Gene hpk-1 (Nematode worm)

hpk-1

Species: Nematode worm
Alias: hpk-1, CE04430, F20B6.8, aSWK178, F20B6.8a
External Links: Wormbase Link ,
Annotation: WormBase Physical Map location: X: 4218520-4215494, WormBase Genetic Map location: n/a,

Classification

Group: CMGC
Family: DYRK
Subfamily: HIPK

Sequence

Name Sequence Type Origin Length Description Download
hpk-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 337 Kinase domain by global Sugen HMM Fasta, JSON
hpk-1.AA Protein Genbank 821 None Fasta, JSON

Protein domain

Protein domains of hpk-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase hpk-1.AA HIPK 122-458 68 7.50000000001e-238 757.53 In-house 1-329 (329) Show / Hide 
Range on Protein: 122-458
Range on HMM: 1-329/329
Sequence Identity: 68% (231 aa)

YEVLEFLGKGTFGQVVKAWKKGTSEIVAIKILKKHPSYARQGQIEVSILSRLSNENSEEFNFVRAFECFNHKSHTCLVFEMLEQNLYDFLKQNKFMPLPL
||||||||.||||||||.||.||.|.|||||||.||.||||||||||||..||.||..|..||||.|||.||.||||||||||||||||.||||||||||
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADEYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLPL

NAIRPILFQVLTALLKLKSLGLIHADLKPENIMLVDPQQQPYRVKVIDFGSASHRSKAVTNTYLQSRYYRAPEIILGLPFNESIDMWSLGCVIAELFLGW
..|||||.||||||.|||.||||||||||||||||||...||||||||||||||.||.|.||||||||||||||||||||.|..||||||||||||||||
KHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLGW

PLYPGSSEYDQIRFIIQTQGLPPTSMLESASKLHRFFKEVKSESPNHTNVGGSYYRLKTVEEYEASSSTAKSKETRKYIFNVIDDISRVCYGFESDPVEH
|||||..||||||.|.|||.|| ...|..|.| ||||...       .... ...|||..||.|...| .||||.||||||..||...|.. ........
PLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRD-------KQSKFRPWRLKHIEEHEQQTS-VKSKEARKYIFNCLDDMPEVNMLVDPERQDY

LCDRIDRQEFVDVLKKMLVLNPDFRITPAEGLESKFV
....|||.|||.|||||...... ||||.|.|...||
RVEKIDRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase hpk-1.AA DYRK 122-458 38 8.10000000001e-176 590.38 In-house 1-320 (320) Show / Hide 
Range on Protein: 122-458
Range on HMM: 1-320/320
Sequence Identity: 38% (131 aa)

YEVLEFLGKGTFGQVVKAWKKGTSEIVAIKILKKHPSYARQGQIEVSILSRLSNE-NSEEFNFVRAFECFNHKSHTCLVFEMLEQNLYDFLKQNKFMPL-
||.||..|||.||||||.|...| |.|||||........||.|||..||..|... . .....|.....|.|. |.|.|||.|..|||.|||.|.| .. 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

PLNAIRPILFQVLTALLKLKSL-GLIHADLKPENIMLVDPQQQPYRVKVIDFGSASHRSKAVTNTYLQSRYYRAPEIILGLPFNESIDMWSLGCVIAELF
.||..|....|.||.|..|...  .||.|||||||||..| ......|||||||... .. .  ||.|||.|||||.|||.|....||||||||..||||
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQP-RNKSTIKVIDFGSSCFEHQ-RIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELF

LGWPLYPGSSEYDQIRFIIQTQGLPPTSMLESA--SKLHRFFKEVKSESPNHTNVGGSYYRLKTVEEYEASSSTAKSKETRKYIFNVIDDISRVCYGFES
.||||.||..||||...|....|.||  |....  .. |.||..                  .. .| . .. . |...............  ...  ..
TGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC------------------FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGR

DPVEHLCDRIDRQEFVDVLKKMLVLNPDFRITPAEGLESKFV
 . .....  |...|.| .||.|...|. ||||.. |. ...
RNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase hpk-1.AA CMGC 122-458 21 5.5e-103 339.34 In-house 1-513 (513) Show / Hide 
Range on Protein: 122-458
Range on HMM: 1-513/513
Sequence Identity: 21% (111 aa)

YEVLEFLGKGTFGQVVKAWKKGTS--------------EIVAIKILKKHPSYARQGQ-------------IEVSILSRLS------------NENSEEFN
||... .|.||.|.|.|.. | |               ||||||..|. . | .|..              |..|| .|.             .|  . |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

FVRAFECFNHKS-----------------HTCLVFEMLEQNLYDFLKQNK--------------------------FMPLPLNAIRPILFQVLTALL--K
 |. ...| ||                  | .|||| ....||...|.|.                             ... .|| . .|.|..|    
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

LKSLG--LIHADLKPENIMLVDPQQQP----------------YRVKVIDFGSASHRSKA-----------------------VTNTYLQSRYYRAPEII
. | .   || |||||||.. .  . .                .|.|..|||.| . ..                           .| ..|.||||||.
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LGLP----------FNESIDMWSLGCVIAELFLG--------WPLYPGSSE-----------YDQIRFIIQTQGLPPTSMLESASKLHRFFKEVKSESPN
|| .          ....|||||.||..||...|        .|| ||.||           .||.  |... | |. .|....   | | .  .. . .
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGK-RH-F-N-FCKHEEE

HTNVGGSYYRLKTVE----EYEASSSTAKSKETRKYIFNVIDDISRVCYGFES-----------------------DPVEHL------CDRIDRQEFVDV
  |. . ... |. .    .   .... .|.  |.||.. ..   . .  ...                        .. .       ... . ....| 
WPNMIKLPWYNKFPKKWNWQ---TMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDL

LKKMLVLNPDFRITPAEGLESKFV
|||||...|| |||... |.  . 
LKKMLQYDPDKRITAEQALQHPYF
Kinase hpk-1.AA YAK 122-403 41 2.6e-100 339.58 In-house 1-289 (347) Show / Hide 
Range on Protein: 122-403
Range on HMM: 1-289/347
Sequence Identity: 41% (123 aa)

YEVLEFLGKGTFGQVVKAWKKGTSEIVAIKILKKHPSYARQGQIEVSILSRL-SNENSEEFN----FVRAFECFNHKSHTCLVFEMLEQNLYDFLKQNKF
| ||  ||.||||||||  . .| |..|.|..|  . |  |.  |. ||  |   .  .. |    ..|    | || | |||||||. |||..||||||
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

MPLPLNAIRPILFQVLTALLKLKSLGLIHADLKPENIMLVDPQQQPYRVKVIDFGSASHRSKAVTNTYLQSRYYRAPEIILGLPFNESIDMWSLGCVIAE
  .  . ||  . |.| ..  |..  .|| |||||||||  |  .|  .|.|||||.    | |. || |.|.||.||||.. ..  |||||||||..||
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKP-NKP-EIKIIDFGSSCQEKKMVY-TYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAE

LFLGWPLYPGSSEYDQIRFIIQTQGLPPTSMLESASKLHRFFKEVKS-------ESPNHTNVGGSYYRLKTVEEYEASSSTAKSKETRKYIFNV
|||| |..|| |||.||  || . | ||  |..      ..|.              |  |    || .|| ..|. .. . . || ..| |..
LFLGLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYFHCHDGSNSDDNNNNNNNNNGKPYYYIFKTKQDYQIDEKI-QLKESKTY-FQY
Kinase hpk-1.AA DYRK2 122-361 39 3.4e-87 283.59 In-house 1-239 (318) Show / Hide 
Range on Protein: 122-361
Range on HMM: 1-239/318
Sequence Identity: 39% (96 aa)

YEVLEFLGKGTFGQVVKAWKKGTSEIVAIKIL---KKHPSYARQGQIEVSILSRLSNENSEE-FNFVRAFECFNHKSHTCLVFEMLEQNLYDFLKQNKFM
||.||..||| ||||||.  . | . ||||..   |.   ...| ..|. ||....  .  . .| |. .. |    |.|..|| |  |||...|.|.| 
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKR---FHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQ

PLPLNAIRPILFQVLTALLKLKSLGLIHADLKPENIMLVDPQQQPYRVKVIDFGSASHRSKAVTNTYLQSRYYRAPEIILGLPFNESIDMWSLGCVIAEL
 . |. .|.  ...|..|  |.   .||.|||||||.|   |. .  .|||||||          || |||.|||||.|||.... .|||||.||..|||
GFSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLK--QWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAEL

FLGWPLYPGSSEYDQIRFIIQTQGLPPTSMLESASKLHRFFKEV
. | || ||. | ||.  ..   |.|| .... .  .|.| ...
YTGYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKY
Kinase hpk-1.AA S_TKc 122-458 22 6.5e-79 269.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 122-458
Range on HMM: 1-231/231
Sequence Identity: 22% (78 aa)

YEVLEFLGKGTFGQVVKAWKKGTSEIVAIKILKKHPSYARQGQIEVSILSRLSNENSEEFNFVRAFECFNHKSHTCLVFEMLEQ---NLYDFLKQNKF--
||.|. .|||.||.| |...|.| .||||||.|      .. . |..||..         | |. ...| . .| ..|.|....   .|.|..|...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

--MPLPLNAIRPILFQVLTALLKLKSLGLIHADLKPENIMLVDPQQQPYRVKVIDFGSASHRSKAVTNTYLQSRYYRAPEIILGLPFNE-SIDMWSLGCV
   |.|   .| .. |.. ||  . |.| || |||||||.| .      ..|..|||.| .      .|.  ...|.|||..   ...  ..|.||.||.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

IAELFLGWPLYPGSSEYDQIRFIIQTQGLPPTSMLESASKLHRFFKEVKSESPNHTNVGGSYYRLKTVEEYEASSSTAKSKETRKYIFNVIDDISRVCYG
..|.. | |..|   .....  .|                                                                            
LYEMLCGYPPFP---QMQMMFKKIG---------------------------------------------------------------------------

FESDPVEHLCDRIDRQEFVDVLKKMLVLNPDFRITPAEGLE-------SKFV
               .|. | ..|.|. .|. |.|  | |.         ..
--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase hpk-1.AA DYRK1 122-365 41 3.3e-76 259.47 In-house 1-244 (321) Show / Hide 
Range on Protein: 122-365
Range on HMM: 1-244/321
Sequence Identity: 41% (102 aa)

YEVLEFLGKGTFGQVVKAWKKGTSEIVAIKILKKHPSYARQGQIEVSILSRLSNENSEE-FNFVRAFECFNHKSHTCLVFEMLEQNLYDFLKQNKFMPLP
||.   .||| |||||||. . . | |||||.|   ..  | |||. .|  . ..  |. .. |.  . | .. | |||||.|  |||| |.  .|    
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LNAIRPILFQVLTALLKLKS--LGLIHADLKPENIMLVDPQQQPYRVKVIDFGSASHRSKAVTNTYLQSRYYRAPEIILGLPFNESIDMWSLGCVIAELF
|| .| .  |..|||| . .  | .|| |||||||.|. |.     .|.|||||. .  . . . |.|||.||.||..||.... .||||||||.. |. 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRS--AIKIIDFGSSCQLGQRIYQ-YIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMH

LGWPLYPGSSEYDQIRFIIQTQGLPPTSMLESASKLHRFFKEVKSES
 | ||. ||.| ||.  |.   |.||  |...| | |..|.  . ..
TGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKDPDNT
Kinase hpk-1.AA Pkinase 122-458 24 1.4e-57 202.41 Pfam 1-293 (293) Show / Hide 
Range on Protein: 122-458
Range on HMM: 1-293/293
Sequence Identity: 24% (87 aa)

YEVLEFLGKGTFGQVVKAWKKGTSEIVAIKILKKHPSYARQGQI-----EVSILSRLSNENSEEFNFVRAFECFNHKSHTCLVFEMLEQ-----NLYDFL
|.... .|.|.||.| |. .|||..|||.||.||.     . |.     |..|. ||. .|      || ...|  |.| ..|.| .|       |.|..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPN-----IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

K---QNKFMPLPLNAIRPILFQVLTALLKLKSLGLIHADLKPENIMLVDPQQQPYRVKVIDFGSAS---HRSKAVTNTYLQSRYYRAPEIIL-GLPFNES
.   ...|. .. . .. .. |.| .|  . | | || |||||||....  . . .||..|||.|    . ..  ..|.  ...|.|||.|. | .   .
STWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

IDMWSLGCVIAELFLGWPLYPGS----SEYDQIRFIIQTQGLPPTSMLESASKLHRFFKEVKSESPNHTNVGGSYYRLKTVEEYEASSSTAKSKETRKYI
.||||.||...|...| |..||.    . .||.  | .. | |. .  .  .   .||     . .                                  
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----------------------------------

FNVIDDISRVCYGFESDPVEHLCDRIDRQEFVDVLKKMLVLNPDFRITPAEGLESKFV
                 . . .      .|. |..|..| ..|  |.|... |.....
-----------------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase hpk-1.AA PRP4 122-348 37 2.7e-53 183.37 In-house 1-229 (320) Show / Hide 
Range on Protein: 122-348
Range on HMM: 1-229/320
Sequence Identity: 37% (87 aa)

YEVLEFLGKGTFGQVVKAW-KKGTSEIVAIKILKKHPSYARQGQIEVSILSRLSNE--NSEE-FNFVRAFECFNHKSHTCLVFEMLEQNLYDFLKQN-KF
|.|  . |.| |. |...  .  . | |||||.   ..  . |  |. || .|..    ... |  || |. |||. | ||||| .  || . ||.  | 
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

MPLPLNAIRPILFQVLTALLKLKSLGLIHADLKPENIMLVDPQQQPYRVKVIDFGSASHRSKAVTNTYLQSRYYRAPEIILGLPFNESIDMWSLGCVIAE
  | |.|.|    | . ||  || .. .|||.|| ||.    ..     | .||||||| .      ||.||.|||||||.| |.  .||||| || ..|
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNESKNT---LKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYE

LFLGWPLYPGSSEYDQIRFIIQTQGLPPTSML
|. |  ..||..  . ....    |  |  |.
LYTGKIMFPGKTNNHMLKLFMDYKGKMPNKMI
Kinase hpk-1.AA CLK 122-263 29 1.2e-48 143.55 In-house 1-161 (350) Show / Hide 
Range on Protein: 122-263
Range on HMM: 1-161/350
Sequence Identity: 29% (48 aa)

YEVLEFLGKGTFGQVVKAWKKGTS-EIVAIKILKKHPSYARQGQIEVS-ILSRLSNE-NSEEFNF---VRAFECFNH-KSHTCLVFEMLEQNLYDFLKQN
||..  || |||| ||. |    .   ||.|| . .  |  . ..|.. |.  . .  ...  .    .. ...|.. . | |.|||..  ..|||.| |
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

K------FMPLPLNAIRPILFQVLTALLKLKSLGLIHADLKPENIMLVDP------QQQPY
.      . |.|...|| . .| ..|. .| ...|.| ||||||| .||.      .  .|
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRFTHFDCTFKY
Kinase hpk-1.AA RCK 198-333 39 7.4e-40 123.96 In-house 77-223 (298) Show / Hide 
Range on Protein: 198-333
Range on HMM: 77-223/298
Sequence Identity: 39% (59 aa)

LVFEMLEQNLYDFLKQ--NKFMPLPLNA--IRPILFQVLTALLKLKSLGLIHADLKPENIMLVD-----PQQQPYRVKVIDFGSA-SHRSKA-VTNTYLQ
.||| ...||| ..|    .  .|| |   |. |..|.| .|  . . |  | ||||||||. .      .| ....|..|||.. . |||   |  |  
FVFEYMDMNLYQMMKDFKERRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTD-YVS

SRYYRAPEIILGL-PFNESIDMWSLGCVIAELFLGWPLYPGSSEYDQI
.|.|||||..|     |. .|.|..||...||   .||.||||| |||
TRWYRAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQI
Kinase hpk-1.AA CDK 198-458 22 5.3e-36 112.57 In-house 95-284 (284) Show / Hide 
Range on Protein: 198-458
Range on HMM: 95-284/284
Sequence Identity: 22% (64 aa)

LVFEMLEQNLYDFLKQNKFMPLPLNAIRPILFQVLTALLKLKSLGLIHADLKPENIMLVDPQQQ--PYRVKVIDFGSASHRSKAV-------TNTYL---
.||| ... |. ...           |. ...| | .|  . | . .| |||| || |.. . .  . |.|. ||| |  | . .       ..||    
MVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNI-LINNNGEVKCGRLKIADFGLA--RAFGIPHQMSEPNRTYTHEV

QSRYYRAPEIIL-GLPFN--ESIDMWSLGCVIAELFL---GWPLYPGSSEYDQIRFIIQTQGLPPTSMLESASKLHRFFKEVKSESPNHTNVGGSYYRLK
  . |||||. |     .   .|||||.||..||.|.   . || ||.|| ||.  |... | |  ..  . .||  .                      
VTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY----------------------

TVEEYEASSSTAKSKETRKYIFNVIDDISRVCYGFESDPVEHLCDRIDRQEFVDVLKKMLVLNPDFRITPAEGLESKFV
                                                     | | |||...|. ||.  . |.... 
-----------------------------------------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase hpk-1.AA CLK 265-326 42 3.7e-22 62.6 In-house 186-249 (350) Show / Hide 
Range on Protein: 265-326
Range on HMM: 186-249/350
Sequence Identity: 42% (29 aa)

VKVIDFGSAS-------HRSKAVTNTYLQSRYYRAPEIILGLPFNESIDMWSLGCVIAELFLGWPLYPG
..|||||||        | |  |     ..| |||||.||||....  | || ||.. || .|  |...
ICVIDFGSATKIRFDHEHHSTIV-----STRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQT
Kinase hpk-1.AA RCK 122-156 51 5.1e-13 37.36 In-house 1-35 (298) Show / Hide 
Range on Protein: 122-156
Range on HMM: 1-35/298
Sequence Identity: 51% (18 aa)

YEVLEFLGKGTFGQVVKAWKKGTSEIVAIKILKKH
| ... ||.||.| |.|| .| | |||||| .|..
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQK
Kinase hpk-1.AA CDK 122-154 44 5.3e-11 31.28 In-house 1-38 (284) Show / Hide 
Range on Protein: 122-154
Range on HMM: 1-38/284
Sequence Identity: 44% (17 aa)

YEVLEFLGKGTFGQVVKAWKKGTS-----EIVAIKILK
|| || .| ||.|.| ||  | |      .|||.| ..
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIR
Kinase hpk-1.AA TyrKc 122-457 17 2.6e-08 -88.19 SMART 1-280 (280) Show / Hide 
Range on Protein: 122-457
Range on HMM: 1-280/280
Sequence Identity: 17% (66 aa)

YEVLEFLGKGTFGQVVKAWKKGTSEIVAIKILKKHPSYARQGQIEVSILSRL--SNENSEEFNFVRAFECFNHK------SHTCLVFEMLEQ-NLYDFLK
 . .. || | ||.|.|.  |   . ||.| ||..    .    | .|...|  ...|    ... .  |  ..         ..|.|  .  .| |.|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPN--IVRLYGV--CTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

QNK-FMPLPLNAIRPILFQVLTALLKLKSLGLIHADLKPENIMLVDPQQQPYRVKVIDFG-SASHRSK----AVTNTYL-----QSR-----YYRAPEII
 ..    |..     . .|.      | | ..|| ||   |... ...    .||. ||| |  . ..    . . .|      ...        ||| |
KHRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

LGLPFNESIDMWSLGCVIAELF-LGWPLYPG-----SSEYDQIRFIIQTQGLPPTSMLE--SASKLHRFFKEVKSESPNHTNVGGSYYRLKTVEEYEASS
    |..  | || | .. |.| .| . |||      | .. |... |   .|.    .  |                                      
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------------------

STAKSKETRKYIFNVIDDISRVCYGFESDPVEHLCDRIDRQEFVDVLKKMLVLNPDFRITPAEGLESKF
                                     .  .|  .. |.    .|. | | .| . ..|
----------------------------------F-VCCPDEMYQIMKQCWHEDPEDRPTFSE-IHECF
Kinase hpk-1.AA DYRK1 427-458 40 2.5e-05 14.11 In-house 290-321 (321) Show / Hide 
Range on Protein: 427-458
Range on HMM: 290-321/321
Sequence Identity: 40% (13 aa)

DRQEFVDVLKKMLVLNPDFRITPAEGLESKFV
| . | |..|.||  .|  |||| . |. .|.
DYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase hpk-1.AA Pkinase_Tyr 122-156 35 3.6e-05 18.13 Pfam 1-39 (270) Show / Hide 
Range on Protein: 122-156
Range on HMM: 1-39/270
Sequence Identity: 35% (14 aa)

YEVLEFLGKGTFGQVVKAWKK----GTSEIVAIKILKKH
 . .. ||.| ||.|.|.  |    .|   ||.|.|| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG
Kinase hpk-1.AA PRP4 429-458 43 4.5e-05 14.62 In-house 291-320 (320) Show / Hide 
Range on Protein: 429-458
Range on HMM: 291-320/320
Sequence Identity: 43% (13 aa)

QEFVDVLKKMLVLNPDFRITPAEGLESKFV
. | |.| |.|.| |  |||. | |.  |.
HQFKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase hpk-1.AA RCK 429-458 30 0.000124 10.3 In-house 269-298 (298) Show / Hide 
Range on Protein: 429-458
Range on HMM: 269-298/298
Sequence Identity: 30% (9 aa)

QEFVDVLKKMLVLNPDFRITPAEGLESKFV
|. .....|||  .|. |||... |. .. 
QDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase hpk-1.AA DYRK2 431-458 28 0.004607 5.43 In-house 291-318 (318) Show / Hide 
Range on Protein: 431-458
Range on HMM: 291-318/318
Sequence Identity: 28% (8 aa)

FVDVLKKMLVLNPDFRITPAEGLESKFV
|.| .|. ..  |. |.||...|. .. 
FIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase hpk-1.AA CLK 422-458 29 0.007255 3.62 In-house 314-350 (350) Show / Hide 
Range on Protein: 422-458
Range on HMM: 314-350/350
Sequence Identity: 29% (11 aa)

LCDRIDRQEFVDVLKKMLVLNPDFRITPAEGLESKFV
.|.  . ... | ..|||   |  ||| .. |   | 
DCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF