYMM
Kinase H05L14.1.AA TTBKL 461-740 26 1.1e-60 203.62 In-house 1-288 (288) Show / Hide 
Range on Protein: 461-740
Range on HMM: 1-288/288
Sequence Identity: 26% (82 aa)

WKVVRLLGSGGFGDVYKVFDDKAKGPKKTHYALKTESEGGKKAMLRLKVEMQVMITISDARKKSKGDVNRHFVDFIDRGKSEELKCKYIVMSLVGPSLDD
|..|...|.|||| ||.| |   .. ||...|.| |         ||  ....|.   . ..|      .||  ... || .  .. ..||.|.||.|.|
WMIVKMIGEGGFGQVYHVWD---MKDKKDCAAMKEE-------KNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRK--DYNFMVMTLCGPNLQD

CRRKFGVN--LSNTSTPYIIAIQTLESIRDLHNLGYLHRDIKPANFAVGVGAK----ESTVFMLDFGIGRSYLDP----------KTKQHRAPRK---KV
 |..  ..  .| ... . |.||.|......|  |..|||.||.|...|. ..    . .|. .|||. | |...          .....|.||.   |.
LRKMMPNKKRFSDGTW-SRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKA

KFLGTLRYASRACMLEVDQGRKDDLECWIYMVFDIFDPKNGVSWKKQRDRVKIREAKQLFFDGKAQYDY-----APISLRPIIIYINSLQFQTTPEYANL
 | ||.||.| .  .  .|||.||| .|.||.   ...     |.   |. .| ..|.   | .  .|       | .. ..  .. ||... .| |  .
PFRGTTRYCSPNMHDRKEQGRHDDLWSWMYMIIELHCG---LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMI

VKTL
 . .
YECF
Kinase H05L14.1.AA CK1-Unique 461-686 29 7.9e-48 163.88 In-house 1-233 (337) Show / Hide 
Range on Protein: 461-686
Range on HMM: 1-233/337
Sequence Identity: 29% (70 aa)

WKVVRLLGSGGFGDVYKVFDDKAKG---PKKTHYALKTESEGGKKAMLRLKVEMQVMITISDAR---KKSKGDVNRHFVDFIDRGKSEELKCKYIVMSLV
|.|  ..|.||.|.|..| .. . |     .  |. |||  . .|   ||..|  ||  |.      |..     |||   .| . .     ..||| ..
WCVIKHIGYGGYGCVHRV-IFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYW-----RHFCEVHDFHQHRDW--WWIVMTMH

GPSLDDCRRKFGV---NLS---NTSTPYIIAIQTLESIRDLHNLGYLHRDIKPANFAVGVGA--KESTVFMLDFGIGRS-YLDPKTKQHRAPRKKVKFLG
|||.. |... .     |.   |  .    . |.|. |.  |  |..||..||.|.  .     .. . .|||.|| |.  .  .  | | ||....| |
GPSMEECCMMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRG

TLRYASRACMLEVDQGRKDDLECWIYMVFDIFDPKNGVSWK
...|....| .....||.||.| | ||  ....   |.|||
CKDYCPCSCHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK
Kinase H05L14.1.AA CK1-Unclassified 461-667 32 1.4e-37 108.45 In-house 1-200 (244) Show / Hide 
Range on Protein: 461-667
Range on HMM: 1-200/244
Sequence Identity: 32% (69 aa)

WKVVRLLGSGGFGDVYKVFDDKAKGPKKTHYALKTESEGGKKAMLRLKVEMQVMITISDARKKSKGDVNRHFVDFIDRGKSEELKCKYIVMSLVGPSLDD
 .|.. .|.| ||..||. . .     ....|.| |..  |     |. | ..|    .   .  .   ...   .  |. |.  . ..||.| ||||.|
YRVIEKIGQGSFGEIYKCINMQ----TNEEVAIKLEKKNSK--HPQLCYEAKIMQYLQNGHNC-DNFI-KGIPKMYWCGQEEQGDYNIMVMDLLGPSLED

----CRRKFGVNLSNTSTPYIIAIQTLESIRDLHNLGYLHRDIKPANFAVG-VGAKESTVFMLDFGIGRSYLDP-KTKQHRAPRKKVKFLGTLRYASRAC
    | |||     .  |   || | .. |  ||| ...|||||| || .|  | .  .|.. |||..  |.|. ||..|   | . .. || ||||   
LFNMCNRKF-----SLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINA

MLEVDQGRKDDLE
 | . |.|.||||
HLGIEQSRRDDLE
Kinase H05L14.1.AA CK1 461-667 33 3.4e-34 115.2 In-house 1-200 (271) Show / Hide 
Range on Protein: 461-667
Range on HMM: 1-200/271
Sequence Identity: 33% (70 aa)

WKVVRLLGSGGFGDVYKVFDDKAKGPKKTHYALKTESEGGKKAMLRLKVEMQVMITISDARKKSKGDVNRHFVDFIDRGKSEELKCKYIVMSLVGPSLDD
 .|.| .|.| |||.|.. .   .| .  |.| | |..  | .   |. | ...    .  ..  .    ..   .  |. |. .. ..||.| ||||.|
YRVGRKIGQGSFGDIYLGINM-TNGEEN-HVAIKLEKNKSK-HP-QLHYEAKIYKILQGH-NC-DN-QCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLED

----CRRKFGVNLSNTSTPYIIAIQTLESIRDLHNLGYLHRDIKPANFAVGV-GAKESTVFMLDFGIGRSYLDPKTKQHRAPRKKVKFLGTLRYASRACM
    | |||        |   || | .. |  .|| ...|||||| || .|. | .. .|.. |||.   |.|.||.||   | . .. || ||||    
LFNFCNRKF-----SLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTH

LEVDQGRKDDLE
| . |.|.||.|
LGIEQSRRDDME
Kinase H05L14.1.AA TTBK 548-736 34 1.1e-32 112.88 In-house 72-257 (257) Show / Hide 
Range on Protein: 548-736
Range on HMM: 72-257/257
Sequence Identity: 34% (65 aa)

YIVMSLVGPSLDDCRRKFGVNLSNTSTPYIIAIQTLESIRDLHNLGYLHRDIKPANFAVG-VGAKESTVFMLDFGIGRSYLDPKTKQHRAPRKKVKFLGT
|.||.| | .| | |||      . ||   . .| |.||.  |..|.||||||| |||.| . ..   ..|||||  | |.  .  . |.||.   | ||
YMVMQLQGKNLADLRRKQPRGCFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACG-EVRPPREVAGFRGT

LRYASRACMLEVDQGRKDDLECWIYMVFDIFDPKNGVSWKKQRDRVKIREAKQLFFDGKAQYDYAPISLRPIIIYINSLQFQTTPEYANL
 ||||    .  . ||.|||    ||            | | .|. .. | |.  .| .   .  |  ..  .  |.||.....|.|. .
VRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQ--LPWRKIKDKDQVGEMKEK-YDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase H05L14.1.AA CK1-D 549-736 31 2.8e-28 96.76 In-house 72-261 (261) Show / Hide 
Range on Protein: 549-736
Range on HMM: 72-261/261
Sequence Identity: 31% (61 aa)

IVMSLVGPSLDD----CRRKFGVNLSNTSTPYIIAIQTLESIRDLHNLGYLHRDIKPANFAVGVGAKESTVFMLDFGIGRSYLDPKTKQHRAPRKKVKFL
.|| |.||||.|    |.||| .      |  ..| | .  |  .|   ..|||||| || .|.| . ..|...|||. . | |..|.|| . | .    
MVMDLLGPSLEDLFNYCHRKFSLK-----TVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLT

GTLRYASRACMLEVDQGRKDDLECWIYMVFDIFD---PKNGVSWKKQRDRVKIREAKQLFFDGKAQYDYAPISLRPIIIYINSLQFQTTPEYANL
|| ||||    . ..| |.||||   |..        |  |.    .|..      |..    .   .  |      . |  .|.|.  |.|. |
GTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase H05L14.1.AA CK1-A 549-736 33 5.3e-26 88.77 In-house 72-261 (261) Show / Hide 
Range on Protein: 549-736
Range on HMM: 72-261/261
Sequence Identity: 33% (65 aa)

IVMSLVGPSLDD----CRRKFGVNLSNTSTPYIIAIQTLESIRDLHNLGYLHRDIKPANFAVGVGAKESTVFMLDFGIGRSYLDPKTKQHRAPRKKVKFL
.|| |.||||.|    |.|.| .      |  ..| | .  |  .|. ...|||||| || .|.|     .|..|||. . | |..|.||   |.  .  
MVMDLLGPSLEDLFNFCKRRFTMK-----TVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLT

GTLRYASRACMLEVDQGRKDDLECWIY--MVFDIFD-PKNGV-SWKKQRDRVKIREAKQLFFDGKAQYDYAPISLRPIIIYINSLQFQTTPEYANL
|| ||||    | ..| |.||.|   |  | |     |  |.    |.    || | |..    .      |  .  .. |. .|.|. .|.|  |
GTARYASINAHLGIEQSRRDDMESMGYVMMYFNRGKLPWQGMKAMTKKQKYEKISE-KKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase H05L14.1.AA S_TKc 461-702 16 1.2e-10 -20.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 461-702
Range on HMM: 1-231/231
Sequence Identity: 16% (47 aa)

WKVVRLLGSGGFGDVYKVFDDKAKGPKKTHYALKTESEGGKKAMLRLKVEMQVMITISDARKKSKGDVNRHFVDFIDRGKSEELKCKYIVMSLVGP---S
....|..|.|.|| |||. . |     . ..|.|  .        ... |.|..                . | ..|   .   .. |.|| ...    .
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK-------EHIRREIQILKK-----------HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGD

LDDCRRKFGVN-----LSNTSTPYIIAIQTLESIRDLHNLGYLHRDIKPANFAVGVGAKESTVFMLDFGIGRSYLDPKTKQHRAPRKKVKFLGTLRYA--
| |  .| | .     ..   . .... |... .  .|..| .|||.||.|  .       ..   |||. | .                | ||. |   
LFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWYMAP

-----SR------------ACMLE----VDQGRKDDLECWIYMVFDIFDPKNGVSWK---------KQRDRVKIREAKQ--------LFF
     ..            . ||      .     ...  . ..          . |           ..|  . || |         .|
EVLGYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase H05L14.1.AA TTBK 461-509 36 4e-06 17.8 In-house 1-46 (257) Show / Hide 
Range on Protein: 461-509
Range on HMM: 1-46/257
Sequence Identity: 36% (18 aa)

WKVVRLLGSGGFGDVYKVFDDKAKGPKKTHYALKTESEGGKKAMLRLKV
||||.  | |||| .|   |   .   . . |.| ||   .|  |.. |
WKVVKKIGGGGFGEIYEAKDMINH---HEQVAIKVESAQQPKQVLKMEV
Kinase H05L14.1.AA CK1-A 461-476 56 0.000104 12.37 In-house 1-16 (261) Show / Hide 
Range on Protein: 461-476
Range on HMM: 1-16/261
Sequence Identity: 56% (9 aa)

WKVVRLLGSGGFGDVY
...|| .||| |||.|
YRLVRKIGSGSFGDIY
Kinase H05L14.1.AA Pkinase 461-482 40 0.000654 14.91 Pfam 1-22 (293) Show / Hide 
Range on Protein: 461-482
Range on HMM: 1-22/293
Sequence Identity: 40% (9 aa)

WKVVRLLGSGGFGDVYKVFDDK
....| .|||.|| |||  . .
YHIGRKIGSGSFGCVYKCHHKG
Kinase H05L14.1.AA Worm6 718-736 26 0.003634 7.61 In-house 261-279 (279) Show / Hide 
Range on Protein: 718-736
Range on HMM: 261-279/279
Sequence Identity: 26% (5 aa)

IIIYINSLQFQTTPEYANL
|  || .......|.|...
IMDYIDQYSYWDRPDYKFI
Kinase H05L14.1.AA CK1-D 461-476 50 0.004878 6.37 In-house 1-16 (261) Show / Hide 
Range on Protein: 461-476
Range on HMM: 1-16/261
Sequence Identity: 50% (8 aa)

WKVVRLLGSGGFGDVY
... | .||| |||.|
YRIGRKIGSGSFGDIY
Kinase H05L14.1.AA CK1 719-734 31 0.087094 2.17 In-house 256-271 (271) Show / Hide 
Range on Protein: 719-734
Range on HMM: 256-271/271
Sequence Identity: 31% (5 aa)

IIYINSLQFQTTPEYA
. |...|.|. .| |.
LNYCRQLHFEEKPDYM
Kinase H05L14.1.AA Pkinase 581-604 41 0.2082 6.06 Pfam 116-139 (293) Show / Hide 
Range on Protein: 581-604
Range on HMM: 116-139/293
Sequence Identity: 41% (10 aa)

QTLESIRDLHNLGYLHRDIKPANF
|.|. .  .|. | .|||.||.|.
QILRGLEYCHSMGIIHRDLKPENI