Gene H25P06.2 (Nematode worm)

H25P06.2

Species: Nematode worm
Alias: CE23826, H25P06.2a, H25P06.2b, H25P06.2, aSWK165
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: I: 11331577-11341191, WormBase Genetic Map location: No interpolated position.,

Classification

Group: CMGC
Family: CDK
Subfamily: CDK9

Sequence

Name Sequence Type Origin Length Description Download
H25P06.2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 340 Kinase domain by global Sugen HMM Fasta, JSON
H25P06.2.AA Protein Genbank 489 None Fasta, JSON

Protein domain

Protein domains of H25P06.2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase H25P06.2.AA CDK9 85-424 75 9.40000000001e-297 992.12 In-house 1-340 (340) Show / Hide 
Range on Protein: 85-424
Range on HMM: 1-340/340
Sequence Identity: 75% (255 aa)

YEKLNKIGQGTFGQVLQGRKSRNSEVFKARCKNTGRMVALKKILMENEKEGFPITALREVKMLEQLKHPNITDLIEVCSAKSTGTTGSKDRATFYLVMAL
||||.|||||||||||||||||||||||||.|...||||.||.||||||||||||||||.|||..|||.|...|||.|..|.|.....|||||||||...
YEKLAKIGQGTFGQVLQGRKSRNSEVFKARHKKNKRMVAMKKVLMENEKEGFPITALREIKMLQLLKHENVVNLIEICRTKATAYNRYKDRATFYLVFDF

CAHDLAGLLSNPKIRMSLVHIKTMMKHLMSGLNKLHRSKILHRDMKAANVLISKDGILKLADFGLARPFVQRENGAGPRPLYTNRVVTLWYRPPELLLGD
|.|||||||||.....||.|||.||.|||.||...||.||||||||||||||.||||||||||||||.|.|..|.|..||||||||||||||||||||||
CEHDLAGLLSNMNVKFSLGHIKKMMQHLMNGLYYIHRNKILHRDMKAANVLITKDGILKLADFGLARAFSQPKNDAPNRPLYTNRVVTLWYRPPELLLGD

RQYGTKIDVWGAGCIMAEMWTRQPIMQGDTEQKQLQLISGLCGSINKDVWPNCVNMPLWSAMSSEPNSALPQGKYRILPNKMKNLMKFDAPDSKTDPFGK
|.||..||.|||||||||||||.|||||.|||.||||||.|||||..||||||.||.||..|||||||.||.|..|.....|||.|||||||||||||||
RNYGPPIDMWGAGCIMAEMWTRSPIMQGNTEQHQLQLISQLCGSITPDVWPNCENMELWNKMSSEPNSELPKGQKRKVKDRMKNYMKFDAPDSKTDPFGK

NVKQHDSATDDDALHLLEILLAIDPDKRPTSDEAEDDIWF
||||||||||..|.||...||.|||.||..||||.|..||
NVKQHDSATDQQACHLIDKLLNIDPKKRMDSDEALDHDWF
Kinase H25P06.2.AA CDK 85-424 36 3.6e-150 483.76 In-house 1-284 (284) Show / Hide 
Range on Protein: 85-424
Range on HMM: 1-284/284
Sequence Identity: 36% (131 aa)

YEKLNKIGQGTFGQVLQGRKSRNSEVFKARCKNTG-----RMVALKKILMEN-----EKEGFPITALREVKMLEQLKHPNITDLIEVCSAKSTGTTGSKD
||||.|||.||.|           .|.|||.|.||     ..|||||| |||     |||||||||.||...| .| ||||  |..||  |.. ... ||
YEKLEKIGEGTYG-----------VVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KD

R--ATFYLVMALCAHDLAGLLSNPKIRMSLVHIKTMMKHLMSGLNKLHRSKILHRDMKAANVLISKDGI-----LKLADFGLARPFVQREN-GAGPRPLY
.   ..|.|.  . |||.....          ||..|. |..||. .|. .|.|||.| .| ||...|.     ||.||||||| |  ... . .|.  |
KHENKLYMVFEYMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMS-EPNRTY

TNRVVTLWYRPPELLLGDRQYG--TKIDVWGAGCIMAEMWT---RQPIMQGDTEQKQLQLISGLCGSINKDVWPNCVNMPLWSAMSSEPNSALPQGKYRI
|..|||||||.||||||...|.  | ||.|..|||.|||.|   |.|...||.|. || .|. .||. . |.||... .|..                  
THEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------

LPNKMKNLMKFDAPDSKTDPFGKNVKQHDSATDDDALHLLEILLAIDPDKRPTSDEAEDDIWF
                                     .||. .|. ||.|| ....| .. .|
-------------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase H25P06.2.AA CMGC 85-424 23 2.4e-119 394.08 In-house 1-513 (513) Show / Hide 
Range on Protein: 85-424
Range on HMM: 1-513/513
Sequence Identity: 23% (124 aa)

YEKLNKIGQGTFGQVLQGRKSRNSEVFKARC--------------KNTGRMVALKKIL---MEN------EKEGFPITALREVKMLEQLK----------
||...|||.||.|           .|.|.|.              ..|...||.|||    .|.      ||.||||.||||.|.|..|.          
YEIIKKIGEGTYG-----------VVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRR

-------HPNITDLIEVCSAKSTGTTGSKDR-------ATFYLVMALCAHDLAGLLSNPK--------IRMSLVH------------IKTMM------KH
       |.||  |....  | . .....|.         .|||. .. |||.... | .        . .|  |            || .|      . 
DDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQ

LMSGLN--KLHRSK--ILHRDMKAANVLISKD--------------------GILKLADFGLARPFVQREN----------------GAGPRPLYTNRVV
.  ||.   .|. .  |.|||.| .|.||...                    |.||..|||||| . ....                . .|.  ||..||
ILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDD-KPNRPYTHYVV

TLWYRPPELLLGD---------RQYGTKIDVWGAGCIMAEMWTR--------QPIMQGDTE-----------QKQLQLISGLCGSIN-------------
|.|||.||.|||.         ..|.|.||.|..|||.|||.|.        .|. .|..|           . ||..|  ..|...             
TRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFC

--KDVWPNCVNMPLWSA-------------MS------SEPNSALPQGKYRILPNKMKNLMK-----------------------FDAPDSKTDPFGKNV
  .. |||....| .               .|       ..|  .|. ... . |..... .                       |.          . .
KHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFN----------H-Q

KQHDSATDDDALHLLEILLAIDPDKRPTSDEAEDDIWF
 . ..  |..|..||. .| .|||||.| ..| .  .|
-FKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase H25P06.2.AA CRK7 85-346 40 1.3e-110 373.8 In-house 1-289 (343) Show / Hide 
Range on Protein: 85-346
Range on HMM: 1-289/343
Sequence Identity: 40% (122 aa)

YEKLNKIGQGTFGQVLQGRKSRNSEVFKARCKNTGRMVALKKILMENE---KEGFPITALREVKMLEQLKHPNITDLIEVCSAKSTGTTGSKDRATFYLV
||... || ||.||           | ||..|.|| ||||||. |.||   |||||||| ||.|.| ||.|.||  | |.   |       |....||.|
YEMIMQIGEGTYGQ-----------VYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMV

MALCAHDLAGLLSNPKIR-MSLVHIKTMMKHLMSGLNKLHRSKILHRDMKAANVLISKDGILKLADFGLARPFVQRENGAGPRPLYTNRVVTLWYRPPEL
     |||.||| .. .   |. ..| .|| |. |.. .|. ..|||| | .|.|.   |..|.|||||||..   |     |. |||||.|||||||||
FEYMDHDLMGLLESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEK----RRPYTNRVITLWYRPPEL

LLGDRQY--------------------------------------GTKIDVWGAGCIMAEMWTRQPIMQGDTEQKQLQLISGLCGSINKDVWPNCVNMPL
|||. .|                                      |. ||.|. |||..|  |..|| ||  | .|| .|. .||| | ..||.   .|.
LLGEERYTEQHILKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPW

WSAM
| .|
WNTM
Kinase H25P06.2.AA CDC2 85-424 34 2.1e-85 262.37 In-house 1-301 (301) Show / Hide 
Range on Protein: 85-424
Range on HMM: 1-301/301
Sequence Identity: 34% (120 aa)

YEKLNKIGQGTFGQVLQGRKSRNSEVFKARCKNTGRMVALKKILMENEKEG--FPITALREVKMLEQLK-HPNITDLIEVCSAKSTGTTGSKDRATFYLV
|.|..||| ||.|           .|.|.. . |...||||||  |.| ||  .| ||.||   |  || ||||. | .|                 |.|
YQKIEKIGEGTYG-----------VVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-----------NKLYMV

MALCAHDLAGLLS--NPK-IRMSLVHIKTMMKHLMSGLNKLHRSKILHRDMKAANVLISKDGILKLADFGLARPFVQRENGAGPRPLYT--NRVVTLWYR
   . .||  ..   .||   |..  .|  |. . .|.. .|. .|.||| |  | ||.|.| .|.||||||| |        |   ||    |||||||
FEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGI------PIRTYTTEHEVVTLWYR

PPELLLGDRQYGTKIDVWGAGCIMAEM---WTRQPIMQGDTEQKQLQLISGLCGSINKDVWPNCVNMPLWSAMSSEPNSALPQGKYRILPNKMKNLMKFD
.||.|||...| | .|.|  |||.|||    |. |. .|| |  ||  |    |. | . ||.. ..| . .   . .   ..   .|.||..|.     
APEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLS---KICPNNQKK-----

APDSKTDPFGKNVKQHDSATDDDALHLLEILLAIDPDKRPTSDEAEDDIWF
             |.  | .|.... ||. .|..|| || ...|| .  .|
-------------KNQ-SCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase H25P06.2.AA CDK7 85-341 38 3.9e-80 213.0 In-house 1-234 (288) Show / Hide 
Range on Protein: 85-341
Range on HMM: 1-234/288
Sequence Identity: 38% (100 aa)

YEKLNKIGQGTFGQVLQGRKSRNSEVFKARCKNTGRMVALKKIL----MENEKEGFPITALREVKMLEQLKHPNITDLIEVCSAKSTGTTGSKDRATFYL
|||. .|| |.|.            |.||. ..||. || |||      .  | |   ||.||.|.|  ..|.|. .|| .  .||            .|
YEKIKHIGEGQFAT-----------VYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKS----------NIQL

VMALCAHDLAGLLSNPKIRMSLVHIKTMMKHLMSGLNKLHRSKILHRDMKAANVLISKDGILKLADFGLARPFVQRENGAGPRPLYTNRVVTLWYRPPEL
|. .   ||       .| .   |||  |. .  ||  .||  |||||.|  | |....|.||.||||||| .     |. |   ||  ||| ||| |||
VFDFMDWDLEVVIKDKSIILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFY-----GS-PNRIYTHQVVTRWYRAPEL

LLGDRQYGTKIDVWGAGCIMAEMWTRQPIMQGDTEQKQLQLISGLCGSINKDVWPNCVNMP
| | |.||| .|.|  |||.||   | |.. || .  ||. |    |  .   |||   |.
LFGARHYGTGVDMWSVGCIFAELMLRVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMM
Kinase H25P06.2.AA S_TKc 85-424 23 1.5e-78 268.21 SMART 1-231 (231) Show / Hide 
Range on Protein: 85-424
Range on HMM: 1-231/231
Sequence Identity: 23% (83 aa)

YEKLNKIGQGTFGQVLQGRKSRNSEVFKARCKNTGRMVALKKILMENEKEGFPITALREVKMLEQLKHPNITDLIEVCSAKSTGTTGSKDRATFYLVMAL
||.|.|||.|.||.| ..|. .           ||| ||.|.|          ....||...|.. .||||  |..|.               .|.|| .
YEILRKIGKGAFGKVYKCRHKK-----------TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----------DHLYMVMEY

CAH---DLAGLLSNPKIR-----MSLVHIKTMMKHLMSGLNKLHRSKILHRDMKAANVLISKDGILKLADFGLARPFVQRENGAGPRPLYTNRVVTLWYR
| .   ||  .. . . .     ..  |.. .|. . ..|. .|. .|.||| | .|.|...   .|..|||||| .             |  ..|.||.
CDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYM

PPELLLGDRQYGT-KIDVWGAGCIMAEMWTRQPIMQGDTEQKQLQLISGLCGSINKDVWPNCVNMPLWSAMSSEPNSALPQGKYRILPNKMKNLMKFDAP
.||.|    .||. |.|.|  |||..|| ...|  .  ..|. ...|                                                     
APEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------------------------------------------------

DSKTDPFGKNVKQHDSATDDDALHLLEILLAIDPDKRPTSDEAED-------DIWF
                  ...|..... .|  ||.||||  ||         . ||
------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase H25P06.2.AA PITSLRE 85-346 39 1.6e-75 257.23 In-house 1-243 (295) Show / Hide 
Range on Protein: 85-346
Range on HMM: 1-243/295
Sequence Identity: 39% (106 aa)

YEKLNKIGQGTFGQVLQGRKSRNSEVFKARCKNTGRMVALKKILME--NEKEGFPITALREVK-MLEQLKHPNITDLIEVCSAKSTGTTGSKDRATFYLV
...||.|. ||.|           .|..|. | |.. ||||.. ||   ||||||||.|||..  |  |.||||  . |.      |... |     |.|
FQCLNRIHEGTYG-----------VVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIV----MGSNMDK----IYMV

MALCAHDLAGLLSNPK---IRMSLVHIKTMMKHLMSGLNKLHRSKILHRDMKAANVLISKDGILKLADFGLARPFVQRENGAGPRPLYTNRVVTLWYRPP
|    |||..|. | |    . ..  ||..|  | .|   .|  .|.||| | .| |.|  ||||..|||||| . .       .  ||  ||||||| |
MEYVEHDLKSLMENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSP------IKPYTPCVVTLWYRAP

ELLLGDRQYGTKIDVWGAGCIMAEMWTRQPIMQGDTEQKQLQLISGLCGSINKDVWPNCVNMPLWSAM
||||| . | | .|.|  |||.||. | .|..||. |  |.. |  . |  .   ||    .|.| .|
ELLLGCKKYSTPVDMWSVGCIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMM
Kinase H25P06.2.AA CDK5 85-343 40 1.1e-73 232.11 In-house 1-233 (287) Show / Hide 
Range on Protein: 85-343
Range on HMM: 1-233/287
Sequence Identity: 40% (105 aa)

YEKLNKIGQGTFGQVLQGRKSRNSEVFKARCKNTGRMVALKKILMENEKEGFPITALREVKMLEQLKHPNITDLIEVCSAKSTGTTGSKDRATFYLVMAL
|||..||| ||.|            |.||| |.|. .||||.. ...| || | ||.||. .|  |||.||  |. |  .    |          ||   
YEKMEKIGEGTYGT-----------VYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLT----------LVFEF

CAHDLAGLLSNPKIRMSLVHIKTMMKHLMSGLNKLHRSKILHRDMKAANVLISKDGILKLADFGLARPFVQRENGAGPRPLYTNRVVTLWYRPPELLLGD
|  ||   . . .  |..  || .|  |. ||   |  ..||||.|  | ||.| |.|||||||||| |     |  |   |.  |||||||||  |.| 
CDQDLKKYMDSCNGEMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAF-----GI-PVRCYSHEVVTLWYRPPDVLMGS

RQYGTKIDVWGAGCIMAEMW-TRQPIMQGDTEQKQLQLISGLCGSINKDVWPNCVNMPLW
..| | ||.| .|||.|||  . .|   |  .. || .|  . |. . | ||   ..| .
KHYSTSIDMWSCGCIFAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDY
Kinase H25P06.2.AA CDK-Unclassified 85-342 31 3.5e-72 236.74 In-house 1-271 (324) Show / Hide 
Range on Protein: 85-342
Range on HMM: 1-271/324
Sequence Identity: 31% (89 aa)

YEKLNKIGQGTFGQVLQGRKSRNSEVFKARCKNTGRMVALKKILMENEKE----------GFPITALREVKMLEQLKHPNITDLIEVCSAKSTGT---TG
|. . |.|.||||           .|.||.  .| . || |||   |.|            ..||..||.. | ...| || .....    .        
YRMQCKYGEGTFG-----------CVCKAIDFQTQKHVAIKKIMVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHYDHDRCSKNPYY

SKDRATFYLVMALCAHDLAGLLSNPKIRMSLVHIKTMMKHLMSGLNKLHRSKILHRDMKAANVLISKDG-----ILKLADFGLARPFV------QRENGA
.     ||.||     .. . | |. .  |   |. .|. . .|.. ||  || ||| | .|..|.  .     .||.||||.|.         .   .|
DNLHPSFYMVMEYMPYTWYNQLHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPA

GPRPLYTNRVVTLWYRPPELLLGDRQYGTKIDVWGAGCIMAEMWTRQPIMQGDTEQKQLQLISGLCGSINKDVWPNCVNMPL
.|  .|.  |.| ||| ||||.|...|.| .|.|..|||.||.  . || || ||  |.  |... |. . | ||. . ||.
DPMQQYSTQVSTRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDMWPDWRYMPD
Kinase H25P06.2.AA Pkinase 85-424 25 1e-71 249.4 Pfam 1-293 (293) Show / Hide 
Range on Protein: 85-424
Range on HMM: 1-293/293
Sequence Identity: 25% (90 aa)

YEKLNKIGQGTFGQVLQGRKSRNSEVFKARCKNTGRMVALKKILMENEKEGFPITALR--EVKMLEQLKHPNITDLIEVCSAKSTGTTGSKDRATFYLVM
|... |||.|.||.|           .|.. |.||..||.|.|  ..||.....|..|  |....  |.||||  |....            .   |.||
YHIGRKIGSGSFGCV-----------YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----------KDHIYMVM

ALCAH-----DLAGLLS-NPKIRM--SLVHIKTMMKHLMSGLNKLHRSKILHRDMKAANVLISKDGIL----KLADFGLARPFVQRENGAGPRPLYTNRV
 .| .     ||. ..|   . ..  |  ..| .|. . .||. .|. .|.|||.| .|.||...| .    |..|||||. |        . . .| ..
EYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFC

VTLWYRPPELLLGDRQYGTKIDVWGAGCIMAEMWTRQPIMQGD----TEQKQLQLISGLCGSINKDVWPNCVNMPLWSAMSSEPNSALPQGKYRILPNKM
.|.||..||...|.. ||.|.|.|..|||..|| ...|. .|.    .   |.|.|    | ...  ||.  .... .  .  . .              
GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--------------

KNLMKFDAPDSKTDPFGKNVKQHDSATDDDALHLLEILLAIDPDKRPTSDEAEDDIWF
                 .  .    ........... .|. || |||| ...  . ||
-----------------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase H25P06.2.AA CDK10 85-342 38 4.9e-68 232.33 In-house 1-233 (285) Show / Hide 
Range on Protein: 85-342
Range on HMM: 1-233/285
Sequence Identity: 38% (99 aa)

YEKLNKIGQGTFGQVLQGRKSRNSEVFKARCKNTGRMVALKKILMENEKEGFPITALREVKMLEQLKHPNITDLIEVCSAKSTGTTGSKDRATFYLVMAL
.||||..| ||.|            |..||   .  .|||||. |. ||.| || .|||...| |..|.|| .| ||   ..            .|||  
FEKLNRVGEGTYGI-----------VYRARDMRSDEIVALKKVRMDKEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQHL--------DSIFLVMQY

CAHDLAGLLSNPKIRMSLVHIKTMMKHLMSGLNKLHRSKILHRDMKAANVLISKDGILKLADFGLARPFVQRENGAGPRPLYTNRVVTLWYRPPELLLGD
|  ||| || |     .  ..| .|  .. ||  ||.  ..|||.| .|.|.. .| .|.||||||| .     |  ..|. | ..|||||| |||||| 
CEQDLASLLDNMPQPFTETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMY-----GVPVKPM-TPKMVTLWYRAPELLLGC

RQYGTKIDVWGAGCIMAEMWTRQPIMQGDTEQKQLQLISGLCGSINKDVWPNCVNMPL
|.  | ||.| .|||..|.   .|.| |  | .|...|  | |. .  .||   ..|.
RTQTTAIDMWAVGCILGELLVHKPLMPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPM
Kinase H25P06.2.AA Pkinase_Tyr 85-251 28 9.9e-17 57.28 Pfam 1-159 (270) Show / Hide 
Range on Protein: 85-251
Range on HMM: 1-159/270
Sequence Identity: 28% (51 aa)

YEKLNKIGQGTFGQVLQGRKSRNSEVFKARCKNTGRMVALKKI---LMENE--KEGFPITALREVKMLEQL-KHPNITDLIEVCSAKSTGTTGSKDRAT-
 ... |.|.| ||.| .|.            .||.  || |..    |. .  .| |    .||.|.. || .||||  |. ||.         ...   
ITFGKKLGEGAFGEVYKGTWKG-------DPDNTKIPVAVKMLKEGAMHEQNCREDF----MREAKIMKQLGHHPNIVRLYGVCT---------DQGEPN

-FYLVMALCAH-DLAGLLSNP---KIRMSLVHIKTMMKHLMSGLNKLHRSKILHRDMKAANVLISKDGILKLADFGLAR
  |.|| ...| ||   | ..   | . .. ..  |     .|.. |.. .. |||  | |.|...... | .||||||
QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase H25P06.2.AA TyrKc 85-422 17 4.2e-12 -26.99 SMART 1-280 (280) Show / Hide 
Range on Protein: 85-422
Range on HMM: 1-280/280
Sequence Identity: 17% (66 aa)

YEKLNKIGQGTFGQVLQGRKSRNSEVFKARCKNTGRMVALKKILMENEKEGFPITALREVKMLEQL--KHPNITDLIEVCSAKSTGTTGSKDR-----AT
 ... |.| | ||.| .|. .              ..|| |..  .          .|| ... .|  .||||  |. ||. ..        |       
ITLGKKLGEGAFGEVYKGTWK--------------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQG--------RNFMYIEP

FYLVMALCAH-DLAGLLSNPKIRMSLVHIKTMMKHLMSGLNKLHRSKILHRDMKAANVLISKDGILKLADFGLARPFVQR-ENGAGPRPLYT-----NRV
 ..|| ...| ||   | ... . .. .   ..    .| . ||. .. |||  | |.|...... | .||||.|      ..|      |.     .. 
LMIVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGK

--VTLWYRPPELLLGDRQYGTKIDVWGAGCIMAEMWTR-----QP--------------IMQGDTEQKQLQL--ISGLCGSINKDVWPNCVNMPLWSAMS
  . .   .|| .  .. . || |||  |  | |. |.                     ..||.   .      .|                        
TMLPIRWMAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------

SEPNSALPQGKYRILPNKMKNLMKFDAPDSKTDPFGKNVKQHDSATDDDALHLLEILLAIDPDKRPTSDEAEDDI
                                  |         ..|.    . .   . ||..|||  |  ...
----------------------------------F-------VCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase H25P06.2.AA CRK7 384-424 30 8e-06 15.76 In-house 301-343 (343) Show / Hide 
Range on Protein: 384-424
Range on HMM: 301-343/343
Sequence Identity: 30% (13 aa)

KNVKQHDS--ATDDDALHLLEILLAIDPDKRPTSDEAEDDIWF
... .|      . ..| ||  .|. ||.|| |  |. .  ||
EEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase H25P06.2.AA CDK7 391-424 29 1.4e-05 10.36 In-house 255-288 (288) Show / Hide 
Range on Protein: 391-424
Range on HMM: 255-288/288
Sequence Identity: 29% (10 aa)

SATDDDALHLLEILLAIDPDKRPTSDEAEDDIWF
.|  ||.|.|.. ... .| || |  ..     |
TAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase H25P06.2.AA CDK10 398-424 33 0.002134 7.38 In-house 259-285 (285) Show / Hide 
Range on Protein: 398-424
Range on HMM: 259-285/285
Sequence Identity: 33% (9 aa)

LHLLEILLAIDPDKRPTSDEAEDDIWF
..||..|.  .| || |..|. .  .|
RRLLNFLFMYNPKKRATAEECLESSYF
Kinase H25P06.2.AA PITSLRE 395-424 33 0.002989 7.94 In-house 266-295 (295) Show / Hide 
Range on Protein: 395-424
Range on HMM: 266-295/295
Sequence Identity: 33% (10 aa)

DDALHLLEILLAIDPDKRPTSDEAEDDIWF
| .. ||  .|  .| .| | ..| .. ||
DTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase H25P06.2.AA CDK5 394-424 25 0.005168 4.82 In-house 257-287 (287) Show / Hide 
Range on Protein: 394-424
Range on HMM: 257-287/287
Sequence Identity: 25% (8 aa)

DDDALHLLEILLAIDPDKRPTSDEAEDDIWF
|   . ||. .| ..|..| . ..|    .|
DEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase H25P06.2.AA CDK-Unclassified 404-424 23 0.051178 2.27 In-house 304-324 (324) Show / Hide 
Range on Protein: 404-424
Range on HMM: 304-324/324
Sequence Identity: 23% (5 aa)

LLAIDPDKRPTSDEAEDDIWF
... .|..|..  |.    ||
MVMYQPYNRWKCMEILQHPWF