Gene K06H7.8 (Nematode worm)
K06H7.8
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| K06H7.8.AA | Protein | Genbank | 346 | None | Fasta, JSON |
| K06H7.8.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 280 | Kinase domain by global Sugen HMM | Fasta, JSON |
Protein domains of K06H7.8.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | K06H7.8.AA | TTBKL | 20-283 | 39 | 5.5e-147 | 494.6 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 20-283 Range on HMM: 1-288/288 Sequence Identity: 39% (113 aa) YKVVQKLGEGGCGSVFKVEDTSEKGQHYALKVEFKS-QDAGNILKMEVQILSQLI--SKKHVAKCVASGKKERYSYMVMTLLGESLDSLLKKHGPF--LN ...|...||||.|.|..|.|.. |....|.|.|... . ....||||..|..| ...|..||..|||...|..|||||.|..|. | |.. . .. WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS VSTQVRIGICILFGIKQVHDIGYLHRDLKPANVAMGCKGS-ADE-RYFLVLDFGLARQYIADEDDG--------LKMRRPRE---KTYFRGTARYCSVAM ..|..||||..|...||.||.|..|||.||.|...|.... ... |.....|||.||||. ..... ..|||||. |. |||| ||||..| DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM HDRYEQGRVDDLWALVYILAEMRCRLAWHDVDDKVEIGEMKRKIHDEVLFAK------SPVQMLSFVKTVRSTLFYHRPDYEKLFKLL |||.||||.||||.. |...|..|.| |....|| ||..||.. .||.|| . .| ....|.|..|| .|.|||||...... HDRKEQGRHDDLWSWMYMIIELHCGLPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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| Kinase | K06H7.8.AA | CK1 | 20-279 | 30 | 8.8e-102 | 344.45 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 20-279
Range on HMM: 1-339/339
Sequence Identity: 30% (103 aa)
YKVVQKLGEGGCG-SVFKV-----EDTSEKG----QHYALKVEFK-SQDAGNILKMEVQILSQLIS--------------------KKHVAKCVASGKKE
.|||.|.||||.| ..|| .|.. .. ..||.||| | | . . |..|.|.. .| ..|. ... .|...
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED
RYS-YMVMTLLGESLDSLLK--KH-GPFLNVSTQVRIGICILFGIKQVHDIGYLHRDLKPANVAMGCKGS-----------ADERYFLVLDFGLAR-QYI
.| ||||||||..|..|.| . . ....| ..|.|..|......||.|..|||.||.|..|| ..| ..| . ..|||.|| .|.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR
ADEDDG---------LKMRRPRE---KTYFRG-TARYCSVAMHDRYEQGRVDDLWALVYILAEMR-CR--LAWHDVDDKVE-----IGEMKRKIHDEVLF
. ... ..|.||| |. ||| ||||||...|.. ||||.||||.. | |.|. . | |....|. . ...||....|| ..
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM
AK------------SPVQMLSFVKTVRSTLFYHRPDYEKL
.| .. ..| .|| .|.|||||..
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
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| Kinase | K06H7.8.AA | TTBK | 20-279 | 39 | 4.5e-71 | 242.43 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 20-279 Range on HMM: 1-257/257 Sequence Identity: 39% (104 aa) YKVVQKLGEGGCGSVFKVEDTSEKGQHYALKVEFKSQDAGNILKMEVQILSQLISKKHVAKCVASGKKERYSYMVMTLLGESLDSLLKK--HGPFLNVST |||.| | || | .. .| . . |.||| ..| .||||| .| .| ..|| . . | ... ||||.|.|..| | | | | ..|| WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVE-SAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCF-SLST QVRIGICILFGIKQVHDIGYLHRDLKPANVAMGCKGSADERYFLVLDFGLARQYIADEDDGLKMRRPREKTYFRGTARYCSVAMHDRYEQGRVDDLWALV .|.|. || .|...|..|.|||| || | ||| . .. | |||||||||. . . | ||| . ||||.|| |. | | || |||| | TLRLGVQILQSIESIHSVGFLHRDIKPSNFAMG-RNPSTCRKCYMLDFGLARQYTNACGE---VRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLF YILAE-MRCRLAWHDVDDKVEIGEMKRKIHDEVLFAKSPVQMLSFVKTVRSTLFYHRPDYEKL |.| | . | | . || ..|||| | .| | .. |.. ..| . |||| . YMLVEFVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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| Kinase | K06H7.8.AA | Worm6 | 20-279 | 32 | 1.3e-55 | 191.09 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 20-279 Range on HMM: 1-279/279 Sequence Identity: 32% (91 aa) YKVVQKLGEGGCGSVFKVEDTSEKGQ-HYALKVEFK-SQDAGNILKMEVQILSQLISKK--HVAKCVASGKKER--YSYMVMTLLGESLDSLLKKHGP-- .||..|.||||.|.|.||||.| | ..|.|.| . . . . ||||. .| . .| |. | . ||... . |.||||.|..| . |.|. | WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNL-WDLRKNRPDR FLNVSTQVRIGICILFGIKQVHDIGYLHRDLKPANVAMGC---KGSADERYFLVLDFGLAR--QYIADEDDGLKMRRPR-EKTYFRGTARYCSVAMHDRY . ..| .|.| | .| ..| .|..|||.||.| . | | . ... ||||..| .|. ..| ..| || .. |||| ||...| |.. KFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYC---NKGNELRTPRWTACGFRGTVRYAPLACHKGQ EQGRVDDLWALVYILAEMRCR-LAWHDVDDK--VE-IGEMKRKIHD----EVLFAKSPV-QMLSFVKTVRSTLFYHRPDYEKL ||.| ||. | ..|| . | |. ..|. || ... .|. . . .|.. | .. . . .. .. ||||... EQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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| Kinase | K06H7.8.AA | CK1 | 20-220 | 28 | 4.8e-34 | 114.66 | In-house | 1-206 (271) | Show / Hide |
Range on Protein: 20-220 Range on HMM: 1-206/271 Sequence Identity: 28% (62 aa) YKVVQKLGEGGCGSVFKVEDTSEKGQH--YALKVEFKSQDAGNILKMEVQILSQLIS------KKHVAKCVASGKK--ERYSYMVMTLLGESLDSLLKKH |.|..|.|.| | ....... .|. .| |.| . . . |. |..|. .| ...... .|. . | .|||.|||.||..|... YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHP-QLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFC GPFLNVSTQVRIGICILFGIKQVHDIGYLHRDLKPANVAMGCKGSADERYFLVLDFGLARQYIADEDDGLKMR-----RPREKTYFRGTARYCSVAMHDR . . . | . |. .. | || ...|||.|| | || .| . ... ||||| .|. ... ||. . ||||| |. .| NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYII-DFGLAKRYR-------DDKTHQHIPYRENKNLTGTARYASINTHLG YEQGRVDDLWALVYIL .||.| ||. .| |.| IEQSRRDDMESLGYVL |
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| Kinase | K06H7.8.AA | CK1-Unclassified | 20-176 | 28 | 1.1e-32 | 93.8 | In-house | 1-164 (244) | Show / Hide |
Range on Protein: 20-176 Range on HMM: 1-164/244 Sequence Identity: 28% (47 aa) YKVVQKLGEGGCGSVFKVEDTSEKGQHYALKVEFKSQDAGNILKMEVQILSQLISKK-------HVAKCVASGKK--ERYSYMVMTLLGESLDSLLKKHG |.|..|.| | | ..|. .. .. ...|.|.| | . |. |..|. .| . ...|. .|. ..| .|||.|||.||..|... . YRVIEKIGQGSFGEIYKCINMQTN-EEVAIKLEKKNSK-HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCN PFLNVSTQVRIGICILFGIKQVHDIGYLHRDLKPANVAMGCKGSADERYFLVLDFGLARQYIA-DED ... | |. .. | ..| ...|||.|| | || | . ... ||||. || |.. RKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYII-DFGLSKRYIDMDKT |
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| Kinase | K06H7.8.AA | CK1-Unique | 20-220 | 21 | 8.3e-27 | 89.98 | In-house | 1-220 (337) | Show / Hide |
Range on Protein: 20-220 Range on HMM: 1-220/337 Sequence Identity: 21% (49 aa) YKVVQKLGEGGCGSVFKVEDTSEK-----GQHYALKVEFKSQDAG----NILKMEVQILSQLI--SK--KHVAKCVASGKKERYSYMVMTLLGESLDSLL ..| ..| || | | .| . . |. | | .. |.. . .. . | .|. . ... ....|||..| |.... WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC KKHGP-FLNVS------TQVRIGICILFGIKQVHDIGYLHRDLKPANVAMGCKGSADERYFLVLDFGLARQ--YIADEDDGLKMRRPREKTYFRGTARYC . .. . . .. | .|..| | |..||..||.|. . .... . .||.| | . . .| ||..| |||. .|| MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFV---SNNHQIRQPRPITPFRGCKDYC SVAMHDRYEQGRVDDLWALVYIL . . | |.|| ||. ..| | PCSCHQCREHGRRDDMESWFYML |
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| Kinase | K06H7.8.AA | Dual | 20-220 | 29 | 5.3e-24 | 77.49 | In-house | 1-213 (282) | Show / Hide |
Range on Protein: 20-220 Range on HMM: 1-213/282 Sequence Identity: 29% (65 aa) YKVVQKLGEGGCGSVFKVEDTSE---KGQHYALKVEFKSQDAGNILKMEVQILSQLISK----------KHVAKCVASGK--KERYSYMVMTLLGESLDS |||. || || . | .| . | | ..|.||.| . .... ... |.. | || . . |.|| . | ||. WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQE LLKKHG-PFLNVSTQVRIGICILFGIKQVHDIGYLHRDLKPANVAMGCKGSADERYFLVLDFGLARQYIADED-DGLKMRRPREKTYFRGTARYCSVAMH ..| . |.... ..| | |. | ||||||. |||| . | .|| .||...| || | | | .| | . |..|| . | IRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLG--MDETTVYMQDFRIVRKYI---DPENKKHRTARKKVKMYGCGRYACRACM DRYEQGRVDDLWALVYIL .||| ||| . .| . MQKDQGRKDDLECWIYMV |
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| Kinase | K06H7.8.AA | CK1-A | 20-279 | 29 | 2.3e-21 | 72.15 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 20-279 Range on HMM: 1-261/261 Sequence Identity: 29% (78 aa) YKVVQKLGEGGCGSVFKVEDTSEKGQHYALKVEFKSQDAGNILKMEVQILSQLISKKHVAKCVASGKKERYSYMVMTLLGESLDSLLKKHGPFLNVSTQV |..|.|.| | | .. . . ..|. |.|.| . . | | .. .| . . |. | ||| ||| ||. | . | . YRLVRKIGSGSFGDIY-LGINITNGEEVAIKME-SNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVL RIGICILFGIKQVHDIGYLHRDLKPANVAMGCKGSADERYFLVLDFGLARQYIADEDDGLKMRRPREKTYFRGTARYCSVAMHDRYEQGRVDDLWALVYI . .. | || ...|||.|| | || | . ||. |||||..| |. . || ||||| |. | || | ||. .. |. MLADQMIMRIEYVHEKNFIHRDIKPDNFLMGI-GRHCNKLFLI-DFGLAKKY-RDSRTRQHIPY-REDKNLTGTARYASINAHLGIEQSRRDDMESMGYV LAEM-RCRLAWHDV-----DDKVE-IGEMKRKIHDEVLFAKSPVQMLSFVKTVRSTLFYHRPDYEKL . | .| | . | | | | | . |.| .| .. ... .|. | ||| | MMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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| Kinase | K06H7.8.AA | CK1-G | 20-216 | 32 | 7.5e-18 | 57.01 | In-house | 1-194 (266) | Show / Hide |
Range on Protein: 20-216 Range on HMM: 1-194/266 Sequence Identity: 32% (64 aa) YKVVQKLGEGGCGSVFKVEDTSEKGQHYALKVEFKSQDAGNILKMEVQILSQLISKK-HVAKCVASGKKERYSYMVMTLLGESLDSLLKKHGPFLNVSTQ |.| | |.| | .| . . . | | | | .| |. | . .| .. . . | | ||| ||| || | . | | YRVGKKIGCGNFGELFEGKNMYN-NEHVAIKFEPMKSRAPQ-LHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTV VRIGICILFGIKQVHDIGYLHRDLKPANVAMGCKGSADERYFLVLDFGLARQYIADEDDGLKMRRP-REKTYFRGTARYCSVAMHDRYEQGRVDDLWAL . . | .. ...||. . || || | | ... |.. . |||.|.||| | | | ||. ||||| |. | || | ||. || CMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYI---DPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEAL |
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| Kinase | K06H7.8.AA | S_TKc | 20-287 | 21 | 3.5e-15 | 45.75 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 20-287 Range on HMM: 1-231/231 Sequence Identity: 21% (60 aa) YKVVQKLGEGGCGSVFKVEDTSEKGQHYALKVEFKSQDAGNILKMEVQILSQLISKKHVAKCVASGKKERYSYMVMTLLGE---SLDSLLKKHGPF---- |....|.|.|. |.|.|. ... |...|.|. . .. |.|||.. ... |. . . |||| ... .| ...||.|. YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF -LNVSTQVRIGICILFGIKQVHDIGYLHRDLKPANVAMGCKGSADERYFLVLDFGLARQYIADEDDGLKMRRPREKTYFRGTARYCS--VAMHDRYEQGR .. . .. |. ... |. | .||||||.|. . . |||||||. | | || |.. | |. PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL----------------TTFCGTPWYMAPEVL-----GYGK -VDDLWALVYILAEMRC-RLAWHDVDDKVEIGEMKRKIHDEVLFAKSPVQMLSFVKTVRSTLFYHRPDYEKLFK-----LLEDVM | |.. ||.|| | . .. .. .| .|| . ....|.. .|| .... . . CKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | K06H7.8.AA | Pkinase | 20-226 | 25 | 4.8e-11 | 40.12 | Pfam | 1-208 (293) | Show / Hide |
Range on Protein: 20-226 Range on HMM: 1-208/293 Sequence Identity: 25% (56 aa) YKVVQKLGEGGCGSVFKVEDTSEKGQHYALKVEFKSQDAGNILKM-----EVQILSQLISKKHVAKCVASGKKERYSYMVMTLLGE-----SLDSLLK-- |....|.|.|. |.|.| . .. |. .|.|. |. . . .. |.||. | . ... .. . ... |||| ... .| .... YHIGRKIGSGSFGCVYKCHHKGT-GKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW KHGPF-LNVSTQVRIGICILFGIKQVHDIGYLHRDLKPANVAMGCKGSADERYFLVLDFGLARQYIADEDDGLKMRRPREKTYFRGTARYCSVAMHD-RY .||.| . . .. || |.. |. | .||||||.|. . .| |. . . |||||.|. . . | | || .|.. . . RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFD--------Y-NNS-MTTFCGTPWYMAPEVIRGGQ EQGRVDDLWALVYILAEMRCR . |. | |.. ||.|| |. YYGPKVDMWSCGCILYEMLCG |
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| Kinase | K06H7.8.AA | CK1-Unclassified | 185-220 | 50 | 3.5e-09 | 23.28 | In-house | 171-206 (244) | Show / Hide |
Range on Protein: 185-220 Range on HMM: 171-206/244 Sequence Identity: 50% (18 aa) REKTYFRGTARYCSVAMHDRYEQGRVDDLWALVYIL ||. . ||||| |. .| .||.| ||| .| |.| RENKNLTGTARYASINAHLGIEQSRRDDLESLGYVL |
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| Kinase | K06H7.8.AA | CK1-G | 238-279 | 36 | 1.1e-07 | 21.97 | In-house | 223-266 (266) | Show / Hide |
Range on Protein: 238-279 Range on HMM: 223-266/266 Sequence Identity: 36% (16 aa) IGEMKRKIHDEVLFAK--SPVQMLSFVKTVRSTLFYHRPDYEKL ||. |||. |.| |.|. . . ||. | |||. | IGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL |
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| Kinase | K06H7.8.AA | CK1 | 238-277 | 26 | 1e-06 | 19.02 | In-house | 231-271 (271) | Show / Hide |
Range on Protein: 238-277 Range on HMM: 231-271/271 Sequence Identity: 26% (11 aa) IGEMKRKIHDEVLFAK-SPVQMLSFVKTVRSTLFYHRPDYE |.|.|... |.|.. |... . . .|. |. .|||. IMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM |
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| Kinase | K06H7.8.AA | TyrKc | 20-245 | 17 | 6.7e-05 | -143.43 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 20-245 Range on HMM: 1-280/280 Sequence Identity: 17% (50 aa) YKVVQKLGEGGCGSVFKVEDTSEKGQHYALKV---EFKSQDAGNILKMEVQILSQL-ISKKHVAKCVASGKKE-------RYSYMVMTLL-GESLDSLLK . .||||| | |.| . . ..| |. . | .|...| . ... .... .. ..|| . . .|.. |. ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR KHGPFLNVSTQVRIGICILFGIKQVHDIGYLHRDLKPANVAMGCKGSADERYFLVLDFGLARQYIAD------EDDGLKMRRPREK-------------T ||.| |.... . . . | | |. .. |||| |. | .. . ||||.| | .| |. . .| KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN YF--------------------RGTARYCS--------VAMHDRYEQGRVDDLWALVY------ILAEMRCRLAW---HDVDDKVEIGEMKRKI | .| | .. . .||. . . .| .|| . .| .| | .... YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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