Gene K11C4.1 (Nematode worm)
K11C4.1
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
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K11C4.1.kin_dom | Protein Kinase Domain | Sugen global kinase HMM prediction | 255 | Kinase domain by global Sugen HMM | Fasta, JSON |
K11C4.1.AA | Protein | Genbank | 308 | None | Fasta, JSON |
Protein domains of K11C4.1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | K11C4.1.AA | Worm6 | 19-281 | 41 | 5.1e-124 | 418.32 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 19-281 Range on HMM: 1-279/279 Sequence Identity: 41% (115 aa) FTVFKKLGEGTFGAVYAVRDDAGAE---HALKAEL--ATEKIPLLKLELYVMQKLSMKGPKHMATLIDKGRHEN--FNYIVMKFLGKSLQDAKKTGPDGH ..| ||.|||.||||| | |. . . |.|.| ...|.. ||.|..|.... .. .| ...|.|. .| ||||||...||.|.| .|. ||.. WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK LTLGSAIGASIQCLEALEELHWCGFLHRDVKPGNFCLGR---AELGELRKIFVLDFGLCR--KFVDDRNVMLQPR-RKAPYRGTPRYAPIASHNRAEHGR ...| ... .||||||.|.||.|||.|||||||||| || .|..|...|. ||||.|| |. .. |.. .|| ....|||.||||.|.|.. |..| FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR KDDVESWFYMLVDFTNAALPWKVVNEIPQVGEMKKNSRFDP---LVTQLLAGCPVDEYRLIMNHIDGLSFFMEPNYGLI |||.||||||.|... |||. ... .|. || | . . ......|| .|.. || ||..|.. .|.| | KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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Kinase | K11C4.1.AA | CK1 | 19-281 | 29 | 1.6e-108 | 366.82 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 19-281 Range on HMM: 1-339/339 Sequence Identity: 29% (99 aa) FTVFKKLGEGTFG-AVYAV-----RDDAG------AEHALKAELA-TEKIPLLKLELYVMQKLSMKG---------PKHMAT----------LIDKGRHE ..| ||.||| || ..| | .| . | |.|.| . ... . ...|.|.|.|. .| ||. . ....|. . WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED N-FNYIVMKFLGKSLQDAKK--TGPDGHLTLGSAIGASIQCLEALEELHWCGFLHRDVKPGNFCLGRAE-----------LGELRKIFVLDFGLCR-KFV . .||.|| ||..|.| .| . ........... ||.|||||..|.|||.|||.||.|||.||.| .|.|.....|||..| |.. DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR DDRN------------VMLQPRR---KAPYRG-TPRYAPIASHNRAEHGRKDDVESWFYMLVDFTNAA--LPWKVVNEIPQ-----VGEMKKNSR--FDP |... .. .||. |...|| |.||..|..|.. |.||.||..||||||.... |||. ... . |..||.... . . DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM LVTQLLAGCPVD------EYRLIMNHIDGLSFFMEPNYGLI ..... ..|| . |. ||..|..|... .|.| | STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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Kinase | K11C4.1.AA | TTBKL | 19-285 | 33 | 2.5e-82 | 277.76 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 19-285 Range on HMM: 1-288/288 Sequence Identity: 33% (96 aa) FTVFKKLGEGTFGAVY--AVRDDAGAEHALKAELAT-EKIP-LLKLELYVMQKLSMKGPKHMATLIDKGRHENFNYIVMKFLGKSLQDAKKTGPDGH-LT ... |..||| ||.|| .. |.. . |.|.|. . |... .|.|..|. ||...| .| ..... |. ...|..|| .|..||| .|. | .. .. WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS LGSAIGASIQCLEALEELHWCGFLHRDVKPGNFCLGRAEL-GEL-RKIFVLDFGLCRKFVDDRN-----------VMLQPRR---KAPYRGTPRYAPIAS |.. .||||.|| ..| |||.||||||.|.|.| . .| | ....|||..|..... . | ||. ||| |||.||. .. DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM HNRAEHGRKDDVESWFYMLVDFTNAALPWKVVNEIPQVGEMKKNSRFDPLVTQLL--AGCPVDEYRLIMNHIDGLSFFMEPNYGLIYSTL |.|.| ||.|| ||.||.. . |||. ... ....||||. . | . ..|| .| .| |. |.. ..|.|. || . HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCP-SEFCKFMKHLRSLRYYDRPDYEMIYECF |
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Kinase | K11C4.1.AA | TTBK | 19-281 | 40 | 2.2e-69 | 236.79 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 19-281 Range on HMM: 1-257/257 Sequence Identity: 40% (106 aa) FTVFKKLGEGTFGAVYAVRDDAGA-EH-ALKAELATEKIPLLKLELYVMQKLSMKGPKHMATLIDKGRHENFNYIVMKFLGKSLQDAKKTGPDGHLTLGS .| || | | || .| | |. |.| | | . ||.| |..|| . .| | ||...|||.||. .||.| | |.| .|.. WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGC--DHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLST AIGASIQCLEALEELHWCGFLHRDVKPGNFCLGRAELGELRKIFVLDFGLCRKFVDDRNVMLQPRRKAPYRGTPRYAPIASHNRAEHGRKDDVESWFYML .. .| |...|. | ||||||.|| || .||. . ||.. ||||| |... || | .||| ||| | .| | ||.|| | |||| TLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPS-TCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYML VDFTNAALPWKVVNEIPQVGEMKKNSRFDPLVTQLLAGCPVDEYRLIMNHIDGLSFFMEPNYGLI | | . ||| . ||||||. ..| . || || | .. |.|| | .. |.| || VEFVQGQLPWRKIKDKDQVGEMKE--KYDHRM--LLKHCP-HEFHQFMDHIKSLNYEDRPDYQLI |
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Kinase | K11C4.1.AA | CK1-Unique | 19-233 | 30 | 4.3e-50 | 171.82 | In-house | 1-239 (337) | Show / Hide |
Range on Protein: 19-233 Range on HMM: 1-239/337 Sequence Identity: 30% (73 aa) FTVFKKLGEGTFGAVYAVRDDAGA-------EHALKAELATEKIP--LLKLELYVMQKLSMKG-----PKHMATLIDKGRHENFNYIVMKFLGKSLQDAK . |.|..| | .| |. | . . ... | | . . .|. |. || .. .|. ..| . | .||| ..|.|. . WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC KTGPDG-HLTLG------SAIGASIQCLEALEELHWCGFLHRDVKPGNFCLGRAELGELRKIFVLDFGLCRK--FVDDRNVMLQPRRKAPYRGTPRYAPI . . ||. || . |||...| || ||.||. ||.|.|.. . ... ...||.| ||. ||. ... ||| ..|.||...|.|. MM-MKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPC ASHNRAEHGRKDDVESWFYMLVDFTNAA--LPWKVVNEIP ..| ||||.|| |||||||.. | ||. || SCHQCREHGRRDDMESWFYMLYHLVHNTRGLSWKLDKIIP |
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Kinase | K11C4.1.AA | CK1-A | 19-281 | 29 | 6.6e-32 | 109.95 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 19-281 Range on HMM: 1-261/261 Sequence Identity: 29% (80 aa) FTVFKKLGEGTFGAVY-AVRDDAGAEHALKAELATEKIPLLKLELYVMQKLSMKGPKHMATLIDKGRHENFNYIVMKFLGKSLQDAKKTGPDGHLTLGSA . . .|.| | || .| .. | | |.| | . . | | | | . | .| . .. |. ..| .|| || || | . . |. YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRIL--QGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFC-KRRFTMKTV IGASIQCLEALEELHWCGFLHRDVKPGNFCLGRAELGELRKIFVLDFGLCRKFVDDR-NVMLQPRRKAPYRGTPRYAPIASHNRAEHGRKDDVESWFYML . | . .| .| .|.|||.|| || .| |.|..|||| .|. | | .. | || ||| | | | |.||.|| |.. LMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGR--HCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVM VDFTNAALPWKVVNEIPQVGEMKKNS--RFDPLVTQLLAGCPVDEYRLIMNHIDGLSFFMEPNYGLI . | . |||. . . | | . . || | | |. ..||.. .| | .|.| . MYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPA-EFCMYMNYCRNLRFEEQPDYMYL |
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Kinase | K11C4.1.AA | Dual | 19-227 | 32 | 4.5e-30 | 98.23 | In-house | 1-226 (282) | Show / Hide |
Range on Protein: 19-227 Range on HMM: 1-226/282 Sequence Identity: 32% (75 aa) FTVFKKLGEGTFGAVYAVRDDAG-----AEHALKAEL-ATEKIPL-LKLELYVMQKLSM-----K--GPKHMATLIDKGRHEN--FNYIVMKFLGKSLQD | . || | |. || |... .|| | || | || | || | . | | |. ..| | | .|.|| | |||. WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQE AKKTGPDGHLTLGSAIGASIQCLEALEELHWCGFLHRDVKPGNFCLGRAELGEL-RKIFVLDFGLCRKFVD-DRNVMLQPRRKAPYRGTPRYAPIASHNR . | |. . || |.|. || |.|||..|| || | ||. ... .||.. ||..| . .| | . |. ||| .| . IRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCG---LGMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQ AEHGRKDDVESWFYMLVD-FTNAA-LPWK . |||||.|.| ||. | . .. ..|. KDQGRKDDLECWIYMVFDLMDPEHGMSWR |
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Kinase | K11C4.1.AA | CK1-D | 19-281 | 28 | 2e-28 | 97.34 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 19-281 Range on HMM: 1-261/261 Sequence Identity: 28% (77 aa) FTVFKKLGEGTFGAVYAVRD-DAGAEHALKAELATEKIPLLKLELYVMQKLSMKGPKHMATLIDKGRHENFNYIVMKFLGKSLQDAKKTGPDGHLTLGSA . . .|.| | || .| . .. | |.| | . | | |..| . . |.| . .. |. ..| .|| || || | . . | YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYK--MMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYC-HRKFSLKTV IGASIQCLEALEELHWCGFLHRDVKPGNFCLGRAELGELRKIFVLDFGLCRKFVDDR-NVMLQPRRKAPYRGTPRYAPIASHNRAEHGRKDDVESWFYML . . | . .| .| |.|||.|| || .| |.. ....|||| ... | | . | . || ||| | | | |.||.|| |.| LMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNM--VYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVL VDFTNAALPWKVVNEIP--QVGEMKKNSRFDPLVTQLLAGCPVDEYRLIMNHIDGLSFFMEPNYGLI . | .|||. . . | | . . . . .| .| | |. ||. | | |.| . MYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPS-EFQQYMNYCRNLKFDDKPDYCYL |
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Kinase | K11C4.1.AA | CK1 | 123-226 | 37 | 7.2e-17 | 54.78 | In-house | 113-216 (271) | Show / Hide |
Range on Protein: 123-226 Range on HMM: 113-216/271 Sequence Identity: 37% (39 aa) QCLEALEELHWCGFLHRDVKPGNFCLGRAELGELRKIFVLDFGLCRKFVDDR-NVMLQPRRKAPYRGTPRYAPIASHNRAEHGRKDDVESWFYMLVDFTN | .. .| .| ..|.|||.|| ||. || . .... |||| ...||. . . | . . || ||| | .| | .|.|| || |.|. | QMIQRIEYVHNKNFIHRDIKPDNFLMGR-YGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDMESLGYVLMYFLR AALPW ||| GSLPW |
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Kinase | K11C4.1.AA | CK1-Unclassified | 19-102 | 30 | 1.8e-15 | 42.14 | In-house | 1-92 (244) | Show / Hide |
Range on Protein: 19-102 Range on HMM: 1-92/244 Sequence Identity: 30% (28 aa) FTVFKKLGEGTFGAVYAVRDD-AGAEHALKAELATEKIPLLKLELYVMQKLSMKG-----PKHMATLIDKGRH--ENFNYIVMKFLGKSLQD . | .|.| | || .| . . . | |.| | .. |.|.|. | ..|| | .|. . .. |. ...|..|| .||.|| | YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLED |
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Kinase | K11C4.1.AA | CK1 | 19-102 | 25 | 6e-13 | 41.1 | In-house | 1-93 (271) | Show / Hide |
Range on Protein: 19-102 Range on HMM: 1-93/271 Sequence Identity: 25% (24 aa) FTVFKKLGEGTFGAVYAVRDDAGAEH----ALKAELATEKIPLLKLELYVMQKLSM---KG-PKHMATLIDKGRH--ENFNYIVMKFLGKSLQD . | .|.|.| || .| . . .. | | | .. | |.|. | .... | . .. .... |. ...|..|| .||.|| | YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLED |
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Kinase | K11C4.1.AA | CK1-Unclassified | 123-175 | 34 | 8.7e-13 | 34.09 | In-house | 112-164 (244) | Show / Hide |
Range on Protein: 123-175 Range on HMM: 112-164/244 Sequence Identity: 34% (19 aa) QCLEALEELHWCGFLHRDVKPGNFCLG-RAELGELRKIFVLDFGLCRKFVD-DRN | .. .| || ..|.||| || ||. | . .. ... |||| ...| |.. QMIQRIEYLHNKNFIHRDIKPDNFLMGKLG--KNHHQVYIIDFGLSKRYIDMDKT |
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Kinase | K11C4.1.AA | S_TKc | 19-273 | 23 | 8.3e-12 | -3.75 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 19-273 Range on HMM: 1-231/231 Sequence Identity: 23% (63 aa) FTVFKKLGEGTFGAVYAVRDDA-GAEHALKAELATEKIPLLKLELYVMQKLSMKGPKHMATLIDKGRHENFNYIVMKFLGK---SLQD-AKKTGPDGH-- ... .|.|.|.|| || .|. | . |.| .. |. ...| . .. .|.| .. .. |.|| ... .| | || |. | YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF -LTLGSAIGASIQCLEALEELHWCGFLHRDVKPGNFCLGRAELGELRKIFVLDFGLCRKFVDDRNVMLQPRRKAPYRGTPRYAPIASHNRAEHGR-KDDV .. | | ..||| .| |..|||.|| | | . | . ||||.|.. . ||| | . .|. | |. PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDW ESWFYMLVDFTNAALPWKVVNEIPQVGEMKKNSRFDPLVTQLLAGCPV-D-EYRLIMNHIDG-------LSFF | .| . |. |. .| |. . .| . ... .| . | | |. . .| WSCGCILYEMLCGYPPFP------QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | K11C4.1.AA | Pkinase | 19-194 | 22 | 5.9e-07 | 25.67 | Pfam | 1-179 (293) | Show / Hide |
Range on Protein: 19-194 Range on HMM: 1-179/293 Sequence Identity: 22% (43 aa) FTVFKKLGEGTFGAVYAVRDDAGAE-HALKAELATEKIPLLK----L--ELYVMQKLSMKGPKHMA--TLIDKGRHENFNYIVMKFLGK-----SLQDAK ... .|.|.|.|| || .. . |.| .. . . . |...|..|. | .|.| . .. |.|| .... .| | YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-----HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI KTGPDGHL--TLGSAIGASIQCLEALEELHWCGFLHRDVKPGNFCLG-RAELGELRKIFVLDFGLCRKFVDDRNVMLQPRRKAPYRGTPRYAP .| .| . . .. | |..|| .| .|..|||.|| |. . . .... .. . ||||...| . . |||.|.. STWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMA |
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Kinase | K11C4.1.AA | CK1-Unclassified | 188-226 | 48 | 1.4e-05 | 12.5 | In-house | 178-216 (244) | Show / Hide |
Range on Protein: 188-226 Range on HMM: 178-216/244 Sequence Identity: 48% (19 aa) GTPRYAPIASHNRAEHGRKDDVESWFYMLVDFTNAALPW || ||| | .| | .|.|| || | |. | ||| GTARYASINAHLGIEQSRRDDLESLGYVLIYFLKGSLPW |
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Kinase | K11C4.1.AA | TyrKc | 19-285 | 18 | 0.000308 | -154.1 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 19-285 Range on HMM: 1-280/280 Sequence Identity: 18% (59 aa) FTVFKKLGEGTFGAVYAVRDDAGAEHALKAELATEKIPLLKLELYVMQKL--------SMKGPKHMATLID-------KGRHENFNYIVMKFLGKSLQDA | |||||| || || . . . | | . . . |. .| || . | . . . . . | | . |.. ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYG----VCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH KKTGPDGHLTLGSAIGASIQCLEALEELHWCGFLHRDVKPGNFCLGRAELGELRKIFVLDFGLCRKFVDD-----RNVMLQP----RRK--APYRGTPRY ... |.. . ..| . | || .. ||| | .|. . . ||||.|. || . . . .| |.| .. RPK-----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA-- APIASHNRAEHGRKDDVESWFYM----LVD-----------FTNAALPWKVV----NEIPQVGEMKKNSRFDPLVTQLLAG-----CPVDEYRLIMNHID |...| | ||. . |. . . .| | |. . | . || . |. || ----------------PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQ-IM---- GLSFFME-----PNYGLIYSTL .. .| |. |.. . -KQCWHEDPEDRPTFSEIHECF |
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Kinase | K11C4.1.AA | CK1 | 248-279 | 33 | 0.069126 | 2.52 | In-house | 240-271 (271) | Show / Hide |
Range on Protein: 248-279 Range on HMM: 240-271/271 Sequence Identity: 33% (11 aa) VTQLLAG-CPVDEYRLIMNHIDGLSFFMEPNYG | || .| .|. | .|.. .|.|. .|.| VEQLCKGNFPN-EFAMYLNYCRQLHFEEKPDYM |